Cognitive Impairment Clinical Trials

43 studies are recruiting for cognitive impairment in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. Cancer and Mild Cognitive Impairment Dyadic Intervention

   The purpose of this study is to see whether programs that include both a patient and their spouse or a patient and family caregiver (known as a dyad) are helpful for families in which one member of the dyad has cancer and mild memory difficulties and/or concerns. Participant and their spouse or par…

   Stage

   Not phased

   Ages

   18 to 100

   Site

   Duke University, Durham, North Carolina

   Run by

   Duke University

   See if you can join NCT05144516 on ClinicalTrials.gov

2. Cognitive Screening Made Easy for PCPs - Administrative Supplement

   This project will facilitate early detection of cognitive decline in older adults through development and implementation of an automated risk assessment and cognitive screening tool for use in primary care. By providing an automated tool developed specifically to address the needs of PCPs, it will …

   Stage

   Not phased

   Ages

   60 and older

   Site

   Family Wellness Clinic, Austin, Texas

   Locations

   3 in total

   Run by

   University of Texas at Austin

   See if you can join NCT06928298 on ClinicalTrials.gov

3. Neuromodulation and Neuroimaging in Older Children With Mild Traumatic Brain Injury

   Mild traumatic brain injury (mTBI) often causes persistent motor and cognitive deficits in children resulting in functional limitations. We are testing a brain stimulation method along with evaluating objective tools to help record and restore communication among affected brain areas, which will fa…

   Stage

   Not phased

   Ages

   10 to 15

   Site

   Ghazala Saleem, Buffalo, New York

   Run by

   State University of New York at Buffalo

   See if you can join NCT05762796 on ClinicalTrials.gov

4. Biomarker Exploration in Aging, Cognition and Neurodegeneration

   The purpose of this research study is to understand the factors that underlie changes in thinking and memory with increasing age. The investigators will test the usefulness of MRI, PET, and cognitive testing in detecting subtle changes in the brain that precede cognitive decline. An addendum to thi…

   Stage

   Phase 3

   Ages

   60 and older

   Site

   University of California, Irvine, Irvine, California

   Run by

   University of California, Irvine

   See if you can join NCT03860857 on ClinicalTrials.gov

5. Transcranial Direct Current Stimulation and Rehabilitation to Ameliorate Impairments in Neurocognition After Stroke

   The purpose of this study is to determine whether a non-invasive brain stimulation technique, transcranial direct current stimulation (tDCS), combined with traditional cognitive therapy will improve cognitive function in patients with subacute stroke.

   Stage

   Not phased

   Ages

   18 to 90

   Site

   Penn Medicine Rehabilitation, Philadelphia, Pennsylvania

   Run by

   University of Pennsylvania

   See if you can join NCT04897334 on ClinicalTrials.gov

6. Study of ALTO-101 in Patients With Schizophrenia

   This is a Phase 2, double-blind, placebo-controlled, two-way crossover study to compare the efficacy of ALTO-101T versus placebo in change in electroencephalogram (EEG) cognitive processing markers and measures of cognition. Additional goals are to assess pharmacokinetic (PK), safety, and tolerabil…

   Stage

   Phase 2

   Ages

   21 to 55

   Site

   Site 5038, Garden Grove, California

   Locations

   14 in total

   Run by

   Alto Neuroscience

   See if you can join NCT06502964 on ClinicalTrials.gov

7. Diet and Cognitive Training in Hematologic Cancer Survivors

   The goal of this clinical trial is to examine feasibility of a cognitive intervention program in blood cancer survivors. The main questions it aims to answer are: * is it feasible to combine a ketogenic diet supplementation and online cognitive training in an intervention program * will patients us…

   Stage

   Not phased

   Ages

   21 and older

   Site

   University of Alabama at Birmingham, Birmingham, Alabama

   Run by

   University of Alabama at Birmingham

   See if you can join NCT05708716 on ClinicalTrials.gov

8. Effect of High-Intensity Exercise to Attenuate Cognitive Function Limitations and Train Exercise Habits in Older People Living With HIV

   People aging with HIV are at higher risk for Alzheimer's disease and related dementias, and although physical activity is a promising target to mitigate such risk, this population engages in low levels of physical activity. Few studies have tested cognitive effects of exercise interventions or exam…

   Stage

   Not phased

   Ages

   50 to 80

   Site

   University of Colorado Denver, Aurora, Colorado

   Locations

   3 in total

   Run by

   University of Alabama at Birmingham

   See if you can join NCT06013579 on ClinicalTrials.gov

9. Investigating the Effects of Wearable Robotic Exoskeleton for Improving Mobility and Cognition in Persons With MS

   The purpose of this research study is to evaluate the usefulness of a wearable robotic exoskeleton device (Ekso-GT), to improve learning and memory, and gait therapy in persons with walking disability due to Multiple Sclerosis. The study will evaluate the mobility, learning and memory, and walking …

   Stage

   Not phased

   Ages

   18 to 75

   Site

   Kessler Foundation, West Orange, New Jersey

   Run by

   Kessler Foundation

   See if you can join NCT04855825 on ClinicalTrials.gov

10. HEARS-NPS: Addressing Hearing Loss as a Common Unmet Contributor of Neuropsychiatric Symptoms

    This randomized controlled trial study aims to evaluate a revised hearing care intervention for older adults with Alzheimer's Disease and Related Dementias (ADRD). The community-delivered hearing care intervention utilizes tailored strategies to assess impact on communication, neuropsychiatric symp…

    Stage

    Not phased

    Ages

    60 to 100

    Site

    Johns Hopkins Memory and Alzheimer's Treatment Center, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT06930560 on ClinicalTrials.gov

11. Passive Sensor Identification of Digital Biomarkers to Assess Effects of Orally Administered Nicotinamide Riboside

    This project's main goal is to use state-of-the-art passive sensing techniques to identify digital biomarkers that relate to bioenergetic changes in the brain due to nicotinamide riboside supplementation in those with mild cognitive impairment and mild Alzheimer's dementia.

    Stage

    Not phased

    Ages

    18 to 89

    Site

    McLean Hospital, Belmont, Massachusetts

    Run by

    Mclean Hospital

    See if you can join NCT05245903 on ClinicalTrials.gov

12. MitoQ for Early-phase Schizophrenia-spectrum Disorder and Mitochondrial Dysfunction

    The goal of this double-blind, placebo-controlled randomized clinical trial is to test the effect of 12 weeks of orally administered MitoQ (mitoquinol mesylate) supplementation on cognition in 50 people with early phase schizophrenia-spectrum disorders (E-SSD) who have mitochondrial dysfunction (ca…

    Stage

    Phase 2

    Ages

    18 to 35

    Site

    McLean Hospital, Belmont, Massachusetts

    Locations

    3 in total

    Run by

    Mclean Hospital

    See if you can join NCT06191965 on ClinicalTrials.gov

13. Impact of a Multimodal Lifestyle Intervention on Dementia Risk Factors and Attitude Related to Dementia Risk: A Logistical Pilot Study

    Many individuals develop dementia, and dementia has multiple causes, yet we currently have limited treatment options. A critical observation of the effectiveness of the available dementia treatments is that they tend to be more effective when started early. Previous studies have shown that multimod…

    Stage

    Not phased

    Ages

    65 to 75

    Site

    Smith Family Clinic for Genomic Medicine, Huntsville, Alabama

    Run by

    HudsonAlpha Institute for Biotechnology

    See if you can join NCT07146412 on ClinicalTrials.gov

14. Benefits of Nicotinamide Riboside Upon Cognition and Sleep

    Poor sleep quality and short sleep duration may be a mechanistic component of cognitive impairment in older adults, associated with a decline in brain-derived neurotrophic factor. Increasing the availability of nicotinamide adenine dinucleotide (NAD+) with supplementation of its precursor, nicotina…

    Stage

    Not phased

    Ages

    65 to 85

    Site

    Buffalo Veteran Affairs Medical Center, Buffalo, New York

    Locations

    3 in total

    Run by

    State University of New York at Buffalo

    See if you can join NCT05500170 on ClinicalTrials.gov

15. A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors

    Up to 25% of intensive care unit (ICU) survivors experience cognitive impairment comparable in severity to mild Alzheimer's disease and related dementias after hospital discharge. Older ICU survivors (ages 60 and older) are at highest risk for delirium and subsequent cognitive impairment, which con…

    Stage

    Not phased

    Ages

    60 and older

    Site

    University of Washington, Seattle, Washington

    Run by

    University of Washington

    See if you can join NCT06411561 on ClinicalTrials.gov

16. Amygdala Memory Enhancement

    The objective is to understand how amygdala activation affects other medial temporal lobe structures to prioritize long-term memories. The project is relevant to disorders of memory and to disorders involving affect and memory, including traumatic brain injury and post-traumatic stress disorder.

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Washington University School of Medicine, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT05065450 on ClinicalTrials.gov

17. Leveraging Social Networks to Improve Sleep and Mindfulness Among Older Adults in Residential Housing Facilities

    The aim of this study is to design a sleep and mindfulness intervention to improve sleep, quality of life, and cognitive function among older adults.

    Stage

    Not phased

    Ages

    55 and older

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Run by

    Brigham and Women's Hospital

    See if you can join NCT06989619 on ClinicalTrials.gov

18. Remimazolam for Cataract Surgery

    The goal of this study is to assess any post operative cognitive changes following benzodiazepine administration during cataract surgery. The investigators will compare effects of Midazolam vs. Remimazolam on cognition at the time of discharge from the post operative care unit and the next day foll…

    Stage

    Phase 4

    Ages

    65 and older

    Site

    Ronald Reagan UCLA Medical Center, Department of Anesthesiology & Perioperative Medicine, Los Angeles, California

    Run by

    University of California, Los Angeles

    See if you can join NCT05980117 on ClinicalTrials.gov