Heart Failure Clinical Trials in Sioux Falls, South Dakota

7 studies are recruiting for heart failure in Sioux Falls, South Dakota right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Barostim-Enabled NEurohormonal Intervention For Improving Treatment of Heart Failure

   The purpose of BENEFIT-HF is to demonstrate the safety and effectiveness of Baroreflex Activation Therapy (BAT) with the Barostim System in participants with heart failure, defined as NYHA Functional Class II or III, LVEF < 50% and NT-proBNP < 5,000 pg/mL despite being treated with Guideline-Direct…

   Stage

   Not phased

   Ages

   18 and older

   Site

   North Central Heart, Sioux Falls, South Dakota

   Locations

   11 in total

   Run by

   CVRx, Inc.

   See if you can join NCT07232030 on ClinicalTrials.gov

2. NORM-HF Pivotal Study

   This is an international, multi-center, prospective, randomized, open-label blinded endpoint study designed to demonstrate that use of the FIRE1 NORM™ System in the management of New York Heart Association Class II/III HF patients is superior for reducing the combined endpoint of worsening HF event…

   Stage

   Not phased

   Ages

   18 and older

   Site

   North Central Heart - Avera Hospital, Sioux Falls, South Dakota

   Locations

   9 in total

   Run by

   Foundry Innovation & Research 1, Limited (FIRE1)

   See if you can join NCT07574593 on ClinicalTrials.gov

3. Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

   The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose for children. The primary objective of this study is to evaluate the PK…

   Stage

   Not phased

   Ages

   0 to 20

   Site

   Avera McKennan Hospital & University Medical Center, Sioux Falls, South Dakota

   Locations

   52 in total

   Run by

   Duke University

   See if you can join NCT04278404 on ClinicalTrials.gov

4. Assessment of CCM in HF With Higher Ejection Fraction

   The AIM HIGHer Clinical Trial will evaluate the safety and efficacy of Cardiac Contractility Modulation (CCM) therapy in patients with heart failure with LVEF ≥40% and ≤70%.

   Stage

   Not phased

   Ages

   18 and older

   Site

   North Central Heart, Sioux Falls, South Dakota

   Locations

   105 in total

   Run by

   Impulse Dynamics

   See if you can join NCT05064709 on ClinicalTrials.gov

5. PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III

   This is a prospective, multi-center, open label, randomized control clinical trial evaluating the safety and efficacy of the Cordella™ Pulmonary Artery Sensor System in NYHA Class II-III Heart Failure Patients (PROACTIVE-HF-2 Trial). The study contains of 5 arms: NYHA II Cohort - To demonstrate saf…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Sanford, Sioux Falls, South Dakota

   Locations

   48 in total

   Run by

   Endotronix, Inc.

   See if you can join NCT05934487 on ClinicalTrials.gov

6. The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR

   The objective of this prospective, randomized, double- blinded (patient and assessors), sham-controlled clinical trial is to assess the safety and efficacy of the CMCS in treating heart failure with functional regurgitation (FMR).

   Stage

   Not phased

   Ages

   18 and older

   Site

   North Central Heart-Avera, Sioux Falls, South Dakota

   Locations

   92 in total

   Run by

   Cardiac Dimensions, Inc.

   See if you can join NCT03142152 on ClinicalTrials.gov

7. HF2 Registry - Hemodynamic Frontiers in Heart Failure Registry

   The purpose of the HF2 (Hemodynamic Frontiers in Heart Failure) registry is to collect relevant patient-level demographic, clinical, laboratory, and hemodynamic data from patients implanted with pulmonary artery pressure sensor at participating centers to advance scientific knowledge about ambulato…

   Stage

   Not phased

   Ages

   18 to 100

   Site

   Sanford Health, Sioux Falls, South Dakota

   Locations

   12 in total

   Run by

   University of Kansas Medical Center

   See if you can join NCT06425848 on ClinicalTrials.gov