Bladder Cancer Clinical Trials

85 studies are recruiting for bladder cancer in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. A Multi-Center Natural History of Urothelial Cancer and Rare Genitourinary Tract Malignancies

   Background: Tumors in the genitourinary tracts can occur in the kidney, bladder, prostate, and testicles and can have common and rare histologies. Some cancers that occur along the genitourinary (GU) tract are rare. Some GU tumors are so rare that they are not included in treatment studies or tissu…

   Stage

   Not phased

   Ages

   18 and older

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT04923178 on ClinicalTrials.gov

2. IDOV-Immune for Advanced Solid Tumors

   This is a Phase I clinical trial evaluating an investigational treatment called IDOV-Immune, a type of oncolytic virus therapy, for adults with advanced solid tumors that have not responded to standard treatments. Oncolytic viruses are designed to infect and destroy cancer cells and have the potent…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Washington University School of Medicine, St Louis, Missouri

   Locations

   5 in total

   Run by

   ViroMissile, Inc.

   See if you can join NCT06910657 on ClinicalTrials.gov

3. Comparison of Intravesical Therapy and Surgery as Treatment Options for Bladder Cancer 2

   Bladder cancer is the most common urinary tract cancer and the 6th most common cancer in the US. Yet bladder cancer research is underfunded relative to other common cancers. As a result, bladder cancer care is prone to evidence gaps that produce decision uncertainty for both patients and clinicians…

   Stage

   Not phased

   Ages

   18 and older

   Site

   H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida

   Locations

   6 in total

   Run by

   University of Washington

   See if you can join NCT07225127 on ClinicalTrials.gov

4. A Study of a Side Effects and Resource Navigation Program for People With Cancer

   The purpose of this study is to find out if the navigation program helps participants manage immunotherapy treatment better than usual care. Investigators will also look at how the navigation program impacts participants' quality of life. Investigators will measure quality of life by having partici…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Memorial Sloan Kettering Basking Ridge (All Protocol Activities), Basking Ridge, New Jersey

   Locations

   8 in total

   Run by

   Memorial Sloan Kettering Cancer Center

   See if you can join NCT07646847 on ClinicalTrials.gov

5. Study Investigating Intravesical HDAC Inhibition to Improve Response to Immuno-Oncology Agents

   In this study, we aim to evaluate the safety and efficacy of neoadjuvant combination using intravesical romidepsin and durvalumab in cisplatin-ineligible patients with muscle invasive bladder cancer (MIBC).

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Moffitt Cancer Center, Tampa, Florida

   Run by

   H. Lee Moffitt Cancer Center and Research Institute

   See if you can join NCT06963346 on ClinicalTrials.gov

6. Radiation Combined With BIspecific T-Cell Engager in DLL3 Expressing Tumors

   Phase I study to examine safety of the addition of concurrent tarlatamab with standard palliative and consolidative RT regimens , with a main cohort of N=20-24 patients with extracranial anatomic radiation sites. I) After lead in of 10 patients demonstrating safety of treatment, allow for expansion…

   Stage

   Phase 1

   Ages

   18 to 99

   Site

   Arizona Cancer Center at UMC North/University Medical Center, Tucson, Arizona

   Locations

   2 in total

   Run by

   University of Arizona

   See if you can join NCT06814496 on ClinicalTrials.gov

7. PROGRESS: Precision Oncology Using Genomic Reflexive Evaluations for Study Selection and Survival

   This is a hybrid decentralized, single-arm, interventional study designed to evaluate the impact of precision medicine navigation and reflexive expert review of next-generation sequencing (NGS) for patients with stage IV solid tumor malignancies (breast, lung, colorectal, and bladder cancers). The …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina

   Run by

   UNC Lineberger Comprehensive Cancer Center

   See if you can join NCT06896162 on ClinicalTrials.gov

8. A Study of Surgical Techniques During Cystectomy

   The purpose of this study is to look at two standard surgical techniques used during a radical cystectomy and see whether they influence outcomes such as length of stay in the hospital and infections after surgery. This trial will evaluate whether the following surgical methods influence outcomes: …

   Stage

   Phase 3

   Ages

   21 and older

   Site

   Memorial Sloan Kettering at Basking Ridge (Consent Only), Basking Ridge, New Jersey

   Locations

   7 in total

   Run by

   Memorial Sloan Kettering Cancer Center

   See if you can join NCT06703476 on ClinicalTrials.gov

9. Predicting BCG Response

   To date, there are no diagnostics capable of predicting treatment response to intravesical BCG. Because of this severe limitation, nearly 50% of patients treated with BCG fail therapy and will a) require additional intravesical therapy or b) require cystectomy. A urine-based diagnostic that possess…

   Stage

   Not phased

   Ages

   18 to 90

   Site

   Cedars-Sinai Medical Center, Los Angeles, California

   Locations

   6 in total

   Run by

   Cedars-Sinai Medical Center

   See if you can join NCT04564781 on ClinicalTrials.gov

10. Integrated Cancer Repository for Cancer Research

    The iCaRe2 is a multi-institutional resource created and maintained by the Fred \& Pamela Buffett Cancer Center to collect and manage standardized, multi-dimensional, longitudinal data and biospecimens on consented adult cancer patients, high-risk individuals, and normal controls. The distinct char…

    Stage

    Not phased

    Ages

    19 to 110

    Site

    Advent Health, Greenwood Village, Colorado

    Locations

    42 in total

    Run by

    University of Nebraska

    See if you can join NCT02012699 on ClinicalTrials.gov

11. Predicting Response to Immunotherapy From Analysis of Live Tumor Biopsies (ELEPHAS-05)

    This study will collect tumor specimens with correlated clinical and demographic data from patients who are undergoing a biopsy or similar procedure to obtain tumor tissue as a normal course of their medical management or diagnostic work-up for suspected or confirmed cancer.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mercy Hospital - FTS, Fort Smith, Arkansas

    Locations

    8 in total

    Run by

    Elephas

    See if you can join NCT07327489 on ClinicalTrials.gov

12. Specimen Collection for Validation of UroAmp: A Next Generation Sequencing Platform for Detection and Surveillance of Bladder Cancer

    This is a prospective, multicenter observational study designed to collect urine and tumor biospecimens and associated clinical data from patients undergoing evaluation, treatment, or surveillance for urothelial carcinoma.

    Stage

    Not phased

    Ages

    18 and older

    Site

    UT Southwestern Medical Center, Dallas, Texas

    Locations

    23 in total

    Run by

    Convergent Genomics, Inc.

    See if you can join NCT07673016 on ClinicalTrials.gov

13. Atezolizumab Plus Etoposide and Platinum in Small Cell Bladder Cancer

    This is a single arm, Phase II trial involving the use of atezolizumab plus platinum and etoposide for patients with locally advanced urothelial cancer. The primary goal of this trial is to assess the pathologic complete response rate at cystectomy in patients after being treated with a combination…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Johns Hopkins University: Sibley Memorial Hospital, Washington D.C., District of Columbia

    Locations

    2 in total

    Run by

    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

    See if you can join NCT05312671 on ClinicalTrials.gov

14. 18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection

    Background: Fibroblast-activation protein (FAP) is an enzyme that appears in high numbers in cancer-associated fibroblasts of certain cancer types. [18F]FAPI-74 is a new PET (positron emission tomography) tracer, a substance that is injected into a person s body before an imaging scan. Researchers …

    Stage

    Phase 2

    Ages

    18 to 120

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    National Cancer Institute (NCI)

    See if you can join NCT06503146 on ClinicalTrials.gov

15. Adjuvant Concurrent Immunotherapy and Radiotherapy for the Treatment of Bladder Cancer

    The primary objective of this Phase I study is to establish the safety of adjuvant concurrent immunotherapy and radiation therapy for urothelial bladder cancer.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    Abramson Cancer Center at Penn Medicine

    See if you can join NCT06586255 on ClinicalTrials.gov

16. Intravesical Treatment of Bladder Cancer at Home, Multi-modal Treatment Support

    The proposed project will have two separate cohorts. The first will be to perform a more in-depth qualitative assessment of the barriers and facilitators for treatment compliance for non-muscle invasive bladder cancer. The second arm will be to create and test a BCG at home program. Participants in…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Abramson Cancer Center, Philadelphia, Pennsylvania

    Run by

    Abramson Cancer Center at Penn Medicine

    See if you can join NCT07048496 on ClinicalTrials.gov

17. Characterizing the Microvascular Environment of Bladder Cancer With Super-Resolution Ultrasound Localization Microscopy

    The project will include 30 patients with bladder cancer who are candidates for bladder removal. After signing the consent form, the study team will collect some clinical data, such as age, past medical history, past surgical history, and information about your current disease. At the day of surger…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Duke University, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT06986304 on ClinicalTrials.gov

18. Bladder Cancer Screening Trial

    There is currently no accepted screening strategy for patients at high risk of developing bladder cancer. This study will ask patients to complete a urine test every 6 months for 2 years to help assess if routine screening helps finding bladder cancer at an earlier stage.

    Stage

    Not phased

    Ages

    50 and older

    Site

    University of Texas Southwestern Medical Center, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT05646485 on ClinicalTrials.gov

19. Clinical Evaluation of BCDx for Monitoring of Recurrence in Non-Muscle Invasive Bladder Cancer

    BCDx is a urine-based multi-omic assay for early cancer recurrence detection in patients with a history of bladder cancer. This prospective, blinded study evaluates its efficacy in detecting recurrent NMIBC, offering a noninvasive monitoring solution.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Arkansas Urology Research Center, Little Rock, Arkansas

    Locations

    3 in total

    Run by

    Early is Good Inc.

    See if you can join NCT05982561 on ClinicalTrials.gov

20. A Study of 68Gallium PSMA-PET/CT Scans in People With Bladder Cancer or Skin Cancer

    The purpose of this study is to see whether 68Gallium PSMA-PET/CT scans are an effective way to detect sites of cancer in people with metastatic bladder cancer or skin cancer. The study researchers want to learn if a 68Gallium PSMA PET/CT scan will work better, the same, or not as well as the PET/C…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Memorial Sloan Kettering Basking Ridge (Consent Only), Basking Ridge, New Jersey

    Locations

    7 in total

    Run by

    Memorial Sloan Kettering Cancer Center

    See if you can join NCT05562791 on ClinicalTrials.gov

21. Intravesical GEM/DOCE for HR BCG-Unresponsive NMIBC

    The goal of this clinical trial is to learn whether a combination of two chemotherapy drugs, Gemcitabine and Docetaxel, can treat high-grade non-muscle-invasive bladder cancer (HG-NMIBC) in adults whose cancer failed conventional BCG therapy. The drugs are given directly into the bladder (intravesi…

    Stage

    Phase 2

    Ages

    18 to 99

    Site

    University of Iowa, Iowa City, Iowa

    Run by

    Michael A. O'Donnell

    See if you can join NCT07322263 on ClinicalTrials.gov

22. Metabolism Evaluation Through Resting Indirect Calorimetry in Bladder Cancer (METRICS)

    This study is being done to learn more about energy needs and muscle function during treatment for bladder cancer. These insights can help improve future patient care. The study team found in a previous study that resting energy can be different than what estimates show. Patients with bladder cance…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Kansas Medical Center, Kansas City, Kansas

    Locations

    2 in total

    Run by

    University of Kansas Medical Center

    See if you can join NCT06721260 on ClinicalTrials.gov

23. Comprehensive Multimodal Prehabilitation Alone or With Neoadjuvant Therapy Before Major Cancer Surgery

    In this 2-arm, non-randomized, phase II trial, the investigators will evaluate the efficacy and safety of comprehensive multimodal prehabilitation (CMMP) alone or in combination with planned neoadjuvant (NAT) in pre-frail/frail patients with probable/proven pancreaticobiliary, ovarian, kidney, or b…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Houston Methodist Neal Cancer Center, Houston, Texas

    Run by

    The Methodist Hospital Research Institute

    See if you can join NCT07050771 on ClinicalTrials.gov

24. Intravesical Gemcitabine and Docetaxel for Low Grade Intermediate Risk Bladder Cancer

    Bladder cancer is the 8th most common cancer in the UF Health Cancer Center catchment area and the 7th most common cancer presenting to UFHealth. Most newly diagnosed cases are stage I bladder cancer, which is defined by having no deep muscle invasion and no evidence of disease beyond the bladder. …

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of Florida, Gainesville, Florida

    Run by

    University of Florida

    See if you can join NCT06488222 on ClinicalTrials.gov

25. Bladder Cancer Longitudinal Biorepository for Development of Novel Therapeutics/Biomarkers

    The purpose of this study is to create a registry, which is a "bank" of information about patients who have had similar medical conditions and treatments. The registry will be used by researchers to learn more about long term outcome of patients with bladder cancer, how bladder cancer tissues are r…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Kansas Medical Center, Kansas City, Kansas

    Run by

    University of Kansas Medical Center

    See if you can join NCT03413982 on ClinicalTrials.gov