Asthma Clinical Trials

63 studies are recruiting for asthma in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. QUARTZ: Comparative Effectiveness of Switching From Albuterol to Albuterol/Budesonide Versus Adding Low-dose ICS or LTRA to Albuterol

   The QUARTZ study is a retrospective observational cohort study using a prevalent new-user design and U.S. healthcare claims data to evaluate treatment effectiveness among patients with asthma. The study compares the real-world effectiveness of switching from albuterol-only rescue therapy to albuter…

   Stage

   Not phased

   Ages

   18 to 99

   Site

   Research Site, Wilmington, Delaware

   Run by

   AstraZeneca

   See if you can join NCT07787117 on ClinicalTrials.gov

2. Personalized Environment and Genes Study

   Despite the overwhelming focus on genetic and genomic causes of human disease over the past two decades, it has been estimated that genetics is currently known to explain only 20% and 40% of the etiology of common disease. Thus, it is becoming increasingly apparent that human disease is a consequen…

   Stage

   Not phased

   Ages

   18 to 120

   Site

   University of North Carolina, Chapel Hill, North Carolina

   Locations

   2 in total

   Run by

   National Institute of Environmental Health Sciences (NIEHS)

   See if you can join NCT00341237 on ClinicalTrials.gov

3. Study of the Effect of Innate on the Inflammatory Response to Endotoxin

   Background: - Innate immunity is the process by which white blood cells and other parts of the immune system sense and respond to potential infections by causing an inflammation. Researchers are interested in studying how the body responds to certain environmental factors, and whether the body s re…

   Stage

   Not phased

   Ages

   18 to 100

   Site

   NIEHS Clinical Research Unit (CRU), Research Triangle Park, North Carolina

   Run by

   National Institute of Environmental Health Sciences (NIEHS)

   See if you can join NCT01143480 on ClinicalTrials.gov

4. Boosting Referrals to Asthma Specialists for Patients Seen at the Emergency Room for an Asthma Exacerbation

   This study is testing a new way to help adults with asthma get follow up care after an emergency room (ER) visit for an asthma attack. Many people who come to the ER for asthma never see an asthma specialist afterward, even though specialists can offer treatments such as advanced inhalers or biolog…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Tampa General Hospital Emergency Room, Tampa, Florida

   Run by

   Juan Carlos Cardet

   See if you can join NCT07396987 on ClinicalTrials.gov

5. A Study to Investigate the Efficacy and Safety of Tezepelumab Compared With Placebo in Children 5 to < 12 Years Old With Severe Asthma

   To assess the efficacy and safety of tezepelumab in pediatric participants with severe uncontrolled asthma on medium to high-dose inhaled corticosteroids (ICS) and at least one additional asthma controller medication with or without oral corticosteroids.

   Stage

   Phase 3

   Ages

   5 to 11

   Site

   Research Site, Montgomery, Alabama

   Locations

   147 in total

   Run by

   AstraZeneca

   See if you can join NCT06023589 on ClinicalTrials.gov

6. Role of Genetic Factors in the Development of Lung Disease

   This study is designed to evaluate the genetics involved in the development of lung disease by surveying genes involved in the process of breathing and examining the genes in lung cells of patients with lung disease. The study will focus on defining the distribution of abnormal genes responsible fo…

   Stage

   Not phased

   Ages

   2 to 90

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Locations

   2 in total

   Run by

   National Heart, Lung, and Blood Institute (NHLBI)

   See if you can join NCT00001532 on ClinicalTrials.gov

7. A Study to Compare the Efficacy, Safety and Tolerability of FF/UMEC/VI With FF/VI in 12-17-year-olds With Asthma

   The primary purpose of this study is to evaluate the effects of Fluticasone Furoate (FF)/ Umeclidinium (UMEC)/ Vilanterol (VI) on lung function compared with FF/VI after 24 weeks of treatment.

   Stage

   Phase 3

   Ages

   12 to 17

   Site

   GSK Investigational Site, Birmingham, Alabama

   Locations

   67 in total

   Run by

   GlaxoSmithKline

   See if you can join NCT05757102 on ClinicalTrials.gov

8. ASTHMAXcel Voice Study

   The objective of this study is to conduct a randomized controlled trial (RCT) to compare the adapted and refined ASTHMAXcel Voice platform to usual care (UC). It is hypothesized by the investigator team that ASTHMAXcel Voice will be associated with improved clinical and process outcomes, asthma qua…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Montefiore Medical Center, The Bronx, New York

   Run by

   Montefiore Medical Center

   See if you can join NCT06935084 on ClinicalTrials.gov

9. A Study Evaluating Disease Characteristics and Outcomes in Participants With Asthma in Routine Clinical Practice

   The main aim of the study to describe the characteristics of participants with asthma across the spectrum of disease severity, including sociodemographic and clinical characteristics, treatment and disease burden, biomarkers, and both disease-specific and generic health-related quality of life. The…

   Stage

   Not phased

   Ages

   6 and older

   Site

   Del Sol Research Management, LLC - Mesa - Site Number: 840123, Mesa, Arizona

   Locations

   62 in total

   Run by

   Sanofi

   See if you can join NCT07556159 on ClinicalTrials.gov

10. A Study to Learn How Different Amounts of the Study Medicine Called PF-08103402 Are Tolerated and Act in the Body in Healthy Adults or Adults With Mild To-moderate Asthma

    The purpose of this study is to learn about the safety of a new study medicine called PF-08103402 in healthy adults (do not have disease) and or in adults with mild-to-moderate asthma. This is the first time the study medicine is being given to people. For Parts A, B, C, D and F, the study is seeki…

    Stage

    Phase 1

    Ages

    18 to 65

    Site

    Pfizer Clinical Research Unit - New Haven, New Haven, Connecticut

    Run by

    Pfizer

    See if you can join NCT07660731 on ClinicalTrials.gov

11. NHALES (Natural History of Asthma With Longitudinal Environmental Sampling)

    Background: - Asthma is a serious clinical and public health problem. Researchers want to collect data to better understand how bacteria and other things in the environment can affect people's asthma. Eligibility: - Nonsmoking adults age 18 - 60 who have moderate to severe asthma. Design: * Partici…

    Stage

    Not phased

    Ages

    18 to 60

    Site

    NIEHS Clinical Research Unit (CRU), Research Triangle Park, North Carolina

    Run by

    National Institute of Environmental Health Sciences (NIEHS)

    See if you can join NCT02327897 on ClinicalTrials.gov

12. A Randomized, Double-Blind, Placebo-Controlled Trial on Efficacy and Safety of Fluticasone Propionate/Albuterol Sulfate Combination in Participants 12 Years and Older With Asthma

    The primary objective of the trial is to evaluate the efficacy of fluticasone propionate/albuterol sulfate multidose dry powder inhaler with electronic module (Fp/ABS eMDPI). Secondary objectives are: * To evaluate the efficacy of Fp/ABS eMDPI administered four times daily * To evaluate the safety …

    Stage

    Phase 3

    Ages

    12 and older

    Site

    Teva Investigational Site 12087, Phoenix, Arizona

    Locations

    189 in total

    Run by

    Teva Branded Pharmaceutical Products R&D LLC

    See if you can join NCT06664619 on ClinicalTrials.gov

13. A Phase II Study to Investigate Lung Function With 2 Different Doses of Inhaled Glycopyrronium Taken With BFF Compared to BFF in Participants of 4 to Less Than 12 Years of Age With Asthma

    The purpose of this study is to evaluate the effect of 2 different GP metered dose inhaler (MDI) doses relative to placebo MDI as add-on treatment to BFF MDI on lung function in participants 4 to less than 12 years of age with asthma.

    Stage

    Phase 2

    Ages

    4 to 11

    Site

    Research Site, Bakersfield, California

    Locations

    43 in total

    Run by

    AstraZeneca

    See if you can join NCT07525375 on ClinicalTrials.gov

14. A Study of Depemokimab in Participants of 6 to 11 Years of Age

    This study is aimed at assessing depemokimab as an add-on medicine for the treatment of asthma with type-2 inflammation in participants of 6 to 11 years of age. This study will test how the body processes depemokimab, how the drug works in the body, and its safety and tolerability.

    Stage

    Phase 3

    Ages

    6 to 11

    Site

    GSK Investigational Site, Mobile, Alabama

    Locations

    3 in total

    Run by

    GlaxoSmithKline

    See if you can join NCT07671001 on ClinicalTrials.gov

15. Registry of Asthma Characterization and Recruitment 3 (RACR3)

    This is a multi-center, non-interventional registry to create and maintain a database of participants to serve as a recruitment source for current and future DAIT NIAID-sponsored Childhood Asthma in Urban Settings (CAUSE) studies.

    Stage

    Not phased

    Ages

    Any age

    Site

    Children's Hospital Colorado: Allergy Program, Aurora, Colorado

    Locations

    7 in total

    Run by

    National Institute of Allergy and Infectious Diseases (NIAID)

    See if you can join NCT05272241 on ClinicalTrials.gov

16. A Study to Evaluate Brenipatide Compared With Placebo in Adult Participants With Uncontrolled Moderate to Severe Asthma

    The purpose of this study is to assess the safety and efficacy of brenipatide at different dose levels compared with placebo in participants with moderate-to-severe asthma. Study participation will last approximately 65 weeks, including screening, treatment, and follow-up periods.

    Stage

    Phase 2

    Ages

    18 to 75

    Site

    AMR Clinical, Tempe, Arizona

    Locations

    121 in total

    Run by

    Eli Lilly and Company

    See if you can join NCT07219173 on ClinicalTrials.gov

17. Roll-over Study for Participants Who Have Completed a Previous Clinical Study With Benralizumab (Fasenra) and Benefit From Continued Treatment

    The rationale of the roll-over study (ROSY) is to provide continuous access to study treatment for participants who have completed or exited a parent study and are deemed appropriate for continued benralizumab treatment, as judged by the Investigator, while monitoring long-term safety and tolerabil…

    Stage

    Phase 3

    Ages

    6 and older

    Site

    Research Site, Toronto, Ontario

    Locations

    45 in total

    Run by

    AstraZeneca

    See if you can join NCT07444567 on ClinicalTrials.gov

18. A Study of Efficacy and Safety of Depemokimab Compared With Placebo in Adults and Adolescents With at Risk Type 2 Asthma

    The aim of this study is to evaluate the efficacy of depemokimab administered as an adjunctive therapy, in participants with Type 2 asthma at risk of exacerbations compared to the guideline recommended standard of care (SoC).

    Stage

    Phase 3

    Ages

    12 and older

    Site

    GSK Investigational Site, Little Rock, Arkansas

    Locations

    17 in total

    Run by

    GlaxoSmithKline

    See if you can join NCT07456033 on ClinicalTrials.gov

19. Evaluating the Efficacy and Safety of PT027 Compared With PT007 Administered As Needed in Participants 12 to < 18 Years of Age With Asthma

    The purpose of this study is to compare the effect of budesonide/albuterol metered-dose inhaler (BDA MDI) with albuterol sulfate metered-dose inhaler (AS MDI), both administered as needed, on the annualized rate of severe asthma exacerbations in adolescents with a documented clinical diagnosis of a…

    Stage

    Phase 3

    Ages

    12 to 17

    Site

    Research Site, Anchorage, Alaska

    Locations

    150 in total

    Run by

    AstraZeneca

    See if you can join NCT06307665 on ClinicalTrials.gov

20. Measuring the Effect of Dupilumab Treatment on Mucociliary Clearance (MCC) in Subjects With Moderate to Severe Asthma

    Single center, randomized, placebo- controlled study to assess change in mucociliary clearance of moderate to severe asthma patients after treatment with dupilumab or placebo.

    Stage

    Phase 4

    Ages

    18 and older

    Site

    The University of Pittsburgh Asthma Institute at UPMC, Pittsburgh, Pennsylvania

    Run by

    Sally E. Wenzel MD

    See if you can join NCT04743791 on ClinicalTrials.gov

21. Comparison of Microglial Activation in Severe Asthma and Healthy Controls

    The goal of this clinical trial is to learn about how asthma influences brain function. The main questions it aims to answer are: * How airway inflammation in asthma affects the brain; and, * Whether airway inflammation in asthma is related to symptoms of depression and anxiety Over the course of 3…

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Center for Healthy Minds, Madison, Wisconsin

    Run by

    University of Wisconsin, Madison

    See if you can join NCT06299592 on ClinicalTrials.gov

22. ENV-294 for Moderate-to-Severe Asthma: A 12-Week Study in Adults

    This study will evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and potential efficacy of ENV-294 in adults with moderate to severe asthma who are receiving background treatment with inhaled corticosteroids (ICS) and long-acting beta₂-agonists (LABA). Participants w…

    Stage

    Phase 2

    Ages

    18 to 75

    Site

    Enveda Investigative Site, Birmingham, Alabama

    Locations

    18 in total

    Run by

    Enveda Therapeutics

    See if you can join NCT07301255 on ClinicalTrials.gov

23. A Comparative Study to Investigate the Difference in Blood Levels of Two Different Formulations of GSK5784283

    The purpose of this study is to compare how two different formulations of the study medicine (GSK5784283) move through the body over time (pharmacokinetic [PK] study) in healthy adults. The aim of the study is to see how the body processes GSK5784283 and determine if the study medicine is safe, how…

    Stage

    Phase 1

    Ages

    18 to 60

    Site

    GSK Investigational Site, Austin, Texas

    Run by

    GlaxoSmithKline

    See if you can join NCT07712393 on ClinicalTrials.gov

24. Giving Asthmatics Intramuscular Steroids for Preventing Return to the Emergency Department

    This study aims to compare the efficacy of a one-time IM dose of dexamethasone versus a 5-day course of prednisone in adult ED patients presenting with asthma exacerbations. This is a randomized, controlled, double-blind, non-inferiority trial conducted at two urban EDs within the Montefiore Health…

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Montefiore Medical Center, The Bronx, New York

    Run by

    Montefiore Medical Center

    See if you can join NCT07228052 on ClinicalTrials.gov

25. Dose Range Finding Study to Assess Efficacy and Safety of Tozorakimab in Adults With Uncontrolled Asthma on Medium-to-High Dose Inhaled Corticosteroids

    This is a dose-range finding, double-blind, placebo-controlled, phase IIb study designed to assess efficacy and safety of tozorakimab administered subcutaneously in adult participants with uncontrolled asthma receiving medium-to-high dose inhaled corticosteroids.

    Stage

    Phase 2

    Ages

    18 to 75

    Site

    Research Site, Bakersfield, California

    Locations

    221 in total

    Run by

    AstraZeneca

    See if you can join NCT06932263 on ClinicalTrials.gov