Amputation Clinical Trials

36 studies are recruiting for amputation in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Baltimore, Maryland 4 Ann Arbor, Michigan 3 Austin, Texas 3 Boston, Massachusetts 3 Cambridge, Massachusetts 3 Chicago, Illinois 3 Minneapolis, Minnesota 3 Seattle, Washington 3

Studies now recruiting

  1. Controlling Locomotion Over Continuously Varying Activities for Agile Powered Prosthetic Legs

    The overall goal of this project is to model human joint biomechanics over continuously-varying locomotion to enable adaptive control of powered above-knee prostheses. The central hypothesis of this project is that variable joint impedance can be parameterized by a continuous model based on measura…

    Stage
    Not phased
    Ages
    18 to 65
    Site
    Rehab Lab, University of Michigan, Ann Arbor, Michigan
    Run by
    University of Michigan

    See if you can join NCT06138977 on ClinicalTrials.gov

  2. PO vs IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation

    This is a Phase III clinical randomized control trial to investigate differences between patient with an infected nonunion treated by PO vs. IV antibiotics. The study population will be 250 patients, 18 years or older, being treated for infected nonunion after internal fixation of a fracture with a…

    Stage
    Phase 3
    Ages
    18 and older
    Site
    Indiana University, Indianapolis, Indiana
    Locations
    13 in total
    Run by
    Major Extremity Trauma Research Consortium

    See if you can join NCT05699174 on ClinicalTrials.gov

  3. Personalizing Thromboprophylaxis for Patients With Peripheral Artery Disease

    The goal of this clinical trial is to determine whether a personalised blood clot prevention plan is more effective than standard treatment in adults with peripheral artery disease (PAD) who have undergone a procedure to restore blood flow to their legs. The main questions it aims to answer are: * …

    Stage
    Not phased
    Ages
    18 and older
    Site
    Massachusetts General Hospital, Boston, Massachusetts
    Locations
    2 in total
    Run by
    Massachusetts General Hospital

    See if you can join NCT07613840 on ClinicalTrials.gov

  4. Comparing the Attentional Demands and Functional Outcomes in People With Transradial Amputation

    Different ways of controlling an upper-limb prosthesis can affect how easy it is to use and how helpful it is in everyday activities. One common method, called direct control, uses signals from two muscles and can make switching between movements difficult. Another clinically available option, call…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Hanger Inc., Austin, Texas
    Locations
    2 in total
    Run by
    Virginia Commonwealth University

    See if you can join NCT07075042 on ClinicalTrials.gov

  5. Evaluating the Experience of Upper Limb Prosthesis Use

    The goal is to understand the critical factors associated with outcome acceptance following upper limb loss. The investigators aim to develop a unified theoretical model that describes the psychosocial experience of upper limb prosthesis use and predicts outcome acceptance following upper limb loss…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Louis Stokes VA Medical Center, Cleveland, Ohio
    Run by
    Louis Stokes VA Medical Center

    See if you can join NCT04855214 on ClinicalTrials.gov

  6. Cryo NerVe Block Extremity AmputatioN RegIStry for Post Operative and pHantom Limb Pain

    The goal of this Registry is to see how the device is used when freezing nerves during an amputation procedure.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Berkshire Medical Center, Pittsfield, Massachusetts
    Locations
    6 in total
    Run by
    AtriCure, Inc.

    See if you can join NCT06908538 on ClinicalTrials.gov

  7. Short-term Implanted Electrodes Following Regenerative Peripheral Nerve Surgery for Improving Prosthetic Limb Control Signals

    The device, a bipolar percutaneous intramuscular electromyography electrode, is intended for use in upper-limb amputation patients who have received the regenerative peripheral nerve interface surgical procedure, in order to enable the use of advanced prosthetic arms and hands.

    Stage
    Not phased
    Ages
    22 to 75
    Site
    University of Michigan, Ann Arbor, Michigan
    Run by
    University of Michigan

    See if you can join NCT03260400 on ClinicalTrials.gov

  8. Influence Of A Slope Adaptive Foot On Participation Of Veterans With Lower-Limb Amputations

    Veterans with below-knee amputations are limited by prosthetic feet that cannot adapt to sloped and uneven terrain. This limitation results in reduced mobility, reduced balance confidence, and a higher risk of falls among some individuals who use below-knee prostheses, which have been shown to nega…

    Stage
    Not phased
    Ages
    18 to 89
    Site
    Minneapolis VA Health Care System, Minneapolis, MN, Minneapolis, Minnesota
    Run by
    VA Office of Research and Development

    See if you can join NCT07266077 on ClinicalTrials.gov

  9. Assessing Ambulatory and Non-ambulatory Community Mobility in People With Lower Limb Amputation

    Mobility is a fundamental aspect of daily life, enabling individuals to participate in social, occupational, and recreational activities. Community mobility, defined as movement in environments outside the home, is particularly important for quality-of-life. Following lower limb amputation (LLA), m…

    Stage
    Not phased
    Ages
    18 to 85
    Site
    Virginia Commonwealth University, Richmond, Virginia
    Run by
    Virginia Commonwealth University

    See if you can join NCT07387744 on ClinicalTrials.gov

  10. Human Penile Allotransplantation

    Injuries to the genitalia are of concern to the military with emphasis placed on the surgical reconstruction and psychological health of these Wounded Warriors. However, despite significant surgical advances in microvascular surgery and autologous free tissue transfer, conventional reconstructions …

    Stage
    Phase 2
    Ages
    18 to 69
    Site
    Johns Hopkins University School of Medicine, Baltimore, Maryland
    Run by
    Johns Hopkins University

    See if you can join NCT02395497 on ClinicalTrials.gov

  11. A Novel Approach to Upper Extremity Amputation to Augment Volitional Control and Restore Proprioception

    The hypothesis of this research protocol is that the investigators will be able to redesign the manner in which upper limb amputations are performed so as to enable volitional control of next generation prosthetic devices and restore sensation and proprioception to the amputated limb. The investiga…

    Stage
    Not phased
    Ages
    18 to 65
    Site
    Walter Reed National Military Medical Center, Bethesda, Maryland
    Locations
    4 in total
    Run by
    Brigham and Women's Hospital

    See if you can join NCT03882073 on ClinicalTrials.gov

  12. AMI Construction in Lower Extremity Residual Limbs

    This study will involve the development of a novel approach to lower extremity residual limb surgical revision that offers the promise of augmenting volitional motor control, restore proprioception and reverse atrophy

    Stage
    Not phased
    Ages
    18 to 65
    Site
    Brigham and Women's Hospital, Boston, Massachusetts
    Locations
    3 in total
    Run by
    Brigham and Women's Hospital

    See if you can join NCT04063592 on ClinicalTrials.gov

  13. Bio Leg: Advancing Mobility (BAM)

    Following transfemoral amputation, regaining functional mobility, particularly the ability to navigate curbs, ramps, long distances, and the ability to stand is challenging and often unattainable. Use of advanced prosthetic limb technology can dramatically influence mobility outcomes. The purpose o…

    Stage
    Not phased
    Ages
    40 to 70
    Site
    Brooks Rehabilitation, Jacksonville, Florida
    Run by
    University of Florida

    See if you can join NCT07613502 on ClinicalTrials.gov

  14. Prosthetic Performance Enhancement Trial

    The purpose of this research is to determine the feasibility of an uneven terrain walking program for lower limb prosthesis users. The training is designed to induce step-to-step variability during walking within a safe environment, with the aim of improving walking skill and confidence.

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of Nevada Las Vegas, Las Vegas, Nevada
    Run by
    University of Nevada, Las Vegas

    See if you can join NCT06419920 on ClinicalTrials.gov

  15. Evaluation of a Powered Ankle Prosthesis Capable of Bidirectional Control Via Neural Recording and Cutaneous Stimulation in Free-Space and Walking Tasks

    The purpose of this study is to evaluate the performance of a powered ankle prosthesis capable of bidirectional control via neural recording and cutaneous stimulation, during free-space and walking tasks. This research aims to assess the sense of embodiment with the device, gait symmetry, and stabi…

    Stage
    Not phased
    Ages
    18 to 70
    Site
    MIT Media Lab, Cambridge, Massachusetts
    Run by
    Massachusetts Institute of Technology

    See if you can join NCT07645729 on ClinicalTrials.gov

  16. Autologous Volar Fibroblast Injection Into the Stump Site of Amputees

    This study is a clinical trial testing the safety and efficacy of volar fibroblast (skin cells from the palm or sole) injections for thickening the epidermal (skin) layer at the stump site in people with below the knee amputations. The study will enroll adults seen at Johns Hopkins.

    Stage
    Phase 2
    Ages
    18 to 65
    Site
    Department of Dermatology at Johns Hopkins University, Baltimore, Maryland
    Run by
    Johns Hopkins University

    See if you can join NCT03947450 on ClinicalTrials.gov

  17. Regulatory Clearance of the Glide Control Strategy for Upper Limb Prostheses

    The investigators will test the following hypothesis: Use of Glide results in improved functional performance, satisfaction, and usage metrics as compared to use of a standard Direct Control (DC) prosthesis. This study will compare the use of Glide [Experimental] prosthesis with a DC [Standard] pro…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Advanced Arm Dynamics, Redondo Beach, California
    Run by
    Infinite Biomedical Technologies

    See if you can join NCT06539936 on ClinicalTrials.gov

  18. Regenerative Peripheral Nerve Interface for Control of Lower Limb Prostheses

    Individuals with an above-knee lower limb amputation are known to walk more slowly, expend more energy, have a greater risk of falling, and have reduced quality of life compared to individuals without amputation and those with below knee amputation. One of the driving factors behind these deficits …

    Stage
    Not phased
    Ages
    18 to 75
    Site
    University of Michigan, Ann Arbor, Michigan
    Run by
    University of Michigan

    See if you can join NCT06275282 on ClinicalTrials.gov

  19. Can an Array of Micro-electrodes Implanted in a Human Nerve Record Neural Signals and Provide Feedback?

    The investigators will investigate the device feasibility of human peripheral nerves and muscles recording and stimulation using percutaneous Utah Slanted Electrode Arrays (pUSEAs) implanted into residual peripheral arm nerves and EMG electrodes implanted in the residual muscles of patients with li…

    Stage
    Not phased
    Ages
    18 to 65
    Site
    The University Orthopaedic Center, Salt Lake City, Utah
    Run by
    University of Utah

    See if you can join NCT05505513 on ClinicalTrials.gov

  20. Influence of Prosthetic Foot Stiffness on Transtibial Osseointegrated Bone-Anchored Limb Outcomes

    A clinical trial utilizing cross-over study design in which individuals with transtibial amputation using either a bone-anchored limb or standard socket prosthesis will perform activities of daily living with varying prosthetic foot stiffness categories to complete the following 4 Specific Aims: 1)…

    Stage
    Phase 1
    Ages
    18 and older
    Site
    University of Colorado, Anschutz Medical Campus, Aurora, Colorado
    Run by
    University of Colorado, Denver

    See if you can join NCT07263945 on ClinicalTrials.gov

  21. Impact of Improving Footwear Options

    Veterans with leg amputations have limited footwear options because their artificial feet do not change shapes for different shoes. Studies have shown that women with amputations receive more frequent prosthetics care than men, but are less satisfied with the fit, comfort, and appearance of their p…

    Stage
    Not phased
    Ages
    18 to 89
    Site
    Minneapolis VA Health Care System, Minneapolis, MN, Minneapolis, Minnesota
    Run by
    VA Office of Research and Development

    See if you can join NCT05601869 on ClinicalTrials.gov

  22. Feasibility of Neural Feedback for Lower Limb Amputees

    The purpose of this study is to evaluate the effectiveness of providing sensation of the missing limb to individuals with lower limb loss, including above and below knee amputees. The approach involves delivering small electrical currents directly to remaining nerves via implanted stimulating elect…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Louis Stokes VA Medical Center, Cleveland, Ohio
    Run by
    Louis Stokes VA Medical Center

    See if you can join NCT03409133 on ClinicalTrials.gov

  23. Evaluation of Myoelectric Implantable Recording Array (MIRA) in Participants With Transradial Amputation

    The purpose of this research study is to see how well a new type of myoelectric prosthesis works. A myoelectric prosthesis is a robotic limb for amputees that is controlled by sensing the activity of muscles in the body above the amputation level. This study involves a medical procedure to implant …

    Stage
    Not phased
    Ages
    22 to 70
    Site
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
    Run by
    Boninger, Michael, MD

    See if you can join NCT05768802 on ClinicalTrials.gov

  24. Effects of Microprocessor-controlled Prosthetic Knees on Fall-related Health Outcomes in Limited Community Ambulators

    The goal of this study is to find out if using microprocessor-controlled prosthetic knees (MPKs), prosthetic knees with a built-in computer, improves health outcomes related to falls in adults who use above-knee prostheses. The main questions are: * Do individuals with MPKs have fewer fall-related …

    Stage
    Not phased
    Ages
    18 and older
    Site
    Hanger Inc., Austin, Texas
    Run by
    Hanger Institute for Clinical Research and Education, LLC

    See if you can join NCT06937242 on ClinicalTrials.gov

  25. Study of Efficacy of the MyoTrain System in a Population of Individuals With Trans-radial Limb Loss

    The investigators propose to evaluate the efficacy of MyoTrain in a prospective clinical study involving 16 individuals with trans-radial upper-limb loss over a period of 206 days. These individuals will be randomized to Group A (Control Group using standard motor imagery training) and Group B (who…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Hanger Clinic - Grand Rapids, Grand Rapids, Michigan
    Run by
    Infinite Biomedical Technologies

    See if you can join NCT05888428 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.