Diabetes Mellitus, Type 2 Clinical Trials

60 studies are recruiting for diabetes mellitus, type 2 in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. A Trial Evaluating AMG 127 in Healthy Participants and Participants With Type 2 Diabetes Mellitus

   The main objective of this trial is to assess the safety and tolerability of AMG 127 as single dose and multiple doses in healthy participants and participants with type 2 diabetes mellitus (T2DM).

   Stage

   Phase 1

   Ages

   18 to 75

   Site

   Orange County Research Center, Lake Forest, California

   Locations

   2 in total

   Run by

   Amgen

   See if you can join NCT07590193 on ClinicalTrials.gov

2. Re-Engineered Discharge for Diabetes Care Transitions

   The goal of this project is to test a novel bedside SDOH screening intervention coupled with post-discharge navigation for hospitalized patients with a diabetes diagnosis to reduce unmet social needs, compared to usual care.

   Stage

   Not phased

   Ages

   18 and older

   Site

   UMASS Memorial Healthcare System, Worcester, Massachusetts

   Run by

   University of Massachusetts, Worcester

   See if you can join NCT06869057 on ClinicalTrials.gov

3. Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial

   Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease globally. While weight loss through lifestyle modification is the standard treatment, most patients regain weight limiting ultimate improvement in liver disease. On the other end of the spectru…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Brigham and Women's Hospital, Boston, Massachusetts

   Locations

   2 in total

   Run by

   Pichamol Jirapinyo, MD, MPH

   See if you can join NCT06138821 on ClinicalTrials.gov

4. OASIS: Peer Support for T2DM in Appalachia (Peer Coaches)

   The goal of this clinical trial is to compare the effects of peer coaching models in older adults with unmanaged type two diabetes. The main questions it aims to answer are: * Are peer coaching models effective at promoting Type 2 Diabetes Mellitus self-management? * If effective, which facets of t…

   Stage

   Not phased

   Ages

   55 and older

   Site

   Barren River Area Development District, Bowling Green, Kentucky

   Locations

   2 in total

   Run by

   The University of Texas Medical Branch, Galveston

   See if you can join NCT06003634 on ClinicalTrials.gov

5. OASIS: Peer Support for T2DM in Appalachia (Peer Participant)

   The goal of this clinical trial is to compare the effects of peer coaching models in older adults with unmanaged type two diabetes. The main questions it aims to answer are: * Are peer coaching models effective at promoting Type 2 Diabetes Mellitus self-management? * If effective, which facets of t…

   Stage

   Not phased

   Ages

   55 and older

   Site

   Barren River Area Development District, Bowling Green, Kentucky

   Locations

   2 in total

   Run by

   The University of Texas Medical Branch, Galveston

   See if you can join NCT06336122 on ClinicalTrials.gov

6. Primary Care Pragmatic, Real World Experience for Automated Insulin Delivery

   The goal of this randomized controlled trial is to compare the efficacy and safety of the iLet Bionic Pancreas (BP) System in adults with insulin-treated diabetes (type 1 diabetes or type 2 diabetes) compared to standard of care when ordered by primary care providers. The main question it aims to a…

   Stage

   Not phased

   Ages

   18 to 89

   Site

   University of Colorado Anschutz Medical Campus, Aurora, Colorado

   Locations

   2 in total

   Run by

   University of Colorado, Denver

   See if you can join NCT07011147 on ClinicalTrials.gov

7. Glucose and Activity Tracking for Sedentary Behavior Interventions in Older People With Type 2 Diabetes (TRACK T2D)

   The overarching goal of this explanatory mixed methods study is to evaluate how older people living with type 2 diabetes (T2D) integrate continuous glucose monitor (CGM) and activity data in diabetes self-management, and how this technology supports reduced sedentary behavior (SB) and improved gluc…

   Stage

   Not phased

   Ages

   55 and older

   Site

   University of Minnesota, Minneapolis, Minnesota

   Run by

   University of Minnesota

   See if you can join NCT07524205 on ClinicalTrials.gov

8. Milk for Diabetes Prevention

   Individuals with lactase non-persistence (LNP; determined by a functional variant in the LCT gene [rs4988235, GG genotype]) are susceptible to lactose intolerance in adulthood due to deficiency of lactase, the enzyme which digests milk lactose sugars. However, many LNP individuals still drink ≥1 cu…

   Stage

   Not phased

   Ages

   18 to 70

   Site

   HCHS/SOL Bronx Field Center, The Bronx, New York

   Run by

   Albert Einstein College of Medicine

   See if you can join NCT06513026 on ClinicalTrials.gov

9. Mixed Methods Study of Health-Related Social Needs in African American Adults With Chronic Kidney Disease and Type 2 Diabetes Mellitus

   The overarching goal of this study is to understand facilitators and barriers to self-care, develop and refine a culturally tailored intervention to improve clinical outcomes, quality of life (QOL), and self-care behaviors in African American adults with diabetic kidney disease (DKD) experiencing h…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Medical College of Wisconsin, Milwaukee, Wisconsin

   Run by

   Medical College of Wisconsin

   See if you can join NCT05692388 on ClinicalTrials.gov

10. Implementing Scalable, PAtient-centered, Team-based, Technology-enabled Care for Adults With Type 2 Diabetes (iPATH)

    Sixteen institutions will be selected from a HRSA uniform data system and have data collected for up to 3 years. Eight institutions will begin the iPATH practice transformation during year one, the other eight institutions will begin iPATH in year two. FQHC administrators, clinicians and staff will…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Board of Trustees of the Leland Stanford Junior University, Stanford, California

    Locations

    4 in total

    Run by

    Stanford University

    See if you can join NCT06251323 on ClinicalTrials.gov

11. Gemini Study: A Prospective, Multicenter Evaluation of Performance and Safety of the Eversense Gemini System With Flash Glucose Measurement Feature

    A prospective, multicenter evaluation of performance and safety of the Eversense Gemini System with flash glucose measurement feature. The purpose of this clinical investigation is to evaluate the accuracy of the Gemini System with new technological flash glucose monitoring (FGM) feature enhancemen…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Headlands Research - AMCR Institute, Escondido, California

    Run by

    Senseonics, Inc.

    See if you can join NCT07386340 on ClinicalTrials.gov

12. ROME GS System Study

    The purpose of this clinical investigation is to demonstrate that the proposed physical changes to the ROME GS Sensor do not have any adverse impact on safety and performance when compared to the Eversense 365 Sensor.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Headlands Research - AMCR Institute, Escondido, California

    Locations

    4 in total

    Run by

    Senseonics, Inc.

    See if you can join NCT07518004 on ClinicalTrials.gov

13. Normal-weight Diabetes: Adipocyte-directed Therapy With Pioglitazone or Tirzepatide

    This study is to investigate how adipocyte (fat cell) function and fat distribution differ between individuals with normal-weight type 2 diabetes (NWD), those with overweight type 2 diabetes (OWD), and normal-weight controls without diabetes (NWC). The study will assess whether adipocyte-directed t…

    Stage

    Phase 4

    Ages

    30 to 70

    Site

    Stanford University, Palo Alto, California

    Locations

    2 in total

    Run by

    Stanford University

    See if you can join NCT06657209 on ClinicalTrials.gov

14. Boosting Emotional Well-being and Happiness in Outpatients Living With Diabetes

    The focus of this study is to test the efficacy of an 8-week, remotely delivered, positive-psychology-motivational interviewing (PP-MI) intervention, with additional twice weekly text messages for a total of 16 weeks (with interactive, algorithm-driven, goal-focused text messages in the final 8 wee…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT05420051 on ClinicalTrials.gov

15. Project Dulce for Arab Americans With Type 2 Diabetes

    Arab Americans (AA) face many challenges in diabetes self-management due to the limited educational resources and support available for them. The cultural and linguistic barriers between patients and health care providers lead to poor diabetes management and outcomes. This study (Project Dulce Arab…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Metro Caring, Denver, Colorado

    Locations

    2 in total

    Run by

    Scripps Whittier Diabetes Institute

    See if you can join NCT05580536 on ClinicalTrials.gov

16. Transformative Research in Diabetic Nephropathy 2.0

    The goal of this observational study is to learn more about kidney health in adults with diabetic kidney disease and other groups. Researchers will study kidney tissue and other samples. They want to learn how sodium-glucose cotransporter-2 (SGLT2) inhibitors, a type of diabetes medicine, may affec…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Penn Presbyterian Medical Center, Philadelphia, Pennsylvania

    Run by

    University of Pennsylvania

    See if you can join NCT07444203 on ClinicalTrials.gov

17. Pilot-Testing Real-Time Engagement for Learning to Effectively Control Type 2 Diabetes

    The goal of this study is to pilot test features of a new smartphone app and to gather feedback related to wearing a continuous glucose monitor (CGM) and a Fitbit device, as well as to obtain input on health behavior-focused messages delivered through the app. The study will enroll English-speaking…

    Stage

    Not phased

    Ages

    16 to 24

    Site

    Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania

    Run by

    University of Pittsburgh

    See if you can join NCT07270016 on ClinicalTrials.gov

18. Blood Markers of Early Pancreas Cancer

    Identifying biomarkers of early pancreatic ductal adenocarcinoma (PDAC) could facilitate screening for individuals at higher than average risk and expedite the diagnosis in individuals with symptoms and substantially improve an individual's chance of surviving the disease. The investigators propose…

    Stage

    Not phased

    Ages

    19 and older

    Site

    Unversity of Nebraska Medical Center, Omaha, Nebraska

    Run by

    University of Nebraska

    See if you can join NCT03568630 on ClinicalTrials.gov

19. Use of CGM in Kidney Transplant Recipients

    The investigators want to study the impact CGM (continuous glucose monitoring) has on patients glycemic control as determined by time in range (TIR 70-180 mg/dL) in the Diabetic Kidney Transplant population.

    Stage

    Not phased

    Ages

    18 and older

    Site

    UC Davis Health, Sacramento, California

    Run by

    University of California, Davis

    See if you can join NCT04783441 on ClinicalTrials.gov

20. Drug Interaction Potential of Pro-Inflammatory Conditions

    Pro-inflammatory cytokines, which are elevated in pro-inflammatory disease states (e.g., type II diabetes mellitus [T2DM], irritable bowel diseases [IBD], and end stage renal disease [ESRD]) have been shown to inhibit hepatic drug-metabolizing enzymes, including members of the cytochrome P450 (CYP)…

    Stage

    Not phased

    Ages

    12 to 99

    Site

    Indiana University Hospital, Indianapolis, Indiana

    Run by

    Indiana University

    See if you can join NCT07360938 on ClinicalTrials.gov

21. Improving Diabetes Care With Strategies For Addressing Health-Related Social Needs and Community Partnerships

    The goal of this study is to develop, implement, and evaluate a patient-centered triage and referral model designed to improve health outcomes for individuals with uncontrolled type 2 diabetes mellitus (T2DM) and unmet health-related social needs. The intervention builds on the existing THRIVE infr…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Boston Medical Center, Boston, Massachusetts

    Run by

    Boston Medical Center

    See if you can join NCT07043426 on ClinicalTrials.gov

22. Family Model DSME in FBOs in the RMI

    Health disparities in the Republic of the Marshall Islands are striking, with extremely high rates of type 2 diabetes. Documented prevalence of type 2 diabetes in the Marshall Islands ranges from 20%-50%.This is significantly higher than the global (8.5%) and United States (11%) prevalence. Diabete…

    Stage

    Not phased

    Ages

    18 and older

    Site

    UAMS Institute for Community Health Innovation, Springdale, Arkansas

    Run by

    University of Arkansas

    See if you can join NCT05502016 on ClinicalTrials.gov

23. Post Prandial Individual Responses to Different Foods

    This study aims to understand why people respond differently to the same foods, especially when it comes to changes in blood sugar after eating. A continuous glucose monitors (CGMs) will be used to observe how individuals respond to specific meals and drinks (e.g., Oral Glucose Tolerance Test, OGTT…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Stanford University, Stanford, California

    Run by

    Stanford University

    See if you can join NCT06989164 on ClinicalTrials.gov

24. SCS for Patient With Painful Diabetic Neuropathy and Peripheral Arterial Disease

    Peripheral arterial disease (PAD) affects over 230 million adults worldwide and is a highly morbid, costly, and disabling condition. Ischemic leg pain drives disability in PAD patients and results from oxygen supply-demand mismatch, autonomic dysfunction, and muscle breakdown. This leg pain, which …

    Stage

    Not phased

    Ages

    19 to 89

    Site

    University of Nebraska Medical Center, Omaha, Nebraska

    Run by

    University of Nebraska

    See if you can join NCT06480786 on ClinicalTrials.gov

25. Linking Education, Produce Provision, and Community Referrals to Improve Diabetes Care (LINK)

    This is a pragmatic randomized controlled trial (pRCT) that aims to test the effect of produce provision, diabetes education, and community referrals on hemoglobin A1c levels in individuals with type 2 diabetes experiencing food insecurity.

    Stage

    Not phased

    Ages

    18 and older

    Site

    The Ohio State University Wexner Medical Center, Columbus, Ohio

    Run by

    Ohio State University

    See if you can join NCT05472441 on ClinicalTrials.gov