Cervical Cancer Clinical Trials

75 studies are recruiting for cervical cancer in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. GCCC 2578 Randomized Photon vs Proton RT for Newly Diagnosed Gynecologic Primaries

   The purpose of study is to compare the side effects of two different forms of radiation for endometrial and cervical cancer. If you decide to enroll in this study, you will be randomized to one of two treatment groups. This study will compare two standard of care treatments: "Conventional" pHoton r…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Maryland Proton Treatment Center, Baltimore, Maryland

   Locations

   5 in total

   Run by

   University of Maryland, Baltimore

   See if you can join NCT07415681 on ClinicalTrials.gov

2. Distance-Based Exercise to Preserve Function and Prevent Disability

   This clinical trial studies whether an exercise program can be successfully delivered to patients receiving treatment for cancer through virtual sessions and allow patients to exercise in their own home. Treatments for cancer can cause side effects such as fatigue and loss of strength. These side e…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Kaiser Permanente Dublin, Dublin, California

   Locations

   18 in total

   Run by

   Alliance for Clinical Trials in Oncology

   See if you can join NCT07059884 on ClinicalTrials.gov

3. A Trial of Robotic Versus Open Hysterectomy Surgery in Cervix Cancer

   This is a randomized controlled trial to compare survival for patients who undergoe robotic assisted laparoscopy versus open hysterectomy and lymph node assessment for the treatment of early stage cervical cancer.

   Stage

   Not phased

   Ages

   18 and older

   Site

   City of Hope, Duarte, California

   Locations

   156 in total

   Run by

   GOG Foundation

   See if you can join NCT04831580 on ClinicalTrials.gov

4. A Study of Sacituzumab Govitecan (IMMU-132) in Patients With Recurrent or Persistent Cervical Cancer

   This is a non-randomized Phase 2 study of sacituzumab govitecan (IMMU-132) in subjects with recurrent or persistent cervical cancer.

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Smilow Cancer Hospital at Yale New Haven, New Haven, Connecticut

   Locations

   2 in total

   Run by

   Yale University

   See if you can join NCT05838521 on ClinicalTrials.gov

5. Feasibility of HPV Self-Collection Kits for Cervical Cancer Screening

   This study is testing and implementing an equity-focused, community-based intervention that improves women's access to cervical cancer screening and adherence to follow up after an abnormal result. The study's objective is to assess and compare the feasibility of different methods of distributing a…

   Stage

   Not phased

   Ages

   25 and older

   Site

   Washington University School of Medicine, St Louis, Missouri

   Run by

   Washington University School of Medicine

   See if you can join NCT07453459 on ClinicalTrials.gov

6. Strategies to Close the Gap From Cervical Cancer Diagnosis to Treatment in Botswana

   Investigators will test the effectiveness of adaptive strategies on timely adoption of cervical cancer treatment in Botswana using a pragmatic trial design.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Nyangabgwe Referral Hospital, Francistown, North-East District

   Locations

   3 in total

   Run by

   Abramson Cancer Center at Penn Medicine

   See if you can join NCT05952141 on ClinicalTrials.gov

7. Study of RGT-490 in Patients With PIK3CA-Mutated Advanced Solid Tumors

   This is a phase 1/1b, open-label, multicenter study consisting of sequential parts designed to evaluate the safety, tolerability, and effects pharmacokinetic (PK) profile, and antitumor activity of RGT-490, an investigational oral therapy, in adults with locally advanced or metastatic solid tumors …

   Stage

   Phase 1

   Ages

   18 and older

   Site

   START Los Angeles, Los Angeles, California

   Locations

   5 in total

   Run by

   Regor Pharmaceuticals Inc.

   See if you can join NCT07524322 on ClinicalTrials.gov

8. Radiation Combined With BIspecific T-Cell Engager in DLL3 Expressing Tumors

   Phase I study to examine safety of the addition of concurrent tarlatamab with standard palliative and consolidative RT regimens , with a main cohort of N=20-24 patients with extracranial anatomic radiation sites. I) After lead in of 10 patients demonstrating safety of treatment, allow for expansion…

   Stage

   Phase 1

   Ages

   18 to 99

   Site

   Arizona Cancer Center at UMC North/University Medical Center, Tucson, Arizona

   Locations

   2 in total

   Run by

   University of Arizona

   See if you can join NCT06814496 on ClinicalTrials.gov

9. Trial of Single Protein Encapsulated Doxorubicin, SPEDOX-6 in Advanced Malignancies

   This is a Phase 1b/IIa dose escalation clinical trial determining the recommended phase II dose of SPEDOX-6 in subjects with advanced, therapy-refractory soft-tissue sarcoma (STS); triple-negative breast cancer (TNBC); Non-small cell lung cancer (NSCLC); cervical cancer; ovarian cancer; KRAS mutant…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Chao Family Comprehensive Cancer Center University of California, Irvine, Orange, California

   Run by

   University of California, Irvine

   See if you can join NCT07064018 on ClinicalTrials.gov

10. Navigation Intervention for Adolescent and Young Adult Cancer Survivors

    The investigators propose to: 1) Adapt an evidence-based cancer-focused patient navigation (PN) program for the Adolescent and Young Adult (AYA) cancer survivor population; and 2) Plan and conduct an effectiveness-implementation trial of this program within Kaiser Permanente Southern California (KP…

    Stage

    Not phased

    Ages

    21 to 45

    Site

    KP Southern California - Department of Research & Evaluation, Pasadena, California

    Run by

    Kaiser Permanente

    See if you can join NCT07406087 on ClinicalTrials.gov

11. A Clinical Trial to Assess PVX7 Immunotherapy Regimens in Advanced Cervical Cancer Patients

    A Feasibility Trial of PVX7 vaccine in advanced cervical cancer patients who have completed primary definitive therapy.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    The University of Alabama at Birmingham, Birmingham, Alabama

    Locations

    2 in total

    Run by

    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

    See if you can join NCT06315257 on ClinicalTrials.gov

12. E7 T-cell Receptor (TCR) -T Cell Induction Therapy for Locoregionally Advanced HPV-associated Cancers

    The goal of this study is to determine the feasibility of administration of a single dose of E7 TCR-T cells as induction therapy prior to definitive treatment (chemoradiation or surgery) of locoregionally advanced HPV-associated cancers. The intent of E7 TCR-T cell treatment is to shrink or elimina…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Rutgers Cancer Institute, New Brunswick, New Jersey

    Locations

    2 in total

    Run by

    Christian Hinrichs

    See if you can join NCT05639972 on ClinicalTrials.gov

13. E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers

    This is a phase II clinical trial to assess the clinical activity of immunotherapy with E7 TCR-T cells for metastatic HPV-associated cancers. HPV-associated cancers in include cervical, throat, penile, vulvar, vaginal, anal, and other cancers. Participants will receive a conditioning regimen, E7 TC…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Locations

    3 in total

    Run by

    Christian Hinrichs

    See if you can join NCT05686226 on ClinicalTrials.gov

14. Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors

    A Phase 1 Open-Label, First-in-human, Dose Escalation and Expansion Study to Determine the Safety, Tolerability, Dosimetry, Pharmacokinetics, and Preliminary Efficacy of 212Pb-DOTAM-GRPR1 in Adult Participants with Recurrent or Metastatic GRPR-expressing Tumors

    Stage

    Phase 1

    Ages

    18 and older

    Site

    UK Markey Cancer Center, Lexington, Kentucky

    Locations

    8 in total

    Run by

    Orano Med Theranostics, SAS

    See if you can join NCT05283330 on ClinicalTrials.gov

15. Novel, One Stop, Affordable, Point of Care and AI Supported System of Screening, Triage and Treatment Selection for Cervical Cancer in LMICs

    Artificial intelligence (AI) is fast gaining reputation as a highly promising solution for cervical cancer screening. AI-based detection of cervical neoplasias is named automated visual exam (AVE) by the National Cancer Institute, USA. The investigators propose to develop and evaluate the performan…

    Stage

    Not phased

    Ages

    25 to 49

    Site

    University of Cincinnati, Cincinnati, Ohio

    Locations

    2 in total

    Run by

    International Agency for Research on Cancer

    See if you can join NCT06042543 on ClinicalTrials.gov

16. Physical Activity Intervention Among Older Women With Gynecologic Cancers (Fit4Treatment)

    The primary purpose of the study is to determine which of four components (symptom-burden tailored app, exercise partner, oncology provider engagement, coaching) added to a core intervention of a wearable activity tracker and commercially available app, will improve physical activity. The findings …

    Stage

    Not phased

    Ages

    60 and older

    Site

    Northwestern University, Chicago, Illinois

    Run by

    Northwestern University

    See if you can join NCT05743517 on ClinicalTrials.gov

17. Blood and Urine HPVDNA as Minimally Invasive Biomarkers for Cervical Cancer Detection and Surveillance Following Treatment

    The purpose of this study is to determine if ctHPVDNA (circulating tumor HPV DNA) can be used as a non-invasive biomarker for identification and treatment monitoring of cervical cancer by characterizing correlation between plasma ctHPVDNA, urine transrenal HPVDNA (TrHPVDNA) levels and presence of c…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Melissa Knutsen, Chapel Hill, North Carolina

    Locations

    2 in total

    Run by

    UNC Lineberger Comprehensive Cancer Center

    See if you can join NCT04743674 on ClinicalTrials.gov

18. Using Reiki Therapy to Improve Symptoms Associated With Brachytherapy in Patients With Gynecological Malignancies

    The goal of this open label, randomized, controlled clinical trial is to assess the benefits of providing Reiki therapy to subjects receiving their first brachytherapy treatment for gynecological malignancies. Participants will either receive a session of Reiki therapy or usual care during the stan…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Huntsman Cancer Institute, Salt Lake City, Utah

    Run by

    University of Utah

    See if you can join NCT05979610 on ClinicalTrials.gov

19. Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors

    This study is designed to characterize the safety, tolerability, and anti-tumor activity of MDX2001 in patients with advanced solid tumors.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Sarah Cannon Research Institute, Denver, Colorado

    Locations

    6 in total

    Run by

    ModeX Therapeutics, An OPKO Health Company

    See if you can join NCT06239194 on ClinicalTrials.gov

20. Study of Pembrolizumab and Lenvatinib in Metastatic and Recurrent Cervix Cancer (LenPem Cervix)

    The main purpose of this study is to gather information about an investigational drug combination, Lenvatinib in combination with pembrolizumab, that may help to treat cervical cancers. In this study, we are looking to see whether the combination of lenvatinib and pembrolizumab has any effect on sl…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    UT Southwestern Medical Center, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT06266338 on ClinicalTrials.gov

21. PRGN-2009 in Combination With Pembrolizumab in Patients With Recurrent or Metastatic Cervical Cancer

    This Phase 2 study will evaluate the efficacy and safety of PRGN-2009 in combination with pembrolizumab in patients with pembrolizumab-resistant recurrent or metastatic cervical cancer.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of Arkansas for Medical Sciences, Little Rock, Arkansas

    Locations

    3 in total

    Run by

    Precigen, Inc

    See if you can join NCT06157151 on ClinicalTrials.gov

22. Early Pelvic Floor Physical Therapy for Women Undergoing Pelvic Radiation for Gynecologic Malignancies

    This is a single arm phase II study in which 28 patients who will be undergoing definitive pelvic external beam radiation therapy for cervical cancer will receive pelvic floor physical therapy 4 weeks after completing radiation therapy.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Cincinnati, Cincinnati, Ohio

    Run by

    University of Cincinnati

    See if you can join NCT07447895 on ClinicalTrials.gov

23. Leveraging Methylated DNA Markers (MDMs) in the Detection of Endometrial Cancer, Ovarian Cancer, and Cervical Cancer

    The overarching objective of this project is to develop a pan-gynecologic cancer detection test using gynecologic (unique endometrial, cervical, and ovarian cancer) cancer-specific methylated DNA markers and high-risk human papilloma virus (HR-HPV) detected in vaginal fluid and/or plasma. This prop…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mayo Clinic, Phoenix, Arizona

    Locations

    24 in total

    Run by

    Mayo Clinic

    See if you can join NCT05051722 on ClinicalTrials.gov

24. Patient Preference for Subcutaneous vs. Intravenous Immune Therapy

    The study will evaluate patient and Health Care Professional- reported preference for Subcutaneous (SC) compared with IV nivolumab administration or similarly for SC compared with IV pembrolizumab.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania

    Run by

    Diwakar Davar

    See if you can join NCT07223424 on ClinicalTrials.gov

25. A Study of VET3-TGI in Patients With Solid Tumors

    VET3-TGI is an oncolytic immunotherapy designed to treat advanced cancers. VET3-TGI has not been given to human patients yet, and the current study is designed to find a safe and effective dose of VET3-TGI when administered by direct injection into tumor(s) (called an intratumoral injection) or whe…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    USC/Norris Comprehensive Cancer Center, Los Angeles, California

    Locations

    7 in total

    Run by

    KaliVir Immunotherapeutics

    See if you can join NCT06444815 on ClinicalTrials.gov