Anxiety Clinical Trials

135 studies are recruiting for anxiety in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Open-Label Psilocybin Study in Transdiagnostic Population

   The primary objective of this study is to investigate the safety, feasibility, and tolerability of psilocybin treatment in individuals with functional impairment due to psychiatric symptoms. The secondary objective of this study is to determine whether individuals with functional impairments due to…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Connecticut Mental Health Center - Yale School of Medicine, New Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT06442423 on ClinicalTrials.gov

2. The Mindful Smartphone Use Study

   The goal of this clinical trial is to understand the feasibility and acceptability on a mindfulness-based intervention to address co-existing smartphone addiction and psychological distress among adolescents ages 13-19 self-reporting elevated levels of depression and/or anxiety symptoms and problem…

   Stage

   Not phased

   Ages

   13 to 19

   Site

   Brown University, Providence, Rhode Island

   Run by

   Brown University

   See if you can join NCT07892807 on ClinicalTrials.gov

3. Impact of Virtual Reality on Anxiety in Patients Undergoing Interventional Procedures

   Periprocedural anxiety is a common problem for patients who undergo interventional pain procedures. Virtual Reality (VR) is an immersive experience that has gained acceptance in the medical field as a tool for reducing anxiety and pain for patients.Research Aim: To evaluate the effect of immersive …

   Stage

   Not phased

   Ages

   18 to 80

   Site

   Anesthesiology Pain Medicine Center, Chicago, Illinois

   Run by

   Northwestern University

   See if you can join NCT05744336 on ClinicalTrials.gov

4. VITAL - Virginia Tech Accelerated Holographic LIFU for Anxiety

   Testing repeated applications of low-intensity focused ultrasound (LIFU) on anxiety symptoms and outcomes.

   Stage

   Not phased

   Ages

   18 to 65

   Site

   Fralin Biomedical Research Institute at VTC, Roanoke, Virginia

   Run by

   Virginia Polytechnic Institute and State University

   See if you can join NCT07404878 on ClinicalTrials.gov

5. Digital Intervention for Physical Activity

   The present study will assess the effects of a four-week digitally delivered intervention on physical activity and depressive symptoms among adults experiencing at least moderate depressive symptoms. The main questions this research aims to answer are: * Does a digitally-delivered intervention incr…

   Stage

   Not phased

   Ages

   19 to 40

   Site

   Kinesiology Building, Auburn, Alabama

   Run by

   Auburn University

   See if you can join NCT07130734 on ClinicalTrials.gov

6. Focused Ultrasound for Behavioral Health

   This is a double-blind, within-participant crossover, multi-site dose-finding study evaluating the safety, feasibility, and preliminary efficacy of repeated low-intensity focused ultrasound (LIFU) stimulation using the ATTN201 device across seven candidate deep-brain targets in adults with subsyndr…

   Stage

   Not phased

   Ages

   22 to 80

   Site

   Attune, San Francisco Clinical Research Center, San Francisco, California

   Locations

   2 in total

   Run by

   Attune Neurosciences Inc

   See if you can join NCT07851038 on ClinicalTrials.gov

7. Music Interventions During Wide-Awake Hand Surgery

   The purpose of this study is to examine if patients have a lower anxiety level during wide awake hand surgery while listening to their choice of music vs standardized relaxation music. Patients who are planning to undergo wide awake (local anesthetic only hand surgery) and agree to participate will…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Wisconsin, Madison, Wisconsin

   Run by

   University of Wisconsin, Madison

   See if you can join NCT05472909 on ClinicalTrials.gov

8. Evaluation of the PACE/PACENET BHL Clinical Program

   The SUpporting Seniors Receiving Treatment And INtervention (SUSTAIN) program is a telephone-based clinical service designed to help identify and manage behavioral health issues among PACE/PACENET enrollees. The purpose of the current project is to a) explore moderators of treatment response among …

   Stage

   Not phased

   Ages

   65 and older

   Site

   Department of Psychiatry (Center for Psychotherapy Research), University of Pennsylvania, Philadelphia, Pennsylvania

   Run by

   University of Pennsylvania

   See if you can join NCT02463266 on ClinicalTrials.gov

9. A Mechanistic Study to Assess a Single Dose of CYB003 in Participants With Depression and Anxiety

   The goal of this study is to learn how psychedelics may help symptoms of depression and anxiety. Participants with major depressive disorder experiencing symptoms of depression and anxiety will receive one dose of either a drug related to psilocybin or a placebo. Assessments include interviews, sel…

   Stage

   Phase 2

   Ages

   21 to 65

   Site

   The Ohio State University Department of Psychiatry, Columbus, Ohio

   Run by

   Ohio State University

   See if you can join NCT06820723 on ClinicalTrials.gov

10. Development of a College Student-Delivered Cognitive-Behavioral Therapy (CBT) Intervention for Rural High School Students

    This research is being done to find out the effectiveness, feasibility, and acceptability of a college student-delivered cognitive-behavioral therapy (CBT) intervention in high schools in rural Schuylkill County, Pennsylvania to treat mental health problems (i.e. depression and anxiety) in adolesce…

    Stage

    Not phased

    Ages

    13 to 18

    Site

    Penn State College of Medicine, Hershey, Pennsylvania

    Run by

    Milton S. Hershey Medical Center

    See if you can join NCT07240792 on ClinicalTrials.gov

11. Readiness and Progress in Emotion Regulation Therapy

    This study is an open trial designed to examine individual changes that occur before, during, and after 6 modules of Emotion Regulation Therapy (ERT) delivered via telehealth for individuals in New York State who are experiencing elevated worry, rumination, or self-criticism.

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Teachers College, Columbia University, New York, New York

    Run by

    Teachers College, Columbia University

    See if you can join NCT07478393 on ClinicalTrials.gov

12. SER Familia: A Family-Based Intervention Addressing Syndemic Conditions Among Latino Families

    This study aims to prevent syndemic health conditions by decreasing acculturative stress and promoting resilience via SER Familia (Salud, Estrés y Resilencia en Familias/ Health, Stress, and Resilience in Families), a family-based intervention. SER Familia is a six-session intervention co-developed…

    Stage

    Not phased

    Ages

    12 to 100

    Site

    Duke School of Nursing, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT06627764 on ClinicalTrials.gov

13. Sleep, Dreaming, and Virtual Reality for Mental Health

    People spend approximately one-third of their lives asleep, yet sleep is often underused as an opportunity to support psychological well-being. Contemplative traditions, including Tibetan Dream Yoga, have developed practices that use waking imagination and lucid dreaming to explore perception, awar…

    Stage

    EARLY_Phase 1

    Ages

    18 and older

    Site

    Northwestern University, Evanston, Illinois

    Locations

    2 in total

    Run by

    Northwestern University

    See if you can join NCT07408206 on ClinicalTrials.gov

14. Heart Rate Variability Biofeedback for Anxiety in Autistic Youth

    Heart rate variability biofeedback (HRVB) is a breathing-based intervention that reduces anxiety in a range of populations. Second-generation wearable HRVB devices not only deliver scheduled biofeedback practice sessions but also allow patients to practice HRVB in-the-moment when it is needed most.…

    Stage

    Phase 2

    Ages

    12 to 17

    Site

    Lurie Center, Lexington, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT07812233 on ClinicalTrials.gov

15. Psychological Prehabilitation for Complex Gastrointestinal Surgery

    The goal of this clinical trial is to learn if a psychological program before surgery can help adults who have lasting stress from past medical experiences. The program is called PREPARE-GI. It is for adults having planned, complex surgery on the digestive system, also called gastrointestinal (GI) …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Northwestern Memorial Hospital, Chicago, Illinois

    Run by

    Northwestern University

    See if you can join NCT07865052 on ClinicalTrials.gov

16. CommunityRx-Dementia + Peer Navigation (CRxDpeer)

    The CRxDpeer intervention, delivered by a trained peer navigator, in practice called a "peer mentor", includes three evidence-based components: (a) focused education about common social (e.g., food and housing insecurity) and caregiving (e.g., respite and end of life care) needs, (b) activation of …

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Chicago, Chicago, Illinois

    Run by

    University of Chicago

    See if you can join NCT07346183 on ClinicalTrials.gov

17. The Use of a Comfort Tote to Improve Recovery in Pediatric and Adolescent Patients After Surgery

    The goal of this clinical trial is to learn if the use of Comfort Tote can treat pain and anxiety in adolescents with idiopathic scoliosis undergoing posterior spinal fusion. The study aims to answer two questions: 1. To characterize the effectiveness and determine the impact of integrative therapy…

    Stage

    Not phased

    Ages

    12 to 21

    Site

    NewYork Presbyterian Hospital / Columbia University Irving Medical Center, New York, New York

    Run by

    Columbia University

    See if you can join NCT07632833 on ClinicalTrials.gov

18. Adapting and Pilot Testing a Skills-based Smoking Cessation Intervention to Address Developmental and Health-related Stress Among Adults Who Smoke

    Smoking remains the leading preventable cause of death in the United States, and there are persistent and significant disparities in tobacco use among transgender and gender diverse (TGD) individuals. Stigma, discrimination, gender dysphoria, and other gender minority stressors likely contribute to…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Fenway Health, Boston, Massachusetts

    Locations

    3 in total

    Run by

    Massachusetts General Hospital

    See if you can join NCT06654414 on ClinicalTrials.gov

19. Mind-body Resilience Program for Cardiac Arrest Survivors and Their Caregivers: Recovering Together After Cardiac Arrest

    The purpose of this study is to pilot two resilience interventions for cardiac arrest survivors and their informal caregivers, Recovering Together after Cardiac Arrest 1 and Recovering Together after Cardiac Arrest 2 . The data the investigators gather in this study will be used to further refine t…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mount Sinai Health System, New York, New York

    Locations

    2 in total

    Run by

    Icahn School of Medicine at Mount Sinai

    See if you can join NCT07143357 on ClinicalTrials.gov

20. IMST for Dementia Risk Reduction

    Using a 2-arm, RCT approach, the primary goal of the study is to evaluate the feasibility and preliminary efficacy of Inspiratory Muscle Strength Training (IMST) as a non-pharmacologic intervention to reduce cardiovascular and cognitive risks in older adults. Next, investigators will examine second…

    Stage

    Not phased

    Ages

    60 to 80

    Site

    Florida State University, Tallahassee, Florida

    Run by

    Florida State University

    See if you can join NCT07349706 on ClinicalTrials.gov

21. HBOT Effects on First Responders' Cognition and Well-Being

    The goal of this study is to examine changes in cognitive functioning and post-concussive symptoms following hyperbaric oxygen therapy (HBOT) in current and former first responders with a history of traumatic brain injury. The main questions it aims to answer are: 1. Do cognitive functioning and po…

    Stage

    Phase 2

    Ages

    18 to 75

    Site

    Summit Hyperbarics and Wellness, Boise, Idaho

    Run by

    Summit Hyperbarics and Wellness

    See if you can join NCT07852728 on ClinicalTrials.gov

22. Binaural Beats for Postoperative Pain and Anxiety Reduction

    To deliver a 30-minute binaural beats audio intervention in PACU and collect pain and anxiety outcomes immediately following surgery, and 4 hours following surgery completion in adults undergoing ambulatory total knee arthroplasty and total hip arthroplasty (TKA and THA).

    Stage

    Not phased

    Ages

    18 to 99

    Site

    Univeristy of Miami Health System, Miami, Florida

    Run by

    University of Miami

    See if you can join NCT07437469 on ClinicalTrials.gov

23. Preoperative Music Intervention for Anxiety in Hip and Knee Arthroplasty

    Many patients feel anxious before joint replacement surgery. This anxiety is common - affecting roughly 1 in 3 patients - and research has shown that patients who are more anxious before surgery tend to have more pain afterward and may need more pain medication during recovery. Listening to music b…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Columbia University Irving Medical Center - Milstein Hospital, New York, New York

    Run by

    Columbia University

    See if you can join NCT07845695 on ClinicalTrials.gov

24. Neurobiological Mechanisms of Aging and Stress on Prospective Navigation

    Two hallmarks of both healthy aging and age-related disease are 1) memory and navigational deficits, particularly in orienting towards goal locations and planning how to navigate to them, and 2) increased susceptibility to stress and altered regulation of the stress response. However, there are mar…

    Stage

    Not phased

    Ages

    65 to 80

    Site

    Center for Advance Brain Imaging, Atlanta, Georgia

    Run by

    Georgia Institute of Technology

    See if you can join NCT03896529 on ClinicalTrials.gov

25. Mobile Cognitive Behavioral Therapy in Early Stroke Recovery

    This study aims to pilot "Maya," a mobile cognitive behavioral therapy app, for use in adults with stroke experiencing depression and/or anxiety. This study will assess the acceptability, feasibility, and preliminary efficacy of Maya within the acute rehabilitation period.

    Stage

    Not phased

    Ages

    18 to 79

    Site

    Weill Cornell Medicine, New York, New York

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT07639606 on ClinicalTrials.gov