HIV Infections Clinical Trials

47 studies are recruiting for hiv infections in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Clinical Trial to Evaluate the Safety and Immunogenicity of Hiltonol, Poly-ICLC-adjuvanted CD40.HIVRI.Env (VRIPRO) in Adult Participants Who Previously Participated in HVTN 706

   The clinical schedule will consist of 3 injections of CD40.HIVRI.Env (VRIPRO) at weeks 0, 4, and 24.40 volunteers without HIV and in overall good health, aged 18 to 60 years, who previously participated in the HVTN 706 trial.

   Stage

   Phase 1

   Ages

   18 to 60

   Site

   Bridge HIV CRS, San Francisco, California

   Locations

   9 in total

   Run by

   National Institute of Allergy and Infectious Diseases (NIAID)

   See if you can join NCT06665646 on ClinicalTrials.gov

2. Couples Motivational Interviewing to Reduce Drug Use and HIV Risk in Vulnerable Male Couples

   This study utilizes a randomized controlled trial design to evaluate the efficacy of couples motivational interviewing (MI) to reduce the frequency and severity of illicit drug use and frequency of HIV transmission risk behavior (TRB). Participants are randomized to one of two conditions: couples M…

   Stage

   Not phased

   Ages

   18 to 55

   Site

   Hunter College, New York, New York

   Locations

   3 in total

   Run by

   Hunter College of City University of New York

   See if you can join NCT06307977 on ClinicalTrials.gov

3. Implementation Study of Lenacapavir Pre-exposure Prophylaxis for HIV Prevention

   The goal of this observational study is to generate real-life information on the use of lenacapavir (LEN, YEZTUGO®, (YTG)) for pre-exposure prophylaxis (PrEP) across diverse clinical settings in the United States. The study will characterize how PrEP is initiated, used, and discontinued in routine …

   Stage

   Not phased

   Ages

   18 and older

   Site

   UAB 1917 Research Clinic, Birmingham, Alabama

   Locations

   38 in total

   Run by

   Gilead Sciences

   See if you can join NCT07473778 on ClinicalTrials.gov

4. Development and Evaluation of a Virtual Reality Tool for At-Risk Trauma-Exposed Young People

   This is a multi-phased study, funded through a National Institute on Drug Abuse (NIDA) K24 grant that aims to ultimately refine a virtual reality tool through qualitative and quantitative research targeting HIV and substance abuse risk behavior among at-risk young people who have experienced psycho…

   Stage

   Not phased

   Ages

   15 to 30

   Site

   National Crime Victims Research and Treatment Center, Charleston, South Carolina

   Run by

   Medical University of South Carolina

   See if you can join NCT05816083 on ClinicalTrials.gov

5. SCOPE: Observational Study of the Consequences of the Protease Inhibitor Era

   SCOPE is an observational, prospective study of HIV-1 infected volunteers designed to provide a specimen bank of samples with carefully characterized clinical data. SCOPE specimens will be used to examine multiple questions involving virologic, immunologic, and host factors involved in HIV-1 infect…

   Stage

   Not phased

   Ages

   18 and older

   Site

   San Francisco General Hospital, San Francisco, California

   Run by

   University of California, San Francisco

   See if you can join NCT00187512 on ClinicalTrials.gov

6. Microbiome Metabolites and Alcohol in HIV to Reduce CVD RCT

   Among people living with HIV, heavy drinking increases the risk of heart disease and death. Studies suggest that alcohol changes the number and kind of bacteria in your gut and these changes increase the risk of heart disease and death. This randomized controlled trial will determine whether a pill…

   Stage

   Phase 2

   Ages

   18 to 89

   Site

   Vanderbilt University Medical Center, Nashville, Tennessee

   Run by

   Vanderbilt University Medical Center

   See if you can join NCT05288790 on ClinicalTrials.gov

7. Positive Peers Intervention Clinical Trial

   The goal of this clinical trial is to learn if the Positive Peers mobile app intervention increases rates of viral suppression in young (13-34 y/o) persons with HIV. Does use of the Positive Peers app improve viral suppression among young minority persons with HIV? What user characteristics are ass…

   Stage

   Not phased

   Ages

   13 to 34

   Site

   Northeast Valley Health Corporation, Van Nuys, California

   Locations

   7 in total

   Run by

   MetroHealth Medical Center

   See if you can join NCT06388109 on ClinicalTrials.gov

8. Screen2Prevent (S2P)

   Screen2Prevent is a study intended to improve HIV prevention and detection through implementation and evaluation of three different broad-scale HIV screening approaches a) targeted, b) universally offered opt-in, and c) universally offered opt-out in Emergency Departments (EDs) by leveraging digita…

   Stage

   Not phased

   Ages

   14 to 24

   Site

   University of South Florida, Tampa, Florida

   Locations

   5 in total

   Run by

   Westat

   See if you can join NCT07728123 on ClinicalTrials.gov

9. A Study to Investigate Cabotegravir Ultra Long-Acting (CAB ULA) Plus Rilpivirine Ultra Long-Acting (RPV ULA) in Adults and Adolescents With HIV Who Are Virologically Suppressed

   This study compares the efficacy, safety and tolerability of CAB ULA and RPV ULA administered with CAB long acting (LA) and RPV LA administered in adults and adolescents with HIV who are virologically suppressed on anti-retroviral therapy (ART).

   Stage

   Phase 3

   Ages

   12 and older

   Site

   GSK Investigational Site, Phoenix, Arizona

   Locations

   88 in total

   Run by

   ViiV Healthcare

   See if you can join NCT07650916 on ClinicalTrials.gov

10. Study of Lenacapavir, Teropavimab, and Zinlirvimab Versus Cabotegravir and Rilpivirine in Virologically Suppressed Adults With HIV-1 on Oral Daily Antiretroviral Therapy

    The goal of this clinical study is to compare how effective a long-acting injectable treatment of lenacapavir (LEN), teropavimab (TAB), and zinlirvimab (ZAB) versus (CAB) and rilpivirine (RPV) injections given every 8 weeks in adults with HIV-1 whose virus is well controlled on daily oral treatment…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Optimus Medical Group, San Francisco, California

    Locations

    19 in total

    Run by

    Gilead Sciences

    See if you can join NCT07682961 on ClinicalTrials.gov

11. First Time in Human Study of Long Acting VH4524184 Formulations

    The purpose of this study is to identify 1 or more doses of parenterally administered VH4524184 that are safe, well tolerated and yield a PK drug exposure profile necessary to deliver a long-acting antiretroviral therapy for the treatment of HIV-1 infection.

    Stage

    Phase 1

    Ages

    18 to 55

    Site

    GSK Investigational Site, Lenexa, Kansas

    Locations

    3 in total

    Run by

    ViiV Healthcare

    See if you can join NCT06310551 on ClinicalTrials.gov

12. Dasatinib for HIV-1 Reservoir Reduction

    This study will test if the medicine dasatinib can lower the hidden amount of HIV in the body, called the HIV "reservoir." It will also check if dasatinib is safe and easy to take for people living with HIV who have a suppressed viral load while on antiretroviral therapy (ART). Adults 18 years or o…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Northwestern University CRS (Site # 2701), Chicago, Illinois

    Locations

    3 in total

    Run by

    National Institute of Allergy and Infectious Diseases (NIAID)

    See if you can join NCT07342491 on ClinicalTrials.gov

13. A Phase 2b Study Evaluating Oral VH4524184 Regimens in Treatment Naïve Persons With HIV-1 (INNOVATE Study)

    This clinical study is testing a new medication, VH4524184, to see if it can effectively treat HIV-1 in adults who have never received treatment for their infection. The study is comparing two different doses of VH4524184, each taken with the medications emtricitabine and tenofovir alafenamide (FTC…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    GSK Investigational Site, Bakersfield, California

    Locations

    123 in total

    Run by

    ViiV Healthcare

    See if you can join NCT07202546 on ClinicalTrials.gov

14. A Study to Investigate the Safety and PK of VH4770359 in Healthy Participants

    VH4770359 (also known as GSK4770359) is an antiretroviral compound. This first-in-human study aims to evaluate the safety, tolerability, and pharmacokinetics (PK) of orally administered VH4770359 in healthy participants. The findings from this study will support the design of future clinical studie…

    Stage

    Phase 1

    Ages

    18 to 55

    Site

    GSK Investigational Site, Baltimore, Maryland

    Run by

    ViiV Healthcare

    See if you can join NCT07525544 on ClinicalTrials.gov

15. Sexual Health Advocacy for Guys - a Text Messaging-based HIV Prevention Program for Guys Who Are Into Guys

    SHAG is a text messaging-based HIV prevention program designed for cisgender sexual minority boys and men 13-20 years of age across the United States. Investigators will test it against a control group that receives messages about healthy lifestyle.

    Stage

    Not phased

    Ages

    13 to 22

    Site

    Center for Innovative Public Health Research, San Clemente, California

    Locations

    2 in total

    Run by

    Center for Innovative Public Health Research

    See if you can join NCT06230367 on ClinicalTrials.gov

16. Texting to Reduce Human Immunodeficiency Virus (HIV) Risk

    This is a 3-year study to test the efficacy of a text message-based intervention program. Dental patients at 4 community health centers (n= 266) will be randomized to receive either text messages (TMs) regarding HIV prevention or TMs regarding overall wellness. Prior to enrolling the 266 participan…

    Stage

    Not phased

    Ages

    18 and older

    Site

    South End Community Health Center, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Boston University

    See if you can join NCT06088277 on ClinicalTrials.gov

17. An Effectiveness Trial of the PrEP for WINGS Study

    (Effectiveness Aim 1) To test the comparative effectiveness of PreP for WINGS versus PrEP alone on primary outcomes of increasing PrEP initiation measured by self-report/medical records, recent adherence and longer-term adherence by self-report/medical records over the 6-month follow-up; and second…

    Stage

    Not phased

    Ages

    18 and older

    Site

    The Columbia Community Partnership for Health, New York, New York

    Run by

    Columbia University

    See if you can join NCT06853314 on ClinicalTrials.gov

18. Skeletal Muscle Energetics and Fatiguability in Older Individuals

    The investigators are studying whether metabolic abnormalities in calf (leg) muscle in older people with and others without HIV are associated with decreased abilities to exercise.

    Stage

    Not phased

    Ages

    60 to 90

    Site

    Johns Hopkins Hospital, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT04142047 on ClinicalTrials.gov

19. The TAIL-PrEP Study

    The goal of the TAIL-PrEP study is to understand how to support the safe discontinuation of injectable long-acting cabotegravir (cab-LA) and lenacapavir (LEN) while maximizing the public health impact of biomedical HIV prevention interventions. In Aim 1, the study will pilot test and assess the acc…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Columbia University Irving Medical Center / NewYork-Presbyterian Hospital, New York, New York

    Run by

    Columbia University

    See if you can join NCT06868641 on ClinicalTrials.gov

20. A Setting Focus Overdose Prevention Intervention

    A pilot injection-setting targeted peer-driven intervention to reduce HIV and hepatitis C virus transmission and overdose risk behaviors among people who inject drugs (PWID).

    Stage

    Not phased

    Ages

    18 and older

    Site

    Lighthouse Studies at Peer Point, Baltimore, Maryland

    Run by

    Johns Hopkins Bloomberg School of Public Health

    See if you can join NCT05320835 on ClinicalTrials.gov

21. Assessing the Use of MY-RIDE, a Just-in-time Adaptive Intervention, to Improve HIV Prevention and Substance Use in Youth Experiencing Homelessness

    The purpose of this study is to determine whether Motivating Youth to Reduce Infections, Disconnections, and Emotion dysregulation (MY-RIDE) decreases substance use , to determine whether MY-RIDE increases human immunodeficiency virus (HIV) prevention strategies and to evaluate MY-RIDE effects on w…

    Stage

    Not phased

    Ages

    18 to 25

    Site

    The University of Texas Health Science Center at Houston, Houston, Texas

    Run by

    The University of Texas Health Science Center, Houston

    See if you can join NCT06074354 on ClinicalTrials.gov

22. Women Focused Encounters for Resilience Independence Strength and Eudaimonia

    The goal of this combination Type 1 hybrid and observational study is to evaluate the impact of a peer delivered intervention of acceptance and commitment therapy (ACT) + exercise + social support to address the substance (ab)use, violence, and AIDS/HIV (SAVA) to improve medication adherence for wo…

    Stage

    Not phased

    Ages

    18 and older

    Site

    UC San Diego AntiViral Research Center (AVRC), San Diego, California

    Run by

    University of California, San Diego

    See if you can join NCT06216600 on ClinicalTrials.gov

23. The Test-to-PrEP Study

    To compare the effectiveness of two social network strategies (direct distribution and referral-based distribution) in increasing HIV self-testing (HIVST) completion rates among social network contacts of current Pre-Exposure Prophylaxis (PrEP) clients.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Miami, Miami, Florida

    Run by

    University of Miami

    See if you can join NCT06927856 on ClinicalTrials.gov

24. IMARA for Black Male Caregivers and Girls Empowerment (IMAGE)

    The scientific premise of this research is that individual, interpersonal, and structural factors impact Black girls' sexual reproductive health outcomes (sexually transmitted infection (STI) and Human Immunodeficiency Virus (HIV)) and experience of sexual violence. This study expands STI/HIV preve…

    Stage

    Not phased

    Ages

    13 and older

    Site

    University of Illinois Chicago, Chicago, Illinois

    Run by

    University of Illinois at Chicago

    See if you can join NCT06266416 on ClinicalTrials.gov

25. CAR-T Cells for HIV Infection

    This is a limited-center, open-label dose escalating phase I/IIa study of autologous T cells expressing LVgp120duoCAR molecules in people with HIV infection. It will follow a 3+3 design. Dose escalation decisions will be made when a minimum of three participants have completed the safety-evaluation…

    Stage

    Phase 1

    Ages

    18 to 65

    Site

    University of California, Davis, Sacramento, California

    Locations

    2 in total

    Run by

    Steven Deeks

    See if you can join NCT04648046 on ClinicalTrials.gov