Brain Tumor Clinical Trials

43 studies are recruiting for brain tumor in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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By city

Boston, Massachusetts 9 New York, New York 8 Houston, Texas 6 Washington D.C., District of Columbia 4 Baltimore, Maryland 3 Jacksonville, Florida 3 Los Angeles, California 3 Miami, Florida 3 Phoenix, Arizona 3 Pittsburgh, Pennsylvania 3 Rochester, Minnesota 3 San Francisco, California 3 Tampa, Florida 3

Studies now recruiting

  1. Mapping of Human Cognition

    The purpose of this study is to compare organization of normal brain function as detected using Functional magnetic resonance imaging (fMRI) in normal subjects as opposed to patients with epilepsy or brain tumors, to ascribe precise anatomic labels (including Brodmann Areas) and functional signific…

    Stage
    Not phased
    Ages
    18 to 75
    Site
    The University of Texas Health Science Center at Houston, Houston, Texas
    Run by
    The University of Texas Health Science Center, Houston

    See if you can join NCT05989893 on ClinicalTrials.gov

  2. 000860: A Phase I/II Study of Zotiraciclib for Recurrent Malignant Gliomas With Isocitrate Dehydrogenase 1 or 2 (IDH1 or IDH2) Mutations

    Protocol # 000860 Background: Diffuse gliomas are tumors that affect the brain and spinal cord. Gliomas that develop in people with certain gene mutations (IDH1 or IDH2) are especially aggressive. Better treatments are needed. Objective: To see if a study drug (zotiraciclib) is effective in people …

    Stage
    Phase 1
    Ages
    15 to 99
    Site
    Mayo Clinic Flordia, Jacksonville, Florida
    Locations
    2 in total
    Run by
    National Cancer Institute (NCI)

    See if you can join NCT05588141 on ClinicalTrials.gov

  3. Illuminate: A Clinical Study Evaluating CAR T Immune Cell Therapy (BCB-276) for Patients With Diffuse Intrinsic Pontine Glioma (DIPG).

    This study will evaluate BCB-276, an investigational B7-H3-targeted Chimeric Antigen Receptor (CAR) T cell therapy, in children and young adults with diffuse intrinsic pontine glioma (DIPG). DIPG is a rare and aggressive brain tumor with limited treatment options. CAR T cell therapy uses a patient'…

    Stage
    Phase 2
    Ages
    1 to 26
    Site
    Children's Healthcare of Atlanta, Atlanta, Georgia
    Locations
    6 in total
    Run by
    BrainChild Bio, Inc

    See if you can join NCT07680439 on ClinicalTrials.gov

  4. Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss

    This is a first in human study of TNG456 alone and in combination with abemaciclib in patients with advanced or metastatic solid tumors known to have an MTAP loss. The first part of the study is an open-label, dose escalation and the second part is an open label dose expansion in specific solid tum…

    Stage
    Phase 1
    Ages
    18 and older
    Site
    Mayo Clinic Scottsdale, Scottsdale, Arizona
    Locations
    15 in total
    Run by
    Tango Therapeutics, Inc.

    See if you can join NCT06810544 on ClinicalTrials.gov

  5. Development of MRF for Characterization of Brain Tumors After Radiotherapy

    The purpose of this study is to discover the potential convenience and ease of using a Magnetic Resonance Imaging (MRI) technique, named Magnetic Resonance Fingerprinting (or MRF), to achieve high-quality images within a short scan time of 5 min for viewing the entire brain. This is an advanced qua…

    Stage
    Not phased
    Ages
    18 to 60
    Site
    University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center, Cleveland, Ohio
    Locations
    2 in total
    Run by
    Case Comprehensive Cancer Center

    See if you can join NCT06101069 on ClinicalTrials.gov

  6. EXercise-induced PhysioLogical Adaptations In Neurological Disorders

    The goal of this study is to investigate how a one-time exercise session influences different parameters of brain function in people with neurological diseases compared to healthy volunteers. The main questions the study aims to answer are: * How do fitness level, exercise performance, and physical…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Brigham and Women's Hospital, Boston, Massachusetts
    Run by
    Brigham and Women's Hospital

    See if you can join NCT07883720 on ClinicalTrials.gov

  7. A Study to Measure the Effect of Brain Stimulation on Hand Strength and Function in Patients With Brain Tumors

    The neurosurgical standard of care for treating a patient with a tumor invading hand primary motor cortex (M1) includes performing a craniotomy with intraoperative direct electrical stimulation (DES) mapping and to resect as much tumor as possible without a resultant permanent neurological deficit.…

    Stage
    Not phased
    Ages
    18 to 75
    Site
    Medical College of Wisconsin, Milwaukee, Wisconsin
    Run by
    Medical College of Wisconsin

    See if you can join NCT05023434 on ClinicalTrials.gov

  8. Blood-brain Barrier (BBB) Opening Using Exablate Focused Ultrasound With Standard of Care Treatment of NSCLC Brain Mets

    The purpose of this study is to evaluate the safety and efficacy of targeted blood brain barrier opening with Exablate Model 4000 Type 2.0/2.1 for the treatment of NSCLC brain metastases in patients who are undergoing planned FDA approved, on-label systemic therapy utilizing immune checkpoint inhib…

    Stage
    Phase 3
    Ages
    18 to 100
    Site
    Hoag Memorial Hospital Presbyterian, Newport Beach, California
    Locations
    16 in total
    Run by
    InSightec

    See if you can join NCT05317858 on ClinicalTrials.gov

  9. Panitumumab-IRDye800 to Detect Pediatric Neoplasms During Neurosurgical Procedures

    The objective of the study is to assess safety of panitumumab-IRDye800 in pediatric patients undergoing brain surgery to remove suspected tumors.

    Stage
    Phase 1
    Ages
    0 to 25
    Site
    Stanford Cancer Center, Stanford, California
    Run by
    Stanford University

    See if you can join NCT04085887 on ClinicalTrials.gov

  10. C-SMART vs BE Well for Patients With Brain Tumors

    The goal of this clinical trial is to learn about the acceptability and feasibility of Cognitive Strategies, Mindfulness, and Rehabilitation Therapy (C-SMART) and Brain health Education and Wellness (BE Well) in adults with brain tumors and their caregivers. Participants will be assigned to one of …

    Stage
    Not phased
    Ages
    18 and older
    Site
    Virginia Commonwealth University, Richmond, Virginia
    Run by
    Virginia Commonwealth University

    See if you can join NCT07224503 on ClinicalTrials.gov

  11. Extracellular Impact of Ultrasound-induced Blood-brain Barrier Disruption

    This study seeks to determine the impact of focused ultrasound (FUS) on the composition of the tumor extracellular microenvironment. Researchers will evaluate regions that are very abnormal, as well as regions that have less evidence of disease. A sub-portion of each of these areas will be targeted…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Mayo Clinic Minnesota, Rochester, Minnesota
    Run by
    Mayo Clinic

    See if you can join NCT05733312 on ClinicalTrials.gov

  12. Memantine +/- Raloxifene for Cognitive Preservation After Radiation Therapy to the Brain

    The study investigators are testing to see if patients receiving radiation treatment for brain cancer along with raloxifene plus memantidine take longer to develop memory issues. The study will include anyone over the age of 18 who will be treated with radiation for brain cancer.

    Stage
    Phase 2
    Ages
    18 and older
    Site
    Mays Cancer Center, UT Health San Antonio, San Antonio, Texas
    Run by
    The University of Texas Health Science Center at San Antonio

    See if you can join NCT07470606 on ClinicalTrials.gov

  13. REMIND Maintenance Radiotherapy for Newly Diagnosed Glioblastoma

    REMIND is a single-center feasibility study testing maintenance radiotherapy in adult patients with newly diagnosed glioblastoma. Participants will be consented before starting standard-of-care concurrent temozolomide and radiotherapy. After enrollment, participants will enter an observational lead…

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of Minnesota Radiation Oncology, Minneapolis, Minnesota
    Run by
    University of Minnesota

    See if you can join NCT07831772 on ClinicalTrials.gov

  14. Vision Improvement Through Behavioral Rehabilitation And Neuroplasticity Training

    The VIBRANT (Vision Improvement through Behavioral Rehabilitation And Neuroplasticity Training) study is a prospective, double-blind, crossover design (within-subject) in participants with homonymous hemianopia-a type of visual field loss resulting from damage to the post-chiasmatic visual pathways…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Georgetown University Medical Center, Washington D.C., District of Columbia
    Run by
    Georgetown University

    See if you can join NCT07105358 on ClinicalTrials.gov

  15. Home-based Vision Rehabilitation Guided by Brain Imaging

    The BRIGHT (Behavioral Rehabilitation Through Image-Guided Home-based Training) study aims to evaluate the effectiveness of image-guided, home-based perceptual training at improving visual performance in individuals with visual field loss. Using a prospective, crossover design, BRIGHT combines visu…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Georgetown University Medical Center, Washington D.C., District of Columbia
    Run by
    Georgetown University

    See if you can join NCT07635329 on ClinicalTrials.gov

  16. Treatment Response Assessment Maps to Delineate Necrosis From Tumor After Stereotactic Radiation in Brain Metastases

    This research study is investigating the value of an imaging study of the brain called an MRI (which stands for magnetic resonance imaging), utilized in unique way, to delineate whether the tumor has recurred or whether radiation changes have occurred after a brain metastasis treated with focused r…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Brigham and Women's Hospital, Boston, Massachusetts
    Locations
    2 in total
    Run by
    Brigham and Women's Hospital

    See if you can join NCT04033497 on ClinicalTrials.gov

  17. Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases

    The purpose of this study is to determine whether AGuIX (Activation and Guidance of Irradiation by X-ray) gadolinium-based nanoparticles make radiation work more effectively in the treatment of patients with brain metastases that are more difficult to control with stereotactic radiation alone.

    Stage
    Phase 2
    Ages
    18 and older
    Site
    Brigham and Women's Hospital, Boston, Massachusetts
    Locations
    2 in total
    Run by
    Brigham and Women's Hospital

    See if you can join NCT04899908 on ClinicalTrials.gov

  18. B7-H3.CD28Z.CART in CNS Neoplasms

    The purpose of this research study is to test the safety and effectiveness of a cell therapy at different doses for children and young adults with recurrent or progressive brain tumors. Recurrent/recurred means a tumor that has gone away and then came back. This cell therapy is called B7- H3.CD28Z.…

    Stage
    Phase 1
    Ages
    2 to 21
    Site
    Boston Children's Hospital, Boston, Massachusetts
    Locations
    2 in total
    Run by
    Robbie Majzner

    See if you can join NCT07390539 on ClinicalTrials.gov

  19. Local Control, Quality of Life and Toxicities in Adults With Benign or Indolent Brain Tumors Undergoing Proton Radiation Therapy

    This research study is studying Proton Radiation as a possible treatment for brain tumor. The radiation involved in this study is: -Proton Radiation

    Stage
    Not phased
    Ages
    18 and older
    Site
    Massachusetts General Hospital, Boston, Massachusetts
    Run by
    Massachusetts General Hospital

    See if you can join NCT03286335 on ClinicalTrials.gov

  20. Study of Letrozole in Recurrent Gliomas

    The purpose of this study is to determine the ability of letrozole to penetrate the blood brain barrier and concentrate in gliomas.

    Stage
    EARLY_Phase 1
    Ages
    18 and older
    Site
    University of Cincinnati, Cincinnati, Ohio
    Run by
    University of Cincinnati

    See if you can join NCT03122197 on ClinicalTrials.gov

  21. Ommaya Reservoir Placement for Brain Tumor Biomarker Access

    The purpose of this study is to determine the safety and feasibility of intra-operative Ommaya Reservoir placement during a clinically indicated operation for brain tumor. The Ommaya reservoir will facilitate a longitudinal access to cerebrospinal fluid (CSF) for analysis of potential biomarkers fo…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Mayo Clinic in Rochester, Rochester, Minnesota
    Run by
    Mayo Clinic

    See if you can join NCT04692337 on ClinicalTrials.gov

  22. A Phase 2 and Pharmacodynamic Study of Sitagliptin in Patients With Progressive Grade 4 Gliomas

    The purpose of this study is to evaluate whether treating glioblastoma patients with sitagliptin can improve immune response against the tumor by targeting specific immune cells called myeloid-derived suppressor cells (MDSCs) that suppress your body's natural immune response against cancer. Sitagli…

    Stage
    Phase 2
    Ages
    18 and older
    Site
    Case Comprehensive Cancer Center, Cleveland Clinic Foundation Taussig Cancer Institute, Cleveland, Ohio
    Run by
    Case Comprehensive Cancer Center

    See if you can join NCT07003542 on ClinicalTrials.gov

  23. Registry of Patients With Brain Tumors Treated With STaRT (GammaTiles)

    The objectives of this registry study are to evaluate real-world clinical outcomes and patient reported outcomes that measure the effectiveness and safety of STaRT.

    Stage
    Not phased
    Ages
    Any age
    Site
    HonorHeath Scottsdale Osborn Medical Center, Phoenix, Arizona
    Locations
    54 in total
    Run by
    GT Medical Technologies, Inc.

    See if you can join NCT04427384 on ClinicalTrials.gov

  24. Cognitive Outcomes After Brain Substructure-informed Radiation Planning in Pediatric Patients

    The goal of this trial is to determine whether it is possible to minimize radiation dose to parts of the brain that are important for thinking and learning in children who require radiation to treat their tumor, and if this will help reduce neurocognitive (thinking and learning) impairments in thes…

    Stage
    Not phased
    Ages
    1 to 26
    Site
    Sibley Memorial Hospital, Washington D.C., District of Columbia
    Locations
    2 in total
    Run by
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

    See if you can join NCT05658731 on ClinicalTrials.gov

  25. Cognitive Training in the Virtual Reality Setting With Children Undergoing Radiotherapy for Brain Tumors

    The objective of this study is to estimate the feasibility and acceptability of cognitive training in the virtual reality setting with children undergoing radiotherapy for brain tumors. To achieve this goal, the investigators plan to study children undergoing radiotherapy for brain tumors randomly …

    Stage
    Not phased
    Ages
    8 to 22
    Site
    St. Jude Children's Research Hospital, Memphis, Tennessee
    Run by
    St. Jude Children's Research Hospital

    See if you can join NCT05947045 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.