Glaucoma Clinical Trials

42 studies are recruiting for glaucoma in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Phase 2 Trial to Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral Implant

   Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral Implant

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Glaukos Investigative Site, Grand Junction, Colorado

   Locations

   3 in total

   Run by

   Glaukos Corporation

   See if you can join NCT07075718 on ClinicalTrials.gov

2. A Study About the Safety of ASP2767 and Whether it Helps People With Glaucoma-Related Optic Nerve Damage

   Open-angle glaucoma is the most common type of glaucoma, a disease that damages the nerves in the eye and can lead to vision loss. Current treatments include eye drops, laser treatment, and surgery that help lower eye pressure. However, they do not work for everyone, and the disease may continue to…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Ophthalmic Consultants of Boston and Boston Eye Surgery & Laser Center, Boston, Massachusetts

   Run by

   Astellas Pharma Global Development, Inc.

   See if you can join NCT07770685 on ClinicalTrials.gov

3. Functional and Structural Imaging for Glaucoma

   The specific aims of the clinical studies are to: * Develop a directional high-resolution OCT and OCT angiography prototype to improve imaging of structure and perfusion. * Validate wide-field OCT and OCT angiography parameters to improve early glaucoma detection. * Simulate visual field results by…

   Stage

   Not phased

   Ages

   40 to 85

   Site

   Oregon Health & Science University, Casey Eye Institute, Portland, Oregon

   Run by

   Oregon Health and Science University

   See if you can join NCT01957267 on ClinicalTrials.gov

4. The Glaucoma and Retinopathy Screening Study

   The goal of this clinical trial is to learn if a new screening approach including an artificial intelligence algorithm that analyzes fundus photographs, measurement of eye pressure and visual field testing works to screen for glaucoma. Participants will: Have an image of their fundus (back of the e…

   Stage

   Not phased

   Ages

   40 and older

   Site

   Massachusetts General Hospital Internal Medicine Associates, Boston, Massachusetts

   Locations

   7 in total

   Run by

   Massachusetts Eye and Ear Infirmary

   See if you can join NCT06882356 on ClinicalTrials.gov

5. Study of Corneal Biomechanics in Glaucoma Patients Using Brillouin Microscopy

   This pilot study evaluates the biomechanical properties of the cornea in glaucoma patients using Brillouin microscopy, a non-contact imaging technique. The study aims to compare corneal stiffness between patients with normal-tension glaucoma, high-tension glaucoma, and healthy controls, and to asse…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Maryland School of Medicine, Baltimore, Maryland

   Run by

   University of Maryland, Baltimore

   See if you can join NCT06993597 on ClinicalTrials.gov

6. Optimize Pediatric OCT Imaging

   Handheld optical coherence tomography (OCT) has become an important imaging modality to evaluate the pediatric retina. The objective of this pilot study is to compare a new contact OCT system (Theia Imaging) with an investigational noncontact OCT system (Duke Biomedical Engineering) to assess their…

   Stage

   Not phased

   Ages

   Any age

   Site

   Duke University Eye Center, Durham, North Carolina

   Run by

   Duke University

   See if you can join NCT06139523 on ClinicalTrials.gov

7. Glaucoma Drainage Device and Endothelial Cell Loss Compare Trial

   Glaucoma Drainage Device and Endothelial Cell Loss Compare Trial (DECLARE) is a multi-center, outcome-masked, randomized clinical trial. The purpose of this study is to compare glaucoma drainage device implantation in the anterior chamber (front part of the eye) and sulcus (small space between iris…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of California San Francisco, San Francisco, California

   Locations

   8 in total

   Run by

   University of Pennsylvania

   See if you can join NCT05924477 on ClinicalTrials.gov

8. Optic Nerve Head Strain in Non-glaucoma Subjects

   Persons who do not have glaucoma will have pictures taken of the optic nerve with a standard camera before and 2 weeks after starting to take a daily glaucoma eye drop to lower eye pressure. These data will be used to compare to the same procedure performed with glaucoma patients to study how glauc…

   Stage

   EARLY_Phase 1

   Ages

   30 to 90

   Site

   Johns Hopkins Hospital, Baltimore, Maryland

   Run by

   Johns Hopkins University

   See if you can join NCT07425535 on ClinicalTrials.gov

9. Ocular Blood Flow Imaging for Glaucoma Assessment

   The goal of this clinical trial is to investigate the use of an FDA-cleared retinal blood flow imaging instrument called the XyCAM RI and XyCAM FC (Vasoptic Medical, Inc., Columbia, MD) in glaucoma management. The main question it aims to answer are: * Can the investigators use blood flow to discri…

   Stage

   Not phased

   Ages

   18 to 88

   Site

   University of Maryland Eye Associates at Redwood, Baltimore, Maryland

   Run by

   University of Maryland, Baltimore

   See if you can join NCT05726058 on ClinicalTrials.gov

10. Stem Cell Ophthalmology Treatment Study II

    This study will evaluate the use of autologous bone marrow derived stem cells (BMSC) for the treatment of retinal and optic nerve damage or disease.

    Stage

    Not phased

    Ages

    18 and older

    Site

    MD Stem Cells, Westport, Connecticut

    Locations

    4 in total

    Run by

    MD Stem Cells

    See if you can join NCT03011541 on ClinicalTrials.gov

11. Imaging the Effects of Netarsudil (Rhopressa) on the Trabecular Meshwork in Glaucoma and Ocular Hypertension

    This study evaluates the effects of netarsudil (Rhopressa) on the trabecular meshwork in subjects with ocular hypertension or open-angle glaucoma. Participants will be randomized to receive either netarsudil or placebo (artificial tears). High-resolution imaging using adaptive optics gonioscopy, an…

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Indiana Universtiy School of Optometry, Bloomington, Indiana

    Run by

    Indiana University

    See if you can join NCT07588152 on ClinicalTrials.gov

12. Village-Integrated Eye Worker Trial II

    The vast majority of blindness is avoidable. The World Health Organization (WHO) estimates that 80% of cases of visual impairment could be prevented or reversed with early diagnosis and treatment. The leading causes of visual impairment are cataract and refractive error, followed by glaucoma, age-r…

    Stage

    Not phased

    Ages

    60 and older

    Site

    University of California, San Francisco, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT03752840 on ClinicalTrials.gov

13. Rocklatan vs Latanoprost Post-DSLT

    This is a randomized, double-masked, single-site, prospective, contralateral eye study designed to evaluate the outcomes of Direct Selective Laser Trabeculoplasty (DSLT) followed by the addition of combination netarsudil and latanoprost (Rocklatan) versus latanoprost monotherapy. The study will be …

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Eye Centers of Southeast Texas, Beaumont, Texas

    Run by

    Eye Centers of Southeast Texas

    See if you can join NCT07465913 on ClinicalTrials.gov

14. Comparison of Intraocular Pressure Measurement With the Novel TonoVera Device With Other Commonly Used Devices

    We are testing the accuracy of Reichert's Tono-Vera tonometer by comparing measurements of IOP with this device and measurements with other commonly-used tonometers, including Goldmann Applanation and iCare.

    Stage

    Not phased

    Ages

    Any age

    Site

    Ross Eye Institute, Buffalo, New York

    Run by

    State University of New York at Buffalo

    See if you can join NCT05523622 on ClinicalTrials.gov

15. Strategies for Improving Linkage-to-Care After Eye Disease Screening

    The goal of this randomized, parallel-group, controlled trial is to compare methods of improving linkage-to-care for participants in the Village Integrated Eye Worker II (VIEW II) trial who are referred to the eye hospital following eye disease screening. Participants who are referred to the hospit…

    Stage

    Not phased

    Ages

    60 and older

    Site

    University of California, San Francisco, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT06943599 on ClinicalTrials.gov

16. Change in IOP Fluctuation After DSLT

    This is a prospective, single-center, single-arm, observational study designed to evaluate the change in diurnal intraocular pressure (IOP) fluctuation following Direct Selective Laser Trabeculoplasty (DSLT) in patients with primary open-angle glaucoma (POAG) who are on 1-3 IOP lowering medications…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Ophthalmology Associates, Fort Worth, Texas

    Run by

    Ophthalmology Associates, Fort Worth

    See if you can join NCT07428668 on ClinicalTrials.gov

17. Glaucoma Screening to Enhance At-Risk Californians' Health

    The vast majority of glaucoma cases in the United States go undetected and untreated until the late stages of the disease. Open-angle glaucoma is a progressive condition that is asymptomatic in its early to moderate stages and may be amenable to screening through telemedicine-based approaches. This…

    Stage

    Not phased

    Ages

    50 and older

    Site

    Baywell Health, Oakland, California

    Locations

    2 in total

    Run by

    University of California, San Francisco

    See if you can join NCT06854198 on ClinicalTrials.gov

18. Glaucoma Related Quality of Life

    Subjects with a diagnosis of glaucoma will be handed out different quality of life related questionnaires and their score will be evaluated at baseline and 3-6 months after treatment or surgery was initiated/performed.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Iowa, Dept. of Ophthalmology & Visual Sciences, Iowa City, Iowa

    Run by

    Marc Toeteberg-Harms

    See if you can join NCT07510087 on ClinicalTrials.gov

19. A Trial of Hydrus Microstent Versus Goniotomy

    The goal of this clinical trial is to evaluate the comparative efficacy and safety of Hydrus Microstent, incisional goniotomy, and excisional goniotomy when combined with cataract surgery in patients with mild and moderate open-angle glaucoma. The main questions it aims to answer are: * How do the …

    Stage

    Not phased

    Ages

    40 to 85

    Site

    Massachusetts Eye and Ear, Boston, Massachusetts

    Run by

    Massachusetts Eye and Ear Infirmary

    See if you can join NCT06289491 on ClinicalTrials.gov

20. Trial to Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral Implant

    Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral Implant

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Glaukos Investigative Site, Dothan, Alabama

    Run by

    Glaukos Corporation

    See if you can join NCT07495852 on ClinicalTrials.gov

21. Advancing Pediatric Retinal Imaging With Auto-aligned OCT

    The goal of the current study is to conduct a pilot study to test a new version of the handheld OCT device capable of auto-alignment to image the retina in adult volunteers, and adult and pediatric patients in clinic.

    Stage

    Not phased

    Ages

    0 and older

    Site

    Duke University Eye Center, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT06841575 on ClinicalTrials.gov

22. Treatment of Ocular Discomfort in Glaucoma Patients Using Multiple Topical Medications

    To evaluate glaucoma patients' response to treatment with Xiidra, an FDA-approved drug for ocular surface discomfort, which will be prescribed as standard of care treatment.

    Stage

    Not phased

    Ages

    Any age

    Site

    Doheny Eye Center UCLA, Fountain Valley, California

    Run by

    University of California, Los Angeles

    See if you can join NCT04354545 on ClinicalTrials.gov

23. Automated Applanation Tonometry - Updated

    Goldmann Applanation Tonometry (GAT) is considered the clinical gold standard for eye pressure measurements and yet it is known to be a subjective measurement with limited repeatability and limited portability. Another clinical standard for checking eye pressure is known as the pneumotonometer. Thi…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Duke Eye Center, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT07298356 on ClinicalTrials.gov

24. Biomarkers of Ocular Surface Damage in the Setting of Topical Ocular Hypotensive Medication Use

    The objective of this study is to evaluate whether reduction in topical medication with the injection of a sustained release capsule (Durysta) leads to a reduction in ocular surface inflammation, indicated by levels of caspase-1, an inflammatory biomarker.

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Bascom Palmer Eye Institute, Miami, Florida

    Run by

    University of Miami

    See if you can join NCT07217678 on ClinicalTrials.gov

25. Community Based Treatment for (ComBaT) Glaucoma

    The purpose of this research is to evaluate if intervention and education can change the behavior of someone's willingness to see an eye care provider to prevent blindness and glaucoma. The researchers are investigating if adding additional resources improves participant access to care.

    Stage

    Not phased

    Ages

    40 and older

    Site

    Historic King Solomon Baptist Church, Detroit, Michigan

    Locations

    2 in total

    Run by

    University of Michigan

    See if you can join NCT06124521 on ClinicalTrials.gov