Congenital Heart Disease Clinical Trials

36 studies are recruiting for congenital heart disease in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Rochester, Minnesota 7 Boston, Massachusetts 6 Columbus, Ohio 6 New York, New York 5 Atlanta, Georgia 4 Cleveland, Ohio 4 Los Angeles, California 4 Madison, Wisconsin 4 Durham, North Carolina 3 Salt Lake City, Utah 3 Seattle, Washington 3

Studies now recruiting

  1. Starlight Cardiovascular Lifeline Ductus Arteriosus Stent IDE Study

    Starlight Cardiovascular, Inc. is sponsoring a prospective, multi-center, study to evaluate safety and effectiveness of the Lifeline Ductus Arteriosus Stent System. The study device is a stent that is designed to maintain patency of the Ductus Arteriosus for children who need blood flow through tha…

    Stage
    Not phased
    Ages
    Up to 0
    Site
    UCLA Mattel Children's, Los Angeles, California
    Locations
    10 in total
    Run by
    Starlight Cardiovascular Inc

    See if you can join NCT07114718 on ClinicalTrials.gov

  2. Fontan Associated Liver Disease and the Evaluation of Biomarkers for Disease Severity Assessment

    Background: In Fontan Associated Liver Disease (FALD), congestion of blood in the liver causes cirrhosis. This condition can cause death. Researchers want to understand what triggers this process and find new treatments for it. Objective: To understand how long-term congestion of blood in the liver…

    Stage
    Not phased
    Ages
    18 to 100
    Site
    National Institutes of Health Clinical Center, Bethesda, Maryland
    Run by
    National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

    See if you can join NCT05213598 on ClinicalTrials.gov

  3. Multicenter Trial of ECMO in Children With Severe Cardiac Failure Using the Cardiohelp System

    There are two primary goals of this multicenter clinical trial that combines an FDA device trial and a phase II drug trial in the same study cohort. These two goals are to: 1. To evaluate the safety and effectiveness of the Cardiohelp Device for VA-ECMO (heart-lung support) for up to 30 days of sup…

    Stage
    Phase 2
    Ages
    0 to 16
    Site
    Lucile Packard Children's Hospital, Palo Alto, California
    Locations
    5 in total
    Run by
    Stanford University

    See if you can join NCT06080074 on ClinicalTrials.gov

  4. Autus Valve Continued Access Study (CAS)

    Prospective, single-arm, multi-center, continued access study of the Autus Size-Adjustable Valve in pediatric patients aged 18 months to 16 years requiring surgical pulmonary valve replacement. The Autus Valve may be expanded pre-implant to match the subject's body size. Subjects will be evaluated …

    Stage
    Not phased
    Ages
    1 to 16
    Site
    University of Michigan - Mott Children's Hospital, Ann Arbor, Michigan
    Locations
    10 in total
    Run by
    Edwards Lifesciences

    See if you can join NCT07466745 on ClinicalTrials.gov

  5. Longitudinal Validation of CIRC Technologies

    Cardiovascular disease is the leading cause of death worldwide. Advanced cardiovascular imaging using Magnetic Resonance Imaging (MRI) has proven to be effective in providing gold standard myocardial tissue characterization. Moreover, the intrinsic advantage of MRI's lack of exposure to ionizing ra…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Cleveland Clinic, Cleveland, Ohio
    Run by
    The Cleveland Clinic

    See if you can join NCT07081711 on ClinicalTrials.gov

  6. HFNC vs NIPPV Following Extubation

    This study has the goal to determine the best method of respiratory support following extubation after cardiac surgery (CS). After cardiac surgery for Congenital Heart Disease (CHD), patients remain intubated until the cardiac team determines it is safe for the patient to undergo a trial of extubat…

    Stage
    Not phased
    Ages
    Up to 1
    Site
    Arthur M. Blank Hospital | Children's Healthcare of Atlanta, Atlanta, Georgia
    Run by
    Emory University

    See if you can join NCT05869825 on ClinicalTrials.gov

  7. Dynamic Critical Congenital Heart Screening With Addition of Perfusion Measurements

    The purpose of this study is to implement and externally validate an inpatient ML algorithm that combines pulse oximetry features for critical congenital heart disease (CCHD) screening.

    Stage
    Not phased
    Ages
    Up to 0
    Site
    UC Davis Medical Center, Davis, California
    Locations
    3 in total
    Run by
    University of California, Davis

    See if you can join NCT05637814 on ClinicalTrials.gov

  8. PDA for Kidneys Study

    The goal of this observational study is to gather more information on kidney oxygen levels in babies with a patent ductus arteriosus (PDA), and evaluate the relationships between kidney oxygen levels, PDA status and kidney injury. Researchers will do this by looking at ultrasound images of the hear…

    Stage
    Not phased
    Ages
    Up to 0
    Site
    Meriter Hospital, Inc., Madison, Wisconsin
    Run by
    University of Wisconsin, Madison

    See if you can join NCT06658496 on ClinicalTrials.gov

  9. Application of a Clinical Decision Support System to Reduce Mechanical Ventilation Duration After Cardiac Surgery in Children

    The goal of this study is to evaluate the impact of a clinical decision support system (CDSS) in children receiving mechanical ventilation (MV) after surgery for congenital heart disease (CHD). The main question it aims to answer is: -What is the impact of a CDSS designed to facilitate weaning and …

    Stage
    Not phased
    Ages
    0 to 12
    Site
    Boston Children's Hospital, Boston, Massachusetts
    Run by
    Boston Children's Hospital

    See if you can join NCT05687292 on ClinicalTrials.gov

  10. Development of CIRC Technologies

    Cardiovascular disease is the leading cause of death worldwide. Advanced cardiovascular imaging using Magnetic Resonance Imaging (MRI) has proven to be effective in providing gold standard myocardial tissue characterization. Moreover, the intrinsic advantage of MRI's lack of exposure to ionizing ra…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Cardiovascular Innovation Research Center, Cleveland, Ohio
    Run by
    The Cleveland Clinic

    See if you can join NCT05654272 on ClinicalTrials.gov

  11. Molecular and Cellular Characterization of Cardiac Tissue in Postnatal Development

    The study team will use small pieces of human hearts which are removed as part of a required surgical procedure to study different objectives. One of the objective is how calcium ions pass through the membrane of heart cells in order to tell the heart cell how much force to contract with when the h…

    Stage
    Not phased
    Ages
    Up to 20
    Site
    Emory University School of Medicine, Atlanta, Georgia
    Run by
    Emory University

    See if you can join NCT00243776 on ClinicalTrials.gov

  12. A Study of Invasive Hemodynamic for MACHD Registry

    This research study is being done to provide comparative data to the Mayo Clinic Adult Congenital Heart Disease Registry.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Mayo Clinic Rochester, Rochester, Minnesota
    Run by
    Mayo Clinic

    See if you can join NCT05849025 on ClinicalTrials.gov

  13. Implementation of an Accessible Healthcare Model (ACHD STRONG): Comparing Nurse and Physician Lead Healthcare Transition Education in a RE-AIM Framework

    The study includes patients with congenital heart disease (CHD), as well as their support persons and their providers, who are preparing to make the transition from pediatric to adult care for their CHD. The purpose of this study is to improve the tools available to help find doctors as patients en…

    Stage
    Not phased
    Ages
    12 to 26
    Site
    University of Wisconsin, Madison, Wisconsin
    Run by
    University of Wisconsin, Madison

    See if you can join NCT07559253 on ClinicalTrials.gov

  14. Fontan Fitness Trial

    The goal of this randomized control trial is to learn about physical fitness and exercise habits in children aged 10-17 with the Fontan Circulation through a home-based, digital exercise intervention. The main questions it aims to answer are: * Does a home-based, digital intervention increase physi…

    Stage
    Not phased
    Ages
    10 to 17
    Site
    Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
    Run by
    Children's Hospital of Philadelphia

    See if you can join NCT06918795 on ClinicalTrials.gov

  15. Genetics of Congenital Heart Disease

    Congenital heart disease (CHD) is the most common type of birth defect but the cause for the majority of cardiac birth defects remains unknown. Numerous epidemiologic studies have demonstrated evidence that genetic factors likely play a contributory, if not causative, role in CHD. While numerous ge…

    Stage
    Not phased
    Ages
    Any age
    Site
    Nationwide Children's Hospital, Columbus, Ohio
    Run by
    Nationwide Children's Hospital

    See if you can join NCT01192048 on ClinicalTrials.gov

  16. Psychological Trauma, Post-Traumatic Stress Disorder, and Resilience in Adults With Congenital Heart Disease

    The purpose of this study, entitled "Psychological trauma, post-traumatic stress disorder, and resilience in adults with congenital heart disease in a large population sample", is to evaluate for exposures during a lifetime with congenital heart disease that may be associated with higher likelihood…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire
    Locations
    3 in total
    Run by
    Dartmouth-Hitchcock Medical Center

    See if you can join NCT06952933 on ClinicalTrials.gov

  17. ATrial Tachycardia PAcing Therapy in Congenital Heart

    Congenital heart disease (CHD) affects approximately 1% of newborns in the US, with 25% of those affected having critical conditions requiring open heart surgery within one year of birth. Surgical and medical advances have allowed many patients to live beyond their fourth and fifth decades of life.…

    Stage
    Not phased
    Ages
    Any age
    Site
    Children's Hospital of Orange County (CHOC), Orange, California
    Locations
    15 in total
    Run by
    Ian Law

    See if you can join NCT03209583 on ClinicalTrials.gov

  18. Autologous Induced Pluripotent Stem Cells of Cardiac Lineage for Congenital Heart Disease

    The goal of this clinical trial is to test the safety of lab-grown heart cells made from stem cells in subjects with congenital heart disease. The main questions it aims to answer are: * Is this product safe to deliver to humans * Is the conduct of this trial feasible Participants will be asked to:…

    Stage
    Phase 1
    Ages
    18 to 40
    Site
    Mayo Clinic, Rochester, Minnesota
    Run by
    HeartWorks, Inc.

    See if you can join NCT05647213 on ClinicalTrials.gov

  19. A Study of Hemodynamic Cardiopulmonary Exercise for CHD

    The purpose of this study is to compare the difference in the ability to detect hemodynamic abnormalities between invasive hemodynamic assessments performed at rest versus exercise, to assess the correlation between invasive and noninvasive (Doppler-derived) rest-exercise hemodynamic indices and to…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Mayo Clinic, Rochester, Minnesota
    Run by
    Mayo Clinic

    See if you can join NCT06566196 on ClinicalTrials.gov

  20. Fetal Electrophysiologic Abnormalities in High-Risk Pregnancies Associated With Fetal Demise

    Each year world-wide, 2.5 million fetuses die unexpectedly in the last half of pregnancy, 25,000 in the United States, making fetal demise ten-times more common than Sudden Infant Death Syndrome. This study will apply a novel type of non-invasive monitoring, called fetal magnetocardiography (fMCG) …

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of Wisconsin - Madison, Madison, Wisconsin
    Locations
    2 in total
    Run by
    Medical College of Wisconsin

    See if you can join NCT03775954 on ClinicalTrials.gov

  21. Extracellular Vesicle Micro RNA Profiling in Congenital Heart Disease: Fetal-Maternal Regulation in Neonatal Thrombosis

    Newborns with congenital heart disease (CHD) are at increased risk of developing postpartum and postoperative blood clots after cardiac surgery. The molecular mechanisms that are responsible for the clotting profile predisposing children to blood clots in the early stages of life are currently not …

    Stage
    Not phased
    Ages
    0 to 0
    Site
    Boston Children's Hospital, Boston, Massachusetts
    Run by
    Boston Children's Hospital

    See if you can join NCT06434207 on ClinicalTrials.gov

  22. Skin Pigment/Pulse Oximeter in Congenital Heart Disease (CHD)

    Recent retrospective studies have demonstrated differences between pulse oximeter values (SpO2) and measured arterial oxygen saturation (SaO2) in patients identifying as Black or Hispanic. These retrospective studies have limitations because self-reported race is likely not an accurate metric for l…

    Stage
    Not phased
    Ages
    Up to 18
    Site
    Mount Sinai Hospital, New York, New York
    Run by
    Icahn School of Medicine at Mount Sinai

    See if you can join NCT06575270 on ClinicalTrials.gov

  23. Remote Monitoring in Pregnant Women With Congenital Heart Disease Using Wrist Wearables

    Congenital heart disease (CHD) includes a wide variety of types of disease, including congenital abnormalities of the heart valves. This can range from bicuspid aortic valve and other aortic valve deformities to more complex disease such as tetralogy of Fallot. For many kinds of CHD, the optimal ti…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Cleveland Clinic, Cleveland, Ohio
    Run by
    The Cleveland Clinic

    See if you can join NCT06818760 on ClinicalTrials.gov

  24. Adult Congenital Heart Disease International EValuation of the Effectiveness of SGLT2i Registry

    This real-world, international registry aims to evaluate the current experience with sodium-glucose cotransporter 2 inhibitors (SGLT2i) in adult congenital heart disease (ACHD) patients by investigating the prescription patterns, safety, tolerability, and potential beneficial effects on heart failu…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Johns Hopkins University, Baltimore, Maryland
    Locations
    11 in total
    Run by
    Leiden University Medical Center

    See if you can join NCT06932081 on ClinicalTrials.gov

  25. Pathophysiologic Mechanism for Arrhythmias and Impaired Aerobic Capacity in Tetralogy of Fallot and Other Congenital Heart Diseases

    This study is being done to determine the mechanism(s) contributing to the onset of symptoms (i.e. shortness of breath and/or palpitations) as well as changes in heart structure in patients with congenital heart disease (CHD)

    Stage
    Not phased
    Ages
    18 and older
    Site
    Mayo Clinic in Rochester, Rochester, Minnesota
    Run by
    Mayo Clinic

    See if you can join NCT05122962 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.