Critical Illness Clinical Trials

41 studies are recruiting for critical illness in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

Search these by distance from you

By city

Studies, page 2

1. Behavioral Economic & Staffing Strategies in the ICU

   The overarching goal of this study is to support the "real world" assessment of strategies used to foster adoption of several highly efficacious evidence-based practices in healthcare systems that provide care to critically ill adults with known health disparities. Investigators will specifically e…

   Stage

   Not phased

   Ages

   19 and older

   Site

   University of Iowa Hospitals and Clinics, Iowa City, Iowa

   Locations

   3 in total

   Run by

   University of Nebraska

   See if you can join NCT06184945 on ClinicalTrials.gov

2. The "What Is Important to Us" Communication Intervention Pilot Clinical Trial

   The objective of this study is to conduct a pilot randomized controlled trial (RCT) of a photo-narrative communication intervention developed by our study team with patients/parents of children with severe neurological impairment (SNI) and their pediatric intensive care unit (PICU) clinicians to as…

   Stage

   Phase 2

   Ages

   0 and older

   Site

   Seattle Children's Hospital, Seattle, Washington

   Run by

   Seattle Children's Hospital

   See if you can join NCT06208332 on ClinicalTrials.gov

3. The Role of Brain-Bone Marrow-Gut Interaction Following Major Trauma

   Traumatic injury followed by critical illness provokes pathophysiologic changes in the bone marrow and the gut that contribute to persistent anemia and changes in the microbiome which significantly impact long-term recovery. This project will define the interactions between the stress, chronic infl…

   Stage

   Not phased

   Ages

   18 to 100

   Site

   UF Academic Research Building, Gainesville, Florida

   Locations

   3 in total

   Run by

   University of Florida

   See if you can join NCT06606119 on ClinicalTrials.gov

4. Music Listening: A Mechanistic Trial

   A randomized within-subject crossover trial to compare the effects of live and recorded music listening on biomarkers of stress and pain among children receiving mechanical ventilation in the pediatric intensive care unit.

   Stage

   Not phased

   Ages

   0 to 17

   Site

   UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania

   Run by

   University of Pittsburgh

   See if you can join NCT05541029 on ClinicalTrials.gov

5. Safety and Feasibility of a Self-Balancing Exoskeleton for Rehabilitation in the Thoracic Surgical Intensive Care Unit: a Pilot Trial

   Patients admitted to the Intensive Care Unit (ICU) after thoracic surgery often experience complications related to immobility, such as muscle weakness, pulmonary issues, and longer recovery times. Early mobilization has been shown to improve outcomes, but its implementation is often limited by pat…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Brigham and Women's Hospital, Boston, Massachusetts

   Run by

   Wandercraft

   See if you can join NCT07220733 on ClinicalTrials.gov

6. Establishing Normative Data for Pupillometer Assessments in Neuro-Intensive Care

   The purpose of this study is to collect a large amount of data that may assist in addressing the gap in knowledge of understanding pupillometer readings using a pupillometer device. The aim of this project is to establish normative values for pupillometer data. Measures of central tendency will be …

   Stage

   Not phased

   Ages

   Any age

   Site

   Maria E Denbow, Dallas, Texas

   Run by

   University of Texas Southwestern Medical Center

   See if you can join NCT02804438 on ClinicalTrials.gov

7. PUSH-IT Continuing Enteral Feeds for Tracheostomy

   The goal of this clinical trial is to evaluate nutrition administration in the time around the tracheostomy in patients with breathing tubes. The main questions it aims to answer are: * Will continuing nutrition up to the time of surgery (tracheostomy) decrease nutrition interruptions, thereby incr…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Nuvance Health - Danbury Hospital, Danbury, Connecticut

   Locations

   6 in total

   Run by

   State University of New York at Buffalo

   See if you can join NCT05906472 on ClinicalTrials.gov

8. SC2i Tissue and Data Repository Protocol

   The purpose of this study is to collect samples of blood, urine, cerebrospinal fluid (CSF, the fluid that surrounds the brain and spinal cord), wound tissue and/or wound fluids, and other body fluids and tissues from people who have been seriously injured or ill. The samples will be used to develop…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Grady Health Systems, Atlanta, Georgia

   Locations

   4 in total

   Run by

   Henry M. Jackson Foundation for the Advancement of Military Medicine

   See if you can join NCT02182180 on ClinicalTrials.gov

9. A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors

   Up to 25% of intensive care unit (ICU) survivors experience cognitive impairment comparable in severity to mild Alzheimer's disease and related dementias after hospital discharge. Older ICU survivors (ages 60 and older) are at highest risk for delirium and subsequent cognitive impairment, which con…

   Stage

   Not phased

   Ages

   60 and older

   Site

   University of Washington, Seattle, Washington

   Run by

   University of Washington

   See if you can join NCT06411561 on ClinicalTrials.gov

10. Embedded Palliative Care in the MICU

    The goal of this study is to investigate whether embedding a hospice and palliative care practitioner within a medical intensive care unit will improve patient outcomes and healthcare usage. The practitioner will work solely within the medical intensive care units and offer timely as well as proact…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Barnes Jewish Hospital, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT06574672 on ClinicalTrials.gov

11. The Family Perspectives Project Pilot Trial

    The purpose of the study is to conduct a pilot randomized trial of a program designed to enhance equitable communication and emotional support for families of critically ill patients in order to determine feasibility, acceptability, and participant experience with the program. The primary study pro…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Cedars-Sinai Medical Center, Los Angeles, California

    Run by

    Matthew Modes

    See if you can join NCT06039501 on ClinicalTrials.gov

12. Bright Light Exposure in Surgical Patients

    1. Elucidate the influence of intense light therapy pretreatment in patients undergoing cardiac surgery. We hypothesize that intense light exposure is associated with the peripheral stabilization of Per2 in human buccal swabs and plasma samples before surgery and with a decrease of Troponin I level…

    Stage

    Not phased

    Ages

    18 to 90

    Site

    University of Colorado Denver | Anschutz Medical Campus, Denver, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT03822949 on ClinicalTrials.gov

13. Exhaled Breath: A Novel Technique for Rapid Diagnosis of Respiratory Diseases and Infections

    This study aims to use mass spectrometry techniques to analyze exhaled patient breath in non-COVID ICU-admitted patients requiring ventilation for a rapid and accurate early detection of pulmonary diseases and inflammatory markers.

    Stage

    Not phased

    Ages

    18 to 120

    Site

    Oregon Health and Science University, Portland, Oregon

    Run by

    Oregon Health and Science University

    See if you can join NCT06775106 on ClinicalTrials.gov

14. End-Tidal Oxygen for Intubation in the Emergency Department

    Rapid Sequence Intubation (RSI) is a high-risk procedure in the emergency department (ED). Patients are routinely preoxygenated (given supplemental oxygen) prior to RSI to prevent hypoxia during intubation. For many years anaesthetists have used end-tidal oxygen (ETO2) levels to guide the effective…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Lincoln Medical Center, The Bronx, New York

    Locations

    9 in total

    Run by

    Sydney Local Health District

    See if you can join NCT06578468 on ClinicalTrials.gov

15. Critical Health Assessment and Outcomes Score/Study

    CHAOS is based on the investigator's new and exciting results from pre-clinical and large longitudinal multi-center observational clinical studies of critically ill patients and asymptomatic community-based adults with little or no advanced disease. By integrating approaches from the physical, biol…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Cincinnati, Cincinnati, Ohio

    Locations

    3 in total

    Run by

    Johns Hopkins University

    See if you can join NCT02766166 on ClinicalTrials.gov

16. RCT: Early Feeding After PEG Placement

    Randomized controlled trial to establish evidence on which to base timing of enteral feeding after bedside PEG placement in ventilated Trauma and Surgical ICU patients.

    Stage

    Not phased

    Ages

    18 to 100

    Site

    Carilion Roanoke Memorial Hospital, Roanoke, Virginia

    Run by

    Carilion Clinic

    See if you can join NCT04110613 on ClinicalTrials.gov