Amputation Clinical Trials

36 studies are recruiting for amputation in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

Search these by distance from you

By city

Studies, page 2

1. Multicenter Trial Evaluating the Safety and Efficacy of Autologous Volar Fibroblast Injection Into the Terminal Limb of Amputees.

   The study will enroll 20 adults ages 18-75 with a transtibial amputation with mature residual limbs who are ambulatory prosthesis users. Participants will be randomized to either treatment with low dose volar fibroblast injections (n=10) or to vehicle control (n=10). Participants will undergo a bio…

   Stage

   Phase 2

   Ages

   18 to 75

   Site

   Johns Hopkins Hospital, Baltimore, Maryland

   Run by

   Major Extremity Trauma Research Consortium

   See if you can join NCT04839497 on ClinicalTrials.gov

2. Pro APP Prosthetic Outcome Registry

   A national, multi-center registry of patients using lower-limb prosthesis, their profiles and devices, and their long-term follow-up and clinical outcomes.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Össur Americas, Irvine, California

   Run by

   Össur Iceland ehf

   See if you can join NCT06210620 on ClinicalTrials.gov

3. Target Muscle Re-innervation and Regenerative Peripheral Nerve Interfaces Alone and in Combination for the Treatment of Residual and Phantom Limb Pain in Cancer Patients Who Have Received an Amputation

   This clinical trial evaluates two surgical techniques (targeted muscle re-innervation [TMR] and regenerative peripheral nerve interfaces [RPNI]) alone and in combination for the alleviation of chronic residual limb and phantom limb pain in cancer patients who have had an amputation. Chronic residua…

   Stage

   Not phased

   Ages

   18 and older

   Site

   M D Anderson Cancer Center, Houston, Texas

   Run by

   M.D. Anderson Cancer Center

   See if you can join NCT06840262 on ClinicalTrials.gov

4. Clinical Outcomes With Non-Powered vs. Powered Prosthetic Knees by K2-level Amputees

   The goal of this proposed project is to gather community-based data from the K2-level Transfemoral Amputee (TFA) population to aid in evidence-based prescription of powered prosthetic knees (i.e., choosing the right device to maximize the benefit for each patient). The investigators intend to use t…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Hanger Clinic, Austin, Texas

   Run by

   Liberating Technologies, Inc.

   See if you can join NCT06194838 on ClinicalTrials.gov

5. Effects of Myoelectric Channel Count and Targeting for Upper Limb Prosthetic Control

   The goal of this clinical trial is to systematically evaluate whether or not two commonly held fundamental assumptions for pattern recognition control translates to functional performance when tested on individuals aged 18 years or older with upper limb absence at the transradial level while wearin…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Shirley Ryan AbilityLab, Chicago, Illinois

   Locations

   2 in total

   Run by

   Liberating Technologies, Inc.

   See if you can join NCT07011420 on ClinicalTrials.gov

6. Efficacy and Mechanisms of Virtual Reality Treatment of Phantom Leg Pain.Home-Based Treatment

   After amputation of an arm or leg, up to 90% of subjects experience a "phantom limb", a phenomenon characterized by persistent feelings of the missing limb. Many subjects with a phantom limb experience intense pain in the missing extremity that is often poorly responsive to medications or other int…

   Stage

   Not phased

   Ages

   18 to 100

   Site

   Jefferson Moss Rehabilitation Research Institute, Philadelphia, Pennsylvania

   Locations

   3 in total

   Run by

   Albert Einstein Healthcare Network

   See if you can join NCT07044323 on ClinicalTrials.gov

7. Powered Prosthesis for Use With TF Osseointegration Recipients

   The purpose of this study is to evaluate functional mobility, control, and user satisfaction from persons who have an amputation above the knee and have received osseo-integration (OI) and targeted muscle reinnervation (TMR) surgery, while walking with a powered knee and ankle prosthesis.

   Stage

   Not phased

   Ages

   18 to 70

   Site

   Shirley Ryan AbilityLab, Chicago, Illinois

   Run by

   Shirley Ryan AbilityLab

   See if you can join NCT06160882 on ClinicalTrials.gov

8. Detecting Change in Muscle Parameters, Pain, and Function With NMES for TTA

   The proposal aims to investigate a non-invasive, cost-effective method for rebuilding muscle mass in individuals with transtibial limb loss. Maintaining a healthy, pain-free residual limb is a primary concern for prosthesis users. Amputees commonly experience muscle deficits leading to mobility iss…

   Stage

   Not phased

   Ages

   18 to 100

   Site

   Cranberry Township Building, Pittsburgh, Pennsylvania

   Run by

   Sara Peterson-Snyder

   See if you can join NCT06830876 on ClinicalTrials.gov

9. Enhancing Motor Function in Individuals with Lower Limb Amputation

   The overall goal of this research project is to investigate the effectiveness and the science of peer-based prosthetic skill training in individuals with leg amputation. Our belief is that amputee learners will show improved skill learning when observing demonstrations from other amputees, as oppos…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Nevada, Las Vegas, Las Vegas, Nevada

   Run by

   University of Nevada, Las Vegas

   See if you can join NCT06638723 on ClinicalTrials.gov

10. Understanding How Powered Componentry Impacts K2-Level Transfemoral Amputee Gait

    The goal of this study is to understand how providing power at the knee or ankle individually, or providing power at both the knee and ankle, impacts ambulation for K2 level transfemoral amputees. Aim 1: measure functional performance of K2 level ambulators when using a commercially available passi…

    Stage

    Not phased

    Ages

    18 to 95

    Site

    Shirley Ryan AbilityLab, Chicago, Illinois

    Run by

    Shirley Ryan AbilityLab

    See if you can join NCT06433648 on ClinicalTrials.gov

11. Effectiveness of Frontal Plane Adaptability in a Novel Foot Prosthesis

    People with lower extremity amputation (LEA) have persistent problems with balance, falls, residual limb pain, functional mobility, cognitive attention during gait, and satisfaction with participation in daily activities, despite using prostheses. The purpose of this randomized clinical trial is to…

    Stage

    Not phased

    Ages

    16 and older

    Site

    University of South Florida, Tampa, Florida

    Locations

    3 in total

    Run by

    University of Washington

    See if you can join NCT06214026 on ClinicalTrials.gov