Colorectal Cancer Clinical Trials

162 studies are recruiting for colorectal cancer in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 7

1. A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression

   The goal of this study is to test A2B395, an allogeneic logic-gated Tmod™ CAR T-cell product in subjects with solid tumors including colorectal cancer (CRC), non-small cell lung cancer (NSCLC), head and neck squamous cell carcinoma (HNSCC), triple-negative breast cancer (TNBC), renal cell carcinoma…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Banner MD Anderson Cancer Center, Gilbert, Arizona

   Locations

   10 in total

   Run by

   A2 Biotherapeutics Inc.

   See if you can join NCT06682793 on ClinicalTrials.gov

2. Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors

   The investigational drug to be studied in this protocol, BCA101, is a first-in-class compound that targets both EGFR with TGFβ. Based on preclinical data, this bifunctional antibody may exert synergistic activity in patients with EGFR-driven tumors.

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Moores Cancer Center UC San Diego Health, La Jolla, California

   Locations

   20 in total

   Run by

   Bicara Therapeutics

   See if you can join NCT04429542 on ClinicalTrials.gov

3. 64Cu-LNTH-1363S in Patients With Sarcoma or Gastrointestinal Tract Cancer

   This is a multicenter, open-label, prospective Phase 1/2a study to assess safety and tolerability, establish dosimetry and to identify an optimal imaging dose (radioactivity) and imaging time window of 64Cu-LNTH-1363S, and to compare its imaging biodistribution with FAP expression by IHC in patient…

   Stage

   Phase 1

   Ages

   15 and older

   Site

   City of Hope, Duarte, California

   Locations

   5 in total

   Run by

   Lantheus Medical Imaging

   See if you can join NCT06298916 on ClinicalTrials.gov

4. ColoCare Study - Colorectal Cancer Cohort

   ColoCare is an international prospective cohort study of stage I-IV colorectal cancer patients (ICD-10 C18-C20).

   Stage

   Not phased

   Ages

   18 to 89

   Site

   Cedars-Sinai Medical Center, Los Angeles, California

   Locations

   7 in total

   Run by

   University of Utah

   See if you can join NCT02328677 on ClinicalTrials.gov

5. Tempus CRC Surveillance Study: A ctDNA Biomarker Profiling Study of Patients With CRC Using NGS Assays

   The study is an observational multicenter evaluation of participants with colorectal cancer (CRC) who will receive longitudinal plasma ctDNA biomarker profiling in addition to their standard-of-care therapy and disease surveillance.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Mercy Clinic Oncology - Fort Smith, Fort Smith, Arkansas

   Locations

   20 in total

   Run by

   Tempus AI

   See if you can join NCT05234177 on ClinicalTrials.gov

6. Preserving Fertility After Colorectal Cancer Study

   The PREFACE Study is a prospective, longitudinal cohort study of reproductive health and clinical outcomes among individuals diagnosed with colorectal cancer between age 18 to 49 years.

   Stage

   Not phased

   Ages

   18 to 49

   Site

   Vanderbilt-Ingram Cancer Center, Nashville, Tennessee

   Run by

   Andreana Holowatyj, PhD, MSCI

   See if you can join NCT05239338 on ClinicalTrials.gov

7. Study of TU2218 in Combination With KEYTRUDA®(Pembrolizumab) in Patients With Advanced Solid Tumors

   This study consists of phase 1b and 2a to evaluate safety, Pharmacokinetics, and efficacy of TU2218 in combination with Pembrolizumab in patients with advanced solid tumors.

   Stage

   Phase 1

   Ages

   18 and older

   Site

   CHA University Bundang Medical Center, Seongnam,

   Locations

   11 in total

   Run by

   TiumBio Co., Ltd.

   See if you can join NCT05784688 on ClinicalTrials.gov

8. A Multicenter Cancer Biospecimen Collection Study

   This study will collect de-identified tumor samples, with correlated clinical/demographic data and tissue histology, from patients selected or scheduled for pre-treatment tumor biopsy or who have had a recent pre-treatment tumor biopsy. These specimens and clinical data may be used in subsequent st…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Curebase, San Francisco, California

   Run by

   Cofactor Genomics, Inc.

   See if you can join NCT04510129 on ClinicalTrials.gov

9. A Study of IBI363 in Subjects with Advanced Solid Malignancies

   This is a Phase 2, open-label, multicenter study designed to evaluate the efficacy, safety and tolerability of IBI363 (study drug) in subjects with advanced, refractory solid malignancies.

   Stage

   Phase 2

   Ages

   18 and older

   Site

   University of California, San Francisco (UCSF), San Francisco, California

   Locations

   9 in total

   Run by

   Innovent Biologics (Suzhou) Co. Ltd.

   See if you can join NCT06281678 on ClinicalTrials.gov

10. Urine Metabolites in the Diagnosis of Disease

    The goal of this observational study is to validate a non-invasive, urine-based diagnostic technology for the detection and differentiation of various gastrointestinal (GI) diseases. This research study intends to enroll participants across a range of demographics and GI disease states including co…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Unio Health Partners (Gastroenterology), Encinitas, California

    Locations

    4 in total

    Run by

    Luventix, Inc.

    See if you can join NCT06710067 on ClinicalTrials.gov

11. Study of CRX100 as Monotherapy and in Combination With Pembrolizumab in Patients With Advanced Solid Malignancies

    This clinical study is an open-label, Phase 1, dose-escalation study to determine the safety, tolerability, and efficacy of the drug product produced by Administering CRX100 alone and in combination with Pembrolizumab in advanced solid malignancies. Patients will be screened and evaluated to determ…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    HonorHealth Research Institute, Scottsdale, Arizona

    Locations

    3 in total

    Run by

    BioEclipse Therapeutics

    See if you can join NCT04282044 on ClinicalTrials.gov

12. A First-in-human, Phase I, Open-label, Multicenter Study of NM1F(Anti-PVRIG) in Patients With Advanced Solid Tumors

    A Phase 1 Study to Investigate the Safety, Tolerability, Pharmacokinetics/Pharmacodynamics, and Antitumor Activity of NM1F as Monotherapy and in Combination with Pembrolizumab in Subjects with Locally Advanced/Metastatic Solid Tumors

    Stage

    Phase 1

    Ages

    18 and older

    Site

    NEXT Oncology, Dallas, Dallas, Texas

    Locations

    2 in total

    Run by

    Hefei TG ImmunoPharma Co., Ltd.

    See if you can join NCT05746897 on ClinicalTrials.gov