Inflammation Clinical Trials

47 studies are recruiting for inflammation in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Diagnosis and Management of Inflammatory and Infectious Diseases

   This protocol is being established to cover the evaluation of patients with inflammatory and/or infectious diseases which are not covered under previously existing protocols. The purpose of such a protocol is that frequently patients are referred to us with either diagnosed or undiagnosed illnesses…

   Stage

   Not phased

   Ages

   3 to 100

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Allergy and Infectious Diseases (NIAID)

   See if you can join NCT00557726 on ClinicalTrials.gov

2. Impact of NMES and HPRO on Recovery After SAH- Pilot Study

   The study purpose is to investigate the hypothesis that in adults with SAH, early neuromuscular electrical stimulation (NMES) and high protein supplementation (HPRO) will improve muscle mass, metabolic and inflammatory biomarker profiles, compared to SAH controls receiving standard of care interven…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Maryland Medical Center, Baltimore, Maryland

   Run by

   University of Maryland, Baltimore

   See if you can join NCT03201094 on ClinicalTrials.gov

3. Wild Blueberries for Gut, Brain, and Heart Health in Adults With High Blood Pressure

   The purpose of the study is to determine the effectiveness of wild blueberries on cardiovascular health, cognitive function, and gut microbiota composition in non-Hispanic Black and White adults with elevated blood pressure.

   Stage

   Not phased

   Ages

   45 to 65

   Site

   Georgia State University, Atlanta, Georgia

   Run by

   Georgia State University

   See if you can join NCT06735599 on ClinicalTrials.gov

4. Wild Blueberries for Gut, Brain, and Cardiometabolic Health in Prediabetes

   The goal of this clinical trial is to determine the effectiveness of using a freeze-dried wild blueberry powder on cardiometabolic health, cognitive function, and gut microbiota composition in adult women with prediabetes.

   Stage

   Not phased

   Ages

   20 to 65

   Site

   Georgia State University, Atlanta, Georgia

   Run by

   Georgia State University

   See if you can join NCT06735651 on ClinicalTrials.gov

5. Immune Cell Response to Stimuli

   This study will investigate the response of immune cells (neutrophils, monocytes) to various signals in the test tube to determine how they sense the signals in the body and what substances they produce in response to them. It will determine how the cells may, under certain circumstances, contribut…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   NIEHS Clinical Research Unit (CRU), Research Triangle Park, North Carolina

   Run by

   National Institute of Environmental Health Sciences (NIEHS)

   See if you can join NCT00397280 on ClinicalTrials.gov

6. Natural History of the Human Biological Response to Environmental Exposure and Injury

   Background: Environmental exposures like pollution, diet, and stress can help cause human diseases, or make them worse. Researchers want to better understand how injury and inflammation are caused by these exposures. They want to collect biological and environmental samples and other data. They may…

   Stage

   Not phased

   Ages

   18 to 90

   Site

   NIEHS Clinical Research Unit (CRU), Research Triangle Park, North Carolina

   Run by

   National Institute of Environmental Health Sciences (NIEHS)

   See if you can join NCT04888923 on ClinicalTrials.gov

7. Modulating Exercise Dosage to Improve Concussion Recovery

   Aerobic exercise has emerged as an effective treatment to reduce sport-related concussion symptom severity, yet existing work lacks rigor regarding the precise exercise volume and intensity required to elicit therapeutic effects, how exercise can alter concussion-related pathophysiology, and whethe…

   Stage

   Phase 1

   Ages

   13 to 18

   Site

   University of Colorado Denver, Aurora, Colorado

   Locations

   3 in total

   Run by

   University of Colorado, Denver

   See if you can join NCT05434130 on ClinicalTrials.gov

8. The Impact of a Race-Based Stress Reduction Intervention

   The goal of this clinical trial is to learn whether a stress reduction program called Resilience, Stress, and Ethnicity (RiSE) improves well-being, inflammation, and the epigenome in African American (AA) women who have risk factors for heart or metabolic disease. The main question it aims to answe…

   Stage

   Not phased

   Ages

   50 to 75

   Site

   Loyola University Chicago, Maywood, Illinois

   Run by

   Loyola University

   See if you can join NCT05902741 on ClinicalTrials.gov

9. Ketone Ester And Salt (KEAS) in Older Adults

   Most Americans consume excess dietary salt based on the recommendations set by the American Heart Association and Dietary Guidelines for Americans. High dietary salt impairs blood pressure control by affecting systemic blood vessels and the kidneys. These changes contribute to excess salt consumpti…

   Stage

   Not phased

   Ages

   50 to 85

   Site

   School of Public Health, Bloomington, Indiana

   Run by

   Indiana University

   See if you can join NCT06868719 on ClinicalTrials.gov

10. Trans-Auricular Stimulation for Postoperative Inflammation in Spine Surgery

    This study is a randomized controlled trial that will evaluate the effect of non-invasive auricular vagal nerve stimulation on inflammatory markers, glycemic control, postoperative pain, and inflammation-related clinical outcomes after long-segment spinal fusion surgeries when compared to current a…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Washington University School of Medicine, St Louis, Missouri

    Run by

    Alexander T. Yahanda

    See if you can join NCT07218133 on ClinicalTrials.gov

11. Effects of Freeze-dried Grape Powder on Immune Profiles in Healthy Aging Adults

    The purpose of this study is to investigate the effects of consuming grape powder on immune profiles in healthy middle- and older-aged individuals. Specifically, the investigators are interested in evaluating the potential effects of grapes in influencing markers of immune function, inflammation, a…

    Stage

    Not phased

    Ages

    50 to 75

    Site

    Department of Nutritional Sciences, Storrs, Connecticut

    Run by

    University of Connecticut

    See if you can join NCT07079982 on ClinicalTrials.gov

12. Oxidative Stress and Inflammatory Biomarkers in Gaucher Disease

    The objective of this study is to evaluate oxidative stress and/or inflammation in patients with Gaucher disease type I using a series of biomarkers and correlate with measurements of currently used diagnostic biomarkers.

    Stage

    Not phased

    Ages

    18 to 75

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT02437396 on ClinicalTrials.gov

13. Pilot Study Evaluating the Impact of Stress Reduction on Atherosclerotic : Heart and Mind Study

    The plot study aims to evaluate the effect of 8 weeks of stress reducing intervention on atherosclerotic plaque inflammation in adults, as quantified by positron emission tomography (PET) with fluorine-2-deoxy-D-glucose (FDG) in individuals with increased psychosocial stress.

    Stage

    Not phased

    Ages

    30 to 65

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT04496947 on ClinicalTrials.gov

14. Hormones, Outcomes, and Pain Pathways in Exercise Study

    The goal of the proposed project is to evaluate a mechanical intervention (sports bras designed specifically for full busted women) to alleviate neck, shoulder, arm, and back pain in full-busted women and investigate the contribution of non-mechanical pathways associated with this type of pain in w…

    Stage

    Phase 1

    Ages

    18 to 60

    Site

    University of Houston, Houston, Texas

    Run by

    University of Houston

    See if you can join NCT07579182 on ClinicalTrials.gov

15. Clinical Trial Evaluating the Impact of a Dietary Supplement Containing Humic and Fulvic Acid on Epigenetic Markers of Biological Age, Detoxification, Inflammation, and Oxidative Stress

    The primary purpose of this study is to evaluate the impact of BioToxin Binder, a commercially available dietary supplement containing humic and fulvic acid, on markers of biologic age, detoxification, inflammation, oxidative stress, and related markers among generally healthy adults.

    Stage

    Not phased

    Ages

    40 and older

    Site

    OvationLab, Richmond, Virginia

    Run by

    OvationLab

    See if you can join NCT07579845 on ClinicalTrials.gov

16. Light Therapy to Improve Sleep in TBI: Sleep-active Biomarkers and Glymphatic Function

    This is a clinical trial designed to examine how improved sleep through morning bright light therapy is improving downstream key physiologic processes related to brain health, i.e., mitochondrial function, systemic inflammation, and glymphatic function. All proposed methodology is already approved …

    Stage

    Not phased

    Ages

    18 to 89

    Site

    Oregon Health and Science University, Portland, Oregon

    Run by

    Oregon Health and Science University

    See if you can join NCT07601841 on ClinicalTrials.gov

17. Stress Phenotypes and Preterm Birth

    Pregnancy ends in preterm birth (PTB) for approximately 1 in 10 women, though more often for Non-Hispanic Black women, 14.12% PTB rate, compared to 9.09% for Non-Hispanic White women. Psychosocial stress and childhood trauma each are associated with risk for PTB and PTB has an intergenerational imp…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Columbia University Irving Medical Center, New York, New York

    Run by

    Columbia University

    See if you can join NCT05229666 on ClinicalTrials.gov

18. Impacts of Cash Transfers on Child Neurodevelopment (Auxilio Brasil)

    This study examines the impact of Auxilio Brasil (AB), a cash transfer program to mothers of school-age children, on resource-deprived populations in Brazil and its protective effects on child neurodevelopment and mental health. The investigators will conduct a randomized clinical trial (RCT) among…

    Stage

    Not phased

    Ages

    23 to 45

    Site

    UNIFESP, São Paulo, São Paulo

    Locations

    2 in total

    Run by

    New York State Psychiatric Institute

    See if you can join NCT05477901 on ClinicalTrials.gov

19. Novel Approaches for Improving Vascular Function in Veterans With HFpEF

    This project will evaluate the impact of L-Citrulline, tetrahydrobiopterin (BH4), and atorvastatin administration on physical capacity and vascular function in Veterans with heart failure with preserved ejection fraction (HFpEF).

    Stage

    Phase 1

    Ages

    18 and older

    Site

    VA Salt Lake City Health Care System, Salt Lake City, UT, Salt Lake City, Utah

    Run by

    VA Office of Research and Development

    See if you can join NCT06312748 on ClinicalTrials.gov

20. Biomarkers in Infection

    The purpose of this investigation is to evaluate how early biomarkers of infection and inflammation perform in identifying patients at risk for poor outcome in sepsis and septic shock.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Beth Israel Deaconess Medical Center, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Beth Israel Deaconess Medical Center

    See if you can join NCT02545478 on ClinicalTrials.gov

21. Prebiotic Effects of California Grapes on Gut Health and Cardiometabolic Health in Overweight Men and Women

    The goal of this clinical trial is to assess the impact of table grape consumption on gut microbiome, intestinal permeability, systemic inflammation, and vascular function in healthy overweight men and women aged 45-70 years. The main questions it aims to answer are: * Does daily grape intake alter…

    Stage

    Not phased

    Ages

    45 to 70

    Site

    Ragle Human Nutrition Center, Davis, California

    Run by

    University of California, Davis

    See if you can join NCT06544954 on ClinicalTrials.gov

22. Regulation of Inflammatory Genes in Psoriasis

    Psoriasis is a chronic and recurrent skin disorder characterized by marked inflammatory changes in the skin. An extensive cytokine network including generated by activated dendritic cells and T cells mediates the formation of psoriatic lesions. These immune-response parameters can be used as marker…

    Stage

    Not phased

    Ages

    19 to 99

    Site

    The Kirklin Clinic, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT03125655 on ClinicalTrials.gov

23. Modeling the Effects of Chronic Marijuana Use on Neuroinflammation and HIV-related Neuronal Injury

    This study applies a hypothesis-driven approach to examine the effects of chronic marijuana use on HIV-associated inflammation and its subsequent impacts on central nervous system function, with the goal of identifying the mechanisms through which cannabinoids modulate neurological disorders and ot…

    Stage

    Not phased

    Ages

    25 to 59

    Site

    Biotech Place, Winston-Salem, North Carolina

    Run by

    Wake Forest University Health Sciences

    See if you can join NCT04810858 on ClinicalTrials.gov

24. Low Dose ColchicinE in pAtients With Peripheral Artery DiseasE to Address Residual Vascular Risk

    The Low dose ColchicinE in pAtients with peripheral Artery DiseasE to address residual vascular Risk (LEADER-PAD) trial will evaluate if anti-inflammatory therapy with colchicine will reduce vascular events in patients with symptomatic peripheral artery disease.

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Yale School of Medicine, New Haven, Connecticut

    Locations

    70 in total

    Run by

    Population Health Research Institute

    See if you can join NCT04774159 on ClinicalTrials.gov

25. The Effect of Mindfulness on Vascular Inflammation in Stable Coronary Disease

    This study aims to evaluate the effect of 8 weeks of a stress reduction intervention on atherosclerotic plaque inflammation in adults with stable coronary artery disease, as quantified by positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) in individuals with increased psychosocial…

    Stage

    Not phased

    Ages

    45 to 65

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT04505865 on ClinicalTrials.gov