Liver Cancer Clinical Trials

35 studies are recruiting for liver cancer in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Houston, Texas 6 Boston, Massachusetts 5 Cleveland, Ohio 5 Los Angeles, California 4 San Francisco, California 4 Orange, California 3 Philadelphia, Pennsylvania 3 Pittsburgh, Pennsylvania 3

Studies now recruiting

  1. REGULUS: MRI-guided Adaptive SABR for Liver Cancers

    Single arm unblinded study of simulation-free MRI-guided SABR with adaptive replanning in one session for treatment of patients with liver cancers

    Stage
    Phase 2
    Ages
    18 and older
    Site
    Stanford University, Palo Alto, California
    Run by
    Stanford University

    See if you can join NCT07223307 on ClinicalTrials.gov

  2. Interventional Radiology Liver Directed Therapies and Hypofractionated Image-Guided Radiation Therapy in Veteran and Non-Veteran, Non-surgical Hepatocellular Carcinoma Patients

    This is a research study to evaluate change in Quality of Life, as defined by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 (EORTC C-30), from baseline to 1 month post treatment in two patient cohorts receiving Interventional Radiology Liver Di…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Durham Veterans Administration Health Care System (DVAHCS), Durham, North Carolina
    Locations
    2 in total
    Run by
    Duke University

    See if you can join NCT04933435 on ClinicalTrials.gov

  3. Collection of Blood From Patients With Cancer

    This study will collect blood from patients with cancer to study the level of cells which decrease the immune response (suppressor cells) before and after chemotherapy. Patients 18 years of age and older with cancer may participate. This study does not involve treatment. Participants will have abou…

    Stage
    Not phased
    Ages
    18 and older
    Site
    National Institutes of Health Clinical Center, Bethesda, Maryland
    Run by
    National Cancer Institute (NCI)

    See if you can join NCT00034216 on ClinicalTrials.gov

  4. Follow-Up Study of Subjects Previously Enrolled in Poxviral Vector Gene Transfer Studies

    This study aims to provide long-term follow-up care of patients previously enrolled in a vaccine study that involved poxviral vectors. Vectors are sequences of genetic material that can be used to introduce specific genes into genetic makeup. The study does not involve the use of any drug or biolog…

    Stage
    Not phased
    Ages
    18 and older
    Site
    National Institutes of Health Clinical Center, Bethesda, Maryland
    Run by
    National Cancer Institute (NCI)

    See if you can join NCT00451022 on ClinicalTrials.gov

  5. Distance-Based Exercise to Preserve Function and Prevent Disability

    This clinical trial studies whether an exercise program can be successfully delivered to patients receiving treatment for cancer through virtual sessions and allow patients to exercise in their own home. Treatments for cancer can cause side effects such as fatigue and loss of strength. These side e…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Kaiser Permanente Dublin, Dublin, California
    Locations
    23 in total
    Run by
    Alliance for Clinical Trials in Oncology

    See if you can join NCT07059884 on ClinicalTrials.gov

  6. National Liver Cancer Screening Trial

    The National Liver Cancer Screening Trial is an adaptive randomized phase IV Trial comparing ultrasound-based versus biomarker-based screening in 5500 patients with cirrhosis from any etiology or patients with chronic hepatitis B infection. Eligible patients will be randomized in a 1:1 fashion to A…

    Stage
    Phase 4
    Ages
    18 to 85
    Site
    University of Southern California, Los Angeles, California
    Locations
    19 in total
    Run by
    University of Texas Southwestern Medical Center

    See if you can join NCT06084234 on ClinicalTrials.gov

  7. DESTINY-PANTUMOUR04

    This study will evaluate the effectiveness of T-DXd in patients with HER2-positive (IHC 3+) locally advanced, unresectable, or metastatic solid tumors who have received prior systemic treatment for metastatic or advanced disease and have no satisfactory alternative treatment options in a real-world…

    Stage
    Not phased
    Ages
    18 to 130
    Site
    Research Site, Birmingham, Alabama
    Locations
    18 in total
    Run by
    AstraZeneca

    See if you can join NCT07124000 on ClinicalTrials.gov

  8. Protoacoustic Imaging For 3D Mapping

    The purpose of this study is to test a new imaging technology called radioacoustic imaging (RAI) that may help doctors see where radiation is being delivered during proton therapy. During proton therapy, the radiation treatment produces very small sound signals inside the body. This study will use …

    Stage
    Not phased
    Ages
    18 and older
    Site
    OU Health Stephenson Cancer Center, Oklahoma City, Oklahoma
    Run by
    University of Oklahoma

    See if you can join NCT07832617 on ClinicalTrials.gov

  9. EQUITY GI: A Prospective Study to Enhance Quality, Inclusivity, and Trial Participation in Black Patients With Gastrointestinal Cancer.

    This research study is being conducted to improve the quality of care of participants who have a diagnosis of gastrointestinal cancer (anal, colon, rectal, esophageal, stomach, small bowel, appendix, pancreas, gall bladder, liver, neuroendocrine tumor of gastrointestinal origin). This study has 3 c…

    Stage
    Not phased
    Ages
    18 and older
    Site
    University Hospitals Cleveland Medical Center, Seidman Cancer Center, Case Comprehensive Cancer Center, Cleveland, Ohio
    Run by
    Case Comprehensive Cancer Center

    See if you can join NCT06263088 on ClinicalTrials.gov

  10. Histotripsy Plus Chemotherapy vs Chemotherapy Alone for Advanced Colorectal Liver Metastasis

    The goal of this clinical trial is to learn if histotripsy plus chemotherapy works to treat unresectable, bilobar liver- confined colorectal cancer liver metastasis (CRLM). The main question this clinical trial aims to answer is: • Does the management of this condition with uninterrupted palliative…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Cleveland Clinic, Case Comprehensive Cancer Center, Cleveland, Ohio
    Run by
    Case Comprehensive Cancer Center

    See if you can join NCT07044362 on ClinicalTrials.gov

  11. A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors

    AGX101 is an antibody-drug conjugate (ADC) therapy for tumor-forming cancers. The purpose of this study is to learn about AGX101 effects and safety at various dose levels in an all-comers advanced solid cancer patient population. AGX101will be administered intravenously. Dosing of AGX101 will be re…

    Stage
    Phase 1
    Ages
    18 and older
    Site
    USC/Norris Comprehensive Cancer Center, Los Angeles, California
    Locations
    7 in total
    Run by
    Angiex, Inc.

    See if you can join NCT06440005 on ClinicalTrials.gov

  12. Pre- and Post-operative TEG Indices in Patients With or Without Adenocarcinoma Undergoing Surgical Resection

    The investigators hypothesize that abnormalities in thromboelastography (TEG) parameters in patients with liver, pancreas, biliary, esophageal, colorectal, and lung adenocarcinoma can serve as biomarkers for oncologic disease burden, cancer recurrence and overall survival as well as thrombotic and …

    Stage
    Not phased
    Ages
    18 to 99
    Site
    University of Colorado Denver, Aurora, Colorado
    Locations
    2 in total
    Run by
    University of Colorado, Denver

    See if you can join NCT05517811 on ClinicalTrials.gov

  13. HepQuant: Study to Assess the Role of Blood-based Biomarkers and Quantitative MR Imaging for Patients Receiving Radiation Therapy for Liver Cancer

    This is a pilot and feasibility study assessing the role of quantitative multiparametric MRI and blood-based biomarkers for the measurement of liver function in patients receiving radiation therapy for liver cancer, including hepatocellular carcinoma (HCC), cholangiocarcinoma, or liver metastases r…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Montefiore Medical Center, The Bronx, New York
    Run by
    Montefiore Medical Center

    See if you can join NCT06899152 on ClinicalTrials.gov

  14. Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors

    Patients may be considered if the cancer has come back, has not gone away after standard treatment or the patient cannot receive standard treatment. This research study uses special immune system cells called CARE T cells, a new experimental treatment. The body has different ways of fighting infect…

    Stage
    Phase 1
    Ages
    1 to 21
    Site
    Texas Children's Hospital, Houston, Texas
    Run by
    Baylor College of Medicine

    See if you can join NCT04715191 on ClinicalTrials.gov

  15. Development and Testing of a Patient-facing Educational Tool About Liver Cancer Prevention

    To develop and test liver cancer prevention educational material.

    Stage
    Not phased
    Ages
    18 and older
    Site
    MD Anderson Cancer Center, Houston, Texas
    Run by
    M.D. Anderson Cancer Center

    See if you can join NCT07010315 on ClinicalTrials.gov

  16. DRAGON Registry - International Multicenter Registry and Medical Image Bank for Patients With Primarily Unresectable Liver Cancer or Liver Metastases That Underwent Combined Portal and Hepatic Vein Embolization (PVE/HVE) to Increase Future Liver Remnant Before Resection.

    The DRAGON registry aims to collect data on combined portal and hepatic vein embolization (PVE/HVE) for liver tumors, a technique expected to enhance liver regeneration compared to standard PVE. This collaborative registry focuses on identifying associations between baseline clinical/imaging parame…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Rush University Medical Center, Chicago, Illinois
    Locations
    31 in total
    Run by
    Maastricht University Medical Center

    See if you can join NCT07717437 on ClinicalTrials.gov

  17. Jump: MR Simulation For Radiation Therapy Master Protocol

    This is a master protocol for a prospective Phase I-II study evaluating feasibility and efficacy of incorporating magnetic resonance imaging (MRI) simulation into the planning of radiation treatments.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Brigham and Women Hospital, Boston, Massachusetts
    Locations
    2 in total
    Run by
    Brigham and Women's Hospital

    See if you can join NCT04545957 on ClinicalTrials.gov

  18. Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot Trial

    This is a phase 2a, randomized, double-blinded, placebo-controlled pilot clinical trial determining the impact of riluzole therapy on circulating brain derived neuropathic factor (BDNF) levels in cancer survivors (recently completing prior treatment regimens) or patients who have received whole bra…

    Stage
    Phase 2
    Ages
    18 and older
    Site
    Chao Family Comprehensive Cancer Center, University of California Irvine, Orange, California
    Run by
    University of California, Irvine

    See if you can join NCT06580002 on ClinicalTrials.gov

  19. Multi-analyte Blood Test Clinical Trial

    The objective of this study is the acquisition of whole blood samples and serum samples from participants with untreated Hepatocellular Carcinoma (HCC) and subjects undergoing Hepatocellular Carcinoma (HCC) surveillance. These samples will be used for research purposes to develop and validate the H…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Gastroenterology and Liver Institute, Escondido, California
    Locations
    7 in total
    Run by
    Helio Genomics

    See if you can join NCT05199259 on ClinicalTrials.gov

  20. ET140203 T Cells in Pediatric Subjects With Hepatoblastoma, HCN-NOS, or Hepatocellular Carcinoma

    Open-label, dose escalation, multi-center, Phase I/II clinical trial to assess the safety/tolerability and determine the recommended Phase II Dose (RP2D) of ET140203 T-cells in pediatric subjects who are AFP-positive/HLA-A2-positive and have relapsed/refractory HB, HCN-NOS, or HCC.

    Stage
    Phase 1
    Ages
    1 to 21
    Site
    Children's Hospital Los Angeles, Los Angeles, California
    Locations
    4 in total
    Run by
    Eureka Therapeutics Inc.

    See if you can join NCT04634357 on ClinicalTrials.gov

  21. Integrated Cancer Repository for Cancer Research

    The iCaRe2 is a multi-institutional resource created and maintained by the Fred \& Pamela Buffett Cancer Center to collect and manage standardized, multi-dimensional, longitudinal data and biospecimens on consented adult cancer patients, high-risk individuals, and normal controls. The distinct char…

    Stage
    Not phased
    Ages
    19 to 110
    Site
    Advent Health, Greenwood Village, Colorado
    Locations
    42 in total
    Run by
    University of Nebraska

    See if you can join NCT02012699 on ClinicalTrials.gov

  22. Predicting Response to Immunotherapy From Analysis of Live Tumor Biopsies (ELEPHAS-05)

    This study will collect tumor specimens with correlated clinical and demographic data from patients who are undergoing a biopsy or similar procedure to obtain tumor tissue as a normal course of their medical management or diagnostic work-up for suspected or confirmed cancer.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Mercy Hospital - FTS, Fort Smith, Arkansas
    Locations
    8 in total
    Run by
    Elephas

    See if you can join NCT07327489 on ClinicalTrials.gov

  23. Y-90 Treatment Response Using Transarterial Radioembolization

    This prospective clinical study will examine the ability of contrast-enhanced ultrasound (CEUS) to assess the treatment response of hepatocellular carcinoma (HCC) to transarterial radioembolization (TARE). HCC is the third leading cause of cancer mortality worldwide and the single fastest growing c…

    Stage
    Phase 2
    Ages
    18 and older
    Site
    Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University, Philadelphia, Pennsylvania
    Run by
    Thomas Jefferson University

    See if you can join NCT07145801 on ClinicalTrials.gov

  24. Brodalumab in the Treatment of Immune-Related Adverse Events

    The purpose of this study is to test the safety and effectiveness of using brodalumab in patients who develop side effects from cancer immune therapy. Immune-related side effects are due to activation of the immune system in patients who previously received immunotherapy and the goal of this study …

    Stage
    Phase 1
    Ages
    18 and older
    Site
    Columbia University Irving Medical Center, New York, New York
    Run by
    Brian Henick, MD

    See if you can join NCT06673329 on ClinicalTrials.gov

  25. 68Ga-PSMA-11 PET-directed Radioligand Therapy in Metastatic Hepatocellular Carcinoma (HCC)

    The purpose of this study is to look at the effects (good and bad) of a drug called 177Lu-PSMA-617 (also known as the study drug) when given to participants who have prostate specific membrane antigen (PSMA) positive liver cancer.

    Stage
    Phase 2
    Ages
    18 and older
    Site
    Case Comprehensive Cancer Center, University Hospitals Cleveland Medical Center, Seidman Cancer Center, Cleveland, Ohio
    Run by
    Melissa Lumish

    See if you can join NCT06852820 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.