Cognitive Decline Clinical Trials

33 studies are recruiting for cognitive decline in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

Search these by distance from you

By city

Studies now recruiting

1. Sleep and Circadian Rhythm Biomarkers of Postoperative Delirium

   The goal of this prospective cohort study is to assess potential differences in sleep biomarkers in older adult patients undergoing major orthopedic surgery. The main questions it aims to answer are: 1. To define sleep/circadian biomarkers of delirium (sleep duration, regularity, stability and timi…

   Stage

   Not phased

   Ages

   70 and older

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT06052397 on ClinicalTrials.gov

2. Enhancing Attention and Wellbeing Using Digital Therapeutics

   The goals of the proposed research are to first determine the minimal and/or optimal dose of a digital intervention required for cognitive enhancement, and then to examine the impact of several potential moderators of treatment effects (i.e., cognitive decline, AD polygenic hazard score, cardiovasc…

   Stage

   Not phased

   Ages

   60 to 99

   Site

   University of California San Francisco, San Francisco, California

   Run by

   University of California, San Francisco

   See if you can join NCT06397469 on ClinicalTrials.gov

3. Optimizing CNS DHA Delivery in Elderly Adults at Risk for Dementia

   The purpose of this placebo-controlled trial is to compare the effects of 24-weeks supplementation with LPC-DHA and TAG-DHA on cerebrospinal fluid and blood DHA levels, as well as biomarkers of central neurodegenerative and neurotrophic activity, in elderly adults experiencing early signs of cognit…

   Stage

   Not phased

   Ages

   55 to 82

   Site

   University of Cincinnati, Department of Psychiatry and Behavioral Neuroscience, Cincinnati, Ohio

   Run by

   University of Cincinnati

   See if you can join NCT06933095 on ClinicalTrials.gov

4. Cognitive Impairment in Colorectal Cancer Patients Receiving Cytotoxic Chemotherapy

   The purpose of this research study is to see how the brain changes in patients receiving chemotherapy (cytotoxic drug) treatment for colon or rectal cancer at Parkview Cancer Institute. This information will be used to identify helpful tests to diagnose individuals at risk for developing difficulti…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Parkview Cancer Institute, Fort Wayne, Indiana

   Run by

   Joseph McCollom

   See if you can join NCT05014399 on ClinicalTrials.gov

5. The Effects of Successful OSA Treatment on Memory and AD Biomarkers in Older Adults Study

   The Effects of Successful OSA TreatmENT on Memory and AD BIomarkers in Older AduLts (ESSENTIAL) study is a 5-year, multicenter randomized open-label trial that will screen 400 cognitively normal older adults recruited from well-established sleep clinics at 4 academic medical centers, with newly dia…

   Stage

   Not phased

   Ages

   55 to 85

   Site

   University of Arizona, Tucson, Arizona

   Locations

   4 in total

   Run by

   California Pacific Medical Center Research Institute

   See if you can join NCT05988385 on ClinicalTrials.gov

6. MIND Foods and Aerobic Training in Black Adults With HTN

   The goal of this randomized controlled trial is to determine the impact of Mediterranean-Dash Intervention for Neurodegenerative Delay (MIND) diet and aerobic training on cognition in Black adults with high systolic blood pressure. Researchers will compare Food Delivery and Cooking PLUS Aerobic Tra…

   Stage

   Not phased

   Ages

   35 to 75

   Site

   Eskenazi Health, Indianapolis, Indiana

   Run by

   Indiana University

   See if you can join NCT06152614 on ClinicalTrials.gov

7. Effects of Accelerated rTMS on Cognitive Function

   Cognitive impairment, including mild cognitive impairment (MCI) and mild dementia, is a growing public health challenge with limited effective treatment options. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technique that has shown promise for improving cogn…

   Stage

   Not phased

   Ages

   50 to 90

   Site

   San Francisco Neurology and Sleep Center, San Francisco, California

   Run by

   San Francisco Neurology and Sleep Center

   See if you can join NCT07547319 on ClinicalTrials.gov

8. A Mechanistic Study to Investigate tDCS and Working Memory in MCI Patients

   The current study is a mechanistic study to evaluate working memory gains from application of transcranial direct current stimulation (tDCS) in older adults with mild cognitive impairments (MCI) compared to cognitively healthy control

   Stage

   Not phased

   Ages

   60 to 95

   Site

   University of Florida, Gainesville, Florida

   Run by

   University of Florida

   See if you can join NCT05998031 on ClinicalTrials.gov

9. Evaluating Health Outcomes of AI-Based Fitness Wearables and App Programs in Older Adults Living Alone With Cognitive Decline

   The overarching goal of our research is to develop personalized and accessible healthy aging lifestyle interventions aimed at promoting physical activity (PA) and improving health among community-dwelling older adults living alone with cognitive decline (LACD). To achieve this goal, the purpose of …

   Stage

   Not phased

   Ages

   65 and older

   Site

   The University of Tennessee, Knoxville. Health, Recreation, and Physical Education Building, Knoxville, Tennessee

   Locations

   2 in total

   Run by

   The University of Tennessee, Knoxville

   See if you can join NCT07207993 on ClinicalTrials.gov

10. Polyphenols and Cognitive Decline

    Globally, populations are aging thereby increasing healthcare burden, overall cognitive impairment, and dementia including Alzheimers diseases (AD). The lack of effective treatments makes it essential to develop new strategies for healthy cognitive aging, including interventions to slow or prevent …

    Stage

    Not phased

    Ages

    50 and older

    Site

    University of California, Los Angeles, Los Angeles, California

    Run by

    University of California, Los Angeles

    See if you can join NCT06507254 on ClinicalTrials.gov

11. Exercise Adherence and Cognitive Decline: Phase 2

    The purpose of this study is to conduct a test of a goals-based program to help people exercise more. This program was designed for individuals aged 45-65 from the Black community. Low levels of physical activity are related to health problems such as heart disease, diabetes, and cognitive decline.…

    Stage

    Not phased

    Ages

    45 to 65

    Site

    Recreation Centers in the Denver Metro Area, Aurora, Colorado

    Locations

    2 in total

    Run by

    University of Colorado, Boulder

    See if you can join NCT07127965 on ClinicalTrials.gov

12. Cognitive Status After Removal of Skull Base Meningioma

    The purpose of this prospectively enrolling trial is to assess long-term cognitive outcomes of patients undergoing surgery for resection of a meningioma associated with the frontal and temporal lobes.

    Stage

    Not phased

    Ages

    18 to 89

    Site

    Ohio State University Wexner Medical Center, Columbus, Ohio

    Run by

    Ohio State University

    See if you can join NCT04635657 on ClinicalTrials.gov

13. Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer

    This randomized, placebo-controlled trial aims to assess the feasibility, acceptability, and preliminary efficacy of memantine and the University of Carolina (UNC)'s Get Real \& Heel cancer exercise program (MEM+EX) in addressing cancer-related cognitive impairment (CRCI) and underlying CRCI biomar…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Lineberger Comprehensive Cancer Center at University of North Carolina, Chapel Hill, Chapel Hill, North Carolina

    Run by

    UNC Lineberger Comprehensive Cancer Center

    See if you can join NCT06727773 on ClinicalTrials.gov

14. δ in Dementia Clinical Trials

    The goal of this clinical trial is to demonstrate potential improvements in clinical trial methods relating to dementia and cognitive decline. The main questions it aims to answer are: * Can an intervention's outcome be better assessed by a latent variable ("δ") integrating cognitive performance wi…

    Stage

    Not phased

    Ages

    65 to 100

    Site

    Univeristy of Texas Health Science Center at San Antonio (UTHSCSA), San Antonio, Texas

    Run by

    The University of Texas Health Science Center at San Antonio

    See if you can join NCT05592678 on ClinicalTrials.gov

15. A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses

    The goal of this clinical trial is to test 6 months of aerobic exercise in older adults who are 65 years or older and have mild cognitive impairment (MCI) or probable/possible mild Alzheimer's Disease. The main questions it aims to answer are: * test the effects of aerobic exercise on aerobic fitne…

    Stage

    Not phased

    Ages

    65 and older

    Site

    Arizona State University, Phoenix, Arizona

    Run by

    Arizona State University

    See if you can join NCT05877196 on ClinicalTrials.gov

16. MindWalk Intervention for Older South Asian Caregivers of People With Cognitive Disabilities (CD)

    Older South Asian family caregivers experience elevated psychological stress and limited physical activity (PA) due to caregiving responsibilities and additional factors such as lack of access to services, cultural/linguistic barriers, stigma and discrimination. South Asian family caregivers are es…

    Stage

    Not phased

    Ages

    45 and older

    Site

    American Association of Retired Asians, Bolingbrook, Illinois

    Locations

    8 in total

    Run by

    University of Illinois at Chicago

    See if you can join NCT06002919 on ClinicalTrials.gov

17. Essential Fats For Enhancing Cognitive Thinking (EFFECT) Study

    The proposed research is a randomized crossover trial designed to assess changes in postprandial cognitive function and the gut-brain axis in adults with subjective cognitive complaints who consume 1 study snack per day for 1 week.

    Stage

    Not phased

    Ages

    40 to 75

    Site

    The Ohio State University, Columbus, Ohio

    Run by

    Ohio State University

    See if you can join NCT06223672 on ClinicalTrials.gov

18. mPATH for Low-income Older Adults

    Although empirical research suggests that physical activity interventions benefit cognition and sleep in older adults in general, the possible benefit of physical activity is understudied in low-income older adults. The study aims to test the immediate and sustaining efficacy of an mHealth-facilita…

    Stage

    Not phased

    Ages

    65 and older

    Site

    The Johns Hopkins University, School of Nursing, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT05935241 on ClinicalTrials.gov

19. TMS for Cognitive Decline in Aging and Preclinical AD

    In this research study we want to learn more about the effects of non-invasive brain stimulation on motivation, memory, and brain-network function in cognitively unimpaired older adults and individuals with preclinical Alzheimer's disease. This study will use a form of non-invasive brain stimulatio…

    Stage

    Not phased

    Ages

    40 to 99

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT06956300 on ClinicalTrials.gov

20. Cognitive Screening Made Easy for PCPs - Administrative Supplement

    This project will facilitate early detection of cognitive decline in older adults through development and implementation of an automated risk assessment and cognitive screening tool for use in primary care. By providing an automated tool developed specifically to address the needs of PCPs, it will …

    Stage

    Not phased

    Ages

    60 and older

    Site

    Family Wellness Clinic, Austin, Texas

    Locations

    3 in total

    Run by

    University of Texas at Austin

    See if you can join NCT06928298 on ClinicalTrials.gov

21. Effects of Sabroxy® Supplementation on Insulin Resistance and Cognitive Function in Adults With Mild Cognitive Impairment and Insulin Resistance

    This randomized, double-blind, placebo-controlled, 8-week clinical trial is designed to evaluate the effects of Sabroxy®, a standardized extract of Oroxylum indicum bark, on insulin resistance and cognitive function in adults with mild cognitive impairment and insulin resistance. A total of 120 par…

    Stage

    Not phased

    Ages

    40 to 80

    Site

    San Francisco Research Institute, San Francisco, California

    Run by

    SF Research Institute, Inc.

    See if you can join NCT07220694 on ClinicalTrials.gov

22. Biomarker Exploration in Aging, Cognition and Neurodegeneration

    The purpose of this research study is to understand the factors that underlie changes in thinking and memory with increasing age. The investigators will test the usefulness of MRI, PET, and cognitive testing in detecting subtle changes in the brain that precede cognitive decline. An addendum to thi…

    Stage

    Phase 3

    Ages

    60 and older

    Site

    University of California, Irvine, Irvine, California

    Run by

    University of California, Irvine

    See if you can join NCT03860857 on ClinicalTrials.gov

23. Brain Health in Youth With Normal Weight, Overweight and Obesity at Risk for Type 2 Diabetes (T2D)

    Investigators propose to study youth across the spectrum of body mass index (BMI) and dysglycemia. This approach will allow investigators to disentangle the relationship of key features of type 2 diabetes (T2D) risk (e.g. obesity) with intermediary physiologic changes (e.g. insulin resistance, infl…

    Stage

    Not phased

    Ages

    12 to 17

    Site

    Washington University School of Medicine, St Louis, Missouri

    Locations

    2 in total

    Run by

    Washington University School of Medicine

    See if you can join NCT05277558 on ClinicalTrials.gov

24. Attenuating DEPression With Internet CBT to Slow Cognitive Decline in Older ICU Survivors(ADEPT-ICU)

    Depression affects one-third of intensive care unit (ICU) survivors and represents a potentially modifiable target to slow cognitive decline and reduce the risk of Alzheimer's disease and related dementias (ADRD). Our multi-PI team proposes a two-arm RCT called ADEPT-ICU (Attenuating DEPression wit…

    Stage

    Not phased

    Ages

    50 and older

    Site

    Eskenazi Hospital, Indianapolis, Indiana

    Locations

    2 in total

    Run by

    Indiana University

    See if you can join NCT06627894 on ClinicalTrials.gov

25. Preventing Cognitive Decline by Reducing BP Target Trial

    The PCOT study is a multi-site randomized trial of patients 70 years or older with high BP. The main goal of the study Preventing Cognitive Decline by Reducing BP Target Trial (PCOT) is to conduct a large pragmatic clinical trial (PCT) to test the hypothesis that patients who receive care with a co…

    Stage

    Not phased

    Ages

    70 and older

    Site

    UT Southwestern Medical Center, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT05106036 on ClinicalTrials.gov