Chronic Obstructive Pulmonary Disease Clinical Trials

23 studies are recruiting for chronic obstructive pulmonary disease in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Birmingham, Alabama 4 Boston, Massachusetts 4 Philadelphia, Pennsylvania 4 Pittsburgh, Pennsylvania 4 Kansas City, Kansas 3 Miami, Florida 3 New York, New York 3 Omaha, Nebraska 3 Winston-Salem, North Carolina 3

Studies now recruiting

  1. Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD) Characterized by an Eosinophilic Phenotype

    This is a parallel, Phase 2b/Phase 3, 3-arm study to investigate the efficacy, safety, and tolerability of subcutaneous (SC) treatment with lunsekimig compared with placebo in adult participants (aged 40 to 80 years, inclusive) with inadequately controlled Chronic obstructive pulmonary disease (COP…

    Stage
    Phase 3
    Ages
    40 to 80
    Site
    Chandler Clinical Research Trials- Site Number : 8400025, Chandler, Arizona
    Locations
    221 in total
    Run by
    Sanofi

    See if you can join NCT07190209 on ClinicalTrials.gov

  2. Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD), Characterized by an Eosinophilic Phenotype

    This is a parallel, Phase 2b/Phase 3, 3-arm study to investigate the efficacy, safety, and tolerability of subcutaneous (SC) treatment with lunsekimig compared with placebo in adult participants (aged 40 to 80 years, inclusive) with inadequately controlled Chronic obstructive pulmonary disease (COP…

    Stage
    Phase 3
    Ages
    40 to 80
    Site
    University of Alabama at Birmingham- Site Number : 8400003, Birmingham, Alabama
    Locations
    214 in total
    Run by
    Sanofi

    See if you can join NCT07190222 on ClinicalTrials.gov

  3. A Study to Test the Safety and Effects of Inhaled GDC-6988 in Participants With Muco-obstructive Disease

    This study evaluates the safety, tolerability, and activity of inhaled GDC-6988 in participants with muco-obstructive disease.

    Stage
    Phase 1
    Ages
    18 and older
    Site
    University of Alabama at Birmingham, Birmingham, Alabama
    Locations
    7 in total
    Run by
    Genentech, Inc.

    See if you can join NCT06603246 on ClinicalTrials.gov

  4. Functional Improvement in OSA and COPD With a Telehealth LifeStyle and Exercise Intervention

    The investigators will conduct a Type I hybrid effectiveness-implementation study to test an integrated telehealth intervention among 400 overweight and obese patients with Chronic Obstructive Pulmonary Disease (COPD) and Obstructive Sleep Apnea (OSA). The investigators will include eligible partic…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Boise VA Medical Center, Boise, Idaho
    Locations
    5 in total
    Run by
    Seattle Institute for Biomedical and Clinical Research

    See if you can join NCT06390345 on ClinicalTrials.gov

  5. A Study of BBT002 in Healthy Volunteers (HVs) and in Adult Patients With Chronic Obstructive Pulmonary Disease (COPD) or Chronic Rhiosininusitis With Nasal Polyps (CRSwNP)

    Randomized study of single and multiple doses of BBT002 in healthy volunteers and in adult patients with chronic obstructive pulmonary disease (COPD) or chronic rhinosinusitis with nasal polyps (CRSwNP).

    Stage
    Phase 1
    Ages
    18 to 80
    Site
    Equity Medical Bowling Green, Bowling Green, Kentucky
    Locations
    14 in total
    Run by
    Bambusa Therapeutics

    See if you can join NCT06944925 on ClinicalTrials.gov

  6. A Study to Investigate Airway Inflammation With Dupilumab Subcutaneously in Participants Aged ≥40 to ≤85 Years With Chronic Obstructive Pulmonary Disease.

    LPS18583 is a multinational, randomized, double-blind, placebo-controlled, parallel-group, Phase 4 study with 2 treatment groups. The purpose of this study is to assess the effect of dupilumab compared with placebo on airway inflammation, resistance, and remodeling including mucus plugging and its …

    Stage
    Phase 4
    Ages
    40 to 85
    Site
    University of Alabama at Birmingham - School of Medicine- Site Number : 8400003, Birmingham, Alabama
    Locations
    68 in total
    Run by
    Sanofi

    See if you can join NCT07053423 on ClinicalTrials.gov

  7. Improving Participation in Pulmonary Rehabilitation Through Peer Support and Storytelling

    Chronic Obstructive Pulmonary Disease (COPD) affects approximately 16 million Americans and is characterized by recurrent exacerbations that lead to 1.5 million Emergency Department visits and 700,000 hospitalizations annually. Pulmonary rehabilitation (PR) is a structured program of exercise and s…

    Stage
    Not phased
    Ages
    40 and older
    Site
    Baystate Health, Springfield, Massachusetts
    Run by
    Baystate Medical Center

    See if you can join NCT05399056 on ClinicalTrials.gov

  8. The Cardiovascular Consequences of Sleep Apnea Plus COPD (Overlap Syndrome)

    Major progress has been made in the area of cardiovascular disease, but we believe that further progress will involve mechanistically addressing underlying respiratory causes including chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA). The most common cause of death in …

    Stage
    Phase 2
    Ages
    40 to 79
    Site
    UCSD Sleep Research, La Jolla, California
    Run by
    University of California, San Diego

    See if you can join NCT05237505 on ClinicalTrials.gov

  9. Breathe Easier With Tadalafil Therapy for Dyspnea in COPD-PH

    The investigators will study whether the drug tadalafil improves shortness of breath in 126 Veterans with Chronic Obstructive Pulmonary Disease (COPD) and high blood pressure in the lungs. The investigators will also assess whether tadalafil improves quality of life, home daily physical activity, e…

    Stage
    Phase 2
    Ages
    35 to 89
    Site
    Rocky Mountain Regional VA Medical Center, Aurora, CO, Aurora, Colorado
    Locations
    5 in total
    Run by
    VA Office of Research and Development

    See if you can join NCT05937854 on ClinicalTrials.gov

  10. Evaluating the Safety and Efficacy of dNerva Lung Denervation System in Patients With COPD

    The dNerva Lung Denervation System is one-time treatment intended to improve breathing in Chronic Obstructive Pulmonary Disease (COPD) patients on standard medical care. The purpose of this study is to confirm the safety and efficacy of the Nuvaira Lung Denervation System in the treatment of COPD.

    Stage
    Not phased
    Ages
    40 to 80
    Site
    University of Alabama-Birmingham Hospital - UAB Lung Health Center, Birmingham, Alabama
    Locations
    10 in total
    Run by
    Nuvaira, Inc.

    See if you can join NCT07051707 on ClinicalTrials.gov

  11. Feasibility of Semaglutide in Advanced Lung Disease

    The goal of this clinical trial is to learn whether semaglutide, an FDA-approved treatment for diabetes and obesity, is feasible and tolerable in patients with advanced lung disease. The main question[s] it aims to answer are: 1. Are patients with advanced lung disease able to tolerate semaglutide …

    Stage
    Phase 1
    Ages
    18 to 80
    Site
    University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
    Run by
    University of Pennsylvania

    See if you can join NCT05746039 on ClinicalTrials.gov

  12. Inclined Versus Standard Exercise for COPD Patients

    This study is designed to provide information regarding how to improve pulmonary rehabilitation for persons with chronic obstructive pulmonary disease (COPD). Pulmonary rehabilitation is an exercise program for COPD patients that is recommended and benefits some, but not all, patients. The question…

    Stage
    Not phased
    Ages
    45 to 80
    Site
    Omaha VA Nebraska-Western Iowa Health Care System, Omaha, NE, Omaha, Nebraska
    Run by
    VA Office of Research and Development

    See if you can join NCT06749262 on ClinicalTrials.gov

  13. Accelerated Pulmonary Rehabilitation in the Preoperative Period

    This proposed project will be a single arm, non-masked study. Participants who are actively smoking with a diagnosis of a new lung nodule, either confirmed or suspicious for lung cancer, with a plan for lung cancer treatment with or without surgical resection will be recruited from the University o…

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of Vermont Medical Center, Burlington, Vermont
    Run by
    University of Vermont

    See if you can join NCT06432972 on ClinicalTrials.gov

  14. The Increase of Lung Capacity Using the Lung Master (Pulmonary Exerciser)

    Investigators are studying how a device called The Lung Master device can help people breathe better. The investigational device increases the amount of air our lungs can hold, which is important for overall lung health. The Lung Master is not approved by the FDA. The study has two visits approxima…

    Stage
    Not phased
    Ages
    19 and older
    Site
    Biomechanics Research Building, Omaha, Nebraska
    Run by
    University of Nebraska

    See if you can join NCT06524856 on ClinicalTrials.gov

  15. Leveraging Lung Cancer Screening to Optimize Screening Outcomes and COPD Management: COPD in LCS Registry

    The COPD in LCS Registry will identify and characterize individuals who have functional or radiographic evidence of COPD and are receiving lung cancer screening. Clinical information will be obtained from study participants including symptom burden, lung cancer risk, spirometry, imaging characteris…

    Stage
    Not phased
    Ages
    50 to 80
    Site
    Thomas Jefferson University, Philadelphia, Pennsylvania
    Run by
    Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University

    See if you can join NCT06974981 on ClinicalTrials.gov

  16. Fitness and Lung Function Among Survivors of Heart Transplant, Leukemia and Infant BPD Through Exercise

    This study aims to more accurately assess cardiac function, ventilation and exercise capacity in a non-invasive fashion, and to better characterize exercise intolerance in the setting of three populations of individuals with chronic diseases of childhood (acute lymphoblastic leukemia (ALL), chronic…

    Stage
    Not phased
    Ages
    8 to 25
    Site
    Masonic Cancer Center, Minneapolis, Minnesota
    Run by
    Masonic Cancer Center, University of Minnesota

    See if you can join NCT05025774 on ClinicalTrials.gov

  17. Boston Early-Onset Chronic Obstructive Pulmonary Disease (COPD) Study

    Chronic obstructive pulmonary disease (COPD) is often caused by cigarette smoking, but genetic predisposition also influences COPD susceptibility. The purpose of this study is to identify genetic factors that predispose some individuals to develop COPD.

    Stage
    Not phased
    Ages
    Any age
    Site
    Brigham and Women's Hospital, Boston, Massachusetts
    Run by
    Brigham and Women's Hospital

    See if you can join NCT01177618 on ClinicalTrials.gov

  18. Comprehensive Patient-Centered Home-based Care Coaching for COPD Self-management

    The Icahn School of Medicine at Mount Sinai will conduct a randomized controlled trial of a self-management support intervention for predominantly minoritized and low-income adults with chronic obstructive pulmonary disease (COPD). The trial will focus on comprehensive screening and targeted manage…

    Stage
    Not phased
    Ages
    40 and older
    Site
    Ichan School of Medicine at Mount Sinai, New York, New York
    Run by
    Icahn School of Medicine at Mount Sinai

    See if you can join NCT06634810 on ClinicalTrials.gov

  19. : Vascular Function in Health and Disease

    Many control mechanisms exist which successfully match the supply of blood with the metabolic demand of various tissues under wide-ranging conditions. One primary regulator of vasomotion and thus perfusion to the muscle tissue is the host of chemical factors originating from the vascular endotheliu…

    Stage
    Phase 1
    Ages
    18 and older
    Site
    George E Wahlen VA Medical Center, Salt Lake City, Utah
    Run by
    Russell Richardson

    See if you can join NCT02966665 on ClinicalTrials.gov

  20. Emphysema Research Registry and Biosample Repository

    The Comprehensive Lung Center (CLC) at the University of Pittsburgh Medical Center (UPMC Health System) provides patients with any type of breathing or lung disorder a full range of diagnostic and therapeutic services. The Emphysema/COPD Research Center (ECRC) is a specialty clinic, within this cen…

    Stage
    Not phased
    Ages
    21 and older
    Site
    University of Pittsburgh Emphysema/COPD Research Center, Pittsburgh, Pennsylvania
    Run by
    University of Pittsburgh

    See if you can join NCT00307281 on ClinicalTrials.gov

  21. Mindful Steps 2.0: Promoting Physical Activity in Patients With COPD and HF

    The goal of this fully-remote randomized controlled trial is to test the efficacy of Mindful Steps in facilitating physical activity compared to usual standard of care among 136 patients with COPD and/or HF. The main question it aims to answer is can this intervention promote physical activity as m…

    Stage
    Not phased
    Ages
    40 and older
    Site
    VA Boston, Boston, Massachusetts
    Locations
    2 in total
    Run by
    Beth Israel Deaconess Medical Center

    See if you can join NCT05934565 on ClinicalTrials.gov

  22. PRagmatic EVAluation of a Quality Improvement Program for People Living With Modifiable High-risk COPD.

    A 3-year cluster randomized controlled trial of the impact of a quality improvement and clinical decision support package versus usual care for patients with modifiable high-risk chronic obstructive pulmonary disease with or without a current diagnosis.

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of Colorado, Denver, Colorado
    Locations
    3 in total
    Run by
    Observational and Pragmatic Research Institute

    See if you can join NCT05306743 on ClinicalTrials.gov

  23. Hyper Polarized Xenon-129 MRI vs Xenon-133 Scintigraphy

    Hyper polarized Xenon-129 MRI will be directly compared to a radioactive Xe-133 scintigraphy to detect defects in lung ventilation from airflow limitation. This study is conducted as a pilot study with intention to conduct a larger clinical trial.

    Stage
    Phase 1
    Ages
    18 and older
    Site
    University of Virginia Health System, Charlottesville, Virginia
    Run by
    University of Virginia

    See if you can join NCT03331302 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.