Colorectal Cancer Clinical Trials

163 studies are recruiting for colorectal cancer in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 6

1. COffee and Metabolites Modulating the Gut MicrobiomE in Colorectal caNCER

   This is research study is assessing the effects of 6-g daily use of freeze-dried instant coffee on liver fat and fibrosis and the gut microbiome and metabolome in patients who have completed routine treatment (including surgery, chemotherapy and radiotherapy) for stage I-III colorectal cancer.

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT05692024 on ClinicalTrials.gov

2. Tumor Cell and DNA Detection in the Blood, Urine and Bone Marrow of Patients With Solid Cancers

   Patients with resectable solid primary cancers and even limited number of metastases are potentially curable. However, most patients develop recurrences despite surgery. Circulating and disseminated tumor cell (CTC/DTC) and circulating cell-free (cf) DNA isolation from the blood, urine and bone mar…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Ellis Fischel Cancer Center, University of Missouri, Columbia, Missouri

   Run by

   University of Missouri-Columbia

   See if you can join NCT02838836 on ClinicalTrials.gov

3. Early-Onset Colorectal Cancer Patients Too Young for Screening

   This is a population-based retrospective study using the Surveillance, Epidemiology, and End Results (SEER) registry and National Cancer Data Base (NCDB) to look at colorectal cancer (CRC) patients younger than 35 and comparing them against CRC patients older than 35 years of age.

   Stage

   Not phased

   Ages

   35 and older

   Site

   Methodist Dallas Medical Center- Clinical Research Institute, Dallas, Texas

   Run by

   Methodist Health System

   See if you can join NCT07559825 on ClinicalTrials.gov

4. Remote Monitoring and Symptom Management Digital Application

   The goal of this clinical trial is to learn if an artificial intelligence phone application called ASSIST can help patients receiving cancer treatment. The main question[s] it aims to answer are: Is ASSIST feasible for patients (meaning can it be used by patients)? Is ASSIST acceptable to patients …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Patrick C. Johnson, MD

   See if you can join NCT07553572 on ClinicalTrials.gov

5. Exogenous and Endogenous Risk Factors for Early-onset Colorectal Cancer

   An increase in early-onset colorectal cancers (eoCRC), defined as a CRC before 50 years, is confirmed globally. CRC pathogenesis has been associated with several risk factors (family history, germline pathogenic variants, obesity, alcohol, physical activity, red meat, and a Western diet). Design: a…

   Stage

   Not phased

   Ages

   18 to 49

   Site

   Department of Medicine-Gastroenterology, Denver Veterans Affairs Medical Center, University of Colorado Hospital, Denver, Colorado

   Locations

   8 in total

   Run by

   San Raffaele University

   See if you can join NCT05732623 on ClinicalTrials.gov

6. A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy

   This study is an open-label Phase Ib (Part A) dose escalation followed by a blinded, randomized, multi cohort Phase 2a (Part B) comparison of combination vs. reference regimens. Currently study will only be enrolling the Phase 1b and the Phase 2a protocol requirements will be added to the study nea…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   University of Colorado Cancer Center, Aurora, Colorado

   Locations

   5 in total

   Run by

   7 Hills Pharma, LLC

   See if you can join NCT06362369 on ClinicalTrials.gov

7. Changes in Reproductive and Sexual Health in People With Early Onset Colorectal Cancer

   The purpose of this study is to find out how cancer treatments (chemotherapy and/or radiation therapy) affect reproductive and sexual health in people with early onset colorectal cancer. The study researchers will observe and track changes in hormone levels and in sexual and reproductive health in …

   Stage

   Not phased

   Ages

   18 to 50

   Site

   Memorial Sloan Kettering Basking Ridge, Basking Ridge, New Jersey

   Locations

   7 in total

   Run by

   Memorial Sloan Kettering Cancer Center

   See if you can join NCT04812912 on ClinicalTrials.gov

8. This is a Phase 1 Trial of ZM008, an Anti-LLT1 Antibody, Used as Single Agent Followed by Combination Treatment With Toripalimab in Patients With Advanced Solid Tumors

   This is a phase 1 dose escalation trial of ZM008, an anti-LLT1 antibody as a single agent followed by combination with Toripalimab in patients with advanced solid tumors who have exhausted all standard therapy available or are intolerant of the same.

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Dana Farber Cancer Institute, Boston, Massachusetts

   Locations

   3 in total

   Run by

   Zumutor Biologics Inc.

   See if you can join NCT06451497 on ClinicalTrials.gov

9. An Evaluation of NGM120 in a Randomized, Double-blind, Placebo-controlled Study in Participants With Colorectal Cancer Who Have Cancer Cachexia.

   A multi-center evaluation of NGM120 in a randomized, double-blind, placebo-controlled study in participants with colorectal cancer who have cancer cachexia.

   Stage

   Phase 2

   Ages

   18 and older

   Site

   NGM Clinical Study Site, Los Angeles, California

   Locations

   28 in total

   Run by

   NGM Biopharmaceuticals, Inc

   See if you can join NCT07033026 on ClinicalTrials.gov

10. A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies

    This is a two-part, open-label, multicenter, dose escalation and dose expansion study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PDx), and anti- tumor activity of ETX-19477, a novel reversible small molecule inhibitor of PARG.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Mayo Clinic, Phoenix, Arizona

    Locations

    14 in total

    Run by

    858 Therapeutics, Inc.

    See if you can join NCT06395519 on ClinicalTrials.gov

11. Biopsy After Radioembolization to Identify Changes in Tumor Cells From the Radiation

    The purpose of this study is to study the way radioembolization works by collecting biopsy samples of participants' tumors after the procedure. This research may improve the way that radioembolization is performed, which could help people whose cancer has spread to the liver. The research may also …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Memorial Sloan Kettering Cancer Center, New York, New York

    Run by

    Memorial Sloan Kettering Cancer Center

    See if you can join NCT04668872 on ClinicalTrials.gov

12. Gastrointestinal Biomarkers in Tissue and Biological Fluid Samples From Colorectal Cancer Patients

    RATIONALE: Studying samples of tissue, blood, urine, stool, and other biological fluids from patients with cancer and from healthy volunteers undergoing colonoscopy or endoscopy may help doctors identify and learn more about biomarkers related to cancer. PURPOSE: This research study is looking at g…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Veterans Affairs Medical Center - Nashville, Nashville, Tennessee

    Locations

    2 in total

    Run by

    Vanderbilt University Medical Center

    See if you can join NCT00899626 on ClinicalTrials.gov

13. Telehealth Intervention for Ostomy Self-Management

    Over one million individuals in the U.S. have ostomies. An ostomy is a surgical procedure that creates an opening in the abdominal wall that allows bodily waste (urinary or fecal) to pass through into an external pouch; in essence, it is the externalization of the gastrointestinal or urinary struct…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    City of hope Medical Center, Duarte, California

    Run by

    City of Hope Medical Center

    See if you can join NCT06528990 on ClinicalTrials.gov

14. Riluzole For Preventing Cognitive Dysfunction in Ca Pts Receiving Chemo (REFOCUS): Pilot Trial

    This is a phase II single-arm, Phase 2a, randomized, double-blinded, placebo-controlled pilot clinical trial determining efficacy of riluzole in preventing cognitive dysfunction in subjects with cancer, who are receiving chemotherapy.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Chao Family Comprehensive Cancer Center, University of California Irvine, Orange, California

    Run by

    University of California, Irvine

    See if you can join NCT07447050 on ClinicalTrials.gov

15. A Study of Single Fraction Stereotactic Body Radiation Therapy (SBRT) Guided by Magnetic Resonance Imaging (MRI) in People With Liver Metastasis From Colorectal Cancer

    The researchers are doing this study to see if one session of high-dose contrast-enhanced MRI-guided SBRT (stereotactic body radiation therapy) is effective for colorectal cancer that has spread to the liver. The researchers will evaluate how well the study treatment can prevent the liver metastasi…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey

    Locations

    7 in total

    Run by

    Memorial Sloan Kettering Cancer Center

    See if you can join NCT06130280 on ClinicalTrials.gov

16. Ultrasound and Photoacoustic Imaging for Enhanced Differential Diagnosis of Rectal Cancer

    The purpose of this study is to demonstrate the functionality of a novel endorectal photoacoustic ultrasound imaging modality in humans with rectal cancer. The study involves testing a previously developed endorectal device to determine its ability to accurately assess rectal tumor response to preo…

    Stage

    Not phased

    Ages

    19 and older

    Site

    Washington University School of Medicine, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT04339374 on ClinicalTrials.gov

17. Binary Oncolytic Adenovirus in Combination With HER2-Specific Autologous CAR VST, Advanced HER2 Positive Solid Tumors

    This study is a first in human Phase 1 study that involves patients with a type of cancer called HER2 (Human Epidermal Growth Factor Receptor 2) positive cancer. This study asks patients to volunteer to take part in a research study investigating the safety and efficacy of using special immune cell…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Baylor St. Luke's Medical Center, Houston, Texas

    Run by

    Baylor College of Medicine

    See if you can join NCT03740256 on ClinicalTrials.gov

18. Reducing Metabolic Dysregulation in Dyads

    This study is a 6-month randomized controlled trail of diet modification designed to reduce chronic inflammation and reverse metabolic dysfunction among obese individuals with one or more polyps found at a colonoscopy screening. We also will recruit an at least overweight partner, who lives in the …

    Stage

    Not phased

    Ages

    9 to 55

    Site

    University of South Carolina, Columbia, South Carolina

    Run by

    University of South Carolina

    See if you can join NCT06117241 on ClinicalTrials.gov

19. Symptom Management and Transitioning to Engagement With Post-treatment Care for Adolescent and Young Adult Cancer Survivors

    The purpose of this study is to determine the effectiveness of a digital health program called AYA STEPS, which is designed to help adolescent and young adult (AYA) cancer survivors manage symptoms and engage in recommended follow-up care.

    Stage

    Not phased

    Ages

    18 to 39

    Site

    Duke Cancer Institute, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT06371768 on ClinicalTrials.gov

20. Cabozantinib Plus Durvalumab With or Without Tremelimumab in Patients With Gastroesophageal Cancer and Other Gastrointestinal Malignancies

    The investigators propose to evaluate the safety of drug combinations in patients with advanced gastroesophageal cancer and other gastrointestinal (GI) malignancies. Finding effective novel therapies for patients with advanced gastric cancer and other GI malignancies is an area of great unmet need.…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania

    Locations

    2 in total

    Run by

    Anwaar Saeed

    See if you can join NCT03539822 on ClinicalTrials.gov

21. cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

    This is an observational case-control study to train and validate a genome-wide methylome enrichment platform to detect multiple cancer types and to differentiate amongst cancer types. The cancers included in this study are brain, breast, bladder, cervical, colorectal, endometrial, esophageal, gast…

    Stage

    Not phased

    Ages

    40 and older

    Site

    City of Hope, Duarte, California

    Locations

    17 in total

    Run by

    Adela, Inc

    See if you can join NCT05366881 on ClinicalTrials.gov

22. Feasibility of the LUM Imaging System for Detection of Gastrointestinal Cancers

    The overall goal of this feasibility study is to assess the initial safety and efficacy of LUM015 in ex vivo far-red imaging of colorectal, pancreatic, and esophageal cancers (adenocarcinoma) using the LUM Imaging System.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Lumicell, Inc.

    See if you can join NCT02584244 on ClinicalTrials.gov

23. Collection of Samples From the United States Population for Optimization and Evaluation of Colorectal Cancer (CRC) Plasma Circulating Free-DNA (cfDNA) Marker Panel Performance

    This study is designed to prospectively collect blood samples and clinical data from patients that have been newly diagnosed with colorectal cancer and scheduled for resection surgery but are pre cancer treatment, subjects who are NOT scheduled for surgery but have histological confirmation of CRC …

    Stage

    Not phased

    Ages

    45 to 84

    Site

    Gastroenterology and Internal Medicine Specialists, Lake Barrington, Illinois

    Run by

    Universal Diagnostics

    See if you can join NCT07310446 on ClinicalTrials.gov

24. GENOCARE: A Prospective, Randomized Clinical Trial of Genotype-Guided Dosing Versus Usual Care

    This is a prospective, randomized study designed to compare genotype-guided dosing to usual care in patients with pancreas cancer and colorectal cancer who are UGT1A1 intermediate metabolizers (*1/*28) (heterozygotes) and usual UGT metabolizers (*1/*1). All patients will be assessed for UGT1A1 geno…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Kentucky, Lexington, Kentucky

    Run by

    Reema A. Patel

    See if you can join NCT05391126 on ClinicalTrials.gov

25. A Prospective, Multi-center, Observational Study for Signal-C Test Evaluation

    To evaluate the performance characteristics of Signal-C™ a plasma circulating free-DNA test, to detect colorectal cancer and advanced precancerous lesions (APL) in an average risk screening population for 45 and over.

    Stage

    Not phased

    Ages

    45 to 84

    Site

    Gastroenterology Consultants of SW Virginia, Raonoke, Virginia

    Run by

    Universal Diagnostics

    See if you can join NCT06059963 on ClinicalTrials.gov