Ischemic Stroke Clinical Trials

30 studies are recruiting for ischemic stroke in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

Search these by distance from you

By city

Studies now recruiting

1. Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY

   The overall goal of the DISCOVERY study is to better understand what factors contribute to changes in cognitive (i.e., thinking and memory) abilities in patients who experienced a stroke. The purpose of the study is to help doctors identify patients at risk for dementia (decline in memory, thinking…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Barrow Neurological Institute, Phoenix, Arizona

   Locations

   31 in total

   Run by

   Massachusetts General Hospital

   See if you can join NCT04916210 on ClinicalTrials.gov

2. Treatment of Acute Ischemic Stroke (ReMEDy2 Trial)

   This is a Phase 2/3 study evaluating the safety and efficacy of DM199 (rinvecalinase alfa) in treating participants with moderate stroke severity, who present within 24 hours of Acute Ischemic Stroke (AIS) onset due to small and medium vessel occlusions. This study focuses on participants with limi…

   Stage

   Phase 2

   Ages

   18 to 90

   Site

   Gulf Health Hospitals d/b/a Thomas Hospital, Fairhope, Alabama

   Locations

   86 in total

   Run by

   DiaMedica Therapeutics Inc

   See if you can join NCT05065216 on ClinicalTrials.gov

3. Global Blood-Brain Barrier Disruption and Post-Stroke Cognitive Decline

   The goal of this study is to gain a better understanding of why some individuals who have suffered a stroke experience post-stroke cognitive decline. Specifically this study is testing whether global disruption of the blood-brain barrier detected at the time of the stroke is informative about the r…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Johns Hopkins Hospital, Baltimore, Maryland

   Run by

   Johns Hopkins University

   See if you can join NCT05556395 on ClinicalTrials.gov

4. K01 Impacts of Lingual Endurance Exercise

   The goal of this clinical trial is to learn whether a tongue endurance exercise program can improve swallowing function in adults with dysphagia after a stroke. It also aims to explore how this exercise may affect brain structure and connectivity involved in swallowing. The main questions it aims t…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Cincinnati, Cincinnati, Ohio

   Run by

   University of Cincinnati

   See if you can join NCT06072924 on ClinicalTrials.gov

5. Post-Stroke Sensory Reweighting on Walking and Balance Outcomes

   The primary objective of this proof-of-concept study is to longitudinally track the development of post-stroke sensory reweighting (PSR), identify associated structural neuroanatomical correlates, and investigate their relationship to walking and fall outcomes.

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Cincinnati College of Medicine, Cincinnati, Ohio

   Run by

   University of Cincinnati

   See if you can join NCT06727097 on ClinicalTrials.gov

6. Strategy for Improving Stroke Treatment Response

   SISTER is a Phase-II, prospective, randomized, placebo-controlled, blinded, dose finding trial that aims to determine the safety and preliminary efficacy of TS23, a monoclonal antibody against the alpha-2 antiplasmin (a2-AP), in acute ischemic stroke.

   Stage

   Phase 2

   Ages

   18 and older

   Site

   University of Alabama Hospital, Birmingham, Alabama

   Locations

   52 in total

   Run by

   Translational Sciences, Inc.

   See if you can join NCT05948566 on ClinicalTrials.gov

7. Continuous Dual Aspiration Technique With Zoom System for Stroke

   This study is designed to evaluate the effectiveness, safety and clinical performance of ADAPT 2.0, first-line aspiration neurothrombectomy with Zoom System with Continuous Dual Aspiration Technique (CDAT).

   Stage

   Not phased

   Ages

   18 and older

   Site

   Huntsville Hospital, Huntsville, Alabama

   Locations

   17 in total

   Run by

   Imperative Care, Inc.

   See if you can join NCT07491952 on ClinicalTrials.gov

8. Feasibility of a Remotely Delivered Step Count Intervention in Chronic Stroke

   The goal of this study is to explore the feasibility of a new approach to rehabilitation that focuses on step count. Participants will complete 6 telephone or Zoom-based sessions with an occupational therapist over 6 weeks and use a step count tracker during that time. They will also complete quest…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Minnesota, Minneapolis, Minnesota

   Run by

   University of Minnesota

   See if you can join NCT07649135 on ClinicalTrials.gov

9. Platelet Expression of FcγRIIa and Arterial Hemodynamics to Predict Recurrent Stroke in Intracranial Atherosclerosis

   An observational study to determine if individuals with increased platelet FcyRIIa will have a higher risk of ischemic events.

   Stage

   Not phased

   Ages

   30 and older

   Site

   Ronald Reagan UCLA Medical Center, Los Angeles, California

   Run by

   University of California, Los Angeles

   See if you can join NCT05518305 on ClinicalTrials.gov

10. Recovery Trajectory for Coma and Disorders of Consciousness

    This study aims to better understand recovery after coma caused by serious neurologic illness or injury. Patients who are unconscious (in a coma or disorder of consciousness) due to conditions such as stroke, cardiac arrest, traumatic brain injury, seizures, brain infection, or other neurologic eme…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT07614074 on ClinicalTrials.gov

11. CTSN Embolic Protection Trial

    This is a prospective, multi-center, randomized effectiveness trial of the CardioGard Embolic Protection Cannula in high-risk valve surgery patients.

    Stage

    Not phased

    Ages

    60 and older

    Site

    CHI St. Vincent Heart Institute, North Little Rock, Arkansas

    Locations

    28 in total

    Run by

    Icahn School of Medicine at Mount Sinai

    See if you can join NCT06027788 on ClinicalTrials.gov

12. Testing the Effectiveness of a Novel Intervention to Improve Medication Adherence in Stroke Survivors

    The goal of this study is to test if Savvy, a multimodal intervention (consisting of psychological exercises, a weekly pill organizer, and a text message reminder system) can improve medication adherence in stroke survivors. The main questions it aims to answer are: * Can the Savvy tool improve med…

    Stage

    Not phased

    Ages

    18 to 99

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Massachusetts General Hospital

    See if you can join NCT07414732 on ClinicalTrials.gov

13. External Post-Operative Skull Prosthesis to Prevent Sunken Flap Syndrome in Craniectomy Patients

    Patients that undergo decompressive craniectomy are at risk of delayed changes in brain function known as "Sunken Flap Syndrome" or "Syndrome of the Trephined." The goal of this clinical trial is to see if placing a prosthetic over patients' skull defects can prevent "Sunken Flap Syndrome." The mai…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Johns Hopkins Bayview Medical Center, Baltimore, Maryland

    Locations

    2 in total

    Run by

    Johns Hopkins University

    See if you can join NCT06899711 on ClinicalTrials.gov

14. Michigan Initial Experience Using Tigertriever for Thrombectomy

    The purpose of this research study is to collect data about the effectiveness (i.e. how the device works) and safety (how safe it is to use such a device) of the Tigertriever in restoring blood flow by removing thrombus (or blood clot) from a large intracranial vessel (blood vessel in the brain) in…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Henry Ford Hospital, Detroit, Michigan

    Run by

    Henry Ford Health System

    See if you can join NCT07363525 on ClinicalTrials.gov

15. Implementation of Onsite Rapid CYP2C19 Assay for Genotype Guided Dual Antiplatelet Therapy After Acute Ischemic Stroke

    The goal of this observational study is to use a genetic test to help doctors prescribe the most effective medications after a patient has a stroke. One type of stroke is caused by a blood clot in brain vessels. After a patient has this kind of stroke, they are often given a combination of two bloo…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Virginia, Charlottesville, Virginia

    Run by

    University of Virginia

    See if you can join NCT06292117 on ClinicalTrials.gov

16. Imaging the Pathogenesis of Cerebral Small Vessel Disease

    Cerebral small vessel disease (CSVD) can lead to vascular cognitive impairment and dementia (VCID). The hallmark of CSVD is the appearance and progression of white matter hyperintensities (WMH) on MRI. The goal of this study it to recruit and follow individuals at risk for WMH progression and use s…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Kennedy Krieger Institute, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT05703386 on ClinicalTrials.gov

17. Personalized Transcranial Direct Current Stimulation in Stroke Recovery

    The central objective of this application is to explore the neural substrate of personalized tDCS (ptDCS) and to determine whether the paradigm for each stroke patient can predict the amount of sustained clinical improvement through increased connectivity as measured by a biomarker of plasticity.

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Houston Methodist Hospital, Houston, Texas

    Run by

    The Methodist Hospital Research Institute

    See if you can join NCT06286800 on ClinicalTrials.gov

18. Combined Thrombectomy for Distal MediUm Vessel Occlusion StroKe

    A phase III, randomized, multi-center, investigational, open label clinical trial that will examine whether treatment with endovascular thrombectomy is superior to standard medical therapy alone in patients who suffer a Distal Medium Vessel Occlusion Ischemic Stroke within 12 hours from time last s…

    Stage

    Not phased

    Ages

    18 and older

    Site

    UI Health Care Medical Center, Iowa City, Iowa

    Locations

    4 in total

    Run by

    Raul Nogueira

    See if you can join NCT05983757 on ClinicalTrials.gov

19. Augmented Renal Clearance in Neurocritical Care

    Stroke, severe brain injury, uncontrolled seizures and brain infections are the most common life-threatening neurological illnesses in the world with an estimated combined annual hospital management cost of up to 44 billion dollars. Seizures and infections are common complications following acute n…

    Stage

    Not phased

    Ages

    18 to 85

    Site

    UK HealthCare, Lexington, Kentucky

    Locations

    3 in total

    Run by

    University of Alberta

    See if you can join NCT07410624 on ClinicalTrials.gov

20. A Study Of Vagus Nerve Stimulation (VNS) With Mobility Training For Gait Recovery After Chronic Ischemic Stroke

    The purpose of this study is to evaluate the safety, feasibility, and efficacy of vagus nerve stimulation (VNS) paired with mobility training to improve lower extremity function and gait in individuals with chronic ischemic stroke.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mayo Clinic in Rochester, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT07291024 on ClinicalTrials.gov

21. Psychedelic Healing: Adjunct Therapy Harnessing Opened Malleability

    The main purpose of the current studies is to evaluate the safety and tolerability of psilocybin in patients with chronic stroke.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Johns Hopkins, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT07053917 on ClinicalTrials.gov

22. Adjunctive Intra-arterial Tenecteplase Following Mechanical Thrombectomy (ALLY) II Trial

    The study objective is to evaluate the safety and efficacy of Intra arterial (IA) Tenecteplase (TNK) as an adjunctive therapy in acute ischemic stroke (AIS) patients with large vessel occlusions (LVO) in the anterior circulation of Internal Carotid Artery (ICA), Middle Cerebral Arteries (M1 and M2)…

    Stage

    Phase 2

    Ages

    18 to 85

    Site

    ProMedica Toledo Hospital, Toledo, Ohio

    Run by

    ProMedica Health System

    See if you can join NCT06949228 on ClinicalTrials.gov

23. Transcranial Direct Current Stimulation and Rehabilitation to Ameliorate Impairments in Neurocognition After Stroke

    The purpose of this study is to determine whether a non-invasive brain stimulation technique, transcranial direct current stimulation (tDCS), combined with traditional cognitive therapy will improve cognitive function in patients with subacute stroke.

    Stage

    Not phased

    Ages

    18 to 90

    Site

    Penn Medicine Rehabilitation, Philadelphia, Pennsylvania

    Run by

    University of Pennsylvania

    See if you can join NCT04897334 on ClinicalTrials.gov

24. StrokeNet Thrombectomy Endovascular Platform

    STEP is a Randomized, Multifactorial, Adaptive Platform trial that seeks to optimize the care of patients with acute ischemic stroke (AIS) due to large (LVO) or medium vessel occlusions (MVO).

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Alabama Hospital, Birmingham, Alabama

    Locations

    41 in total

    Run by

    Medical University of South Carolina

    See if you can join NCT06289985 on ClinicalTrials.gov

25. Stroke Recovery Initiative - Registry for Stroke Research Studies

    The Stroke Recovery Initiative is a nation-wide participant recruitment registry that connects people who have had a stroke with researchers who are working to develop new approaches to improve recovery after stroke.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of California, San Francisco, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT03318432 on ClinicalTrials.gov