Aortic Stenosis Clinical Trials in Boston, Massachusetts

5 studies are recruiting for aortic stenosis in Boston, Massachusetts right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis

   The purpose of this study is to evaluate the efficacy, safety and tolerability of pelacarsen (TQJ230) administered subcutaneously once monthly compared to placebo in slowing the progression of calcific aortic valve stenosis.

   Stage

   Phase 2

   Ages

   50 to 80

   Site

   Tufts Medical Center, Boston, Massachusetts

   Locations

   140 in total

   Run by

   Novartis Pharmaceuticals

   See if you can join NCT05646381 on ClinicalTrials.gov

2. REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE

   The purpose of this study is to generate clinical evidence on valve safety and performance in subjects treated by redo Transcatheter Aortic Valve Replacement (TAVR).

   Stage

   Not phased

   Ages

   18 to 105

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Locations

   71 in total

   Run by

   Medtronic Cardiovascular

   See if you can join NCT06777368 on ClinicalTrials.gov

3. Staged Complete Revascularization for Coronary Artery Disease vs Medical Management Alone in Patients With AS Undergoing Transcatheter Aortic Valve Replacement

   Patients undergoing transcatheter aortic valve replacement (TAVR) often have concomitant coronary artery disease (CAD) which may adversely affect prognosis. There is uncertainty about the benefits and the optimal timing of revascularization for such patients. There is currently clinical equipoise r…

   Stage

   Not phased

   Ages

   Any age

   Site

   Tufts Medical, Boston, Massachusetts

   Locations

   72 in total

   Run by

   University of British Columbia

   See if you can join NCT04634240 on ClinicalTrials.gov

4. PARTNER 3 Trial - Aortic Valve-in-Valve

   This study will assess the safety and effectiveness of the SAPIEN 3/SAPIEN 3 Ultra transcatheter heart valve (THV) in patients with a failing aortic bioprosthetic valve.

   Stage

   Not phased

   Ages

   Any age

   Site

   Brigham and Women's Hospital, Boston, Massachusetts

   Locations

   51 in total

   Run by

   Edwards Lifesciences

   See if you can join NCT03003299 on ClinicalTrials.gov

5. The HALT Biomarker Study

   The purpose of the HALT Biomarkers study are to identify a panel of circulating proteins that discriminates between patients with and without Hypo-Attenuated Leaflet Thickening (HALT) and can be used to supplement the diagnosis of HALT; to characterize changes in circulating proteins after treatmen…

   Stage

   Phase 1

   Ages

   65 and older

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Locations

   3 in total

   Run by

   Massachusetts General Hospital

   See if you can join NCT04552275 on ClinicalTrials.gov