Autism Spectrum Disorder Clinical Trials

104 studies are recruiting for autism spectrum disorder in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Developing Brain, Impulsivity and Compulsivity

   Background: Impulsivity is acting 'without thinking.' Compulsivity is being overly inflexible. People vary in how impulsive or compulsive they are. Extreme versions of these behaviors play a role in mental disorders. Researchers want to study changes in the brain to learn more about these behaviors…

   Stage

   Not phased

   Ages

   6 to 80

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Mental Health (NIMH)

   See if you can join NCT04631042 on ClinicalTrials.gov

2. Buspirone for Anxiety in Autistic Youth

   The purpose of the study is to do a preliminary trial to determine if buspirone is effective, safe, and tolerable in autistic youth with anxiety.

   Stage

   Phase 4

   Ages

   7 to 17

   Site

   Lurie Center, Lexington, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT07439042 on ClinicalTrials.gov

3. Characterization of Dysmorphology in Subjects With Creatine Transporter Deficiency

   Background: Creatine transporter deficiency (CTD) is a genetic disorder that mainly affects the brain in males. CTD causes intellectual disability that can be mild to severe. People with CTD may have seizures and behavioral issues. They may have slow growth and tire easily. CTD may sometimes be con…

   Stage

   Not phased

   Ages

   2 to 40

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

   See if you can join NCT05600946 on ClinicalTrials.gov

4. Effects of Multiple-Session Transcranial Direct Current Stimulation (tDCS) on Behavioral, Physiological, and Electrophysiological Measures With Adults With Autism Spectrum Disorder (ASD)

   The purpose of this clinical trial is to investigate the effects of multiple sessions of transcranial direct current stimulation (tDCS) delivered while participants complete tasks that target social learning with high functioning adults with ASD and/or high traits of ASD. The main question it aims …

   Stage

   Not phased

   Ages

   18 to 35

   Site

   University of New Mexico, Albuquerque, New Mexico

   Run by

   University of New Mexico

   See if you can join NCT06495684 on ClinicalTrials.gov

5. Family-school Partnership Intervention for Early Childhood Education

   Strategies for creating and maintaining reciprocal partnerships between teachers and parents are considered essential elements of developmentally appropriate practice in early childhood education (ECE). Particularly for children who are high-risk for behavioral, developmental, or mental health prob…

   Stage

   Not phased

   Ages

   2 to 6

   Site

   UNT, Denton, Texas

   Run by

   University of North Texas, Denton, TX

   See if you can join NCT06506097 on ClinicalTrials.gov

6. Pimavanserin for Rigid-compulsive Symptoms in Autism Spectrum Disorder

   This Phase 2 study examines the safety, tolerability, and preliminary efficacy of pimavanserin in individuals with Autism Spectrum Disorder. Male or female participants aged 12 to 40 years of age will be randomized to receive single doses of either placebo or pimavanserin in this randomized, placeb…

   Stage

   Phase 2

   Ages

   12 to 40

   Site

   University of Kansas, Center for Research, Lawrence, Kansas

   Locations

   2 in total

   Run by

   New York State Psychiatric Institute

   See if you can join NCT05999240 on ClinicalTrials.gov

7. A Phase 2A Trial of DT402 for Autism Spectrum Disorder

   A Phase 2A Trial of DT402 Open-Label Study in Adults with Autism Spectrum Disorder

   Stage

   Phase 2

   Ages

   18 to 65

   Site

   Spectrum Neuroscience and Treatment Institute, New York, New York

   Run by

   Definium Therapeutics US, Inc.

   See if you can join NCT07303907 on ClinicalTrials.gov

8. Propranolol for Aggression, Self-Injury, and Severe Disruptive Behavior in Adolescents and Adults With Autism

   The goal of this clinical trial is to learn if propranolol can help reduce challenging behaviors associated with Autism Spectrum Disorder, including aggression, self-injury, and severe disruptive behaviors. Participants will be randomly assigned to receive either propranolol or a placebo (a look-al…

   Stage

   Phase 2

   Ages

   12 to 40

   Site

   New York State Institute for Basic Research (IBR), Staten Island, New York

   Locations

   2 in total

   Run by

   Jeremy Veenstra-vanderweele

   See if you can join NCT07091279 on ClinicalTrials.gov

9. Smart Inhaler and Remote Asthma Management in Adolescents With Intellectual and Developmental Disabilities

   Correct use of daily medications containing inhaled corticosteroids is key for asthma control, yet children with intellectual and developmental disabilities (IDD) face additional barriers to proper inhaler use. Smart inhalers, a novel technology that provides guidance and immediate feedback on inha…

   Stage

   Not phased

   Ages

   10 to 17

   Site

   Children's Hospital Los Angeles, Los Angeles, California

   Run by

   Children's Hospital Los Angeles

   See if you can join NCT07746921 on ClinicalTrials.gov

10. Safety and Tolerability Trial of Lumateperone in Pediatric Patients With Schizophrenia, Bipolar Disorder or Autism Spectrum Disorder

    This is a multicenter, global, 26-week, open-label study to assess the safety and tolerability of lumateperone in pediatric patients with schizophrenia, bipolar disorder or autism spectrum disorder.

    Stage

    Phase 3

    Ages

    5 to 17

    Site

    Southwest Autism Research and Resource Center, Phoenix, Arizona

    Locations

    64 in total

    Run by

    Intra-Cellular Therapies, Inc.

    See if you can join NCT06229210 on ClinicalTrials.gov

11. Evaluation and Refinement of KF-STRIDE Into the Interview!

    Examine the acceptability, usability, feasibility, and initial efficacy of KF-STRIDE 3.0, the data from which will serve as a basis for a future fully powered RCT

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Kessler Foundation, East Hanover, New Jersey

    Run by

    Kessler Foundation

    See if you can join NCT07168941 on ClinicalTrials.gov

12. Adia MED of Winter Park LLC Autism Spectrum Disorder Research Study

    This 24-month study is testing whether adding AdiaVita, an umbilical cord blood-derived stem cell and exosome product, to glutathione therapy helps improve autism symptoms in children ages 3-12 more than glutathione alone. Children will be randomly placed into one of two groups for the first three …

    Stage

    Phase 1

    Ages

    3 to 12

    Site

    Adia Med Of Winter Park, Winter Park, Florida

    Locations

    2 in total

    Run by

    Adia Med of Winter Park LLC

    See if you can join NCT07304440 on ClinicalTrials.gov

13. Prednisone in Adults With an Immune-Mediated Subtype of Autism Spectrum Disorder

    The goal of this clinical trial is to learn how prednisone affects adults with autism spectrum disorder (ASD). It will also learn about the safety of prednisone. The main questions it aims to answer are: * How does prednisone affect the core features and associated target symptoms of ASD in adults …

    Stage

    EARLY_Phase 1

    Ages

    18 to 50

    Site

    MGH Lurie Center for Autism, Lexington, Massachusetts

    Run by

    Christopher John McDougle, M.D.

    See if you can join NCT06934915 on ClinicalTrials.gov

14. Improving Social Communication in Individuals With ASD Using AI

    The purpose of this study is to identify whether researched and commonly used face-to-face interventions can be effectively implemented through artificial intelligence (AI) using an application on the phone or computer. The investigators plan to recruit individuals diagnosed with autism spectrum di…

    Stage

    Not phased

    Ages

    3 to 35

    Site

    Stanford University School of Medicine, Stanford, California

    Run by

    Stanford University

    See if you can join NCT05987774 on ClinicalTrials.gov

15. Auricular Transcutaneous Electrical Nerve Stimulation Treatment of Autism

    In this study, investigators will examine the treatment effects of transcutaneous electrical nerve stimulation with different stimulation frequencies on individuals with autism.

    Stage

    Not phased

    Ages

    18 to 60

    Site

    MGB, Charlestown, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT03827941 on ClinicalTrials.gov

16. Transcranial Magnetic Stimulation (TMS) to Treat Depression in Autism Spectrum Disorder

    This study will assess clinical and behavioral measures along with electroencephalogram (EEG), event-related potentials (ERPS), and eye-tracking (ET) prior to and following a single intermittent Theta Burst Stimulation (iTBS) session to provide preliminary insight into the potential of TMS as an in…

    Stage

    Not phased

    Ages

    18 to 40

    Site

    Yale Psychiatric Hospital, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT06142955 on ClinicalTrials.gov

17. Behavior Analytic Support of Needle-related Hospital Visits for Autistic Patients

    The purpose of this study is to evaluate the effectiveness of the behavior analytic intervention in reducing the number of challenging behaviors exhibited by patients with Autism Spectrum Disorder (ASD) while increasing compliance with needle-related simulations and procedures. A second purpose is …

    Stage

    Not phased

    Ages

    3 and older

    Site

    Boston Medical Center, Boston, Massachusetts

    Run by

    Boston Medical Center

    See if you can join NCT06712784 on ClinicalTrials.gov

18. Evaluating Additive Effects of Including Canines in Regulating Together

    The primary objective is to evaluate the potential additive effect of animal-assisted intervention (AAI) on a manualized behavioral treatment targeting emotion dysregulation (ED) in children with autism spectrum disorder (ASD). Aim 1: Evaluate whether Regulating Together-Canine demonstrates earlier…

    Stage

    Not phased

    Ages

    8 to 15

    Site

    Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

    Run by

    Children's Hospital Medical Center, Cincinnati

    See if you can join NCT05803343 on ClinicalTrials.gov

19. A Study of Esomeprazole in Children With Autism

    Autism is a pervasive developmental disorder characterized by core deficits in social behavior and communication and the presence of repetitive/stereotyped behaviors. The objective of the study is to evaluate the efficacy of Esomeprazole as a treatment for social communication deficits in children …

    Stage

    Phase 2

    Ages

    2 to 6

    Site

    Stanford University School of Medicine, Stanford, California

    Run by

    Stanford University

    See if you can join NCT03866668 on ClinicalTrials.gov

20. A Center Based Early Intervention Program For Preschoolers With Developmental Disorders

    The purpose of this study is to examine the effectiveness of a 12-week early intervention program that will include 12 weekly hours in an intensive center-based preschool environment or in the home to treat social communication deficits in children with developmental disorders. The study will inclu…

    Stage

    Not phased

    Ages

    2 to 5

    Site

    Stanford University School of Medicine, Stanford, California

    Run by

    Stanford University

    See if you can join NCT04026386 on ClinicalTrials.gov

21. Modified Pivotal Response Treatment for Insistence on Sameness in Autistic Youth

    The purpose of this open label trial is to examine the preliminary feasibility, acceptability, and effectiveness of a 12-week behavioral intervention program (1 hour/week) to treat insistence on sameness (e.g., difficulty tolerating changes in routine) in youth with autism spectrum disorder (ASD). …

    Stage

    Not phased

    Ages

    4 to 17

    Site

    401 Quarry Road (Remote Study), Stanford, California

    Run by

    Stanford University

    See if you can join NCT06362733 on ClinicalTrials.gov

22. Trial of Center-Based vs. In-Home Pivotal Response Treatment (PRT) in Autism

    The aim of this clinical trial is to compare the efficacy of a 16-week center-based Pivotal Response Treatment (PRT-C) versus home-based Pivotal Response Treatment (PRT-H) in targeting social communication deficits in young children with autism spectrum disorder (ASD) with significant language dela…

    Stage

    Not phased

    Ages

    2 to 5

    Site

    Stanford University School of Medicine, Stanford, California

    Run by

    Stanford University

    See if you can join NCT04899544 on ClinicalTrials.gov

23. Autism Research Project With Non-Invasive Near-Infrared Light Stimulation

    The investigators have previously shown that the administration of low-level infrared light is a safe and non-invasive procedure which improves cognition and emotion, as well as enhances brain metabolic activity. Based on previous studies, the investigators hypothesize that this methodology, called…

    Stage

    Not phased

    Ages

    4 to 60

    Site

    Seay Psychology Building, Room 3.304, Austin, Texas

    Run by

    Francisco Gonzalez-Lima, PhD

    See if you can join NCT06203938 on ClinicalTrials.gov

24. Trial of an Online Spanish Pivotal Response Treatment Training in Autism Spectrum Disorder

    The goal of this clinical trial is to understand if an online course in Spanish can help Spanish-speaking parents use Pivotal Response Treatment (PRT) to support language and social skills in young children with Autism Spectrum Disorder (ASD). This study aims to reach families who may have trouble …

    Stage

    Not phased

    Ages

    2 to 5

    Site

    Stanford University, Palo Alto, California

    Run by

    Stanford University

    See if you can join NCT06690255 on ClinicalTrials.gov

25. Effectiveness- Implementation Trial of the Function-Based Elopement Treatment

    The goal of this clinical trial is to test whether the Function-Based Elopement Treatment (FBET) can reduce elopement in children aged 4-12 with autism spectrum disorder (ASD), and to assess its feasibility in community-based Applied Behavior Analysis (ABA) clinics. Researchers will evaluate FBET i…

    Stage

    Not phased

    Ages

    4 to 12

    Site

    Marcus Autism Center, Atlanta, Georgia

    Run by

    Emory University

    See if you can join NCT07194083 on ClinicalTrials.gov