Cognitive Decline Clinical Trials

32 studies are recruiting for cognitive decline in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. Attenuating DEPression With Internet CBT to Slow Cognitive Decline in Older ICU Survivors(ADEPT-ICU)

   Depression affects one-third of intensive care unit (ICU) survivors and represents a potentially modifiable target to slow cognitive decline and reduce the risk of Alzheimer's disease and related dementias (ADRD). Our multi-PI team proposes a two-arm RCT called ADEPT-ICU (Attenuating DEPression wit…

   Stage

   Not phased

   Ages

   50 and older

   Site

   Eskenazi Hospital, Indianapolis, Indiana

   Locations

   2 in total

   Run by

   Indiana University

   See if you can join NCT06627894 on ClinicalTrials.gov

2. Preventing Cognitive Decline by Reducing BP Target Trial

   The PCOT study is a multi-site randomized trial of patients 70 years or older with high BP. The main goal of the study Preventing Cognitive Decline by Reducing BP Target Trial (PCOT) is to conduct a large pragmatic clinical trial (PCT) to test the hypothesis that patients who receive care with a co…

   Stage

   Not phased

   Ages

   70 and older

   Site

   UT Southwestern Medical Center, Dallas, Texas

   Run by

   University of Texas Southwestern Medical Center

   See if you can join NCT05106036 on ClinicalTrials.gov

3. Cognitive and Vascular Functioning Following TBI

   This observational study will examine the association of chronic traumatic cerebrovascular injury and cardiovascular risk factors with TBI-related cognitive impairment and vascular dementia. Cerebrovascular, inflammatory, and neurodegenerative blood biomarkers as well as clinical and neuroimaging d…

   Stage

   Not phased

   Ages

   18 to 74

   Site

   Walter Reed National Military Medical Center, Bethesda, Maryland

   Run by

   Walter Reed National Military Medical Center

   See if you can join NCT06034509 on ClinicalTrials.gov

4. A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors

   Up to 25% of intensive care unit (ICU) survivors experience cognitive impairment comparable in severity to mild Alzheimer's disease and related dementias after hospital discharge. Older ICU survivors (ages 60 and older) are at highest risk for delirium and subsequent cognitive impairment, which con…

   Stage

   Not phased

   Ages

   60 and older

   Site

   University of Washington, Seattle, Washington

   Run by

   University of Washington

   See if you can join NCT06411561 on ClinicalTrials.gov

5. Computerized Tests of Cognitive Decline in Presymptomatic Alzheimer's Disease

   The investigators will study performance on computerized cognitive tasks in healthy participants of different ages to gather normative data for newly developed computerized cognitive tests. These tests are designed to permit the early detection of individuals at risk of age-related cognitive declin…

   Stage

   Not phased

   Ages

   18 to 89

   Site

   Neurobehavioral Systems, Inc., Berkeley, California

   Run by

   Neurobehavioral Systems, Inc.

   See if you can join NCT04800588 on ClinicalTrials.gov

6. Study Evaluating the Quality and Effects of Lion's Mane Product on Cognitive Health

   The rationale for this study is to observe differences in cognitive health outcomes such as short term memory and simple reaction time between a consumer-grade and commercially available Lion's mane mushroom product and a placebo control group. Additionally, the study aims to evaluate the impact of…

   Stage

   Not phased

   Ages

   40 to 75

   Site

   People Science, Los Angeles, California

   Run by

   M2 Ingredients

   See if you can join NCT06870136 on ClinicalTrials.gov

7. Alzheimer's Disease Treatment With Combination of 40Hz Light and Cognitive Therapy

   Electrical activity in the brain known as "gamma" brainwaves help connect and process information throughout the brain. These gamma waves are diminished in Alzheimer's disease. New research in Alzheimer's disease mouse models shows that exposure to light flickering at the rate of 40 flashes per sec…

   Stage

   Not phased

   Ages

   50 and older

   Site

   Andrey Vyshedskiy, Miami, Florida

   Run by

   Alzheimer's Light LLC

   See if you can join NCT03657745 on ClinicalTrials.gov