Esophageal Adenocarcinoma Clinical Trials in Cleveland, Ohio

6 studies are recruiting for esophageal adenocarcinoma in Cleveland, Ohio right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms

   The goal of this clinical trial is to develop a method to detect Barrett's esophagus in individuals with a new office based diagnostic test. Barrett's esophagus is a condition in which the flat pink lining of the swallowing tube that connects the mouth to the stomach (the esophagus) becomes damaged…

   Stage

   Not phased

   Ages

   50 and older

   Site

   University Hospitals Cleveland Medical Center, Cleveland, Ohio

   Locations

   5 in total

   Run by

   Case Comprehensive Cancer Center

   See if you can join NCT06687603 on ClinicalTrials.gov

2. Itraconazole in Combination With Ablation for the Prevention of Esophageal Cancer in Patients With High-risk Barrett's Esophagus

   This phase II trial tests how well itraconazole works in combination with the usual standard of care endoscopy with ablation for the prevention of esophageal cancer in patients who have high-risk Barrett's esophagus (BE). BE is a condition in which the lining of the esophagus changes and becomes mo…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Case Western Reserve University, Cleveland, Ohio

   Locations

   6 in total

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT06732388 on ClinicalTrials.gov

3. Surveillance vs. Endoscopic Therapy for Barrett's Esophagus With Low-grade Dysplasia

   The purpose of this study is to learn the best approach to treating patients with known or suspected Barrett's esophagus by comparing endoscopic surveillance to endoscopic eradication therapy. To diagnose and manage Barrett's esophagus and low-grade dysplasia, doctors commonly use procedures called…

   Stage

   Not phased

   Ages

   18 to 89

   Site

   Cleveland VA Medical Research and Education Foundation, Cleveland, Ohio

   Locations

   30 in total

   Run by

   University of Colorado, Denver

   See if you can join NCT05753748 on ClinicalTrials.gov

4. Obeticholic Acid for Prevention in Barrett's Esophagus

   This phase II trial studies the effect of obeticholic acid in treating patients with Barrett's esophagus. Bile acids present in duodenogastroesophageal reflux contribute to neoplastic progression in Barrett's esophagus. Obeticholic acid has shown anti-cholestatic, anti-inflammatory and anti-fibroti…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Case Western Reserve University, Cleveland, Ohio

   Locations

   8 in total

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT04939051 on ClinicalTrials.gov

5. A Study of Sigvotatug Vedotin in Advanced Solid Tumors

   This trial will look at a drug called sigvotatug vedotin (SGN-B6A) alone and with pembrolizumab, with or without chemotherapy, to find out whether it is safe for people who have solid tumors. It will study sigvotatug vedotin to find out what its side effects are. A side effect is anything the drug …

   Stage

   Phase 1

   Ages

   18 and older

   Site

   University Hospitals Cleveland Medical Center, Cleveland, Ohio

   Locations

   158 in total

   Run by

   Seagen, a wholly owned subsidiary of Pfizer

   See if you can join NCT04389632 on ClinicalTrials.gov

6. First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors

   A multicenter, single-arm, first-in-human study to investigate the safety, pharmacokinetics, and preliminary antitumor activity of PLX-61639 in participants with locally advanced or metastatic, relapsed/refractory, SMARCA4-deficient solid tumors who are intolerant of or have failed available, appro…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Research Site, Cleveland, Ohio

   Locations

   10 in total

   Run by

   Plexium, Inc.

   See if you can join NCT07284186 on ClinicalTrials.gov