Diabetes Mellitus, Type 2 Clinical Trials

58 studies are recruiting for diabetes mellitus, type 2 in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Improving the Collaborative Health of Adult Dyads

   This study tests the efficacy of a dyadic intervention to mitigate the adverse health consequences of adults with pre-existing chronic health conditions and their informal carepartners (IC). Socioeconomically disadvantaged, older, and people from rural regions are more likely burdened with greater …

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of South Carolina, Columbia, South Carolina

   Run by

   University of South Carolina

   See if you can join NCT05370014 on ClinicalTrials.gov

2. EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease

   This study is open to adults with type 2 diabetes, high blood pressure, and cardiovascular disease. People can join the study if they have these conditions and do not have a history of heart failure. The purpose of this study is to find out if a medicine called vicadrostat, when taken with empaglif…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Pinnacle Research Group, LLC, Anniston, Alabama

   Locations

   1143 in total

   Run by

   Boehringer Ingelheim

   See if you can join NCT07064473 on ClinicalTrials.gov

3. A Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419 Lower Blood Sugar in People With Type 2 Diabetes

   This study is being done to look at the effect and safety of different doses of NNC0662-0419 in people living with type 2 diabetes when compared to placebo or semaglutide. The purpose of this clinical study is to find out if NNC0662-0419 is effective and safe for treating people living with type 2 …

   Stage

   Phase 2

   Ages

   18 to 75

   Site

   First Valley Medical Group, Lancaster, California

   Locations

   63 in total

   Run by

   Novo Nordisk A/S

   See if you can join NCT07415954 on ClinicalTrials.gov

4. A Research Study Comparing How Well Different Doses of the Medicine UBT251 Lower Blood Sugar in People With Type 2 Diabetes

   The study is testing UBT251 in participants with type 2 diabetes. The purpose of this clinical study is to find out if UBT251 is effective and safe for treating participants with type 2 diabetes. Participants will either get UBT251, UBT251 placebo, semaglutide, or semaglutide placebo. Which treatme…

   Stage

   Phase 2

   Ages

   18 to 75

   Site

   Flourish Research, Birmingham, Alabama

   Locations

   70 in total

   Run by

   Novo Nordisk A/S

   See if you can join NCT07668388 on ClinicalTrials.gov

5. A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in Children and Adolescents With Type 2 Diabetes

   The purpose of this clinical study is to look into how well a study medicine called CagriSema helps children and adolescents living with diabetes lower their blood sugar and body weight. The study has 2 parts: in the first part participant will get either CagriSema or placebo, and in the second par…

   Stage

   Phase 3

   Ages

   10 to 18

   Site

   Encore Medical Research Boynton Beach, Boynton Beach, Florida

   Locations

   58 in total

   Run by

   Novo Nordisk A/S

   See if you can join NCT07282613 on ClinicalTrials.gov

6. A Study of Macupatide (LY3532226) and Eloralintide (LY3841136), Alone or in Combination, in Adults With Obesity or Overweight and With Type 2 Diabetes

   The purpose of this study is to investigate weight reduction with macupatide and eloralintide, alone or in combination, in adult participants with obesity or overweight and with type 2 diabetes. Participation in the study will last about 48 weeks.

   Stage

   Phase 2

   Ages

   18 to 75

   Site

   Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLC, Gilbert, Arizona

   Locations

   42 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT07215559 on ClinicalTrials.gov

7. Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-2-EXTENSION)

   The primary objective of this trial is to evaluate the long-term efficacy, safety, and tolerability of maridebart cafraglutide in participants with obesity and type 2 diabetes mellitus. Trial 20210182 is extension of trial 20210184 (NCT06858878).

   Stage

   Phase 3

   Ages

   18 to 99

   Site

   Gilbert Center for Family Medicine, Gilbert, Arizona

   Locations

   37 in total

   Run by

   Amgen

   See if you can join NCT07684144 on ClinicalTrials.gov

8. A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events

   TRANSFORM is a prospective, randomized, open blinded endpoint (PROBE), event-driven, pragmatic trial in patients who are at increased risk for atherosclerotic cardiovascular (CV) disease but with no known symptomatic CV disease. The trial tests the hypothesis that a Cleerly Coronary Artery Disease …

   Stage

   Not phased

   Ages

   55 and older

   Site

   Chandler Clinical Trials, Chandler, Arizona

   Locations

   125 in total

   Run by

   Cleerly, Inc.

   See if you can join NCT06112418 on ClinicalTrials.gov

9. Diabetes Multimorbidity Typology, Trajectory, and Feasibility of an Audio Diary Mobile Application to Support Self-management

   The goal of this clinical trial is to evaluate whether an audio diary mobile application (Fabla-diabetesMM) is feasible to use and may support self-management in older adults with type 1 or 2 diabetes and multimorbidity. The main questions it aims to answer are: * Is it feasible to adapt and implem…

   Stage

   Not phased

   Ages

   65 and older

   Site

   Emory Healthcare, Atlanta, Georgia

   Run by

   Emory University

   See if you can join NCT07474376 on ClinicalTrials.gov

10. Food Insecurity Reduction & Strategy Team

    This study seeks to address the multifaceted challenges posed by food disparities and their negative consequences on health outcomes, via a comprehensive community health intervention program. Study objectives include: 1. To describe the social-demographic and clinical factors associated with food …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Stanford Medicine, Palo Alto, California

    Run by

    Stanford University

    See if you can join NCT06329375 on ClinicalTrials.gov

11. Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity (ATM)

    The goal of this study is to evaluate the role of transcription factor EB (TFEB) in adipose (fat) tissue macrophages (ATM) in regulating adipose tissue and systemic metabolic function in obesity. The investigators will assess the differences in ATM lipid metabolism in people with metabolically abno…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    University of Missouri School of Medicine, Columbia, Missouri

    Run by

    Bettina Mittendorfer

    See if you can join NCT06571474 on ClinicalTrials.gov

12. Safer Aging With Diabetes Monitoring

    Older adults with type 2 diabetes are at higher risk for severe hypoglycemia and its related complications (including hospitalization and death) when taking insulin. This study proposes to evaluate, in a randomized clinical trial, a strategy of safe insulin prescribing based on an educational progr…

    Stage

    Not phased

    Ages

    75 and older

    Site

    Kaiser Permanente Sacramento, Sacramento, California

    Locations

    6 in total

    Run by

    Kaiser Permanente

    See if you can join NCT06296485 on ClinicalTrials.gov

13. Continuous Glucose Metrics in Patients With Gastroparesis in Type 1 or Type 2 Diabetes

    A pilot study to evaluate and compare glucose metrics using a real-time continuous glucose monitor (FreeStyle Libre 3 sensor) between patients with diabetes and gastroparesis and those with diabetes without gastroparesis.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Cleveland Clinic Foundation, Cleveland, Ohio

    Run by

    Samita Garg

    See if you can join NCT06046833 on ClinicalTrials.gov

14. Investigating the Impact of GLP-1 RA Therapy on Osteosarcopenia in Older Female Adults With Diabetes

    The goal of this study is to learn how GLP-1 receptor agonist therapy affects muscle and bone health in older females over age 65 with type 2 diabetes. The main question it aims to answer is whether or not 6 months of GLP-1 RA therapy affects muscle strength. Participants will: * Receive GLP-1 RA t…

    Stage

    Phase 3

    Ages

    65 and older

    Site

    Grady Memorial Hospital, Atlanta, Georgia

    Run by

    Emory University

    See if you can join NCT07428746 on ClinicalTrials.gov

15. A Trial Evaluating AMG 127 in Healthy Participants and Participants With Type 2 Diabetes Mellitus

    The main objective of this trial is to assess the safety and tolerability of AMG 127 as single dose and multiple doses in healthy participants and participants with type 2 diabetes mellitus (T2DM).

    Stage

    Phase 1

    Ages

    18 to 75

    Site

    Orange County Research Center, Lake Forest, California

    Locations

    2 in total

    Run by

    Amgen

    See if you can join NCT07590193 on ClinicalTrials.gov

16. Re-Engineered Discharge for Diabetes Care Transitions

    The goal of this project is to test a novel bedside SDOH screening intervention coupled with post-discharge navigation for hospitalized patients with a diabetes diagnosis to reduce unmet social needs, compared to usual care.

    Stage

    Not phased

    Ages

    18 and older

    Site

    UMASS Memorial Healthcare System, Worcester, Massachusetts

    Run by

    University of Massachusetts, Worcester

    See if you can join NCT06869057 on ClinicalTrials.gov

17. Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial

    Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease globally. While weight loss through lifestyle modification is the standard treatment, most patients regain weight limiting ultimate improvement in liver disease. On the other end of the spectru…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Pichamol Jirapinyo, MD, MPH

    See if you can join NCT06138821 on ClinicalTrials.gov

18. OASIS: Peer Support for T2DM in Appalachia (Peer Coaches)

    The goal of this clinical trial is to compare the effects of peer coaching models in older adults with unmanaged type two diabetes. The main questions it aims to answer are: * Are peer coaching models effective at promoting Type 2 Diabetes Mellitus self-management? * If effective, which facets of t…

    Stage

    Not phased

    Ages

    55 and older

    Site

    Barren River Area Development District, Bowling Green, Kentucky

    Locations

    2 in total

    Run by

    The University of Texas Medical Branch, Galveston

    See if you can join NCT06003634 on ClinicalTrials.gov

19. OASIS: Peer Support for T2DM in Appalachia (Peer Participant)

    The goal of this clinical trial is to compare the effects of peer coaching models in older adults with unmanaged type two diabetes. The main questions it aims to answer are: * Are peer coaching models effective at promoting Type 2 Diabetes Mellitus self-management? * If effective, which facets of t…

    Stage

    Not phased

    Ages

    55 and older

    Site

    Barren River Area Development District, Bowling Green, Kentucky

    Locations

    2 in total

    Run by

    The University of Texas Medical Branch, Galveston

    See if you can join NCT06336122 on ClinicalTrials.gov

20. Michigan Men's Diabetes Project III(MenDIII): Mind and Motion

    The Michigan Men's Diabetes Project III: Mind \& Motion is an 7-month pilot randomized clinical trial. The investigators are looking to recruit 80 Black men with type 2 diabetes (T2D) (need to have diagnosis for at least one year) that are over the age of 18. Participants also must be under the car…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT06574035 on ClinicalTrials.gov

21. Primary Care Pragmatic, Real World Experience for Automated Insulin Delivery

    The goal of this randomized controlled trial is to compare the efficacy and safety of the iLet Bionic Pancreas (BP) System in adults with insulin-treated diabetes (type 1 diabetes or type 2 diabetes) compared to standard of care when ordered by primary care providers. The main question it aims to a…

    Stage

    Not phased

    Ages

    18 to 89

    Site

    University of Colorado Anschutz Medical Campus, Aurora, Colorado

    Locations

    2 in total

    Run by

    University of Colorado, Denver

    See if you can join NCT07011147 on ClinicalTrials.gov

22. Glucose and Activity Tracking for Sedentary Behavior Interventions in Older People With Type 2 Diabetes (TRACK T2D)

    The overarching goal of this explanatory mixed methods study is to evaluate how older people living with type 2 diabetes (T2D) integrate continuous glucose monitor (CGM) and activity data in diabetes self-management, and how this technology supports reduced sedentary behavior (SB) and improved gluc…

    Stage

    Not phased

    Ages

    55 and older

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT07524205 on ClinicalTrials.gov

23. Knee Osteoarthritis Treatment With Zilretta vs. Kenalog in the Context of Type II Diabetes

    A Phase 2 Randomized Study to Evaluate the Effects of triamcinolone acetonide extended-release (TA-ER; Zilretta) vs. triamcinolone acetonide immediate-release (TA-IR; Kenalog) on Blood Glucose Levels in Diabetic Subjects with Knee Osteoarthritis. Subjects should have Type 2 Diabetes Mellitus (T2DM)…

    Stage

    Phase 4

    Ages

    40 and older

    Site

    University of Kansas Medical Center, Kansas City, Kansas

    Run by

    University of Kansas Medical Center

    See if you can join NCT06478186 on ClinicalTrials.gov

24. Milk for Diabetes Prevention

    Individuals with lactase non-persistence (LNP; determined by a functional variant in the LCT gene [rs4988235, GG genotype]) are susceptible to lactose intolerance in adulthood due to deficiency of lactase, the enzyme which digests milk lactose sugars. However, many LNP individuals still drink ≥1 cu…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    HCHS/SOL Bronx Field Center, The Bronx, New York

    Run by

    Albert Einstein College of Medicine

    See if you can join NCT06513026 on ClinicalTrials.gov

25. Mixed Methods Study of Health-Related Social Needs in African American Adults With Chronic Kidney Disease and Type 2 Diabetes Mellitus

    The overarching goal of this study is to understand facilitators and barriers to self-care, develop and refine a culturally tailored intervention to improve clinical outcomes, quality of life (QOL), and self-care behaviors in African American adults with diabetic kidney disease (DKD) experiencing h…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Medical College of Wisconsin, Milwaukee, Wisconsin

    Run by

    Medical College of Wisconsin

    See if you can join NCT05692388 on ClinicalTrials.gov