Cognitive Impairment Clinical Trials

43 studies are recruiting for cognitive impairment in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Methylphenidate to Address Attention and Executive Deficits Among Children With Sickle Cell Disease

   The purpose of this study is to determine if patients with sickle cell disease (SCD) can consistently take a drug called Methylphenidate (MPH) daily, once a day for 4 weeks to help with any thinking, attention or schoolwork problems and if they have any side effects. The study will assess any think…

   Stage

   Phase 1

   Ages

   8 to 17

   Site

   St. Jude Children's Research Hospital, Memphis, Tennessee

   Run by

   St. Jude Children's Research Hospital

   See if you can join NCT07226219 on ClinicalTrials.gov

2. A Primary Care-Based Psychosocial Intervention To Improve Cognitive & Depression Outcomes in Older Adults With MCI & Early Stage AD

   The purpose of the study is to examine the effect of Problem Adaptation Therapy for Pain (PATH-Pain) on cognitive functioning, depression and pain-related disability in 100 older adults with cognitive impairment, chronic pain, and depression. The study will test if PATH-Pain has better cognitive, a…

   Stage

   Not phased

   Ages

   60 and older

   Site

   Weill Cornell Medicine, White Plains, New York

   Run by

   Weill Medical College of Cornell University

   See if you can join NCT05081596 on ClinicalTrials.gov

3. Cognitive Impairment in Colorectal Cancer Patients Receiving Cytotoxic Chemotherapy

   The purpose of this research study is to see how the brain changes in patients receiving chemotherapy (cytotoxic drug) treatment for colon or rectal cancer at Parkview Cancer Institute. This information will be used to identify helpful tests to diagnose individuals at risk for developing difficulti…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Parkview Cancer Institute, Fort Wayne, Indiana

   Run by

   Joseph McCollom

   See if you can join NCT05014399 on ClinicalTrials.gov

4. ME/CFS Brain Fog: Cognitive Rehabilitation Trial

   The purpose of this study is to compare two approaches to cognitive rehabilitation in adults with post-viral cognitive syndrome, which resulted in brain fog. All participants will be screened for eligibility prior to participation. Most of the procedures will take place over a phone call or secure …

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Alabama at Birmingham, Birmingham, Alabama

   Run by

   University of Alabama at Birmingham

   See if you can join NCT07523113 on ClinicalTrials.gov

5. Early Age-Related Hearing Loss Investigation (EARHLI)

   Early Age-Related Hearing Loss Investigation (EARHLI) is a single site study that will randomize late middle age adults to either a hearing intervention (including hearing aids) or a health education intervention. Participants will be followed for 1 year. This study will provide information on redu…

   Stage

   Not phased

   Ages

   55 to 75

   Site

   Columbia University Medical Center, New York, New York

   Run by

   Columbia University

   See if you can join NCT06174038 on ClinicalTrials.gov

6. Improving Self-Care of Caregivers of Adults in Homecare With Heart Failure and Cognitive Impairment

   This RCT design will enroll 256 informal caregivers (spouse/partner or child) of HHC patients with HF/CI and 60 patients with HF and mild to moderate CI (60 dyads). After collecting baseline data, we will block randomize the caregivers 1:1 to the ViCCY intervention or comparator group, stratifying …

   Stage

   Not phased

   Ages

   18 to 101

   Site

   VNS Health, New York, New York

   Run by

   Visiting Nurse Service of New York

   See if you can join NCT07220798 on ClinicalTrials.gov

7. TDCS to Improve Post-Stroke Cognitive Impairment

   The investigators will conduct a randomized, double-blinded, sham-controlled trial of approximately 60 patients with minor stroke and post-stroke mild cognitive impairment (psMCI). Participants will be individually randomized on enrollment using a random number generator to treatment with anodal tD…

   Stage

   Not phased

   Ages

   18 to 100

   Site

   Johns Hopkins Bayview Medical Center, Baltimore, Maryland

   Run by

   Johns Hopkins University

   See if you can join NCT05195398 on ClinicalTrials.gov

8. Living Independence Through Functional Training

   The purpose of the research is to evaluate the feasibility and benefits of a six-week hybrid task-oriented resistance exercise program for older adults who have been recently discharged from home health care.

   Stage

   Phase 1

   Ages

   65 to 90

   Site

   College of Public Health and Health Professions, University of Florida, Gainesville, Florida

   Locations

   2 in total

   Run by

   University of Florida

   See if you can join NCT07125378 on ClinicalTrials.gov

9. Effect of NAC on Preventing Chemo-Related Cognitive Impairments in Ovarian Ca Pts Treated W/ PBT

   This is a phase I, dose-escalation and phase II dose-expansion clinical trial determining the maximum tolerated dose (MTD) and safety and tolerability of adding N-Acetyl-Cysteine (NAC) to ovarian cancer patients who are receiving a platinum-based therapy (PBT). This study will investigate whether N…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, California

   Run by

   University of California, Irvine

   See if you can join NCT04520139 on ClinicalTrials.gov

10. Effects of Accelerated rTMS on Cognitive Function

    Cognitive impairment, including mild cognitive impairment (MCI) and mild dementia, is a growing public health challenge with limited effective treatment options. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technique that has shown promise for improving cogn…

    Stage

    Not phased

    Ages

    50 to 90

    Site

    San Francisco Neurology and Sleep Center, San Francisco, California

    Run by

    San Francisco Neurology and Sleep Center

    See if you can join NCT07547319 on ClinicalTrials.gov

11. Brain Health in Breast Cancer Survivors

    Endocrine therapy (ET) is widely used to treat hormone receptor positive breast cancer and prevent recurrence by downregulating estrogen function. However, ETs readily cross the blood brain barrier and interfere with the action of estrogen in the brain. Estrogen supports cognition and menopausal st…

    Stage

    Not phased

    Ages

    35 to 65

    Site

    University of California at Los Angeles, Los Angeles, California

    Run by

    Jonsson Comprehensive Cancer Center

    See if you can join NCT04297020 on ClinicalTrials.gov

12. Neurologic Stem Cell Treatment Study

    This is a human clinical study involving the isolation of autologous bone marrow derived stem cells (BMSC) and transfer to the vascular system and inferior 1/3 of the nasal passages in order to determine if such a treatment will provide improvement in neurologic function for patients with certain n…

    Stage

    Not phased

    Ages

    18 and older

    Site

    MD Stem Cells, Westport, Connecticut

    Locations

    3 in total

    Run by

    MD Stem Cells

    See if you can join NCT02795052 on ClinicalTrials.gov

13. A Mechanistic Study to Investigate tDCS and Working Memory in MCI Patients

    The current study is a mechanistic study to evaluate working memory gains from application of transcranial direct current stimulation (tDCS) in older adults with mild cognitive impairments (MCI) compared to cognitively healthy control

    Stage

    Not phased

    Ages

    60 to 95

    Site

    University of Florida, Gainesville, Florida

    Run by

    University of Florida

    See if you can join NCT05998031 on ClinicalTrials.gov

14. Effect of Gerofit Exercise on Cognition in Older Veterans

    Over 50% of the Veterans enrolled for VA health care are over the age of 65. Dementia prevalence increases with age, and with the increase in the population of people ages 65 and older, the total number of people with dementia is also increasing. Older Veterans often have comorbid PTSD, major depre…

    Stage

    Not phased

    Ages

    65 and older

    Site

    VA Greater Los Angeles Healthcare System, West Los Angeles, CA, West Los Angeles, California

    Locations

    2 in total

    Run by

    VA Office of Research and Development

    See if you can join NCT06107842 on ClinicalTrials.gov

15. Effects of Transcutaneous Vagal Nerve Stimulation on Post-Surgical Return to Consciousness, Delirium, and Depression

    This study will examine whether noninvasive, transcutaneous vagal nerve stimulation (tcVNS) can help restore consciousness in patients in the operating room and the Post Anesthesia Care Unit (PACU). The study will also investigate if tcVNS can expedite discharge from the PACU and examine whether tc…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Northwestern University Feinberg School of Medicine, Chicago, Illinois

    Run by

    Northwestern University

    See if you can join NCT07610655 on ClinicalTrials.gov

16. Cognitive Status After Removal of Skull Base Meningioma

    The purpose of this prospectively enrolling trial is to assess long-term cognitive outcomes of patients undergoing surgery for resection of a meningioma associated with the frontal and temporal lobes.

    Stage

    Not phased

    Ages

    18 to 89

    Site

    Ohio State University Wexner Medical Center, Columbus, Ohio

    Run by

    Ohio State University

    See if you can join NCT04635657 on ClinicalTrials.gov

17. Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer

    This randomized, placebo-controlled trial aims to assess the feasibility, acceptability, and preliminary efficacy of memantine and the University of Carolina (UNC)'s Get Real \& Heel cancer exercise program (MEM+EX) in addressing cancer-related cognitive impairment (CRCI) and underlying CRCI biomar…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Lineberger Comprehensive Cancer Center at University of North Carolina, Chapel Hill, Chapel Hill, North Carolina

    Run by

    UNC Lineberger Comprehensive Cancer Center

    See if you can join NCT06727773 on ClinicalTrials.gov

18. A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses

    The goal of this clinical trial is to test 6 months of aerobic exercise in older adults who are 65 years or older and have mild cognitive impairment (MCI) or probable/possible mild Alzheimer's Disease. The main questions it aims to answer are: * test the effects of aerobic exercise on aerobic fitne…

    Stage

    Not phased

    Ages

    65 and older

    Site

    Arizona State University, Phoenix, Arizona

    Run by

    Arizona State University

    See if you can join NCT05877196 on ClinicalTrials.gov

19. Investigating Dynamic Interactions in Distributed Cognitive Control Networks

    The purpose of this study is to investigate the brain activity associated with cognitive tasks (thinking, reasoning, remembering) in order to understand how the brain works during certain tasks and to improve treatment for diseases like dementia and attention deficit disorders. Cognitive (thinking)…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT05927974 on ClinicalTrials.gov

20. Essential Fats For Enhancing Cognitive Thinking (EFFECT) Study

    The proposed research is a randomized crossover trial designed to assess changes in postprandial cognitive function and the gut-brain axis in adults with subjective cognitive complaints who consume 1 study snack per day for 1 week.

    Stage

    Not phased

    Ages

    40 to 75

    Site

    The Ohio State University, Columbus, Ohio

    Run by

    Ohio State University

    See if you can join NCT06223672 on ClinicalTrials.gov

21. Cognitive Training Intervention and Attitudes Towards Genetics

    A pilot study to evaluate feasibility of enrollment of patients in an intervention to improve neurocognitive function in hematopoietic cell transplantation (HCT) survivors using the cognitive training Lumosity program. In addition, patients' interest in receiving information regarding genetic risk …

    Stage

    Not phased

    Ages

    21 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT03094026 on ClinicalTrials.gov

22. 5-Cog 2.0: A Pragmatic Clinical Trial

    Cognitive impairment related to dementia is frequently under-diagnosed in primary care settings. This problem is more prevalent in health disparities populations. The investigators developed the 5-Cog brief cognitive assessment that is simple to use, standardized, takes <5 minutes, does not require…

    Stage

    Not phased

    Ages

    65 and older

    Site

    Indiana University, Bloomington, Indiana

    Locations

    2 in total

    Run by

    Albert Einstein College of Medicine

    See if you can join NCT05515224 on ClinicalTrials.gov

23. Long COVID Brain Fog: Cognitive Rehabilitation Trial

    This study will compare two approaches to cognitive rehabilitation in adults with long COVID with persistent, mild to moderate, cognitive impairment. One approach will feature (A) web-based computer "games" that trains how quickly individuals process information that they receive through their sens…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT06095297 on ClinicalTrials.gov

24. Cognitive Remediation Intervention to Prepare for Transition of Care

    Randomized Controlled Trial (RTC) testing the efficacy of a telehealth adaptation of the Cognitive-Remediation of Executive and Adaptive Deficits in Youth (C-READY) intervention to prepare adolescents with sickle cell disease for transition of care.

    Stage

    Phase 2

    Ages

    10 to 18

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT05336201 on ClinicalTrials.gov

25. Evaluating the Efficacy of the Pain Identification and Communication Toolkit

    This study will evaluate the Pain Identification and Communication Toolkit (PICT), a multicomponent intervention for caregivers of people with Alzheimer's disease and related dementias (ADRD). PICT provides training in observational pain assessment and coaching in effective pain communication techn…

    Stage

    Not phased

    Ages

    21 and older

    Site

    Weill Cornell Medicine, New York, New York

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT06168604 on ClinicalTrials.gov