COPD Clinical Trials

26 studies are recruiting for copd in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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By city

Birmingham, Alabama 6 Philadelphia, Pennsylvania 6 Boston, Massachusetts 5 Pittsburgh, Pennsylvania 5 Chicago, Illinois 4 Cleveland, Ohio 4 Detroit, Michigan 4 Columbus, Ohio 3 DuBois, Pennsylvania 3 Jacksonville, Florida 3 Kansas City, Kansas 3

Studies now recruiting

  1. PEP Buddy in Pulmonary Rehabilitation

    In this study, the investigators will test Veterans with COPD in Pulmonary Rehabilitation. Between two groups, the investigators will give one group a device that assists with breathing and symptoms and the other receives a 'sham' device which does not provide these benefits. The investigators will…

    Stage
    Not phased
    Ages
    40 to 89
    Site
    Cincinnati VA Medical Center, Cincinnati, OH, Cincinnati, Ohio
    Locations
    2 in total
    Run by
    VA Office of Research and Development

    See if you can join NCT07404826 on ClinicalTrials.gov

  2. Collection of Blood From Healthy Patients, Patients With Benign Disease and Patients With Cancer

    To acquire blood samples from subjects for various purposes, including: i) determining the sensitivity and specificity of select DNA methylation markers for the detection of various types of cancer, ii) identifying benign conditions that may induce false positive or false negative results, and iii)…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Allina Health, Virginia Piper Cancer Institute, Coon Rapids, Minnesota
    Locations
    7 in total
    Run by
    Helio Genomics

    See if you can join NCT05181826 on ClinicalTrials.gov

  3. Evaluation of Ventilation Defects Downstream of Mucus Plugs in Patients With Muco-Obstructive Lung Disease

    In this study, xenon MRI will be used to evaluate regional functional consequences of mucus plugs in the lungs of patients with muco-obstructive pulmonary disease. Mucus plugs will be identified using CT imaging, and xenon MRI will be used to evaluate ventilation and gas exchange impairments in reg…

    Stage
    Not phased
    Ages
    18 to 65
    Site
    University of Kansas Medical Center, Kansas City, Kansas
    Run by
    University of Kansas Medical Center

    See if you can join NCT06985225 on ClinicalTrials.gov

  4. Closed Loop Oxygen Control in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Nasal High Flow in the Hospital

    The trial aims to evaluate whether the Airvo 3 device in OptiO2 mode can maintain patients' SpO2 levels within the target range better than manual oxygen titration in hospitalized COPD patients with hypoxemia/respiratory distress.

    Stage
    Not phased
    Ages
    22 and older
    Site
    The University of Alabama at Birmingham, Birmingham, Alabama
    Locations
    4 in total
    Run by
    Fisher and Paykel Healthcare

    See if you can join NCT07222410 on ClinicalTrials.gov

  5. Physiologic Effects of Nasal High Flow on Exercise Tolerance in COPD

    This study aims to assess whether to describe the effects of the administration of nasal high flow (NHF) at 70 liters per minute (L/min) in a 6-Minute Walk Test (6-MWT) among Chronic Obstructive Pulmonary Disease (COPD) patients and to characterize the association between self-reported dyspnea with…

    Stage
    Not phased
    Ages
    18 to 100
    Site
    University of Miami, Miami, Florida
    Run by
    University of Miami

    See if you can join NCT06578156 on ClinicalTrials.gov

  6. Impact of Positive Airway Pressure Therapy on Clinical Outcomes in Older Veterans With Chronic Obstructive Pulmonary Disease and Comorbid Obstructive Sleep Apnea (Overlap Syndrome)

    Obstructive sleep apnea (OSA) and Chronic Obstructive Pulmonary Disease (COPD) are highly prevalent chronic respiratory diseases in the Veteran population. OSA co-occurring with COPD, known as Overlap Syndrome (OVS), is a complex chronic medical condition associated with grave consequences. OVS is …

    Stage
    Not phased
    Ages
    60 and older
    Site
    John D. Dingell VA Medical Center, Detroit, MI, Detroit, Michigan
    Run by
    VA Office of Research and Development

    See if you can join NCT04179981 on ClinicalTrials.gov

  7. Lung Macrophage Populations and Functions in Chronic Obstructive Pulmonary Disease (COPD)-Susceptible Smokers

    Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous disease that affects only a fraction of those who smoke tobacco. The origin of this variability in susceptibility to develop COPD is unclear, but understanding its underlying biology has important implications for our ability to design…

    Stage
    Not phased
    Ages
    40 to 75
    Site
    San Francisco VA Medical Center, San Francisco, California
    Locations
    3 in total
    Run by
    University of California, San Francisco

    See if you can join NCT04722835 on ClinicalTrials.gov

  8. A Multi Center Study Testing a New Implant for Adults With Severe Emphysema

    A study taking place at multiple sites in the United States, Europe and Brazil to evaluate how well a new therapy for severe COPD/emphysema works, and how safe it is.

    Stage
    Not phased
    Ages
    22 and older
    Site
    University of California, San Francisco, San Francisco, California
    Locations
    3 in total
    Run by
    Pulmair Medical, Inc.

    See if you can join NCT07119229 on ClinicalTrials.gov

  9. Effect of Ensifentrine on Sputum Markers of Inflammation in COPD

    This is a randomized, double-blind, placebo-controlled, two-period cross-over study of nebulized ensifentrine (3 mg) or placebo administered BID for two 8-week Treatment Periods. All participants with receive both ensifentrine and placebo during participation. There are 7 in-clinic visits over a to…

    Stage
    Phase 2
    Ages
    40 to 80
    Site
    University of Alabama at Birmingham, Birmingham, Alabama
    Locations
    3 in total
    Run by
    Verona Pharma, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA

    See if you can join NCT05270525 on ClinicalTrials.gov

  10. Phenotyping Resting and Exertional Right Ventricular Dysfunction Among Patients With Chronic Obstructive Pulmonary Disease

    This study plans to learn about heart function among individuals with chronic obstructive pulmonary disease (COPD). In particular, the investigators want to understand the different patterns of right ventricular response during rest and moderate- vs high-intensity exercise. By identifying patterns …

    Stage
    Not phased
    Ages
    40 and older
    Site
    University of Colorado Anschutz Medical Campus, Aurora, Colorado
    Run by
    University of Colorado, Denver

    See if you can join NCT05896579 on ClinicalTrials.gov

  11. Right Ventricular Response to Exercise Among Patients With Chronic Obstructive Pulmonary Disease

    This study plans to learn more about heart function among individuals with chronic obstructive pulmonary disease (COPD). In particular, the investigators want to understand the different patterns of right ventricular response during rest and moderate- vs high-intensity exercise. By identifying patt…

    Stage
    Not phased
    Ages
    40 and older
    Site
    University of Colorado Anschutz Medical Campus, Aurora, Colorado
    Run by
    University of Colorado, Denver

    See if you can join NCT07576894 on ClinicalTrials.gov

  12. Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease

    The purpose of this study is to develop and evaluate the usefulness of hyperpolarized (HP) 129Xe gas MRI for regional assessment of pulmonary function.

    Stage
    Phase 1
    Ages
    3 and older
    Site
    University of Kansas Medical Center, Kansas City, Kansas
    Run by
    Mario Castro, MD, MPH

    See if you can join NCT04624490 on ClinicalTrials.gov

  13. Evaluating the Safety and Efficacy of dNerva Lung Denervation System in Patients With COPD

    The dNerva Lung Denervation System is one-time treatment intended to improve breathing in Chronic Obstructive Pulmonary Disease (COPD) patients on standard medical care. The purpose of this study is to confirm the safety and efficacy of the Nuvaira Lung Denervation System in the treatment of COPD.

    Stage
    Not phased
    Ages
    40 to 80
    Site
    University of Alabama-Birmingham Hospital - UAB Lung Health Center, Birmingham, Alabama
    Locations
    10 in total
    Run by
    Nuvaira, Inc.

    See if you can join NCT07051707 on ClinicalTrials.gov

  14. The Effect of Interval Exercise on Functional Outcomes in Veterans With COPD and OSA

    The term "Overlap Syndrome" (OS) is used to describe the presence of both chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) in a single patient. Due to premature aging, patients with OS are prone to developing functional decline up to 20 years earlier than the general p…

    Stage
    Not phased
    Ages
    Any age
    Site
    Salem VA Medical Center, Salem, VA, Salem, Virginia
    Run by
    VA Office of Research and Development

    See if you can join NCT05254431 on ClinicalTrials.gov

  15. Bronchoscopic RElease of Air Trapped in Hyperinflated Emphysematous Lung - Study 3

    The objective of this study is to assess the safety and efficacy of Apreo BREATHE system when used to support native airways and release trapped air in the treatment of adult COPD patients with emphysema suffering from dyspnea due to hyperinflation despite optimal medical treatment. The Apreo BREAT…

    Stage
    Not phased
    Ages
    40 to 84
    Site
    University of Alabama at Birmingham, Birmingham, Alabama
    Locations
    22 in total
    Run by
    Apreo Health, Inc.

    See if you can join NCT06891755 on ClinicalTrials.gov

  16. Home Hospital for Suddenly Ill Adults

    The investigators propose a home hospital model of care that substitutes for treatment in an acute care hospital. Limited studies of the home hospital model have demonstrated that a sizeable proportion of acute care can be delivered in the home with equal quality and safety, reduced cost, and impro…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Brigham and Women's Hospital, Boston, Massachusetts
    Locations
    2 in total
    Run by
    Brigham and Women's Hospital

    See if you can join NCT03524222 on ClinicalTrials.gov

  17. Leveraging Lung Cancer Screening to Optimize Screening Outcomes and COPD Management: COPD in LCS Registry

    The COPD in LCS Registry will identify and characterize individuals who have functional or radiographic evidence of COPD and are receiving lung cancer screening. Clinical information will be obtained from study participants including symptom burden, lung cancer risk, spirometry, imaging characteris…

    Stage
    Not phased
    Ages
    50 to 80
    Site
    Thomas Jefferson University, Philadelphia, Pennsylvania
    Run by
    Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University

    See if you can join NCT06974981 on ClinicalTrials.gov

  18. Pulmonary Hypertension SOLAR

    The main goal of this study is to develop a noninvasive signature for pulmonary vascular remodeling in Group 3 PH patients, using hyperpolarized 129Xe magnetic resonance imaging (129Xe MRI). Such a signature may identify Group 3 PH responders to PAH-specific therapies. PAH's unique 129Xe MRI signat…

    Stage
    Phase 2
    Ages
    18 and older
    Site
    Duke University Medical Center, Durham, North Carolina
    Run by
    Bastiaan Driehuys

    See if you can join NCT04778046 on ClinicalTrials.gov

  19. Supporting Evidence-based Responses to Emotional Needs in Emphysema

    The goal of this clinical trial is to understand how a Coping Skills Training program can reduce depression and anxiety in people with chronic obstructive pulmonary disease (COPD), particularly those who face health disparities, including those with low income, different racial backgrounds, or thos…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Henry Ford Health System, Detroit, Michigan
    Locations
    2 in total
    Run by
    University of Pennsylvania

    See if you can join NCT06600126 on ClinicalTrials.gov

  20. The Effect of a Technology-Mediated Integrated Walking and Tai Chi Intervention on Physical Function in Veterans With COPD and Chronic Musculoskeletal Pain

    Persons with COPD benefit from being physically active, but they are often limited by chronic musculoskeletal pain. This project will determine whether a non-pharmacologic, integrated, technology-mediated walking and Tai Chi mindfulness intervention can improve physical function in Veterans with CO…

    Stage
    Not phased
    Ages
    40 to 100
    Site
    VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston, Massachusetts
    Run by
    VA Office of Research and Development

    See if you can join NCT05701982 on ClinicalTrials.gov

  21. Genetic Variation in IgG in Alpha 1 Antitrypsin Deficiency

    The goal of this study is to learn whether patients who have a genetic mutation in the genes that cause alpha 1 antitrypsin deficiency also have genetic variation in nearby genes that can increase risk for reduced immune function and respiratory infections. To investigate this hypothesis, we will c…

    Stage
    Phase 4
    Ages
    19 and older
    Site
    University of Alabama at Birmingham, Birmingham, Alabama
    Run by
    University of Alabama at Birmingham

    See if you can join NCT07135427 on ClinicalTrials.gov

  22. Implementation of a Sarcopenia Clinic to Diagnose and Treat Skeletal Muscle Loss Due to COPD

    Sarcopenia, or skeletal muscle loss, impacts up to 40% of COPD patients and is a major cause for morbidity and mortality. Despite the high clinical significance of sarcopenia in COPD, the diagnosis remains elusive because accurate measures of skeletal muscle are not tested during routine clinical c…

    Stage
    Not phased
    Ages
    40 and older
    Site
    Cleveland Clinic Foundation, Cleveland, Ohio
    Run by
    The Cleveland Clinic

    See if you can join NCT07059637 on ClinicalTrials.gov

  23. Acoustic Waveform Respiratory Evaluation

    The study will evaluate the feasibility of using smartphone speakers and microphones to evaluate the caliber of the airways, detect airway obstruction, aid in airway disease diagnosis, and identify disease exacerbations.

    Stage
    Not phased
    Ages
    8 to 70
    Site
    Indiana University, Indianapolis, Indiana
    Locations
    2 in total
    Run by
    Indiana University

    See if you can join NCT06512064 on ClinicalTrials.gov

  24. COPD Resources, Education, and Activity Designed for You Study

    Although COPD self-management treatment programs are effective in reducing COPD-related hospitalizations and increasing quality of life, there is a limited understanding of 'how and why' they work. The proposed research will use an engineering-inspired study design to identify effective COPD self-m…

    Stage
    Not phased
    Ages
    40 and older
    Site
    Rush University Medical Center, Chicago, Illinois
    Run by
    Rush University Medical Center

    See if you can join NCT07125053 on ClinicalTrials.gov

  25. Interprofessional Pharmacogenomics (IPGx) Registry and Repository

    This program collects genetic and health information to help doctors choose the right medications for patients.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Texas A&M Family Care, Bryan, Texas
    Run by
    Texas A&M University

    See if you can join NCT06726590 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.