Inflammation Clinical Trials

48 studies are recruiting for inflammation in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Diagnosis and Management of Inflammatory and Infectious Diseases

   This protocol is being established to cover the evaluation of patients with inflammatory and/or infectious diseases which are not covered under previously existing protocols. The purpose of such a protocol is that frequently patients are referred to us with either diagnosed or undiagnosed illnesses…

   Stage

   Not phased

   Ages

   3 to 100

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Allergy and Infectious Diseases (NIAID)

   See if you can join NCT00557726 on ClinicalTrials.gov

2. Natural History of the Human Biological Response to Environmental Exposure and Injury

   Background: Environmental exposures like pollution, diet, and stress can help cause human diseases, or make them worse. Researchers want to better understand how injury and inflammation are caused by these exposures. They want to collect biological and environmental samples and other data. They may…

   Stage

   Not phased

   Ages

   18 to 90

   Site

   NIEHS Clinical Research Unit (CRU), Research Triangle Park, North Carolina

   Run by

   National Institute of Environmental Health Sciences (NIEHS)

   See if you can join NCT04888923 on ClinicalTrials.gov

3. Role of Inflammation in Vascular Phenotype Associated With E-cigarette Use

   The use of electronic nicotine delivery systems, or e-cigarettes - colloquially referred to as "vaping" - in the United States has increased exponentially since their introduction to the US market in 2007. Prevalence of ever and current e-cigarette use is highest among teenagers and young adults wi…

   Stage

   EARLY_Phase 1

   Ages

   18 to 24

   Site

   Iowa Bioscience Innovation Facility, Iowa City, Iowa

   Locations

   2 in total

   Run by

   University of Iowa

   See if you can join NCT06489249 on ClinicalTrials.gov

4. Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via Infliximab

   This study is a mechanistic randomized controlled trial that investigates whether inhibition of tumor necrosis factor signaling via intravenous infusion of infliximab improves psychomotor speed and executive functioning in depressed individuals who exhibit an inflammatory phenotype.

   Stage

   Phase 2

   Ages

   25 to 50

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT06136546 on ClinicalTrials.gov

5. The Impact of Overnight Active Temperature Regulation on the Gut Microbiome, Inflammation, and Circadian Rhythm.

   This study examines whether two continuous weeks of overnight active temperature regulation (via the Eight Sleep Pod) use affects gut microbiome composition, inflammation, and the body's daily temperature and blood pressure rhythms in postmenopausal women and age-matched men with self-reported poor…

   Stage

   Not phased

   Ages

   45 and older

   Site

   Eight Sleep, Newton Center, Massachusetts

   Run by

   Eight Sleep Inc.

   See if you can join NCT07848594 on ClinicalTrials.gov

6. What is the Effect of Increased Consumption of Fruit Juice on Exercise Capacity and Inflammatory Biomarkers?

   Dietary patterns and physical inactivity common in Western societies have been associated with chronic low-grade inflammation and an increased risk of non-communicable health conditions. Fruits and vegetables contain polyphenols and other bioactive compounds that may have antioxidant and anti-infla…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   Nicholas Institute of Sports Medicine & Athletic Trauma (NISMAT), New York, New York

   Run by

   Northwell Health

   See if you can join NCT07862049 on ClinicalTrials.gov

7. Low Dose ColchicinE in pAtients With Peripheral Artery DiseasE to Address Residual Vascular Risk

   The Low dose ColchicinE in pAtients with peripheral Artery DiseasE to address residual vascular Risk (LEADER-PAD) trial will evaluate if anti-inflammatory therapy with colchicine will reduce vascular events in patients with symptomatic peripheral artery disease.

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Yale School of Medicine, New Haven, Connecticut

   Locations

   86 in total

   Run by

   Population Health Research Institute

   See if you can join NCT04774159 on ClinicalTrials.gov

8. Immune Cell Response to Stimuli

   This study will investigate the response of immune cells (neutrophils, monocytes) to various signals in the test tube to determine how they sense the signals in the body and what substances they produce in response to them. It will determine how the cells may, under certain circumstances, contribut…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   NIEHS Clinical Research Unit (CRU), Research Triangle Park, North Carolina

   Run by

   National Institute of Environmental Health Sciences (NIEHS)

   See if you can join NCT00397280 on ClinicalTrials.gov

9. UCLA REST Study (REsearch on Sleep Techniques)

   Sleep disturbance has a range of negative effects on psychosocial and biological processes important for academic and social success as well as mental and physical health among adolescents and young adults. Limited, inconsistent, and poor quality sleep lead to anxiety, depressive feelings, loneline…

   Stage

   Not phased

   Ages

   18 to 22

   Site

   University of California, Los Angeles, Los Angeles, California

   Run by

   University of California, Los Angeles

   See if you can join NCT05576090 on ClinicalTrials.gov

10. Impact of NMES and HPRO on Recovery After SAH- Pilot Study

    The study purpose is to investigate the hypothesis that in adults with SAH, early neuromuscular electrical stimulation (NMES) and high protein supplementation (HPRO) will improve muscle mass, metabolic and inflammatory biomarker profiles, compared to SAH controls receiving standard of care interven…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Maryland Medical Center, Baltimore, Maryland

    Run by

    University of Maryland, Baltimore

    See if you can join NCT03201094 on ClinicalTrials.gov

11. Wild Blueberries for Gut, Brain, and Heart Health in Adults With High Blood Pressure

    The purpose of the study is to determine the effectiveness of wild blueberries on cardiovascular health, cognitive function, and gut microbiota composition in non-Hispanic Black and White adults with elevated blood pressure.

    Stage

    Not phased

    Ages

    45 to 65

    Site

    Georgia State University, Atlanta, Georgia

    Run by

    Georgia State University

    See if you can join NCT06735599 on ClinicalTrials.gov

12. Wild Blueberries for Gut, Brain, and Cardiometabolic Health in Prediabetes

    The goal of this clinical trial is to determine the effectiveness of using a freeze-dried wild blueberry powder on cardiometabolic health, cognitive function, and gut microbiota composition in adult women with prediabetes.

    Stage

    Not phased

    Ages

    20 to 65

    Site

    Georgia State University, Atlanta, Georgia

    Run by

    Georgia State University

    See if you can join NCT06735651 on ClinicalTrials.gov

13. Modulating Exercise Dosage to Improve Concussion Recovery

    Aerobic exercise has emerged as an effective treatment to reduce sport-related concussion symptom severity, yet existing work lacks rigor regarding the precise exercise volume and intensity required to elicit therapeutic effects, how exercise can alter concussion-related pathophysiology, and whethe…

    Stage

    Phase 1

    Ages

    13 to 18

    Site

    University of Colorado Denver, Aurora, Colorado

    Locations

    3 in total

    Run by

    University of Colorado, Denver

    See if you can join NCT05434130 on ClinicalTrials.gov

14. The Impact of a Race-Based Stress Reduction Intervention

    The goal of this clinical trial is to learn whether a stress reduction program called Resilience, Stress, and Ethnicity (RiSE) improves well-being, inflammation, and the epigenome in African American (AA) women who have risk factors for heart or metabolic disease. The main question it aims to answe…

    Stage

    Not phased

    Ages

    50 to 75

    Site

    Loyola University Chicago, Maywood, Illinois

    Run by

    Loyola University

    See if you can join NCT05902741 on ClinicalTrials.gov

15. Ketone Ester And Salt (KEAS) in Older Adults

    Most Americans consume excess dietary salt based on the recommendations set by the American Heart Association and Dietary Guidelines for Americans. High dietary salt impairs blood pressure control by affecting systemic blood vessels and the kidneys. These changes contribute to excess salt consumpti…

    Stage

    Not phased

    Ages

    50 to 85

    Site

    School of Public Health, Bloomington, Indiana

    Run by

    Indiana University

    See if you can join NCT06868719 on ClinicalTrials.gov

16. Trans-Auricular Stimulation for Postoperative Inflammation in Spine Surgery

    This study is a randomized controlled trial that will evaluate the effect of non-invasive auricular vagal nerve stimulation on inflammatory markers, glycemic control, postoperative pain, and inflammation-related clinical outcomes after long-segment spinal fusion surgeries when compared to current a…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Washington University School of Medicine, St Louis, Missouri

    Run by

    Alexander T. Yahanda

    See if you can join NCT07218133 on ClinicalTrials.gov

17. Effects of Freeze-dried Grape Powder on Immune Profiles in Healthy Aging Adults

    The purpose of this study is to investigate the effects of consuming grape powder on immune profiles in healthy middle- and older-aged individuals. Specifically, the investigators are interested in evaluating the potential effects of grapes in influencing markers of immune function, inflammation, a…

    Stage

    Not phased

    Ages

    50 to 75

    Site

    Department of Nutritional Sciences, Storrs, Connecticut

    Run by

    University of Connecticut

    See if you can join NCT07079982 on ClinicalTrials.gov

18. Oxidative Stress and Inflammatory Biomarkers in Gaucher Disease

    The objective of this study is to evaluate oxidative stress and/or inflammation in patients with Gaucher disease type I using a series of biomarkers and correlate with measurements of currently used diagnostic biomarkers.

    Stage

    Not phased

    Ages

    18 to 75

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT02437396 on ClinicalTrials.gov

19. Pilot Study Evaluating the Impact of Stress Reduction on Atherosclerotic : Heart and Mind Study

    The plot study aims to evaluate the effect of 8 weeks of stress reducing intervention on atherosclerotic plaque inflammation in adults, as quantified by positron emission tomography (PET) with fluorine-2-deoxy-D-glucose (FDG) in individuals with increased psychosocial stress.

    Stage

    Not phased

    Ages

    30 to 65

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT04496947 on ClinicalTrials.gov

20. Hormones, Outcomes, and Pain Pathways in Exercise Study

    The goal of the proposed project is to evaluate a mechanical intervention (sports bras designed specifically for full busted women) to alleviate neck, shoulder, arm, and back pain in full-busted women and investigate the contribution of non-mechanical pathways associated with this type of pain in w…

    Stage

    Phase 1

    Ages

    18 to 60

    Site

    University of Houston, Houston, Texas

    Run by

    University of Houston

    See if you can join NCT07579182 on ClinicalTrials.gov

21. Clinical Trial Evaluating the Impact of a Dietary Supplement Containing Humic and Fulvic Acid on Epigenetic Markers of Biological Age, Detoxification, Inflammation, and Oxidative Stress

    The primary purpose of this study is to evaluate the impact of BioToxin Binder, a commercially available dietary supplement containing humic and fulvic acid, on markers of biologic age, detoxification, inflammation, oxidative stress, and related markers among generally healthy adults.

    Stage

    Not phased

    Ages

    40 and older

    Site

    OvationLab, Richmond, Virginia

    Run by

    OvationLab

    See if you can join NCT07579845 on ClinicalTrials.gov

22. Light Therapy to Improve Sleep in TBI: Sleep-active Biomarkers and Glymphatic Function

    This is a clinical trial designed to examine how improved sleep through morning bright light therapy is improving downstream key physiologic processes related to brain health, i.e., mitochondrial function, systemic inflammation, and glymphatic function. All proposed methodology is already approved …

    Stage

    Not phased

    Ages

    18 to 89

    Site

    Oregon Health and Science University, Portland, Oregon

    Run by

    Oregon Health and Science University

    See if you can join NCT07601841 on ClinicalTrials.gov

23. Stress Phenotypes and Preterm Birth

    Pregnancy ends in preterm birth (PTB) for approximately 1 in 10 women, though more often for Non-Hispanic Black women, 14.12% PTB rate, compared to 9.09% for Non-Hispanic White women. Psychosocial stress and childhood trauma each are associated with risk for PTB and PTB has an intergenerational imp…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Columbia University Irving Medical Center, New York, New York

    Run by

    Columbia University

    See if you can join NCT05229666 on ClinicalTrials.gov

24. Impacts of Cash Transfers on Child Neurodevelopment (Auxilio Brasil)

    This study examines the impact of Auxilio Brasil (AB), a cash transfer program to mothers of school-age children, on resource-deprived populations in Brazil and its protective effects on child neurodevelopment and mental health. The investigators will conduct a randomized clinical trial (RCT) among…

    Stage

    Not phased

    Ages

    23 to 45

    Site

    UNIFESP, São Paulo, São Paulo

    Locations

    2 in total

    Run by

    New York State Psychiatric Institute

    See if you can join NCT05477901 on ClinicalTrials.gov

25. Novel Approaches for Improving Vascular Function in Veterans With HFpEF

    This project will evaluate the impact of L-Citrulline, tetrahydrobiopterin (BH4), and atorvastatin administration on physical capacity and vascular function in Veterans with heart failure with preserved ejection fraction (HFpEF).

    Stage

    Phase 1

    Ages

    18 and older

    Site

    VA Salt Lake City Health Care System, Salt Lake City, UT, Salt Lake City, Utah

    Run by

    VA Office of Research and Development

    See if you can join NCT06312748 on ClinicalTrials.gov