Diabetes Mellitus, Type 2 Clinical Trials

60 studies are recruiting for diabetes mellitus, type 2 in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. A Study of Clazakizumab (LY5724886) in Adults With Elevated hsCRP and at Increased Risk for Cardiovascular Event

   The purpose of this study is to measure the change in high-sensitivity C-reactive protein (hsCRP), a marker of inflammation in the body, with clazakizumab compared with placebo in adults who have elevated hsCRP and at increased risk for cardiovascular event. Participation in the study will last abo…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Heart Center Research, LLC, Huntsville, Alabama

   Locations

   46 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT07783802 on ClinicalTrials.gov

2. EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease

   This study is open to adults with type 2 diabetes, high blood pressure, and cardiovascular disease. People can join the study if they have these conditions and do not have a history of heart failure. The purpose of this study is to find out if a medicine called vicadrostat, when taken with empaglif…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Pinnacle Research Group, LLC, Anniston, Alabama

   Locations

   1142 in total

   Run by

   Boehringer Ingelheim

   See if you can join NCT07064473 on ClinicalTrials.gov

3. A Study to Evaluate Effect of AZD6234 in Adult Participants With Type 2 Diabetes Mellitus and Obesity or Overweight

   The study will evaluate how well AZD6234 works and how safe it is in adults with excess weight or obesity. Efficacy of AZD6234 will be compared to placebo in percent body weight change from baseline at 68 weeks of treatment

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Research Site, Fairhope, Alabama

   Locations

   230 in total

   Run by

   AstraZeneca

   See if you can join NCT07784270 on ClinicalTrials.gov

4. A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in Children and Adolescents With Type 2 Diabetes

   The purpose of this clinical study is to look into how well a study medicine called CagriSema helps children and adolescents living with diabetes lower their blood sugar and body weight. The study has 2 parts: in the first part participant will get either CagriSema or placebo, and in the second par…

   Stage

   Phase 3

   Ages

   10 to 18

   Site

   Encore Medical Research Boynton Beach, Boynton Beach, Florida

   Locations

   58 in total

   Run by

   Novo Nordisk A/S

   See if you can join NCT07282613 on ClinicalTrials.gov

5. A Study of Orforglipron (LY3502970) Compared With Dulaglutide in Pediatric Participants With Type 2 Diabetes

   This study looks at how well a medicine called orforglipron works compared to another medicine called dulaglutide in pediatric participants aged 10 to less than 18 years with type 2 diabetes. The study will also check how safe these medicines are and how the body processes them. Participation in th…

   Stage

   Phase 3

   Ages

   10 to 17

   Site

   Stamford Therapeutics Consortium, Stamford, Connecticut

   Locations

   71 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT07668336 on ClinicalTrials.gov

6. Knee Osteoarthritis Treatment With Zilretta vs. Kenalog in the Context of Type II Diabetes

   A Phase 2 Randomized Study to Evaluate the Effects of triamcinolone acetonide extended-release (TA-ER; Zilretta) vs. triamcinolone acetonide immediate-release (TA-IR; Kenalog) on Blood Glucose Levels in Diabetic Subjects with Knee Osteoarthritis. Subjects should have Type 2 Diabetes Mellitus (T2DM)…

   Stage

   Phase 4

   Ages

   40 and older

   Site

   University of Kansas Medical Center, Kansas City, Kansas

   Run by

   University of Kansas Medical Center

   See if you can join NCT06478186 on ClinicalTrials.gov

7. Reversibility of Brain Glucose Transport in Type 2 Diabetes Mellitus (T2DM)

   The goal of this clinical trial is to learn about the effects of high blood glucose levels in the brain and assess if the changes seen in individuals with poorly control T2DM can be reversed with good glucose control. The main question[s] it aims to answer are: * To determine, whether abnormalities…

   Stage

   Not phased

   Ages

   18 to 60

   Site

   Yale New Haven Hospital (YNHH) Research Unit (HRU), New Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT05776563 on ClinicalTrials.gov

8. Real-time Engagement for Learning to Effectively Control Type 2 Diabetes

   The goal of this clinical trial is to learn if a new smartphone app that pairs glucose and exercise data will help adolescents and young adults with type 2 diabetes improve glycemic control. It will also study how changes in glycemic control are maintained over time. The main questions it aims to a…

   Stage

   Not phased

   Ages

   14 to 26

   Site

   UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania

   Run by

   University of Pittsburgh

   See if you can join NCT06375460 on ClinicalTrials.gov

9. A Research Study Comparing How Well Different Doses of the Medicine UBT251 Lower Blood Sugar in People With Type 2 Diabetes

   The study is testing UBT251 in participants with type 2 diabetes. The purpose of this clinical study is to find out if UBT251 is effective and safe for treating participants with type 2 diabetes. Participants will either get UBT251, UBT251 placebo, semaglutide, or semaglutide placebo. Which treatme…

   Stage

   Phase 2

   Ages

   18 to 75

   Site

   Flourish Research, Birmingham, Alabama

   Locations

   70 in total

   Run by

   Novo Nordisk A/S

   See if you can join NCT07668388 on ClinicalTrials.gov

10. MANAGe-DM: Novel Nurse Case Management to Improve Diabetes Outcomes in Formerly Incarcerated Black Men

    The study is a randomized control trial involving 100 participants (formerly incarcerated Black men with poorly controlled diabetes) to examine the effect of a tailored nurse case manager on glycemic control and other clinical outcomes, self-care behaviors, and quality of life at 6 months post-rand…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Center for Advancing Population Science, Medical College of Wisconsin, Milwaukee, Wisconsin

    Run by

    Medical College of Wisconsin

    See if you can join NCT06031428 on ClinicalTrials.gov

11. Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-2-EXTENSION)

    The primary objective of this trial is to evaluate the long-term efficacy, safety, and tolerability of maridebart cafraglutide in participants with obesity and type 2 diabetes mellitus. Trial 20210182 is extension of trial 20210184 (NCT06858878).

    Stage

    Phase 3

    Ages

    18 to 99

    Site

    Gilbert Center for Family Medicine, Gilbert, Arizona

    Locations

    45 in total

    Run by

    Amgen

    See if you can join NCT07684144 on ClinicalTrials.gov

12. Efficacy of mHealth Apps for Health in a Low-income, Type II Diabetic, Hispanic Population

    The purpose of this study is to determine the effectiveness of mobile health applications in improving health outcomes and the subsequent benefit of improving type II diabetes outcomes in a low socioeconomic Hispanic population. This study will involve a 6-month long commitment where participants w…

    Stage

    Not phased

    Ages

    18 to 64

    Site

    San Diego State University, San Diego, California

    Run by

    San Diego State University

    See if you can join NCT05279729 on ClinicalTrials.gov

13. Efficacy of Using Mobile Health Applications for Health

    The purpose of this study is to determine the effectiveness of mobile health applications in improving health outcomes and type II diabetes outcomes in type 2 diabetics. This study will involve a 6-month long commitment where participants will be expected to weigh themselves every morning, at the s…

    Stage

    Not phased

    Ages

    18 to 64

    Site

    San Diego State University, San Diego, California

    Run by

    San Diego State University

    See if you can join NCT05589155 on ClinicalTrials.gov

14. Research Study on How People With Type 2 Diabetes Tolerate Switching From Semaglutide to Cagrisema

    The purpose of this clinical study is to look at the safety and tolerability of switching from semaglutide to CagriSema, for participants who have type 2 diabetes. All participants will get CagriSema, the treatment being tested. Participants will be in this clinical study for about 6 months.

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Gilbert Center For Family Medicine, Gilbert, Arizona

    Locations

    40 in total

    Run by

    Novo Nordisk A/S

    See if you can join NCT07817251 on ClinicalTrials.gov

15. A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events

    TRANSFORM is a prospective, randomized, open blinded endpoint (PROBE), event-driven, pragmatic trial in patients who are at increased risk for atherosclerotic cardiovascular (CV) disease but with no known symptomatic CV disease. The trial tests the hypothesis that a Cleerly Coronary Artery Disease …

    Stage

    Not phased

    Ages

    55 and older

    Site

    Chandler Clinical Trials, Chandler, Arizona

    Locations

    125 in total

    Run by

    Cleerly, Inc.

    See if you can join NCT06112418 on ClinicalTrials.gov

16. Pre-diabetes in Subject With Impaired Fasting Glucose (IFG) and Impaired Glucose Tolerance (IGT)

    HYPOTHESIS: Impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) have distinct pathophysiologic etiologies. Therefore, therapeutic interventions designed to correct the specific underlying pathogenic abnormalities in IGT and IFG will be required to optimally prevent the progressive b…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    The University of Texas Health Science Center at San Antonio, San Antonio, Texas

    Run by

    The University of Texas Health Science Center at San Antonio

    See if you can join NCT02969798 on ClinicalTrials.gov

17. Phenotyping Genetic Risk for Type 2 Diabetes

    This study tests the hypothesis that non-diabetic individuals with a high genetic risk score for type 2 diabetes have impaired glucose tolerance and insulin resistance compared to those with a low genetic risk score for type 2 diabetes.

    Stage

    Not phased

    Ages

    10 to 70

    Site

    University of Pennsylvania, Philadelphia, Pennsylvania

    Locations

    2 in total

    Run by

    University of Pennsylvania

    See if you can join NCT04024631 on ClinicalTrials.gov

18. Improving the Collaborative Health of Adult Dyads

    This study tests the efficacy of a dyadic intervention to mitigate the adverse health consequences of adults with pre-existing chronic health conditions and their informal carepartners (IC). Socioeconomically disadvantaged, older, and people from rural regions are more likely burdened with greater …

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of South Carolina, Columbia, South Carolina

    Run by

    University of South Carolina

    See if you can join NCT05370014 on ClinicalTrials.gov

19. A Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419 Lower Blood Sugar in People With Type 2 Diabetes

    This study is being done to look at the effect and safety of different doses of NNC0662-0419 in people living with type 2 diabetes when compared to placebo or semaglutide. The purpose of this clinical study is to find out if NNC0662-0419 is effective and safe for treating people living with type 2 …

    Stage

    Phase 2

    Ages

    18 to 75

    Site

    First Valley Medical Group, Lancaster, California

    Locations

    63 in total

    Run by

    Novo Nordisk A/S

    See if you can join NCT07415954 on ClinicalTrials.gov

20. Diabetes Multimorbidity Typology, Trajectory, and Feasibility of an Audio Diary Mobile Application to Support Self-management

    The goal of this clinical trial is to evaluate whether an audio diary mobile application (Fabla-diabetesMM) is feasible to use and may support self-management in older adults with type 1 or 2 diabetes and multimorbidity. The main questions it aims to answer are: * Is it feasible to adapt and implem…

    Stage

    Not phased

    Ages

    65 and older

    Site

    Emory Healthcare, Atlanta, Georgia

    Run by

    Emory University

    See if you can join NCT07474376 on ClinicalTrials.gov

21. Food Insecurity Reduction & Strategy Team

    This study seeks to address the multifaceted challenges posed by food disparities and their negative consequences on health outcomes, via a comprehensive community health intervention program. Study objectives include: 1. To describe the social-demographic and clinical factors associated with food …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Stanford Medicine, Palo Alto, California

    Run by

    Stanford University

    See if you can join NCT06329375 on ClinicalTrials.gov

22. Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity (ATM)

    The goal of this study is to evaluate the role of transcription factor EB (TFEB) in adipose (fat) tissue macrophages (ATM) in regulating adipose tissue and systemic metabolic function in obesity. The investigators will assess the differences in ATM lipid metabolism in people with metabolically abno…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    University of Missouri School of Medicine, Columbia, Missouri

    Run by

    Bettina Mittendorfer

    See if you can join NCT06571474 on ClinicalTrials.gov

23. Safer Aging With Diabetes Monitoring

    Older adults with type 2 diabetes are at higher risk for severe hypoglycemia and its related complications (including hospitalization and death) when taking insulin. This study proposes to evaluate, in a randomized clinical trial, a strategy of safe insulin prescribing based on an educational progr…

    Stage

    Not phased

    Ages

    75 and older

    Site

    Kaiser Permanente Sacramento, Sacramento, California

    Locations

    6 in total

    Run by

    Kaiser Permanente

    See if you can join NCT06296485 on ClinicalTrials.gov

24. Continuous Glucose Metrics in Patients With Gastroparesis in Type 1 or Type 2 Diabetes

    A pilot study to evaluate and compare glucose metrics using a real-time continuous glucose monitor (FreeStyle Libre 3 sensor) between patients with diabetes and gastroparesis and those with diabetes without gastroparesis.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Cleveland Clinic Foundation, Cleveland, Ohio

    Run by

    Samita Garg

    See if you can join NCT06046833 on ClinicalTrials.gov

25. Investigating the Impact of GLP-1 RA Therapy on Osteosarcopenia in Older Female Adults With Diabetes

    The goal of this study is to learn how GLP-1 receptor agonist therapy affects muscle and bone health in older females over age 65 with type 2 diabetes. The main question it aims to answer is whether or not 6 months of GLP-1 RA therapy affects muscle strength. Participants will: * Receive GLP-1 RA t…

    Stage

    Phase 3

    Ages

    65 and older

    Site

    Grady Memorial Hospital, Atlanta, Georgia

    Run by

    Emory University

    See if you can join NCT07428746 on ClinicalTrials.gov