Critical Illness Clinical Trials

39 studies are recruiting for critical illness in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Establishing Normative Data for Pupillometer Assessments in Neuro-Intensive Care

   The purpose of this study is to collect a large amount of data that may assist in addressing the gap in knowledge of understanding pupillometer readings using a pupillometer device. The aim of this project is to establish normative values for pupillometer data. Measures of central tendency will be …

   Stage

   Not phased

   Ages

   Any age

   Site

   Maria E Denbow, Dallas, Texas

   Run by

   University of Texas Southwestern Medical Center

   See if you can join NCT02804438 on ClinicalTrials.gov

2. Behavioral Economic & Staffing Strategies in the ICU

   The overarching goal of this study is to support the "real world" assessment of strategies used to foster adoption of several highly efficacious evidence-based practices in healthcare systems that provide care to critically ill adults with known health disparities. Investigators will specifically e…

   Stage

   Not phased

   Ages

   19 and older

   Site

   University of Iowa Hospitals and Clinics, Iowa City, Iowa

   Locations

   3 in total

   Run by

   University of Nebraska

   See if you can join NCT06184945 on ClinicalTrials.gov

3. Fluorescent Probe for Assessment of Renal Elimination

   Accurate measures of kidney function is important for precision dosing of many medications. The current methods of determining kidney function largely hinge on the use of equations that use common laboratory values such as serum creatinine \& static variables like age \& weight. These are helpful f…

   Stage

   Phase 4

   Ages

   18 to 65

   Site

   UKHealthCare/University of Kentucky, Lexington, Kentucky

   Run by

   Aaron Cook

   See if you can join NCT07643467 on ClinicalTrials.gov

4. VoiceLove: An App-Based COMMunication Tool Designed to Address DeliriUm and Improve Family ENgagement and PatIent/Family SatisfaCtion in CriticAlly Ill PaTiEnts (COMMUNICATE)

   VoiceLove is a phone application allowing family and patients to share information in a secure platform. This project will compare the VoiceLove app to usual care to learn about whether VoiceLove improves patient-family communication, family engagement, and ICU delirium.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Vanderbilt University Medical Center, Nashville, Tennessee

   Run by

   Vanderbilt University Medical Center

   See if you can join NCT06923462 on ClinicalTrials.gov

5. Subanesthetic Ketamine Infusions for Depressive Symptoms in Intensive Care Unit Patients

   Depressive symptoms are common among patients admitted to the intensive care unit (ICU) and may adversely affect recovery, participation in care, treatment adherence, quality of life, and outcomes after critical illness. Conventional antidepressants have limited utility for rapidly treating depress…

   Stage

   Phase 2

   Ages

   18 to 99

   Site

   Mayo Clinic, Jacksonville, Florida

   Locations

   2 in total

   Run by

   Hospital Italiano de Buenos Aires

   See if you can join NCT07639359 on ClinicalTrials.gov

6. Brain Blood Flow and Cerebral Autoregulation Monitoring in Critically Ill Children

   This study uses a non-invasive (external) ultrasound test called Transcranial Doppler (TCD) to measure how blood flows through the major arteries of the brain of children receiving care in the Pediatric Intensive Care Unit (PICU). TCD is already used for clinical reasons in many children, but it is…

   Stage

   Not phased

   Ages

   0 to 17

   Site

   American Family Children's Hospital PICU, Madison, Wisconsin

   Run by

   University of Wisconsin, Madison

   See if you can join NCT07613918 on ClinicalTrials.gov

7. Exogenous Ketone Supplementation in ICU Delirium

   Delirium is a common syndrome in intensive care unit (ICU) patients. Those experiencing delirium may suddenly feel confused, have trouble thinking clearly, struggle to pay attention, or see and hear things that are not real. Delirium is associated with worse long-term outcomes such as cognitive imp…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Vanderbilt University Medical Center, Nashville, Tennessee

   Run by

   Vanderbilt University Medical Center

   See if you can join NCT07364162 on ClinicalTrials.gov

8. Azithromycin for Critical Asthma - Pediatrics

   The CR-AZI Study will assess the immunomodulatory effects of Azithromycin for pediatric Critical Asthma.

   Stage

   Phase 2

   Ages

   3 to 17

   Site

   Johns Hopkins All Children's Hospital, St. Petersburg, Florida

   Run by

   Johns Hopkins All Children's Hospital

   See if you can join NCT06223828 on ClinicalTrials.gov

9. COMPARE-VENT Feasibility Pilot Study

   Cardiac disease complicated by respiratory insufficiency comprises the most frequent indication for cardiac intensive care unit (CICU) admission, with nearly one-third patients requiring advanced respiratory support and over 20% patients requiring invasive mechanical ventilation (IMV). IMV among pa…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Mayo Clinic, 1216 Second Street SW, Rochester, Minnesota

   Run by

   Mayo Clinic

   See if you can join NCT07656259 on ClinicalTrials.gov

10. Improving Needs Among Older Adults

    Millions of older adults receive care in intensive care units (ICUs) annually. However, the quality and accessibility of ICU-based palliative care is highly variable across hospitals and clinicians, due in part to specialists' limited workforce and geographic inconsistency. To address these gaps, t…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Alabama-Birmingham, Birmingham, Alabama

    Locations

    4 in total

    Run by

    Duke University

    See if you can join NCT06588556 on ClinicalTrials.gov

11. PK, Safety and Preliminary Efficacy Study of Montelukast in Critically Ill Infants With Developing Bronchopulmonary Dysplasia

    The purpose of the study is to learn how safe montelukast may be in premature infants at significant risk for Bronchopulmonary Dysplasia (BPD) and to determine how much and how quickly montelukast moves from the stomach into the bloodstream, and how quickly it is removed from the bloodstream. Data …

    Stage

    Phase 1

    Ages

    0 to 0

    Site

    Arkansas Children's Hospital, Little Rock, Arkansas

    Locations

    5 in total

    Run by

    Duke University

    See if you can join NCT07101640 on ClinicalTrials.gov

12. The Effects of Endotracheal Suctioning on Pain and Serum Markers

    The goal of this experimental study is to understand if endotracheal tube (ETT) suctioning increases pain and causes stress on the body in intubated adult ICU patients. These patients are already on ventilators, which means they need suctioning to keep their airways clear, but this procedure may be…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Loma Linda University Medical Center Troesh Medical Campus, Loma Linda, California

    Run by

    Loma Linda University

    See if you can join NCT06692400 on ClinicalTrials.gov

13. MyokinE100 System: Closed Loop Electrical Muscle Stimulation to Mitigate ICU Acquired Weakness in Medical ICU Patients

    The goal of this clinical trial is to learn if a new medical device that sends electrical signals to the thigh muscles is safe and easy to use for people in the ICU (Intensive Care Unit) who are at risk of losing muscle strength. It will also explore whether this treatment can help slow down muscle…

    Stage

    Not phased

    Ages

    18 to 85

    Site

    Mayo Clinic, Rochester, Minnesota

    Locations

    3 in total

    Run by

    Health Discovery Labs

    See if you can join NCT07362862 on ClinicalTrials.gov

14. Digital and Plasma Biomarkers in Delirium

    The goal of this observational study is to learn if there are potential digital and plasma-based biomarkers that could help detect, predict, and prognosticate delirium in older adult patients who are admitted to the intensive care unit (ICU). The main question DELTA aims to answer is: Can digital b…

    Stage

    Not phased

    Ages

    65 and older

    Site

    Scripps Memorial La Jolla Hospital, San Diego, California

    Locations

    2 in total

    Run by

    Scripps Health

    See if you can join NCT07694206 on ClinicalTrials.gov

15. Pervasive Sensing and AI in Intelligent ICU

    Important information related to the visual assessment of patients, such as facial expressions, head and extremity movements, posture, and mobility are captured sporadically by overburdened nurses, or are not captured at all. Consequently, these important visual cues, although associated with criti…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Florida Health Shands Hospital, Gainesville, Florida

    Run by

    University of Florida

    See if you can join NCT05127265 on ClinicalTrials.gov

16. Muscle Recovery After Critical Illness

    The overarching goal of the proposed study is to determine the trajectories of physical recovery and cellular markers involved with the underlying failure to recover muscle after critical illness, while exploring which characteristics are associated with sustained physical disability. This proposal…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Kentucky, Lexington, Kentucky

    Locations

    3 in total

    Run by

    Esther Dupont-Versteegden

    See if you can join NCT05537298 on ClinicalTrials.gov

17. Improving Psychological Outcomes for Acute Respiratory Failure Survivors Using a Self-Management Intervention

    A growing number of patients are surviving a stay in the intensive care unit (ICU) but may experience long-lasting psychological problems, but research evaluating such treatment for ICU patients is scant. The goal of this pilot randomized controlled trial is to evaluate the feasibility, acceptabili…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Johns Hopkins Hospital, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT06341972 on ClinicalTrials.gov

18. Evaluating the Unmet Needs of Older Adults to Promote Functional Recovery After a Critical Illness

    This is a prospective longitudinal study that will evaluate the unmet needs of older adults (65 and older) who return home (either directly or after short-term rehab) after an ICU hospitalization, evaluate the association of these unmet needs with clinically relevant outcomes, and assess barriers a…

    Stage

    Not phased

    Ages

    65 and older

    Site

    Yale New Haven Hospital, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT06006000 on ClinicalTrials.gov

19. Preoperative Fasting vs. Not Fasting in Critically Ill Patients

    The goal of this clinical trial is to learn if fasting or not fasting before a procedure has an effect on recovery in those who are critically ill. The main questions it aims to answer for patients on a breathing machine who are receiving tube feeding are: * Does the risk of lung complications and …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Stanford Medical Center, Palo Alto, California

    Locations

    19 in total

    Run by

    Massachusetts General Hospital

    See if you can join NCT06751043 on ClinicalTrials.gov

20. Optimizing Recovery in Trauma Patients by Integrating Enhanced Nutrition Delivery

    This is a prospective, randomized, controlled trial designed to evaluate the impact of enhanced protein supplementation compared to a standard of care nutrition delivery in critically ill older adult trauma patients. Subjects will be randomized 1:1 to either enhanced nutrition or control arm. Subje…

    Stage

    Not phased

    Ages

    45 and older

    Site

    Duke University Hospital, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT06521086 on ClinicalTrials.gov

21. REmotely Monitored, Mobile Health Supported Multidomain Rehabilitation Program With High Intensity Interval Training for COVID-19

    Multicenter, prospective, randomized controlled trial providing mobile health supported physical rehabilitation to 120 patients who have been critically ill with COVID-19 and who complete at least one exercise session.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Locations

    5 in total

    Run by

    Duke University

    See if you can join NCT05218083 on ClinicalTrials.gov

22. NIBP Validation Study

    The purpose of this study is to compare measurements of blood pressure (BP) between the Philips non-invasive blood pressure (NIBP) system (including NIBP cuff and portable patient monitor) and invasive radial for Subject Group 2 and 3, and radial or umbilical arterial line for neonates (A-line) in …

    Stage

    Not phased

    Ages

    Any age

    Site

    Wake Forest University Health Sciences, Winston-Salem, North Carolina

    Locations

    5 in total

    Run by

    Philips Clinical & Medical Affairs Global

    See if you can join NCT05673408 on ClinicalTrials.gov

23. iNO300 Therapy in Critically Ill Patients With Pneumonia

    The goal of this clinical trial is to learn the formation and recovery rate of methemoglobin (MetHb) in severely sick patients with pneumonia who receive high doses of inhaled nitric oxide (iNO) therapy at 250 parts per million (ppm), not exceeding 300 ppm. Meanwhile, the benefits of the therapy to…

    Stage

    EARLY_Phase 1

    Ages

    18 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT06950294 on ClinicalTrials.gov

24. Reestablishing Sleep and Circadian Alignment in Medical Intensive Care Unit (MICU) Patients Via a Mechanistic RCT of an Sleep Chronobundle

    More than 5 million patients are admitted to the intensive care unit every year in the United States; most of these patients experience profound sleep and circadian disruption. Promotion of circadian alignment (i.e., alignment of the body's clocks) would make it possible to strategically schedule b…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Yale New Haven Hospital Medical Intensive Care Unit (YNHH MICU) at St Raphael's Campus, New Haven, Connecticut

    Locations

    2 in total

    Run by

    Yale University

    See if you can join NCT05551325 on ClinicalTrials.gov

25. Effect of Giving Reduced Fluid in Children After Trauma

    This study is designed to help decide how much intravenous (IV) fluid should be given to pediatric trauma patients. No standard currently exists for managing fluids in critically ill pediatric trauma patients, and many fluid strategies are now in practice. For decades, trauma patients got high volu…

    Stage

    Not phased

    Ages

    0 to 15

    Site

    Columbia University Irving Medical Center NewYork-Presbyterian Morgan Stanley Children's Hospital, New York, New York

    Locations

    4 in total

    Run by

    Columbia University

    See if you can join NCT04201704 on ClinicalTrials.gov