Insulin Resistance Clinical Trials

36 studies are recruiting for insulin resistance in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes

   The investigators are doing this study to learn more about how to prevent type 2 diabetes in teenage girls. The purpose of this study is to find out if taking part in a cognitive-behavioral therapy group, exercise training group, or a combination of cognitive-behavioral therapy and exercise trainin…

   Stage

   Not phased

   Ages

   12 to 17

   Site

   Children's Hospital Colorado, Aurora, Colorado

   Locations

   2 in total

   Run by

   Colorado State University

   See if you can join NCT05543083 on ClinicalTrials.gov

2. Metabolic Adaptations to Weight Loss With and Without Exercise

   Study Purpose: The combination of caloric restriction and exercise is the most common first-line treatment for obesity-related disorders, yet we know very little about how these two very different treatments work together. A deeper understanding about mechanisms underlying the health benefits of ad…

   Stage

   Not phased

   Ages

   18 to 40

   Site

   University of Michigan, Ann Arbor, Michigan

   Run by

   University of Michigan

   See if you can join NCT05806801 on ClinicalTrials.gov

3. ActiveGirls: Physical Activity, Hormone Health, and Diabetes Risk in Early Adolescence

   This study explores how a physical activity program can affect hormone health and diabetes risk in girls ages 8-12 who may be at higher risk. The study aims to address: * Does the 'ActiveGirls' program meet the needs of girls and families in engaging them to increase physical activity? * What is th…

   Stage

   Not phased

   Ages

   8 and older

   Site

   Massachusetts General Hospital, Somerville, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT07102797 on ClinicalTrials.gov

4. New Mechanisms of Obesity

   Given the pervasiveness of Pediatric Obesity, it is imperative to understand its pathophysiology and develop alternative strategies to reverse this condition. Herein, investigators propose to elucidate the interaction between colonic fermentation and insulin resistance in modulating metabolism in y…

   Stage

   Not phased

   Ages

   15 to 22

   Site

   Yale University, New Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT06768827 on ClinicalTrials.gov

5. Effects of Sabroxy® Supplementation on Insulin Resistance and Cognitive Function in Adults With Mild Cognitive Impairment and Insulin Resistance

   This randomized, double-blind, placebo-controlled, 8-week clinical trial is designed to evaluate the effects of Sabroxy®, a standardized extract of Oroxylum indicum bark, on insulin resistance and cognitive function in adults with mild cognitive impairment and insulin resistance. A total of 120 par…

   Stage

   Not phased

   Ages

   40 to 80

   Site

   San Francisco Research Institute, San Francisco, California

   Run by

   SF Research Institute, Inc.

   See if you can join NCT07220694 on ClinicalTrials.gov

6. Intramyocellular Fatty Acid Trafficking in Insulin Resistance States - Effects of Intestinal Delivery of Lipids

   Muscle insulin resistance is a hallmark of upper body obesity (UBO) and Type 2 diabetes (T2DM). It is unknown whether muscle free fatty acid (FFA) availability or intramyocellular fatty acid trafficking is responsible for muscle insulin resistance, although it has been shown that raising FFA with I…

   Stage

   Not phased

   Ages

   18 to 55

   Site

   Mayo Clinic, Rochester, Minnesota

   Run by

   Mayo Clinic

   See if you can join NCT03818178 on ClinicalTrials.gov

7. Brain Health in Youth With Normal Weight, Overweight and Obesity at Risk for Type 2 Diabetes (T2D)

   Investigators propose to study youth across the spectrum of body mass index (BMI) and dysglycemia. This approach will allow investigators to disentangle the relationship of key features of type 2 diabetes (T2D) risk (e.g. obesity) with intermediary physiologic changes (e.g. insulin resistance, infl…

   Stage

   Not phased

   Ages

   12 to 17

   Site

   Washington University School of Medicine, St Louis, Missouri

   Locations

   2 in total

   Run by

   Washington University School of Medicine

   See if you can join NCT05277558 on ClinicalTrials.gov

8. Mitigating the Pro-inflammatory Phenotype of Obesity

   The purpose of this study is to examine the hypothesize that 4 weeks of sympathetic nerve activity (SNA) inhibition (oral clonidine) will cause a significant reduction in circulating blood concentrations and endothelial cell expression of inflammatory markers (e.g., TNF-α, IL-6). Our study is a pro…

   Stage

   Phase 1

   Ages

   18 to 79

   Site

   University of Kansas Medical Center, Kansas City, Kansas

   Run by

   University of Kansas Medical Center

   See if you can join NCT04934228 on ClinicalTrials.gov

9. The Acute T-Rex (Timing of Resistance Exercise) Study

   The primary aim of this study is to evaluate if a single bout of AM vs PM resistance exercise has different effects on insulin sensitivity and sleep. A randomized cross-over trial be used to compare resistance exercise at two different times of the day. Each condition will take place in a laborator…

   Stage

   Not phased

   Ages

   50 to 74

   Site

   University of Utah HPER E Buildling, Salt Lake City, Utah

   Run by

   University of Utah

   See if you can join NCT06366399 on ClinicalTrials.gov

10. Longitudinal Multi-Omic Profiles to Reveal Mechanisms of Obesity-Mediated Insulin Resistance

    This 12-week controlled diet and weight intervention study seeks to define the molecular pathways that link excess body weight to the development of insulin resistance (IR). Blood, adipose and stool are sampled at three timepoints; baseline, peak weight (4 weeks) and post weight loss to monitor cha…

    Stage

    Not phased

    Ages

    35 to 65

    Site

    Stanford University, Stanford, California

    Run by

    Stanford University

    See if you can join NCT05165706 on ClinicalTrials.gov

11. Obesity, Insulin Resistance, and PASC: Persistent SARS-CoV-2

    The investigators are studying the pathophysiologic links between obesity, insulin resistance (IR), adipose tissue infection, and post-acute sequelae of COVID-19 (PASC). This study looks at whether adipose (fat) tissue contributes to PASC by driving chronic inflammation or by serving as a reservoir…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Stanford Health, Palo Alto, California

    Locations

    2 in total

    Run by

    Stanford University

    See if you can join NCT05833217 on ClinicalTrials.gov