Diabetes Mellitus, Type 1 Clinical Trials

32 studies are recruiting for diabetes mellitus, type 1 in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. A Study of Baricitinib (LY3009104) for the Delay of Stage 3 Type 1 Diabetes in At-Risk Children and Adults

   The purpose of this study is to find out if baricitinib can delay the onset of clinical type 1 diabetes (T1D) in people who are at high risk to develop T1D. Participation in the study will last up to approximately 5 years.

   Stage

   Phase 3

   Ages

   1 to 35

   Site

   Tallahassee Memorial HealthCare, Tallahassee, Florida

   Locations

   113 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT07222137 on ClinicalTrials.gov

2. A Study of Baricitinib (LY3009104) to Preserve Beta Cell Function in Children and Adults Newly Diagnosed With Type 1 Diabetes (BARICADE-PRESERVE)

   The purpose of this study is to find out if baricitinib can preserve beta-cell function in participants newly diagnosed with type 1 diabetes. Participation in the study will last about 60 weeks.

   Stage

   Phase 3

   Ages

   1 to 35

   Site

   Barbara Davis Center for Childhood Diabetes, Aurora, Colorado

   Locations

   137 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT07222332 on ClinicalTrials.gov

3. A Safety, Tolerability, and Efficacy Study of VX-880 and VX-017 in Participants With Type 1 Diabetes

   This study will evaluate the safety, tolerability and efficacy of VX-880 infusion and VX-017 infusion in participants with type 1 diabetes (T1D) and impaired awareness of hypoglycemia (IAH) and severe hypoglycemia.

   Stage

   Phase 3

   Ages

   18 to 65

   Site

   City of Hope, Duarte, California

   Locations

   29 in total

   Run by

   Vertex Pharmaceuticals Incorporated

   See if you can join NCT04786262 on ClinicalTrials.gov

4. A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus

   This study is First In Human study for Encapsulated Porcine Islet Cells for Xenotransplantation (OPF-310). The purpose of this study to assess the safety, tolerability, and efficacy of OPF-310 transplantation and to define the recommended Phase 2 dose (RP2D) in adult subjects with unstable Type 1 D…

   Stage

   Phase 1

   Ages

   35 to 70

   Site

   University of Illinois Hospital & Health Sciences System, Chicago, Illinois

   Run by

   Otsuka Pharmaceutical Factory, Inc.

   See if you can join NCT06575426 on ClinicalTrials.gov

5. Diabetes Multimorbidity Typology, Trajectory, and Feasibility of an Audio Diary Mobile Application to Support Self-management

   The goal of this clinical trial is to evaluate whether an audio diary mobile application (Fabla-diabetesMM) is feasible to use and may support self-management in older adults with type 1 or 2 diabetes and multimorbidity. The main questions it aims to answer are: * Is it feasible to adapt and implem…

   Stage

   Not phased

   Ages

   65 and older

   Site

   Emory Healthcare, Atlanta, Georgia

   Run by

   Emory University

   See if you can join NCT07474376 on ClinicalTrials.gov

6. Therapeutic Strategies for Microvascular Dysfunction in Type 1 Diabetes

   The investigators will test the hypothesis that, in adults with type 1 diabetes (T1D), glucagon-like peptide-1 receptor agonism (GLP-1RA, i.e. dulaglutide) enhances insulin-mediated skeletal muscle microvascular perfusion via attenuating endothelial oxidative stress and thereby improving endothelia…

   Stage

   Phase 2

   Ages

   18 to 40

   Site

   AdventHealth Translational Research Institute, Orlando, Florida

   Run by

   AdventHealth Translational Research Institute

   See if you can join NCT05478707 on ClinicalTrials.gov

7. Food Insecurity Reduction & Strategy Team

   This study seeks to address the multifaceted challenges posed by food disparities and their negative consequences on health outcomes, via a comprehensive community health intervention program. Study objectives include: 1. To describe the social-demographic and clinical factors associated with food …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Stanford Medicine, Palo Alto, California

   Run by

   Stanford University

   See if you can join NCT06329375 on ClinicalTrials.gov

8. Continuous Glucose Metrics in Patients With Gastroparesis in Type 1 or Type 2 Diabetes

   A pilot study to evaluate and compare glucose metrics using a real-time continuous glucose monitor (FreeStyle Libre 3 sensor) between patients with diabetes and gastroparesis and those with diabetes without gastroparesis.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Cleveland Clinic Foundation, Cleveland, Ohio

   Run by

   Samita Garg

   See if you can join NCT06046833 on ClinicalTrials.gov

9. Breaking Disparities in Access to Advanced Diabetes Technologies in Children With Type 1 Diabetes

   50 children/adolescents (ages 6 to <18yrs) with T1D in suboptimal control (HbA1c≥8.0%) and lower SES (below 200% poverty line) on insulin therapy (either injections or open-loop pumps) will be recruited at Nemours ~ 1/3 each AA, Hispanic/Latino, non-Hispanic whites. All families that qualify and ag…

   Stage

   Not phased

   Ages

   6 to 17

   Site

   Nemours Children's Health, Jacksonville, Florida

   Locations

   2 in total

   Run by

   Nemours Children's Clinic

   See if you can join NCT05849753 on ClinicalTrials.gov

10. Effect of Inhaled Technosphere Insulin vs RAA Insulin on Exercise-Induced Hypoglycemia in Adults With T1D Using Automated Insulin Delivery

    This investigator-initiated study will enroll about 30 adults 18 to 65 years of age with type 1 diabetes (T1D) who are using the Tandem t:slim X2 insulin pump or Tandem Mobi insulin pump with Control-IQ or Control-IQ+ technology ("Control-IQ" which will refer to either Control-IQ or Control-IQ+). T…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    University of Louisville, Louisville, Kentucky

    Locations

    3 in total

    Run by

    Jaeb Center for Health Research

    See if you can join NCT06880835 on ClinicalTrials.gov

11. Regulation of Brain Glucose Metabolism in Type 1 Diabetes

    This is a prospective randomized placebo-controlled double-blind crossover pilot study determining the effect of dichloroacetate on brain function under clamped hypoglycemia in T1DM.

    Stage

    EARLY_Phase 1

    Ages

    18 to 55

    Site

    Yale-New Haven Hospital, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT05317455 on ClinicalTrials.gov

12. Gemini Study: A Prospective, Multicenter Evaluation of Performance and Safety of the Eversense Gemini System With Flash Glucose Measurement Feature

    A prospective, multicenter evaluation of performance and safety of the Eversense Gemini System with flash glucose measurement feature. The purpose of this clinical investigation is to evaluate the accuracy of the Gemini System with new technological flash glucose monitoring (FGM) feature enhancemen…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Headlands Research - AMCR Institute, Escondido, California

    Run by

    Senseonics, Inc.

    See if you can join NCT07386340 on ClinicalTrials.gov

13. Hybrid Closed Loop Effectiveness Trial in Adults With Type 1 Diabetes

    Minoritized individuals with type 1 diabetes (T1D) have approximately 2% higher average A1c levels and twice the rate of hospitalizations, complications, and mortality as their white counterparts. However, the efficacy trials establishing the benefits of hybrid closed loop (HCL) pump therapy in T1D…

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Boston Medical Center, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Boston Medical Center

    See if you can join NCT06236607 on ClinicalTrials.gov

14. Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease

    Powerful new drugs that can prevent or delay end stage kidney disease (ESKD) - so called sodium-glucose cotransporter-2 inhibitors (SGLT2i) - are now available for patients with type 2 diabetes. Whether these drugs have similar effects in patients with type 1 diabetes (T1D) remains unknown because …

    Stage

    Phase 3

    Ages

    18 to 75

    Site

    Stanford University Medical Center, Stanford, California

    Locations

    19 in total

    Run by

    Alessandro Doria

    See if you can join NCT06217302 on ClinicalTrials.gov

15. Efficacy and Safety of a Ketogenic Diet in Type 1 Diabetes

    Despite strong evidence that tight control of blood sugar reduces the risk of diabetes complications, most people with type 1 diabetes do not achieve recommended blood sugar targets. This randomized controlled trial will test whether a very-low- carbohydrate ketogenic diet can effectively and safel…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Washington University School of Medicine, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT06503809 on ClinicalTrials.gov

16. Genetics Of Autoimmunity In Type I Diabetes

    The purpose of this study is to gain more information about the step-by-step process that causes someone to develop type 1 diabetes. Scientists think that a person's own immune system, directed by genetic and environmental factors play a major role in its development. Participation involves a blood…

    Stage

    Not phased

    Ages

    2 and older

    Site

    Medical College of Wisconsin, Milwaukee, Wisconsin

    Run by

    Medical College of Wisconsin

    See if you can join NCT03648918 on ClinicalTrials.gov

17. Type 1 Diabetes Impacts of Semaglutide on Cardiovascular Outcomes

    This trial plans to learn more about the effects of a medication, semaglutide, on cardiovascular function, kidney function, and insulin sensitivity in adults with type 1 diabetes. This medication has been effective in reducing cardiovascular disease and diabetic kidney disease and improving glucose…

    Stage

    Phase 3

    Ages

    18 to 49

    Site

    University of Colorado Anschutz Medical Campus, Aurora, Colorado

    Locations

    2 in total

    Run by

    University of Colorado, Denver

    See if you can join NCT05819138 on ClinicalTrials.gov

18. Closed Loop and Education for Hypoglycemia Awareness Restoration

    The purpose of the CLEAR study is to determine the effect on counterregulatory responses (CRR) of intervening (by attempting to strictly avoid hypoglycemia) to improve awareness of hypoglycemic symptoms among adults with type 1 diabetes (T1D) who have impaired awareness of hypoglycemia (IAH). IAH a…

    Stage

    Not phased

    Ages

    18 to 75

    Site

    University of California, San Diego, La Jolla, California

    Locations

    8 in total

    Run by

    Milton S. Hershey Medical Center

    See if you can join NCT06325202 on ClinicalTrials.gov

19. Improving Islet Transplantation Outcomes With Gastrin for Type I Diabetes

    This clinical study will evaluate the safety and effectiveness of Gastrin treatment with islet transplantation to help patients with difficult to control type 1 diabetes make insulin again and improve blood sugar control. This study involves two investigational (experimental) products not yet appro…

    Stage

    Phase 1

    Ages

    18 to 68

    Site

    City of Hope Medical Center, Duarte, California

    Run by

    City of Hope Medical Center

    See if you can join NCT03746769 on ClinicalTrials.gov

20. Safety and Efficacy of CELZ-201 in Patients With Recent Onset Type 1 Diabetes

    The brief purpose of this research study is to learn about the safety and efficacy of intra-arterial administration of CELZ-201 in patients with newly diagnosed Type 1 Diabetes Mellitus (T1D).

    Stage

    Phase 1

    Ages

    18 to 35

    Site

    Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, Florida

    Run by

    Creative Medical Technology Holdings Inc

    See if you can join NCT05626712 on ClinicalTrials.gov

21. Starting Technology in At Risk Type 1 Diabetes Study

    Diabetes technology has revolutionized T1D management, disparities in technology access are evident among racial-ethnic minorities, patients with lower socioeconomic status and those with poorly controlled T1D (A1c>8.5%). In order to examine whether diabetes technology can reduce diabetes care burd…

    Stage

    Not phased

    Ages

    18 and older

    Site

    UCLA, Santa Monica, California

    Locations

    3 in total

    Run by

    University of California, Los Angeles

    See if you can join NCT06453928 on ClinicalTrials.gov

22. CBTi for the Treatment of Insomnia in Type 1 Diabetes

    The goal of this study is to learn if treating insomnia with a therapy intervention in people with type 1 diabetes will help to better control sugar levels, sleep, and quality of life. The questions this study aims to answer include: Will this intervention help the insomnia symptoms? Will obtaining…

    Stage

    EARLY_Phase 1

    Ages

    18 to 65

    Site

    University of Illinois Chicago, Chicago, Illinois

    Run by

    University of Illinois at Chicago

    See if you can join NCT07091318 on ClinicalTrials.gov

23. Islet Transplantation in Patients With "Brittle" Type I Diabetes

    The purpose of this study is to learn about the safety of islet transplantation for Type 1 diabetes mellitus, which may provide more normal control of blood sugar without the need for insulin shots. Islets are special clusters of cells within the pancreas that produce insulin. These cells will be o…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    University of Chicago Medical Center, Chicago, Illinois

    Run by

    University of Chicago

    See if you can join NCT01630850 on ClinicalTrials.gov

24. Islet Transplantation in Type 1 Diabetic Kidney Allograft

    The purpose of this study is to learn about the safety of islet transplantation when performed after kidney transplantation, which may provide more normal control of blood sugar without the need for insulin shots. Islets are special clusters of cells within the pancreas that produce insulin. These …

    Stage

    Phase 2

    Ages

    18 to 68

    Site

    The University of Chicago, Chicago, Illinois

    Run by

    University of Chicago

    See if you can join NCT01241864 on ClinicalTrials.gov

25. Behavioral Approaches to Reduce Diabetes Distress in Adults With Type 1 Diabetes: A Pragmatic SMART

    This study is designed to compare two behavioral approaches to reduce diabetes distress ("the expected burdens, concerns, fears, and threats that arise from the challenges of living with diabetes") in adults with type 1 diabetes. At the study baseline, participants will be randomized to take part i…

    Stage

    Not phased

    Ages

    30 and older

    Site

    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

    Run by

    University of North Carolina, Chapel Hill

    See if you can join NCT06405373 on ClinicalTrials.gov