Insulin Resistance Clinical Trials

37 studies are recruiting for insulin resistance in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Sleep Loss and Circadian Misalignment - Mechanisms of Insulin Resistance

   The purpose of this study is to examine the impact of timed cortisol release or differently timed cortisol rhythms on insulin resistance in both men and women undergoing sleep restriction. Chronic sleep loss is highly prevalent, affecting 1 in 3 adults in the US. Chronic sleep loss causes stress wh…

   Stage

   Phase 4

   Ages

   18 to 45

   Site

   Sleep and Performance Research Center, Spokane, Washington

   Run by

   Washington State University

   See if you can join NCT07494084 on ClinicalTrials.gov

2. Study of the Effect of Innate on the Inflammatory Response to Endotoxin

   Background: - Innate immunity is the process by which white blood cells and other parts of the immune system sense and respond to potential infections by causing an inflammation. Researchers are interested in studying how the body responds to certain environmental factors, and whether the body s re…

   Stage

   Not phased

   Ages

   18 to 100

   Site

   NIEHS Clinical Research Unit (CRU), Research Triangle Park, North Carolina

   Run by

   National Institute of Environmental Health Sciences (NIEHS)

   See if you can join NCT01143480 on ClinicalTrials.gov

3. Graded Insulin Suppression Test P&F

   The goal of this study is to learn about how the hormone insulin controls blood sugar in a variety of people. The main question it aims to answer is about how much insulin the body actually needs to maintain a normal blood sugar level. Participants will be asked to come in for a one-day study visit…

   Stage

   Phase 1

   Ages

   18 to 65

   Site

   Columbia University Irving Medical Center, New York, New York

   Run by

   Columbia University

   See if you can join NCT06592261 on ClinicalTrials.gov

4. Alpelisib Challenge Test (ACT)

   The goal of this study is to test a potentially easier method for measuring how much insulin a person is capable of producing than the current gold-standard method, the "hyperglycemic clamp." Participants will come in for a two-day (overnight) visit in which they will first undergo a "hyperglycemic…

   Stage

   Phase 1

   Ages

   18 to 70

   Site

   Columbia University Irving Medical Center, New York, New York

   Run by

   Columbia University

   See if you can join NCT07778524 on ClinicalTrials.gov

5. Prenatal Exercise and Glucose Regulation

   Gestational diabetes mellitus (GDM) is the most common disease during pregnancy and is characterized by an inability to regulate blood glucose (sugar) levels because of resistance to the hormone, insulin, which is responsible for getting glucose out of the blood. Aerobic training (AT, "cardio," for…

   Stage

   Not phased

   Ages

   18 to 35

   Site

   Human Performance Laboratory (HPL) at the University of Central Arkansas, Conway, Arkansas

   Run by

   University of Central Arkansas

   See if you can join NCT07802262 on ClinicalTrials.gov

6. Human Models of Selective Insulin Resistance: Alpelisib, Part I

   The goal of this clinical trial is to understand how the blood sugar-lowering hormone insulin works in healthy adults versus those who are at risk for type 2 diabetes. The study will use a drug called alpelisib, which interferes with insulin's actions in the body, to answer the study's main questio…

   Stage

   Phase 1

   Ages

   18 to 70

   Site

   Columbia University Irving Medical Center, New York, New York

   Run by

   Columbia University

   See if you can join NCT06354088 on ClinicalTrials.gov

7. The Effects of Cognitive Behavioral Therapy on Insulin Resistance in People With HIV

   The goal of this clinical trial is to learn if depression treatment improves insulin resistance, or how the body uses insulin to lower blood sugar, in people with HIV on HIV treatment. Researchers will compare an internet-based (online) depression treatment program called cognitive behavioral thera…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Indiana University Health, Indianapolis, Indiana

   Run by

   Indiana University

   See if you can join NCT07226128 on ClinicalTrials.gov

8. Determining Cell- and Spatially-distinct Skeletal Muscle Transcriptional Aberrations in Insulin Resistance

   The purpose of this study is to find new signs or signals in muscle cells that can help us understand when the body isn't responding well to insulin (a condition called insulin resistance).

   Stage

   Not phased

   Ages

   30 to 65

   Site

   AdventHealth Translational Research Institute, Orlando, Florida

   Run by

   AdventHealth Translational Research Institute

   See if you can join NCT07516509 on ClinicalTrials.gov

9. Prebiotic Inulin for Late-Reproductive Individuals

   This study aims to evaluate the effects of 2 weeks of inulin supplementation in perimenopausal women with overweight or obesity. The primary questions this study seeks to answer are: 1. Does 2 weeks of inulin supplementation alter the gut and vaginal estrobolome compared with placebo? 2. Does 2 wee…

   Stage

   Not phased

   Ages

   40 to 55

   Site

   Milken Institute School of Public Health, Washington D.C., District of Columbia

   Run by

   George Washington University

   See if you can join NCT07724522 on ClinicalTrials.gov

10. A Sensory Strategy to Cut Sugary Beverages in African/American and Latine Adolescents

    The goal of this clinical trial is to test whether replacing sugary sodas with unsweetened, flavored sparkling waters can reduce added sugar intake and improve health in Black/African American and Latine adolescents with obesity who prefer sweet-tasting beverages. The main questions it aims to answ…

    Stage

    Not phased

    Ages

    12 to 18

    Site

    Indiana University Hospital, Indianapolis, Indiana

    Locations

    3 in total

    Run by

    Nana Gletsu Miller

    See if you can join NCT07223151 on ClinicalTrials.gov

11. A Comparison of Neuromuscular Recruitment in Trained and Untrained Adults

    The objective of the study is to use neurological techniques to obtain quantitative measurements of nervous system control of skeletal muscle activity in adults aged 60-85 who are either long-term resistance exercisers or who are untrained.

    Stage

    Not phased

    Ages

    60 to 85

    Site

    Mayo Clinic, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT06820658 on ClinicalTrials.gov

12. Small Extracellular Vesicles and Insulin Action

    The goals of this research study are to: 1) understand why some people with obesity are protected from developing conditions such as type 2 diabetes and cardiovascular disease while others are more likely to develop obesity-related conditions; 2) assess the effect of small extracellular vesicles (s…

    Stage

    Not phased

    Ages

    25 to 55

    Site

    Washington University School of Medicine, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT05933707 on ClinicalTrials.gov

13. Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents

    This research study collects health-related information and blood samples to better understand how body composition, lifestyle habits, and diet influence meta-inflammatory monocytes (MiMos) in adolescents. The hypothesis of this study is that adolescents at risk for metabolic disease have enhanced …

    Stage

    Not phased

    Ages

    14 to 18

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT06007404 on ClinicalTrials.gov

14. Effect of Insulin Lowering on Lipogenesis

    The goal of this clinical trial is to compare a one-week course of diazoxide (2 mg/kg per dose x 14 doses) and placebo in people with obesity and insulin resistance (IR) with metabolic dysfunction-associated steatotic liver disease (MASLD). The main question it aims to answer are how mitigation of …

    Stage

    Phase 1

    Ages

    18 to 65

    Site

    Columbia University Irving Medical Center, New York, New York

    Run by

    Columbia University

    See if you can join NCT07403604 on ClinicalTrials.gov

15. Food and Metabolism Study

    In this study, Investigators are interested in looking at the influence of eating avocados regularly, which are rich in healthy fats, fibers, and unique carbohydrates, on triglyceride and glucose metabolism in people with prediabetes and insulin resistance.

    Stage

    Not phased

    Ages

    40 to 70

    Site

    Clinical Nutrition Research Center at IIT, Chicago, Illinois

    Run by

    Clinical Nutrition Research Center, Illinois Institute of Technology

    See if you can join NCT07624500 on ClinicalTrials.gov

16. Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial

    Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease globally. While weight loss through lifestyle modification is the standard treatment, most patients regain weight limiting ultimate improvement in liver disease. On the other end of the spectru…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Pichamol Jirapinyo, MD, MPH

    See if you can join NCT06138821 on ClinicalTrials.gov

17. Reversal of Lipid-Induced Insulin Resistance

    The purpose of this study is to examine whether weight reduction decreases intramyocellular (IMCL) and hepatic lipid content, and improves insulin sensitivity of muscle and fat tissue in people who are insulin resistant and have a family history of type 2 diabetes. Hepatic mitochondrial oxidation w…

    Stage

    Not phased

    Ages

    18 to 90

    Site

    Yale Center for Clinical Investigation HRU, New Haven, Connecticut

    Locations

    2 in total

    Run by

    Yale University

    See if you can join NCT02193295 on ClinicalTrials.gov

18. Exercise Effects on Adipose Tissue Structure and Function

    Participants will be randomized into one of two different experimental groups: 1) Exercise group and 2) No exercise (control group). Subject participation in the study will involve a series of metabolic tests before and after participants undergo a 10% weight loss program (with or without exercise …

    Stage

    Not phased

    Ages

    18 to 40

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT04812314 on ClinicalTrials.gov

19. Metabolic Effects of Angiotensin-(1-7)

    The overall purpose of this study is to learn more about the metabolic effects of angiotensin-(1-7) in the insulin resistant state associated with obesity. Pharmacologic approaches to increase angiotensin-(1-7) levels or its actions are currently in development for treatment of metabolic-related di…

    Stage

    Phase 1

    Ages

    18 to 60

    Site

    Vanderbilt University Medical Center, Nashville, Tennessee

    Run by

    Vanderbilt University

    See if you can join NCT02646475 on ClinicalTrials.gov

20. Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling

    The goal of this intervention study is to learn about how weight loss impacts molecular signaling of intermuscular adipose tissue (IMAT) in individuals with obesity. The main question it aims to answer is how inflammatory molecules secreted by IMAT promote muscle insulin resistance and inflammation…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    University of Colorado Anschutz, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT06129110 on ClinicalTrials.gov

21. Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD

    Skeletal muscle metabolic health is critical for mobility and an underrecognized target of metabolic acidosis in chronic kidney disease. Impaired muscle mitochondrial metabolism underlies poor physical endurance increasing the risk of mobility disability. The proposed project will use precise in vi…

    Stage

    Phase 2

    Ages

    21 to 85

    Site

    University of California Davis Health, Sacramento, California

    Locations

    2 in total

    Run by

    University of California, Davis

    See if you can join NCT04984226 on ClinicalTrials.gov

22. Cardiometabolic Disease and Substrate Metabolism

    This study's primary purpose is to determine the potential relationship between cardiometabolic disease, specifically insulin resistance (HOMA-IR), and maternal lipid oxidation.

    Stage

    Not phased

    Ages

    18 to 45

    Site

    University of Tennessee Graduate School of Medicine, Knoxville, Tennessee

    Run by

    University of Tennessee Graduate School of Medicine

    See if you can join NCT07565727 on ClinicalTrials.gov

23. Determinants of Insulin Sensitivity by Age, Sex, Race/Ethnicity, BMI, and PCOS Diagnosis

    The study aims to investigate the relationship between fasting insulin and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) across various demographic factors, including age, sex, race/ethnicity, BMI, and polycystic ovary syndrome (PCOS) diagnosis. By analyzing these variables, the stud…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Lilli Health, Houston, Texas

    Run by

    Ali Chappell

    See if you can join NCT05950282 on ClinicalTrials.gov

24. Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes

    The investigators are doing this study to learn more about how to prevent type 2 diabetes in teenage girls. The purpose of this study is to find out if taking part in a cognitive-behavioral therapy group, exercise training group, or a combination of cognitive-behavioral therapy and exercise trainin…

    Stage

    Not phased

    Ages

    12 to 17

    Site

    Children's Hospital Colorado, Aurora, Colorado

    Locations

    2 in total

    Run by

    Colorado State University

    See if you can join NCT05543083 on ClinicalTrials.gov

25. Metabolic Adaptations to Weight Loss With and Without Exercise

    Study Purpose: The combination of caloric restriction and exercise is the most common first-line treatment for obesity-related disorders, yet we know very little about how these two very different treatments work together. A deeper understanding about mechanisms underlying the health benefits of ad…

    Stage

    Not phased

    Ages

    18 to 40

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT05806801 on ClinicalTrials.gov