Esophageal Adenocarcinoma Clinical Trials

34 studies are recruiting for esophageal adenocarcinoma in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. Study of TJ033721 (Givastomig) in Subjects With Advanced or Metastatic Solid Tumors

   This is an open label, multi-center, multiple dose Phase 1 study to evaluate the safety, tolerability, MTD PK, and PD of TJ033721 (givastomig) in subjects with advanced or metastatic solid tumors.

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Stern Center for Cancer Clinical Trials and Research, Orange, California

   Locations

   21 in total

   Run by

   I-Mab Biopharma US Limited

   See if you can join NCT04900818 on ClinicalTrials.gov

2. Study of AZD5863 in Adult Participants With Advanced or Metastatic Solid Tumors

   This research is designed to determine if experimental treatment with AZD5863, a T cell-engaging bispecific antibody that targets Claudin 18.2 (CLDN18.2) and CD3, is safe, tolerable and has anti-cancer activity in patients with advanced solid tumors.

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Research Site, Jacksonville, Florida

   Locations

   25 in total

   Run by

   AstraZeneca

   See if you can join NCT06005493 on ClinicalTrials.gov

3. A Study of Mesothelin-Targeted CAR T-Cell Therapy in People With Esophagogastric Cancer

   Participants will have a sample of their white blood cells, called T cells, collected using a procedure called leukapheresis. The collected T cells will be sent to a laboratory at Memorial Sloan Kettering to be changed (modified) to become MSLN-targeted CAR T cells, the CAR T-cell therapy that part…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey

   Locations

   7 in total

   Run by

   Memorial Sloan Kettering Cancer Center

   See if you can join NCT06623396 on ClinicalTrials.gov

4. Minimally Invasive Molecular Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Adenocarcinoma

   This study will evaluate if the sponge capsule device can accurately detect the presence of Barrett's Esophagus and prevalent dysplasia/adenocarcinoma detection, in a screening population, with and without chronic gastroesophageal reflux disease.

   Stage

   Not phased

   Ages

   18 to 90

   Site

   Mayo Clinic Health Systems - Austin, Austin, Minnesota

   Locations

   9 in total

   Run by

   Mayo Clinic

   See if you can join NCT03961945 on ClinicalTrials.gov

5. Cabozantinib Plus Durvalumab With or Without Tremelimumab in Patients With Gastroesophageal Cancer and Other Gastrointestinal Malignancies

   The investigators propose to evaluate the safety of drug combinations in patients with advanced gastroesophageal cancer and other gastrointestinal (GI) malignancies. Finding effective novel therapies for patients with advanced gastric cancer and other GI malignancies is an area of great unmet need.…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania

   Locations

   2 in total

   Run by

   Anwaar Saeed

   See if you can join NCT03539822 on ClinicalTrials.gov

6. Propranolol With Standard Chemoradiation for Esophageal Adenocarcinoma

   This phase II trial studies the side effects and best dose of propranolol when administered concurrently with SOC neoadjuvant CRT in patients with esophageal carcinoma, with a safety lead-in and dose expansion cohort. Patients who are already on β-blockers will receive standard of care CRT, or defi…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Roswell Park Cancer Institute, Buffalo, New York

   Run by

   Roswell Park Cancer Institute

   See if you can join NCT04682158 on ClinicalTrials.gov

7. Barrett's Esophagitis in Anorexia Nervosa Binge/Purge Subtype

   To better define the presence of Barrett's esophagus (BE) via non-endoscopic testing in an eating disorder cohort with purging (vomiting/rumination) behaviors

   Stage

   Not phased

   Ages

   18 to 65

   Site

   ACUTE Center for Eating Disorders and Severe Malnutrition, Denver, Colorado

   Locations

   3 in total

   Run by

   Denver Health and Hospital Authority

   See if you can join NCT06532734 on ClinicalTrials.gov

8. A Phase II Trial to Evaluate the Effect of Itraconazole on Pathologic Complete Response Rates in Resectable Esophageal Cancer

   Esophageal cancer, which has a low 5-year overall survival rate (<20%) is increasing in incidence. Previous studies have shown that Hedgehog, AKT, and angiogenic signaling pathways are activated in a significant number of esophageal cancers. Itraconazole, a widely used anti-fungal medication, effec…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   VA Palo Alto Health Care System, Palo Alto, CA, Palo Alto, California

   Locations

   7 in total

   Run by

   VA Office of Research and Development

   See if you can join NCT05563766 on ClinicalTrials.gov

9. Progression of Gastroesophageal Reflux Disease and Barrett's Esophagus and the Creation of a Barrett's Registry

   The purpose of this study is to determine or evaluate the risk factors such as smoking, family history etc. that cause esophageal cancer and to determine the genetic changes that lead to esophageal cancer. The investigators hypothesis is that systematic collection of data on the natural history of …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Department of Veterans Affairs Medical Center, Kansas City, Missouri

   Run by

   Midwest Biomedical Research

   See if you can join NCT00574327 on ClinicalTrials.gov