Brain Tumor Clinical Trials

40 studies are recruiting for brain tumor in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. Brodalumab in the Treatment of Immune-Related Adverse Events

   The purpose of this study is to test the safety and effectiveness of using brodalumab in patients who develop side effects from cancer immune therapy. Immune-related side effects are due to activation of the immune system in patients who previously received immunotherapy and the goal of this study …

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Columbia University Irving Medical Center, New York, New York

   Run by

   Brian Henick, MD

   See if you can join NCT06673329 on ClinicalTrials.gov

2. A Study to Measure the Effect of Brain Stimulation on Hand Strength and Function in Patients With Brain Tumors

   The neurosurgical standard of care for treating a patient with a tumor invading hand primary motor cortex (M1) includes performing a craniotomy with intraoperative direct electrical stimulation (DES) mapping and to resect as much tumor as possible without a resultant permanent neurological deficit.…

   Stage

   Not phased

   Ages

   18 to 75

   Site

   Medical College of Wisconsin, Milwaukee, Wisconsin

   Run by

   Medical College of Wisconsin

   See if you can join NCT05023434 on ClinicalTrials.gov

3. LITT Followed by Hypofractionated RT for Newly Diagnosed Gliomas (GCC 20138)

   The purpose of this study is to evaluate the treatment regimen of using Laser Interstitial Thermal Therapy (LITT) and Hypo-fractionated Radiation Therapy to treat patients with newly diagnosed gliomas.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Maryland Proton Treatment Center, Baltimore, Maryland

   Locations

   5 in total

   Run by

   University of Maryland, Baltimore

   See if you can join NCT04699773 on ClinicalTrials.gov

4. Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders

   The study involves up to 5 visits for a fasting blood draw, behavioral assessments, and/or questionnaires. Other samples may be collected when appropriate. This study is currently recruiting. There is no cost for visits or study-related exams.

   Stage

   Not phased

   Ages

   Up to 18

   Site

   Southwestern Research and Resource Center, Phoenix, Arizona

   Locations

   2 in total

   Run by

   Southwest Autism Research & Resource Center

   See if you can join NCT04322734 on ClinicalTrials.gov

5. Non-invasive Glioma Characterization Through Molecular Imaging

   MRI-based sequences can provide non-invasive quantification of intratumoral 2-hydroxyglutarate (2HG) distribution and tumor cellularity in human gliomas and help guide the development of novel glioma therapies.

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Miami, Miami, Florida

   Run by

   University of Miami

   See if you can join NCT03684109 on ClinicalTrials.gov

6. C-SMART vs BE Well for Patients With Brain Tumors

   The goal of this clinical trial is to learn about the acceptability and feasibility of Cognitive Strategies, Mindfulness, and Rehabilitation Therapy (C-SMART) and Brain health Education and Wellness (BE Well) in adults with brain tumors and their caregivers. Participants will be assigned to one of …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Virginia Commonwealth University, Richmond, Virginia

   Run by

   Virginia Commonwealth University

   See if you can join NCT07224503 on ClinicalTrials.gov

7. Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA

   Primary brain tumors are typically treated by surgery, radiation therapy and chemotherapy, either individually or in combination. Present therapies are inadequate, as evidenced by the low 5-year survival rate for brain cancer patients, with median survival at approximately 12 months. Glioma is the …

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Lenox Hill Brain Tumor Center, New York, New York

   Run by

   Northwell Health

   See if you can join NCT02800486 on ClinicalTrials.gov

8. Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss

   This is a first in human study of TNG456 alone and in combination with abemaciclib in patients with advanced or metastatic solid tumors known to have an MTAP loss. The first part of the study is an open-label, dose escalation and the second part is an open label dose expansion in specific solid tum…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Mayo Clinic Scottsdale, Scottsdale, Arizona

   Locations

   15 in total

   Run by

   Tango Therapeutics, Inc.

   See if you can join NCT06810544 on ClinicalTrials.gov

9. The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study

   The Multi-OutcoMe EvaluatioN of radiation Therapy Using the Unity MR-Linac Study (MOMENTUM) is a multi-institutional, international registry facilitating evidenced based implementation of the Unity MR-Linac technology and further technical development of the MR-Linac system with the ultimate purpos…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Allegheny Health Network, Pittsburgh, Pennsylvania

   Locations

   18 in total

   Run by

   UMC Utrecht

   See if you can join NCT04075305 on ClinicalTrials.gov

10. Extracellular Impact of Ultrasound-induced Blood-brain Barrier Disruption

    This study seeks to determine the impact of focused ultrasound (FUS) on the composition of the tumor extracellular microenvironment. Researchers will evaluate regions that are very abnormal, as well as regions that have less evidence of disease. A sub-portion of each of these areas will be targeted…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mayo Clinic Minnesota, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT05733312 on ClinicalTrials.gov

11. Adenovirus Mediated Suicide Gene Therapy With Radiotherapy in Progressive Astrocytoma.

    The primary goal of this Phase I study is to determine the maximum tolerated dose of oncolytic adenovirus mediated double suicide-gene therapy in combination with fractionated stereotactic radiosurgery in patients with recurrent high-grade astrocytoma undergoing resection.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Henry Ford Health System, Detroit, Michigan

    Run by

    Henry Ford Health System

    See if you can join NCT05686798 on ClinicalTrials.gov

12. HOBSCOTCH-CA (HOme-Based Self-management and COgnitive Training CHanges Lives in Brain CAncer)

    The purpose of this study is to assess the ability of the home-based intervention, HOBSCOTCH-CA, to improve the quality of life and cognitive function in Service Members, Veterans and civilians who are survivors of brain cancer or a brain tumor (CA participants). This study will also assess the abi…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Dartmouth-Health Lebanon, Lebanon, New Hampshire

    Run by

    Dartmouth-Hitchcock Medical Center

    See if you can join NCT06930846 on ClinicalTrials.gov

13. Systematic Light Exposure in Pediatric Brain Tumor Survivors

    Children and adolescents treated for a brain tumor often experience fatigue and cognitive symptoms, such as slowed information processing and inattention. These symptoms may cause difficulty carrying out daily activities at home and at school. There are few well-researched, non-pharmacological inte…

    Stage

    Not phased

    Ages

    10 to 18

    Site

    Texas Children's Hospital, Houston, Texas

    Run by

    Baylor College of Medicine

    See if you can join NCT05340881 on ClinicalTrials.gov

14. A Surgical Window of Opportunity Clinical Trial of Troriluzole in Recurrent IDH Wild-Type Glioblastoma

    This research study is studying troriluzole as a possible treatment for recurrent glioblastoma. The name of the study drug involved in this research study is: -Troriluzole (a tripeptide prodrug of riluzole)

    Stage

    EARLY_Phase 1

    Ages

    18 and older

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Locations

    3 in total

    Run by

    Ugonma Chukwueke

    See if you can join NCT06552260 on ClinicalTrials.gov

15. APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors

    To assess: * efficacy of APL-101 as monotherapy for the treatment of NSCLC harboring MET Exon 14 skipping mutations, NSCLC harboring MET amplification, solid tumors harboring MET amplification, solid tumors harboring MET fusion, primary CNS tumors harboring MET alterations, solid tumors harboring w…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Cedars-Sinai Medical Center - Samuel Oschin Comprehensive Cancer Institute, Los Angeles, California

    Locations

    35 in total

    Run by

    Apollomics Inc.

    See if you can join NCT03175224 on ClinicalTrials.gov