Aortic Stenosis Clinical Trials

16 studies are recruiting for aortic stenosis in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. CAPTURE-2: Controlled Arterial Protection to Ultimately Remove Embolic Material

   The objective of this study is to demonstrate safety and efficacy of the EmStop Embolic Protection System when used as indicated to capture and remove thrombus/debris during self-expanding transcatheter aortic valve replacement (TAVR) procedures.

   Stage

   Not phased

   Ages

   22 and older

   Site

   Los Robles Regional Medical Center, Thousand Oaks, California

   Locations

   7 in total

   Run by

   EmStop Inc

   See if you can join NCT07276711 on ClinicalTrials.gov

2. Improved Outcomes With Pre-Procedure Shockwave IVL of Common Femoral Artery Access Site Prior to Large Bore Access and Pre-Closure

   The primary purpose of this study is to observe reduced access site complications in patients with heavily calcified common femoral arteries requiring Transcatheter Aortic Valve Replacement (TAVR)

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Tennessee Medical Center, Knoxville, Tennessee

   Run by

   University of Tennessee Graduate School of Medicine

   See if you can join NCT07205068 on ClinicalTrials.gov

3. Study of the Progression of Chronic Cardiovascular Conditions

   This study will collect physiologic data in patients with cardiovascular conditions and observe the natural history of those conditions for research purposes.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Prolaio, Chicago, Illinois

   Run by

   Prolaio

   See if you can join NCT07420907 on ClinicalTrials.gov

4. A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis

   The purpose of this study is to evaluate the efficacy, safety and tolerability of pelacarsen (TQJ230) administered subcutaneously once monthly compared to placebo in slowing the progression of calcific aortic valve stenosis.

   Stage

   Phase 2

   Ages

   50 to 80

   Site

   Heart Center Research Llc, Huntsville, Alabama

   Locations

   140 in total

   Run by

   Novartis Pharmaceuticals

   See if you can join NCT05646381 on ClinicalTrials.gov

5. REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE

   The purpose of this study is to generate clinical evidence on valve safety and performance in subjects treated by redo Transcatheter Aortic Valve Replacement (TAVR).

   Stage

   Not phased

   Ages

   18 to 105

   Site

   University of Alabama at Birmingham, Birmingham, Alabama

   Locations

   71 in total

   Run by

   Medtronic Cardiovascular

   See if you can join NCT06777368 on ClinicalTrials.gov

6. Correlation Between an Impedance Cardiography Test for Decompensation and the Development of Left Ventricular Replacement Fibrosis

   The purpose of this study is to evaluate the effectiveness of impedance cardiography (ICG), the HYPERGRAPH test, in detecting left ventricular decompensation in patients with aortic stenosis, compared to cardiac magnetic resonance (CMR) imaging findings. The study aims to obtain usable ICG test dat…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Northwestern University, Chicago, Illinois

   Run by

   Dermed Diagnostics, Inc.

   See if you can join NCT07230964 on ClinicalTrials.gov

7. DELINEATE-Prospective

   Heart disease is the leading cause of death in the United States, and echocardiography (or "echo") is the most common way doctors look at the heart. Echo is safe, painless, and can detect major heart problems, including weak heart pumping and valve disease. Valve disease, especially aortic stenosis…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Columbia University Irving Medical Center, New York, New York

   Run by

   Columbia University

   See if you can join NCT07197736 on ClinicalTrials.gov

8. STAR Trial (Siegel Transcatheter Aortic Valve Replacement in Patients With Symptomatic Severe Aortic Stenosis)

   To evaluate the safety and efficacy of Siegel™ TAVR System in the treatment of subjects with symptomatic severe native aortic stenosis.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Piedmont Heart Institute, Atlanta, Georgia

   Run by

   MiRus

   See if you can join NCT07278310 on ClinicalTrials.gov

9. AI in Outpatient Practice for Diagnosing Aortic Stenosis and Diastolic Dysfunction

   Two recently developed artificial intelligence-enabled electrocardiogram (AI-ECG) models have been developed to detect aortic stenosis (AS) and diastolic dysfunction (DD). AI-ECG for AS has a sensitivity of 78% and specificity of 74%, and AI-ECG for DD has a sensitivity of 83% and specificity of 80…

   Stage

   Not phased

   Ages

   60 and older

   Site

   Mayo Clinic, Rochester, Minnesota

   Run by

   Mayo Clinic

   See if you can join NCT06580158 on ClinicalTrials.gov

10. Comparative Imaging Assessment of Valvular Heart Disease

    The purpose of the study is to compare the various 2D and 3D methods of valvular heart disease quantification (Doppler, PISA, VCA, volumetric method) and strain with cardiac magnetic resonance (CMR) measurements of left and right ventricular systolic function strain and myocardial fibrosis assessme…

    Stage

    Not phased

    Ages

    18 to 90

    Site

    Cleveland Clinic, Cleveland, Ohio

    Run by

    The Cleveland Clinic

    See if you can join NCT04126018 on ClinicalTrials.gov

11. Novel Characterization of Sex Specific Biologic Signatures in Valvular Heart Disease

    This project aims to validate sex-specific biologic signatures associated with aortic valve disease developed in a large multicenter CMR registry, using unsupervised phenomapping. The aim to use standard and advanced CMR techniques (MRF, DTI, chemical exchange transfer, and radiomics analysis) is t…

    Stage

    Not phased

    Ages

    18 to 90

    Site

    Cleveland Clinic, Cleveland, Ohio

    Run by

    The Cleveland Clinic

    See if you can join NCT06780241 on ClinicalTrials.gov

12. Staged Complete Revascularization for Coronary Artery Disease vs Medical Management Alone in Patients With AS Undergoing Transcatheter Aortic Valve Replacement

    Patients undergoing transcatheter aortic valve replacement (TAVR) often have concomitant coronary artery disease (CAD) which may adversely affect prognosis. There is uncertainty about the benefits and the optimal timing of revascularization for such patients. There is currently clinical equipoise r…

    Stage

    Not phased

    Ages

    Any age

    Site

    Huntsville Heart Center, Huntsville, Alabama

    Locations

    72 in total

    Run by

    University of British Columbia

    See if you can join NCT04634240 on ClinicalTrials.gov

13. Long Term Evaluation of Cardiac Arrhythmias After Transcatheter Aortic Valve Implantation -The LOCATE Registry

    The purpose of the Long term Evaluation of Cardiac Arrhythmias after Transcatheter Aortic Valve Implantation (LOCATE) Registry is to perform long-term ambulatory monitoring of patients with severe aortic stenosis who undergo trans-catheter aortic valve implantation (TAVI) and develop new onset cond…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Research Medical Center Clinic, Kansas City, Missouri

    Locations

    2 in total

    Run by

    Kansas City Heart Rhythm Research Foundation

    See if you can join NCT06055751 on ClinicalTrials.gov

14. Loss of Y Chromosome in Aortic Stenosis

    The most common heart valve disease in humans is aortic stenosis which is a critical narrowing of the valve through which the heart has to pump blood to the rest of the body. This condition occurs in 2-3% of adults over 65 years of age and when it progresses to a severe stage leads to heart failure…

    Stage

    Not phased

    Ages

    40 and older

    Site

    University of Virginia, Charlottesville, Virginia

    Run by

    University of Virginia

    See if you can join NCT06595407 on ClinicalTrials.gov

15. PARTNER 3 Trial - Aortic Valve-in-Valve

    This study will assess the safety and effectiveness of the SAPIEN 3/SAPIEN 3 Ultra transcatheter heart valve (THV) in patients with a failing aortic bioprosthetic valve.

    Stage

    Not phased

    Ages

    Any age

    Site

    Banner University Medical Center, Phoenix, Arizona

    Locations

    51 in total

    Run by

    Edwards Lifesciences

    See if you can join NCT03003299 on ClinicalTrials.gov

16. The HALT Biomarker Study

    The purpose of the HALT Biomarkers study are to identify a panel of circulating proteins that discriminates between patients with and without Hypo-Attenuated Leaflet Thickening (HALT) and can be used to supplement the diagnosis of HALT; to characterize changes in circulating proteins after treatmen…

    Stage

    Phase 1

    Ages

    65 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Locations

    3 in total

    Run by

    Massachusetts General Hospital

    See if you can join NCT04552275 on ClinicalTrials.gov