Cognitive Decline Clinical Trials

33 studies are recruiting for cognitive decline in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. Cognitive and Vascular Functioning Following TBI

   This observational study will examine the association of chronic traumatic cerebrovascular injury and cardiovascular risk factors with TBI-related cognitive impairment and vascular dementia. Cerebrovascular, inflammatory, and neurodegenerative blood biomarkers as well as clinical and neuroimaging d…

   Stage

   Not phased

   Ages

   18 to 74

   Site

   Walter Reed National Military Medical Center, Bethesda, Maryland

   Run by

   Walter Reed National Military Medical Center

   See if you can join NCT06034509 on ClinicalTrials.gov

2. A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors

   Up to 25% of intensive care unit (ICU) survivors experience cognitive impairment comparable in severity to mild Alzheimer's disease and related dementias after hospital discharge. Older ICU survivors (ages 60 and older) are at highest risk for delirium and subsequent cognitive impairment, which con…

   Stage

   Not phased

   Ages

   60 and older

   Site

   University of Washington, Seattle, Washington

   Run by

   University of Washington

   See if you can join NCT06411561 on ClinicalTrials.gov

3. Computerized Tests of Cognitive Decline in Presymptomatic Alzheimer's Disease

   The investigators will study performance on computerized cognitive tasks in healthy participants of different ages to gather normative data for newly developed computerized cognitive tests. These tests are designed to permit the early detection of individuals at risk of age-related cognitive declin…

   Stage

   Not phased

   Ages

   18 to 89

   Site

   Neurobehavioral Systems, Inc., Berkeley, California

   Run by

   Neurobehavioral Systems, Inc.

   See if you can join NCT04800588 on ClinicalTrials.gov

4. Glucose Variability and Cognition in Prediabetes

   This study examines the association of variability in glucose values over a 10-day period with cognitive function and functional status among individuals with prediabetes, aged 50 or older.

   Stage

   Not phased

   Ages

   50 and older

   Site

   Baltimore VA Geriatric Research Education and Clinical Center (GRECC), Baltimore, Maryland

   Run by

   University of Maryland, Baltimore

   See if you can join NCT04201600 on ClinicalTrials.gov

5. Older Breast Cancer Patients: Risk for Cognitive Decline

   The goal of this study is to evaluate the impact of systemic therapy on cognition in older breast cancer patients, explore change in APE, LM and Cognition domains, measure associations between cognitive decline and QOL, and describe how genetic polymorphisms, inflammatory biomarkers, sleep and phys…

   Stage

   Not phased

   Ages

   60 to 105

   Site

   Georgetown University, Washington D.C., District of Columbia

   Run by

   Georgetown University

   See if you can join NCT03451383 on ClinicalTrials.gov

6. Study Evaluating the Quality and Effects of Lion's Mane Product on Cognitive Health

   The rationale for this study is to observe differences in cognitive health outcomes such as short term memory and simple reaction time between a consumer-grade and commercially available Lion's mane mushroom product and a placebo control group. Additionally, the study aims to evaluate the impact of…

   Stage

   Not phased

   Ages

   40 to 75

   Site

   People Science, Los Angeles, California

   Run by

   M2 Ingredients

   See if you can join NCT06870136 on ClinicalTrials.gov

7. Disease Modifying Potential of 5mg of Melatonin on Cognition and Brain Health in Aging

   The study will examine whether 5mg melatonin (over the counter, OTC) over a 9-month period improves Alzheimer's disease (AD) biomarkers and cognitive function in two groups of individuals: those with mild cognitive impairment (MCI+) and those who are not (MCI-). AD biomarkers will be measured from …

   Stage

   Not phased

   Ages

   56 to 85

   Site

   University of Iowa Hospitals & Clinics, Iowa City, Iowa

   Run by

   Natalie Denburg

   See if you can join NCT03954899 on ClinicalTrials.gov

8. Alzheimer's Disease Treatment With Combination of 40Hz Light and Cognitive Therapy

   Electrical activity in the brain known as "gamma" brainwaves help connect and process information throughout the brain. These gamma waves are diminished in Alzheimer's disease. New research in Alzheimer's disease mouse models shows that exposure to light flickering at the rate of 40 flashes per sec…

   Stage

   Not phased

   Ages

   50 and older

   Site

   Andrey Vyshedskiy, Miami, Florida

   Run by

   Alzheimer's Light LLC

   See if you can join NCT03657745 on ClinicalTrials.gov