Huntington Disease Clinical Trials

15 studies are recruiting for huntington disease in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Study to Evaluate the Pharmacodynamics, Safety and Efficacy of SKY-0515 in Participants With Huntington's Disease

   The goal of this clinical trial is to test if the drug SKY-0515, an oral medication, can lower harmful proteins linked to Huntington's Disease (HD) and improve the symptoms of participants with HD. This study includes men and women aged 25 and older who have HD confirmed by genetic testing and meet…

   Stage

   Phase 2

   Ages

   25 and older

   Site

   Hospital El Cruce, Buenos Aires, Buenos Aires

   Locations

   24 in total

   Run by

   Skyhawk Therapeutics, Inc.

   See if you can join NCT07378644 on ClinicalTrials.gov

2. Pridopidine Phase 3 Study in Huntington's Disease

   The goal of this clinical trial is to learn if pridopidine can slow the clinical decline of Huntington's Disease (HD) in adult participants. It will also inform about the safety of pridopidine. The main questions the study aims to answer are: Does pridopidine slow the overall worsening of HD over 1…

   Stage

   Phase 3

   Ages

   23 to 65

   Site

   University of California, San Diego, La Jolla, California

   Locations

   66 in total

   Run by

   Prilenia

   See if you can join NCT07609108 on ClinicalTrials.gov

3. A Study to Investigate the Efficacy, Safety and Tolerability of Votoplam in Participants With Huntington's Disease

   The purpose is to assess safety and tolerability of votoplam and to determine whether votoplam slows disease progression in patients with early symptomatic Huntington's disease (HD) compared to the control arm. HTT227 - current compound code (former code is PTC518 from PTC Therapeutics), HTT227 is …

   Stage

   Phase 3

   Ages

   21 to 70

   Site

   University of Alabama Birmingham, Birmingham, Alabama

   Locations

   82 in total

   Run by

   Novartis Pharmaceuticals

   See if you can join NCT07326709 on ClinicalTrials.gov

4. Digital Measures for Clinical Trial Endpoints in Huntington's Disease

   MEND-HD is a longitudinal study evaluating the feasibility of passive monitoring of gait and chorea in patients with HD and the meaningfulness of these outcomes for patients with HD and their care partners/support persons. Participants will take part in four virtual visits with study investigators …

   Stage

   Not phased

   Ages

   25 to 65

   Site

   University of Rochester Medical Center, Rochester, New York

   Run by

   University of Rochester

   See if you can join NCT07010705 on ClinicalTrials.gov

5. A Randomized Study of SPK-10001 Gene Therapy in Participants With Huntington's Disease

   The main goal of this study is to evaluate the safety, tolerability, and preliminary efficacy of SPK-10001 in participants with Huntington's Disease.

   Stage

   Phase 1

   Ages

   25 to 65

   Site

   Beth Israel Deaconess Medical Center, Boston, Massachusetts

   Locations

   5 in total

   Run by

   Hoffmann-La Roche

   See if you can join NCT06826612 on ClinicalTrials.gov

6. Safety and Tolerability Study of Human Neural Stem Cells for Huntington's Disease

   The purpose of this research study is to determine whether an implantation of hNSC-01 is a safe and tolerable study intervention for Huntington's disease. This study is the first time that hNSC-01 is being tested in people.

   Stage

   Phase 1

   Ages

   18 to 65

   Site

   University of California, Irvine, Irvine, California

   Run by

   Leslie Thompson

   See if you can join NCT07451613 on ClinicalTrials.gov

7. Cognitive Assessment Tools for Huntington's Disease.

   The purpose of the current proposal is to expand understanding of two currently available cognitive tools that are not typically used in Huntington Disease (HD) clinical trials that might be useful both for initial screening and for clinical trial application. One is the Coding Test and the other i…

   Stage

   Not phased

   Ages

   30 to 65

   Site

   The Ohio State University Wexner Medical Center, Columbus, Ohio

   Run by

   Ohio State University

   See if you can join NCT06546488 on ClinicalTrials.gov

8. Home-based Transcranial Direct Current Stimulation Open Trial for Behavioral and Cognitive Symptoms in Huntington's Disease

   The purpose of this study is to assess feasibility, acceptability, and safety of providing transcranial direct current stimulation( tDCS) to Huntingtons Disease (HD) patients in the early to middle stages and to assess the efficacy of tDCS for HD-related behavioral, cognitive and other symptoms

   Stage

   Not phased

   Ages

   18 to 80

   Site

   The University of Texas Health Science Center at Houston, Houston, Texas

   Run by

   The University of Texas Health Science Center, Houston

   See if you can join NCT05326451 on ClinicalTrials.gov

9. Home-based TDCS (Transcranial Direct Current Stimulation) for Cognitive and Behavioral Symptoms in Huntington's Disease

   The researchers hope to find out effects of transcranial direct current stimulation (tDCS) sessions on the behavioral symptoms of Huntington's Disease. If participants are eligible to continue, they will be provided a device to administer the tDCS for 30 minutes each day and be asked to answer ques…

   Stage

   Not phased

   Ages

   18 to 85

   Site

   University of Texas Health Science Center at San Antonio, San Antonio, Texas

   Run by

   The University of Texas Health Science Center at San Antonio

   See if you can join NCT06843252 on ClinicalTrials.gov

10. Retinal Imaging in Neurodegenerative Disease

    This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the retinal and choroidal microvasculature and structure in persons with mi…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Duke University Medical Center, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT03233646 on ClinicalTrials.gov

11. Longitudinal Endpoint Assessment of Disease Burden in HD

    LEAD-HD is intended to collect and analyze self-reported health information from individuals with Huntington Disease (HD) or prodromal HD participating in a 24-month longitudinal natural history study using remote technologies.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Huntington Study Group, Rochester, New York

    Run by

    Huntington Study Group

    See if you can join NCT06475898 on ClinicalTrials.gov

12. Gut Microbiomes in HD

    The purpose of this study is to find out if there is a connection between the naturally occurring bacteria in our bodies and the progression of Huntington disease. The investigators are trying to determine if patients who are diagnosed with adult-onset HD and who exhibit a rapid rate of disease pro…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Central Florida, Orlando, Florida

    Run by

    University of Central Florida

    See if you can join NCT06448546 on ClinicalTrials.gov

13. Huntington's Disease Biobank: Advancing Remote Monitoring and Deep Phenotyping

    This observational study aims to identify novel biomarkers of disease onset and progression in Huntington's disease by integrating remote monitoring with fluid biomarkers. Using video-based computer vision and mobile app-based cognitive assessments combined with machine learning algorithms, we aim …

    Stage

    Not phased

    Ages

    Any age

    Site

    Stanford University, Palo Alto, California

    Run by

    Stanford University

    See if you can join NCT06941662 on ClinicalTrials.gov

14. NYSCF Scientific Discovery Biobank

    The New York Stem Cell Foundation (NYSCF) Research Institute is performing this research to accelerate diverse disease research using cells from the body (such as skin or blood cells) to make stem cells and other types of cells, conduct research on the samples, perform genetic testing, and store th…

    Stage

    Not phased

    Ages

    0 and older

    Site

    New York Stem Cell Foundation Research Institute, New York, New York

    Run by

    New York Stem Cell Foundation Research Institute

    See if you can join NCT06203106 on ClinicalTrials.gov

15. Extracellular Vesicles for HD

    The primary objective of this study is to discover blood-based biomarker of brain Huntingtin (HTT) protein using extracellular vesicles to be used in evaluating target engagement in HTT lowering clinical trials. Secondary objectives of this study include developing more accurate biomarkers of Hunti…

    Stage

    Not phased

    Ages

    18 to 75

    Site

    University of Central Florida, Orlando, Florida

    Run by

    University of Central Florida

    See if you can join NCT06082713 on ClinicalTrials.gov