Diabetic Foot Ulcer Clinical Trials

36 studies are recruiting for diabetic foot ulcer in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Transverse Tibial Bone Transport (TTT) in the Management of Chronic Diabetic Lower Extremity Wounds

   The purpose of this study is to evaluate the safety and clinical performance of transverse tibial bone transport in patients with chronic ischemic and diabetic lower extremity ulcers. This study will assess wound healing outcomes and limb preservation in a population with limited therapeutic altern…

   Stage

   Not phased

   Ages

   22 and older

   Site

   Mayo Clinic, Jacksonville, Florida

   Run by

   Biodynamik, Inc

   See if you can join NCT07444593 on ClinicalTrials.gov

2. DFC 004 Biomarkers for Active Diabetic Foot Ulcers

   This study is a platform study designed to efficiently test multiple biomarkers to identify diabetic foot ulcers (DFUs) with a higher potential for healing versus not healing that ultimately could be applied at the point of care to drive personalized management decisions, and to better inform clini…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Arizona College of Medicine, Tucson, Arizona

   Locations

   9 in total

   Run by

   University of Michigan

   See if you can join NCT06104969 on ClinicalTrials.gov

3. Evaluating the Efficacy of Perinatal Membrane Allografts in Addition to the Standard of Care for the Treatment of Non-healing Diabetic Foot Ulcers.

   The goal of this clinical trial is to learn if using perinatal tissue allografts improves healing of chronic, non-healing foot ulcers in diabetic patients. The main question that this study aims to answer is: Does the use of perinatal tissue allografts in conjunction with standard of care wound man…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Monroe Biomedical Research, Monroe, North Carolina

   Run by

   Samaritan Biologics

   See if you can join NCT06437028 on ClinicalTrials.gov

4. Evaluating the Efficacy of OCM™ (Omeza® Complete Matrix) in the Treatment of Diabetic Foot Ulcers

   This study aims to compare two treatment approaches for diabetic foot ulcers (DFUs): the standard of care (SOC) alone versus SOC combined with OCM. Researchers will evaluate whether adding OCM increases the likelihood of ulcers healing completely by the end of the trial period.

   Stage

   Not phased

   Ages

   18 and older

   Site

   SitePath Research, Evergreen Park, Illinois

   Locations

   10 in total

   Run by

   Omeza, LLC

   See if you can join NCT07161830 on ClinicalTrials.gov

5. WIREDUP: Wearable Insoles for Recurrent Diabetic Ulcer Prevention

   The primary aim of this study is to demonstrate the impact of the Orpyx® Sensory Insoles (Orpyx Medical Technologies Inc., Calgary AB, Canada) ("Orpyx" or "the Company") as an adjunct to the standard of care (SOC), as compared to SOC alone, on reducing plantar ulceration incidence in individuals wh…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Johns Hopkins Hospital, Baltimore, Maryland

   Run by

   Johns Hopkins University

   See if you can join NCT05950659 on ClinicalTrials.gov

6. Evaluating the Efficacy NeoThelium FT in the Treatment of Diabetic Foot Ulcers

   This is a randomized controlled crossover trial evaluating the efficacy of NeoThelium FT in conjunction with standard of care vs. standard of care alone in treating diabetic foot ulcers.

   Stage

   Not phased

   Ages

   18 and older

   Site

   MedCentris of Alexandria, Alexandria, Louisiana

   Locations

   8 in total

   Run by

   NuScience Medical Biologics, LLC

   See if you can join NCT06938685 on ClinicalTrials.gov

7. Exercise Enhances Wound Healing in Patients With Diabetic Foot Ulcers

   The overarching purpose of this study is to investigate the impact that exercise, as delivered through a medically supervised, outpatient cardiac rehabilitation program, has on the wound healing process in Type 2 diabetics having foot ulcers classified as being Wound, Ischemia, foot Infection (WIfI…

   Stage

   Not phased

   Ages

   20 to 80

   Site

   UNM Cardiac Rehabilitation Services, Albuquerque, New Mexico

   Run by

   University of New Mexico

   See if you can join NCT04791449 on ClinicalTrials.gov

8. Mirragen Diabetic Foot Ulcer Study

   This study is being done to collect data from treatment of patients who have diabetes with non-healing foot wounds and are being treated with a resorbable and biocompatible borate-based bioactive glass fiber matrix. A borate-based bioactive glass fiber matrix is used to cover the ulcer for wound ma…

   Stage

   Not phased

   Ages

   18 to 80

   Site

   UT Health Medical Arts and Research Center, San Antonio, Texas

   Run by

   The University of Texas Health Science Center at San Antonio

   See if you can join NCT06598241 on ClinicalTrials.gov

9. Randomized Evaluation of Nonhealing Diabetic Foot Ulcers With Exclusive Wound Therapy

   The goal of this study is to determine the between-arm difference in the proportion of subjects achieving complete closure of nonhealing diabetic foot ulcers with multiple CAMPs plus SOC versus matched controls over 12 weeks using a modified platform trial design.

   Stage

   Phase 4

   Ages

   18 and older

   Site

   Serena Group- Monroeville, Monroeville, Pennsylvania

   Run by

   Sequence LifeScience, Inc.

   See if you can join NCT07086443 on ClinicalTrials.gov

10. Study Assessing Complete Wound Healing by Comparing Surgenex® PelloGraft in Treating DFU and SanoGraft® in Treating VLU to SOC

    The purpose of this study is to compare Pellograft to standard of care modalities in treating diabetic foot ulcers in human subjects, and to compare Sanograft to standard of care in treating venous leg ulcers. The study will demonstrate wound healing outcomes with comparators including time to woun…

    Stage

    Not phased

    Ages

    18 and older

    Site

    ILD Research, Vista, California

    Locations

    2 in total

    Run by

    Surgenex

    See if you can join NCT06515093 on ClinicalTrials.gov

11. Prospective Case Series Evaluating the Efficacy and Safety of NeoThelium FT for Diabetic Foot Ulcers

    This is a prospective case series evaluating the efficacy and safety of NeoThelium FT Amnion Skin Graft in the Mangement of Diabetic Foot Ulcers

    Stage

    Not phased

    Ages

    18 and older

    Site

    MedCentris of Alexandria, Alexandria, Louisiana

    Locations

    3 in total

    Run by

    NuScience Medical Biologics, LLC

    See if you can join NCT07039396 on ClinicalTrials.gov

12. Trial to Evaluate the Safety and Effectiveness of Treatment With COMS One Device in Subjects With Diabetic Foot Ulcers

    The purpose of this clinical trial is to evaluate the safety and effectiveness of the treatment with the COMS One device in subjects with refractory diabetic foot ulcers (DFUs). The prospective randomized, double-blinded, sham-controlled trial is designed to demonstrate superiority of wound closure…

    Stage

    Not phased

    Ages

    22 to 90

    Site

    Titan Clinical Research, Mesa, Arizona

    Locations

    30 in total

    Run by

    Piomic Medical

    See if you can join NCT05758545 on ClinicalTrials.gov

13. Evaluation of ELU42 Topical Spray for the Treatment of Diabetic Foot Ulcers

    ELU42 01 01 (SuperHealer42) is a Phase I/IIA open label study sponsored by Eluciderm, Inc. that evaluates the safety and preliminary effectiveness of ELU42, a topical small molecule designed to modulate Wnt signaling, for the treatment of chronic diabetic foot ulcers (DFU). ELU42 combines a tankyra…

    Stage

    Phase 1

    Ages

    18 to 75

    Site

    Gateway Clinical Trials, O'Fallon, Illinois

    Locations

    4 in total

    Run by

    Eluciderm Inc

    See if you can join NCT07396376 on ClinicalTrials.gov

14. A Multicenter, Prospective, Controlled Clinical Trial Evaluating the Efficacy of a Single Layer Placental-based Allograft and Standard of Care in the Management of Nonhealing Diabetic Foot Ulcers

    A multicenter, prospective, controlled clinical trial evaluating the efficacy of a single layer placental-based allograft and standard of care in the management of nonhealing diabetic foot ulcers.

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Royal Research, Hollywood, Florida

    Run by

    Applied Biologics, LLC

    See if you can join NCT07159282 on ClinicalTrials.gov

15. Evaluating the Durability of Closure for Diabetic Foot Ulcers Following a Randomized, Controlled, Modified Platform Trial.

    Prospective long-term follow-up on durability of closure evaluated by photographic and thermal scanning.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Detroit Foot and Ankle, Clinton Township, Michigan

    Run by

    Applied Biologics, LLC

    See if you can join NCT07360418 on ClinicalTrials.gov

16. A Multicenter, Prospective, Controlled Modified Multi-Platform Trial Assessing the Efficacy of Human Placental Membrane Products and Standard of Care in the Management of Nonhealing Diabetic Foot Ulcers and Venous Leg Ulcers.

    The study is a multicenter, prospective, controlled modified multi-platform trial assessing the efficacy of human placental membrane products and standard of care in the management of nonhealing diabetic foot ulcers and venous leg ulcers.

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Center for Foot and Ankle Disorders, Philidelphia, Pennsylvania

    Run by

    BioLab Holdings

    See if you can join NCT07364630 on ClinicalTrials.gov

17. Smart Boot Use to Measure Offloading Adherence

    The purpose of this study is to help people with diabetes who develop neuropathic diabetic foot ulcers (DFUs). These ulcers, or sores, if left untreated can increase the chance of amputation. Part of the treatment is to have the person wear a diabetic shoe or boot to help their foot heal. Sometimes…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Rancho Los Amigos National Rehabilitation Center, Downey, California

    Locations

    4 in total

    Run by

    University of Southern California

    See if you can join NCT04460573 on ClinicalTrials.gov

18. EDX110 Randomized Control Trial for Treatment of DFUs

    Prospective, multi-centered, observer blinded, pre-market study, 1:1 randomized control trial, to determine if addition of EDX110 dressing system to standard of care leads to an improvement in diabetic foot ulcers healing compared to just using standard of care.

    Stage

    Not phased

    Ages

    18 to 90

    Site

    Axentra Bio, Phoenix, Arizona

    Locations

    4 in total

    Run by

    ConvaTec Inc.

    See if you can join NCT07209358 on ClinicalTrials.gov

19. Noraxon myoRESEARCH™ Software Gait Analysis Evaluation and Orthotic Gait Correction in Reducing Diabetic Foot Ulceration Or Subsequent Amputation in Patients With a History of a Diabetic Foot Ulceration

    Determining whether the utilization of Noraxon myoRESEARCH Software gait analysis Evaluation and orthotic gait Correction can reduce diabetic foot ulceration Or subsequent amputation in patients with a history of a diabetic foot ulceration.

    Stage

    Not phased

    Ages

    18 to 90

    Site

    Johns Hopkins Hospital, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT04164641 on ClinicalTrials.gov

20. Total Contact Soft Cast in Diabetic Foot Ulcers

    To determine the effectiveness, compliance, patient tolerance, ease of use and safety of total contact soft cast in diabetic foot ulcers.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT04210089 on ClinicalTrials.gov

21. Comprehensive Assistance and Resources for Effective Diabetic Foot Navigation

    The purpose of this interventional study is to assess the effectiveness of CARE-D-Foot, a patient navigator intervention, as compared to usual care, on 20-week diabetic foot ulcer healing. The study will further: * Evaluate fidelity to and acceptability of the CARE-D-Foot-Nav program using mixed me…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Grady Memorial Hospital, Atlanta, Georgia

    Run by

    Emory University

    See if you can join NCT07223268 on ClinicalTrials.gov

22. A Study to Evaluate ENERGI-F703 GEL in Diabetic Foot Ulcer

    This Phase 3 study is a randomized, double-blind, vehicle-controlled, multiple-center, parallel study to evaluate efficacy and safety of ENERGI-F703 GEL compared with vehicle control in subjects with Wagner Grade 1 to Grade 2 diabetic foot ulcers. Baseline target ulcer size (<16 cm2 vs ≥16 cm2 ) wi…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    A and D Doctor Center, Miami, Florida

    Locations

    24 in total

    Run by

    Energenesis Biomedical Co., Ltd.

    See if you can join NCT05930210 on ClinicalTrials.gov

23. Non-Invasive Testing to Evaluate Wound Healing in Diabetes

    Normal group: We will collect normative data from healthy individuals to include baseline data, screening, and images. Up to 500 people will be enrolled and can include normal healthy volunteers, staff and students/trainees. Data will be collected one time with no follow up. Patient group: We will …

    Stage

    Not phased

    Ages

    18 to 89

    Site

    UT Southwestern Medical Center at Dallas, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT04232631 on ClinicalTrials.gov

24. Trial Assessing the Efficacy of Human Placental Membrane Products and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot Ulcers and Venous Leg Ulcers

    The purpose of this study is to evaluate the efficacy of human placental membrane products and standard of care versus standard of care alone in the management of nonhealing diabetic foot ulcers and venous leg ulcers.

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Center for Foot and Ankle Disorders, Philidelphia, Pennsylvania

    Run by

    BioLab Holdings

    See if you can join NCT07089602 on ClinicalTrials.gov

25. Evaluating a Lifestyle Intervention to Prevent Recurrence of Diabetic Foot Ulcers

    People with diabetes often experience foot ulcers, which can harm their ability to move, lower their quality of life, and increase the chances of losing a limb. These diabetic foot ulcers (DFUs) commonly come back (recur) even after they've healed, so it's crucial to stop them from returning to avo…

    Stage

    Not phased

    Ages

    21 and older

    Site

    Keck Hospital of USC, Los Angeles, California

    Locations

    3 in total

    Run by

    University of Southern California

    See if you can join NCT06487780 on ClinicalTrials.gov