Critical Illness Clinical Trials

39 studies are recruiting for critical illness in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. PICU-related Sleep and Circadian Dysregulation Pilot Study

   A single center pilot trial investigating the feasibility of using actigraphy and salivary melatonin levels to measure the sleep and circadian rhythm of critically ill children aged 3 to 6 years old. This study will also measure the feasibility of providing daytime light exposure as well as restric…

   Stage

   Not phased

   Ages

   3 to 6

   Site

   John R. Oishei Children's Hospital, Buffalo, New York

   Run by

   State University of New York at Buffalo

   See if you can join NCT06505447 on ClinicalTrials.gov

2. Behavioral Health Collaborative Care Model in an ICU Recovery Clinic

   Survivors of critical illness are at high risk for mental health issues such as anxiety, depression, and PTSD. This single-site, randomized controlled trial at the Medical University of South Carolina will enroll 150 patients to compare outcomes between a behavioral health Collaborative Care Model …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Medical University of South Carolina, Charleston, South Carolina

   Run by

   Medical University of South Carolina

   See if you can join NCT07372586 on ClinicalTrials.gov

3. The "What Is Important to Us" Communication Intervention Pilot Clinical Trial

   The objective of this study is to conduct a pilot randomized controlled trial (RCT) of a photo-narrative communication intervention developed by our study team with patients/parents of children with severe neurological impairment (SNI) and their pediatric intensive care unit (PICU) clinicians to as…

   Stage

   Phase 2

   Ages

   0 and older

   Site

   Seattle Children's Hospital, Seattle, Washington

   Run by

   Seattle Children's Hospital

   See if you can join NCT06208332 on ClinicalTrials.gov

4. The Role of Brain-Bone Marrow-Gut Interaction Following Major Trauma

   Traumatic injury followed by critical illness provokes pathophysiologic changes in the bone marrow and the gut that contribute to persistent anemia and changes in the microbiome which significantly impact long-term recovery. This project will define the interactions between the stress, chronic infl…

   Stage

   Not phased

   Ages

   18 to 100

   Site

   UF Academic Research Building, Gainesville, Florida

   Locations

   3 in total

   Run by

   University of Florida

   See if you can join NCT06606119 on ClinicalTrials.gov

5. Music Listening: A Mechanistic Trial

   A randomized within-subject crossover trial to compare the effects of live and recorded music listening on biomarkers of stress and pain among children receiving mechanical ventilation in the pediatric intensive care unit.

   Stage

   Not phased

   Ages

   0 to 17

   Site

   UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania

   Run by

   University of Pittsburgh

   See if you can join NCT05541029 on ClinicalTrials.gov

6. Safety and Feasibility of a Self-Balancing Exoskeleton for Rehabilitation in the Thoracic Surgical Intensive Care Unit: a Pilot Trial

   Patients admitted to the Intensive Care Unit (ICU) after thoracic surgery often experience complications related to immobility, such as muscle weakness, pulmonary issues, and longer recovery times. Early mobilization has been shown to improve outcomes, but its implementation is often limited by pat…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Brigham and Women's Hospital, Boston, Massachusetts

   Run by

   Wandercraft

   See if you can join NCT07220733 on ClinicalTrials.gov

7. PUSH-IT Continuing Enteral Feeds for Tracheostomy

   The goal of this clinical trial is to evaluate nutrition administration in the time around the tracheostomy in patients with breathing tubes. The main questions it aims to answer are: * Will continuing nutrition up to the time of surgery (tracheostomy) decrease nutrition interruptions, thereby incr…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Nuvance Health - Danbury Hospital, Danbury, Connecticut

   Locations

   6 in total

   Run by

   State University of New York at Buffalo

   See if you can join NCT05906472 on ClinicalTrials.gov

8. SC2i Tissue and Data Repository Protocol

   The purpose of this study is to collect samples of blood, urine, cerebrospinal fluid (CSF, the fluid that surrounds the brain and spinal cord), wound tissue and/or wound fluids, and other body fluids and tissues from people who have been seriously injured or ill. The samples will be used to develop…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Grady Health Systems, Atlanta, Georgia

   Locations

   4 in total

   Run by

   Henry M. Jackson Foundation for the Advancement of Military Medicine

   See if you can join NCT02182180 on ClinicalTrials.gov

9. A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors

   Up to 25% of intensive care unit (ICU) survivors experience cognitive impairment comparable in severity to mild Alzheimer's disease and related dementias after hospital discharge. Older ICU survivors (ages 60 and older) are at highest risk for delirium and subsequent cognitive impairment, which con…

   Stage

   Not phased

   Ages

   60 and older

   Site

   University of Washington, Seattle, Washington

   Run by

   University of Washington

   See if you can join NCT06411561 on ClinicalTrials.gov

10. Embedded Palliative Care in the MICU

    The goal of this study is to investigate whether embedding a hospice and palliative care practitioner within a medical intensive care unit will improve patient outcomes and healthcare usage. The practitioner will work solely within the medical intensive care units and offer timely as well as proact…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Barnes Jewish Hospital, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT06574672 on ClinicalTrials.gov

11. The Family Perspectives Project Pilot Trial

    The purpose of the study is to conduct a pilot randomized trial of a program designed to enhance equitable communication and emotional support for families of critically ill patients in order to determine feasibility, acceptability, and participant experience with the program. The primary study pro…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Cedars-Sinai Medical Center, Los Angeles, California

    Run by

    Matthew Modes

    See if you can join NCT06039501 on ClinicalTrials.gov

12. Bright Light Exposure in Surgical Patients

    1. Elucidate the influence of intense light therapy pretreatment in patients undergoing cardiac surgery. We hypothesize that intense light exposure is associated with the peripheral stabilization of Per2 in human buccal swabs and plasma samples before surgery and with a decrease of Troponin I level…

    Stage

    Not phased

    Ages

    18 to 90

    Site

    University of Colorado Denver | Anschutz Medical Campus, Denver, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT03822949 on ClinicalTrials.gov

13. Exhaled Breath: A Novel Technique for Rapid Diagnosis of Respiratory Diseases and Infections

    This study aims to use mass spectrometry techniques to analyze exhaled patient breath in non-COVID ICU-admitted patients requiring ventilation for a rapid and accurate early detection of pulmonary diseases and inflammatory markers.

    Stage

    Not phased

    Ages

    18 to 120

    Site

    Oregon Health and Science University, Portland, Oregon

    Run by

    Oregon Health and Science University

    See if you can join NCT06775106 on ClinicalTrials.gov

14. Critical Health Assessment and Outcomes Score/Study

    CHAOS is based on the investigator's new and exciting results from pre-clinical and large longitudinal multi-center observational clinical studies of critically ill patients and asymptomatic community-based adults with little or no advanced disease. By integrating approaches from the physical, biol…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Cincinnati, Cincinnati, Ohio

    Locations

    3 in total

    Run by

    Johns Hopkins University

    See if you can join NCT02766166 on ClinicalTrials.gov