Inflammation Clinical Trials

47 studies are recruiting for inflammation in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. Synbiotic to Attenuate Resorption of the Skeleton

   This randomized, double blind, placebo controlled clinical trial will test the efficacy of a probiotic/prebiotic combination ("synbiotic") on the skeleton in older women.

   Stage

   Not phased

   Ages

   60 and older

   Site

   Hebrew SeniorLife, Roslindale, Massachusetts

   Run by

   Hebrew SeniorLife

   See if you can join NCT06389539 on ClinicalTrials.gov

2. Efficacy of LoDoCo in Improving Exercise Capacity Among Patients With HFpEF and Inflammation

   The purpose of this research study is to determine the effectiveness of low dose colchicine (LoDoCo) on measures of exercise capacity, physical function, frailty, and quality of life, among patients with heart failure with chronic stable preserved ejection fraction (HFpEF) and systemic inflammation…

   Stage

   Phase 2

   Ages

   50 and older

   Site

   UT Southwestern Medical Center, Dallas, Texas

   Run by

   University of Texas Southwestern Medical Center

   See if you can join NCT06130059 on ClinicalTrials.gov

3. Cognitive Remediation

   The goal of this clinical trial is to determine if a neuroscience-based computerized cognitive remediation ("brain training") program can treat neurocognitive dysfunction (i.e., memory or thinking difficulties) that emerges in some older adults following a viral infection. The main questions it aim…

   Stage

   Not phased

   Ages

   60 and older

   Site

   UConn Health, Farmington, Connecticut

   Run by

   Cutter Lindbergh

   See if you can join NCT07171450 on ClinicalTrials.gov

4. Effects of Daily Beef Intake, as a Component of a Heart-Healthy Diet on Cellular Zinc

   The objective of the current study is to test the overarching hypothesis that the beef nutritive matrix is uniquely suited to direct dietary zinc to cellular compartments for improved metabolic function, leading to a greater effect on health outcomes. Specifically, whether beef, as a component of a…

   Stage

   Not phased

   Ages

   55 to 70

   Site

   University of California, Davis; Department of Nutrition, Davis, California

   Run by

   University of California, Davis

   See if you can join NCT05236374 on ClinicalTrials.gov

5. Treatment Research Investigating Depression Effects on Neuroimmune Targets (TRIDENT)

   The purpose of this randomized controlled trial is to understand how a cognitive-behavioral treatment (a form of psychological treatment) for depression changes the gut microbiome (micro-organisms that regulate the health of the gut), immune system, and the brain functioning in people living with H…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Miami Neuroimaging Facility, Coral Gables, Florida

   Locations

   2 in total

   Run by

   Florida International University

   See if you can join NCT05136703 on ClinicalTrials.gov

6. Mango Intake and Gut and Cardiometabolic Health in Hispanic/Latino Adolescents

   Mangos contain a number of nutrients that may improve gut and metabolic health. The purpose of this research is to see how eating mangos every day for 4 weeks instead of snacks high in calories and low in nutrients such as cookies, crackers, chips, and candy can impact adolescent health.

   Stage

   Not phased

   Ages

   12 to 19

   Site

   Academic Surge; Ragle Human Nutrition Research Center, Davis, California

   Run by

   University of California, Davis

   See if you can join NCT07125001 on ClinicalTrials.gov

7. Reducing Metabolic Dysregulation in Dyads

   This study is a 6-month randomized controlled trail of diet modification designed to reduce chronic inflammation and reverse metabolic dysfunction among obese individuals with one or more polyps found at a colonoscopy screening. We also will recruit an at least overweight partner, who lives in the …

   Stage

   Not phased

   Ages

   9 to 55

   Site

   University of South Carolina, Columbia, South Carolina

   Run by

   University of South Carolina

   See if you can join NCT06117241 on ClinicalTrials.gov

8. Focused Orticumab Research for Treating Inflammation in Coronary Arteries

   The goal of this clinical trial is to determine the clinical effect of orticumab treatment on inflammation in study participants with prior myocardial infarction who have elevated coronary inflammation based on CCTA. The main question it aims to answer is: Clinical effects of orticumab treatment on…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Abcentra Investigational Site, Torrance, California

   Locations

   41 in total

   Run by

   Abcentra

   See if you can join NCT06927739 on ClinicalTrials.gov

9. Evaluating Whether Hyperbaric Oxygen Therapy Can Improve VO₂-Max and Reduce Inflammation Markers in Healthy Adults Ages 30-60.

   The purpose of this study is to determine whether hyperbaric oxygen therapy (HBOT) at 1.75 atmospheres of pressure (ATA) improves cardiovascular fitness (VO₂ max) and reduces inflammation in healthy adults. HBOT involves breathing pure oxygen in a pressurized chamber and is considered investigation…

   Stage

   Not phased

   Ages

   30 to 60

   Site

   ATX Hyperbarics, Austin, Texas

   Locations

   2 in total

   Run by

   University of Texas at Austin

   See if you can join NCT07361861 on ClinicalTrials.gov

10. Impact of Haskap Berries on Recovery From High Intensity Resistance Training

    The purpose of this clinical trial is to determine how certain food items affect oxidative stress, inflammation, and performance recovery from exercise induced muscle damage in a resistance trained population. The main questions The investigators aim to answer are the following: * Do Haskaps speed …

    Stage

    Not phased

    Ages

    18 to 35

    Site

    Montana State University, Bozeman, Montana

    Run by

    Montana State University

    See if you can join NCT07344727 on ClinicalTrials.gov

11. Brain Health in Youth With Normal Weight, Overweight and Obesity at Risk for Type 2 Diabetes (T2D)

    Investigators propose to study youth across the spectrum of body mass index (BMI) and dysglycemia. This approach will allow investigators to disentangle the relationship of key features of type 2 diabetes (T2D) risk (e.g. obesity) with intermediary physiologic changes (e.g. insulin resistance, infl…

    Stage

    Not phased

    Ages

    12 to 17

    Site

    Washington University School of Medicine, St Louis, Missouri

    Locations

    2 in total

    Run by

    Washington University School of Medicine

    See if you can join NCT05277558 on ClinicalTrials.gov

12. Role of Inflammation in Vascular Phenotype Associated With E-cigarette Use

    The use of electronic nicotine delivery systems, or e-cigarettes - colloquially referred to as "vaping" - in the United States has increased exponentially since their introduction to the US market in 2007. Prevalence of ever and current e-cigarette use is highest among teenagers and young adults wi…

    Stage

    EARLY_Phase 1

    Ages

    18 to 24

    Site

    Iowa Bioscience Innovation Facility, Iowa City, Iowa

    Locations

    2 in total

    Run by

    University of Iowa

    See if you can join NCT06489249 on ClinicalTrials.gov

13. The Iowa ACEs and Sleep Cohort and Manipulating Sleep in Young Adults With ACEs Studies

    The overall purpose of this study is to understand the role of disrupted sleep in the association of exposure to early life adversity (adverse childhood experiences (ACEs)) with vascular endothelial (dys)function. In Aim 1 (The Iowa ACEs and Sleep Cohort Study), the investigators will utilize a cro…

    Stage

    Not phased

    Ages

    18 to 29

    Site

    Integrative Laboratory of Applied Physiology and Lifestyle Medicine, Iowa City, Iowa

    Run by

    Nathaniel Jenkins

    See if you can join NCT06454344 on ClinicalTrials.gov

14. UCLA REST Study (REsearch on Sleep Techniques)

    Sleep disturbance has a range of negative effects on psychosocial and biological processes important for academic and social success as well as mental and physical health among adolescents and young adults. Limited, inconsistent, and poor quality sleep lead to anxiety, depressive feelings, loneline…

    Stage

    Not phased

    Ages

    18 to 22

    Site

    University of California, Los Angeles, Los Angeles, California

    Run by

    University of California, Los Angeles

    See if you can join NCT05576090 on ClinicalTrials.gov

15. The Impact of Renal Transplant on Coronary Microvascular Function Among Patients With Advanced Chronic Kidney Disease

    People with chronic kidney disease (CKD) often experience faster aging of the heart and blood vessels, which raises the risk of heart problems beyond traditional factors like high blood pressure or cholesterol. One early sign is reduced blood flow in the tiny vessels that supply the heart, measured…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Run by

    Brigham and Women's Hospital

    See if you can join NCT07222683 on ClinicalTrials.gov

16. Immunoinflammatory Response in Post Cardiac Arrest Syndrome (PCAS)

    This is a prospective, observational study to investigate molecular mechanisms mediating the systemic inflammatory process, and changes to metabolism, and their impact on brain injury, survival, and functional outcomes after cardiac arrest. Investigators have shown that cardiac arrest induces chang…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Maine Medical Center, Portland, Maine

    Run by

    MaineHealth

    See if you can join NCT02664831 on ClinicalTrials.gov

17. Safety, Tolerability, and Distribution of Laquinimod Eye Drops : The LION Study

    The LION Study is a prospective, single-center phase 1 clinical trial to evaluate the safety, tolerability, and distribution of Laquinimod administered as topical eye drops for two weeks in human participants.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Spencer Center for Vision Research at the Byers Eye Institute, Palo Alto, California

    Run by

    Quan Dong Nguyen

    See if you can join NCT06161415 on ClinicalTrials.gov

18. Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via Infliximab

    This study is a mechanistic randomized controlled trial that investigates whether inhibition of tumor necrosis factor signaling via intravenous infusion of infliximab improves psychomotor speed and executive functioning in depressed individuals who exhibit an inflammatory phenotype.

    Stage

    Phase 2

    Ages

    25 to 50

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT06136546 on ClinicalTrials.gov

19. Passive Stretching in Peripheral Arterial Disease Patients

    Peripheral artery disease (PAD) leads to higher mortality rates and strains healthcare systems due to increased costs. It causes leg pain during walking due to reduced blood flow. Nitric oxide (NO) deficiency contributes to vascular issues in PAD, with few effective treatments available. Passive ca…

    Stage

    Phase 2

    Ages

    40 to 90

    Site

    University of Wisconsin La Crosse, La Crosse, Wisconsin

    Run by

    University of Wisconsin, La Crosse

    See if you can join NCT06420752 on ClinicalTrials.gov

20. Gut Microbiota-dependent Health Impacts of Haskap Berries

    Polyphenol-rich Haskap berries (Haskap) have untapped therapeutic potential to improve human health, and agricultural producers in northern U.S. states are poised to increase production if consumer demand increases. A critical knowledge gap is that little is known about the interactions between gut…

    Stage

    Not phased

    Ages

    35 to 65

    Site

    Montana State University, Bozeman, Montana

    Run by

    Montana State University

    See if you can join NCT06546020 on ClinicalTrials.gov

21. Improving Maternal Sleep and Mental Health

    The goal of this clinical trial is to test the effectiveness of a Smart Bassinet to prevent/mitigate postpartum mood disorders by augmenting maternal sleep and/or enhancing infant sleep. The investigators will conduct a 2-arm randomized controlled trial (RCT) to compare infant and maternal sleep of…

    Stage

    Not phased

    Ages

    18 to 45

    Site

    University of Colorado Colorado Springs, Colorado Springs, Colorado

    Run by

    University of Colorado, Colorado Springs

    See if you can join NCT06544941 on ClinicalTrials.gov

22. Peripheral Neuroimmune Mechanisms of Hyperthermia

    The goal of this study is to examine how whole-body hyperthermia affects the thermoinflammatory profile, which includes the combined immune and heat shock response, in patients with depression and whether these changes correlate with decreased depression in individuals with Major Depressive Disorde…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Massachusetts General Hospital Depression Clinical & Research Program, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT05366270 on ClinicalTrials.gov