Acute Kidney Injury Clinical Trials

35 studies are recruiting for acute kidney injury in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Neutrophil and Monocyte Deactivation Via the SeLective CytopheretIc Device - A Randomized Clinical Trial in Acute Kidney Injury

   This randomized, controlled, pivotal study is intended to determine whether up to ten sequential 24-hour treatments with the Selective Cytopheretic Device (SCD) will improve survival in patients with Acute Kidney Injury (AKI) requiring continuous kidney replacement therapy (CKRT) when compared to C…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Alabama Birmingham Hospital, Birmingham, Alabama

   Locations

   36 in total

   Run by

   SeaStar Medical

   See if you can join NCT05758077 on ClinicalTrials.gov

2. A Prompt REstart Study of Renin-Angiotensin System Inhibitors After Acute Kidney Injury

   The goal of this pilot clinical trial is to learn if early restart of renin-angiotensin system inhibitor (RASi) medications is feasible and well-tolerated in hospitalized patients with acute kidney injury (AKI). Researchers will compare early RASi restart to usual care. Study participants will rest…

   Stage

   Phase 4

   Ages

   18 and older

   Site

   University of California, San Francisco, San Francisco, California

   Run by

   University of California, San Francisco

   See if you can join NCT07734636 on ClinicalTrials.gov

3. A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kidney Injury.

   This study will enroll adults aged 18 to 80 years diagnosed with sepsis due to a suspected or confirmed bacterial infection, within 7 days of being admitted to the hospital, and who have also developed acute kidney injury within 72 hours of the onset of sepsis. Eligible participants will be randoml…

   Stage

   Phase 2

   Ages

   18 to 80

   Site

   Research Site, Newport Beach, California

   Locations

   74 in total

   Run by

   AstraZeneca

   See if you can join NCT07215702 on ClinicalTrials.gov

4. Droxidopa to Increase Mean Arterial Pressure in Decompensated Cirrhosis Patients With Acute Kidney Injury

   This study tests whether a medication called droxidopa can help improve blood flow to the kidneys in people with liver cirrhosis who develop kidney problems while in the hospital. When someone with cirrhosis experiences kidney injury, having better blood pressure can help their kidneys recover. Dro…

   Stage

   Phase 2

   Ages

   18 to 70

   Site

   Columbia University Irving Medical Center, New York, New York

   Run by

   Giuseppe Cullaro, MD

   See if you can join NCT06937307 on ClinicalTrials.gov

5. The Vancomycin Piperacillin/Tazobactam (VPT) Patient Safety Trial (VPS)

   The VPT Safety Trial (VPS) compares two common antibiotic combinations to see how they affect the kidneys of patients in the hospital with serious infections. Both combinations are approved by the Food and Drug Administration (FDA). The goal is to help doctors know which combination is safer so the…

   Stage

   Phase 4

   Ages

   18 and older

   Site

   Bassett Medical Center, Cooperstown, New York

   Locations

   3 in total

   Run by

   Bassett Healthcare

   See if you can join NCT07556107 on ClinicalTrials.gov

6. A Study of Facilitators and Barriers to Improve Acute Kidney Injury in Children Through Mobile Health Intervention

   The purpose of this study is to improve patient-centered care for acute kidney injury (AKI) in order to decrease the adverse health outcomes associated with this common condition.

   Stage

   Not phased

   Ages

   1 to 18

   Site

   Duke University Medical Center, Durham, North Carolina

   Run by

   Duke University

   See if you can join NCT04403633 on ClinicalTrials.gov

7. Biomarker and Renal Angina Validation to Assess Heart-Kidney Outcomes After Amino Acid Therapy

   The goal of the BRAVE-HEART study is to learn if an amino acid infusion can reduce the risk of developing acute kidney injury after cardiac surgery in children. The main questions it aims to answer are: 1. Does an amino acid infusion decrease the number of participants with acute kidney injury? 2. …

   Stage

   Phase 2

   Ages

   Up to 18

   Site

   Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

   Run by

   Dana Fuhrman

   See if you can join NCT07212595 on ClinicalTrials.gov

8. FST Analysis Supporting Timely Therapy and Risk Assessment Via Clinical Decision Support for Kids

   The goal of this study is to learn whether adding a clinical decision support tool to the electronic medical record helps clinicians use the furosemide stress test in critically ill children at high risk for severe acute kidney injury (AKI). The main question it aims to answer is: Does implementing…

   Stage

   Not phased

   Ages

   Any age

   Site

   Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

   Run by

   Children's Hospital Medical Center, Cincinnati

   See if you can join NCT07718464 on ClinicalTrials.gov

9. LoW Dose-Intensity vs. Standard Dose-Intensity COntinuous Renal ReplaceMent Therapy in Critically Ill Patients (WISDOM)

   An estimated 10-15% of critically ill patients with acute kidney failure in the intensive care unit receive acute dialysis therapy. The majority of these patients initially receive a continuous form of dialysis therapy call continuous renal replacement therapy (CRRT). Prior studies have suggested t…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Mayo Clinic, Rochester, Minnesota

   Locations

   10 in total

   Run by

   University of Alberta

   See if you can join NCT06446739 on ClinicalTrials.gov

10. A Patient-centered Trial of a Process-of-care Intervention in Hospitalized AKI Patients: the COPE-AKI Trial

    The COPE-AKI study is a randomized, pragmatic, parallel-arm trial comparing a multimodal intervention to usual care on hospital-free days through 90 days of study follow up. The primary study hypothesis is that patients randomized to the intervention will have increased odds of more hospital-free d…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Locations

    9 in total

    Run by

    University of Pittsburgh

    See if you can join NCT05805709 on ClinicalTrials.gov

11. Acute Kidney Injury In Care Transitions (ACT): Pragmatic Clinical Trial

    The purpose of this study is to determine the effect of a multidisciplinary intervention at care transitions for acute kidney injury survivors on patient-centered outcomes.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mayo Clinic in Rochester, Rochester, Minnesota

    Locations

    3 in total

    Run by

    Mayo Clinic

    See if you can join NCT07670520 on ClinicalTrials.gov

12. CTSN Embolic Protection Trial

    This is a prospective, multi-center, randomized effectiveness trial of the CardioGard Embolic Protection Cannula in high-risk valve surgery patients.

    Stage

    Not phased

    Ages

    60 and older

    Site

    CHI St. Vincent Heart Institute, North Little Rock, Arkansas

    Locations

    28 in total

    Run by

    Icahn School of Medicine at Mount Sinai

    See if you can join NCT06027788 on ClinicalTrials.gov

13. Ultra-Low Contrast Angiography in AKI

    The aim of this study is to evaluate the safety of ultra-low contrast coronary angiography in patients with pre-existing acute kidney injury.

    Stage

    Phase 3

    Ages

    18 to 100

    Site

    Tulane University Medical Center, New Orleans, Louisiana

    Locations

    2 in total

    Run by

    Tulane University

    See if you can join NCT05906758 on ClinicalTrials.gov

14. QUELIMMUNE (SCD-PED) PediAtric SurVeillance REgistry

    QUELIMMUNE is FDA-approved under an HDE for the treatment of pediatric patients (weight ≥10kg and age ≤22 years) with AKI due to sepsis or a septic condition on antibiotic therapy and requiring RRT. The purpose of this surveillance registry is to prospectively collect safety data among all patients…

    Stage

    Not phased

    Ages

    Up to 22

    Site

    Children's of Alabama, Birmingham, Alabama

    Locations

    15 in total

    Run by

    SeaStar Medical

    See if you can join NCT06517810 on ClinicalTrials.gov

15. Kidney Function in People With Cystic Fibrosis in the Era of HEMT

    The purpose of this study is to find out what causes kidney disease in people with CF. The investigators will study biomarkers in the blood and urine that can either predict who is at risk or detect kidney damage early before it becomes permanent. The study will compare these markers in people with…

    Stage

    Not phased

    Ages

    7 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Locations

    3 in total

    Run by

    University of Virginia

    See if you can join NCT06595420 on ClinicalTrials.gov

16. Acute Normovolemic Hemodilution on Urine Neutrophil Gelatinase-associated Lipocalin Levels

    Acute normovolemic hemodilution (ANH) is performed as a blood conservation technique during surgical procedures with high risk for significant blood loss. It is done by taking out some of the patients blood before surgery actually begins and storing this blood inside of the operating room and givin…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    University of Maryland Medical Center, Baltimore, Maryland

    Run by

    University of Maryland, Baltimore

    See if you can join NCT05349292 on ClinicalTrials.gov

17. Effectiveness-Implementation Evaluation of Acute Kidney Injury Decision Support

    Study Purpose: This study is testing an artificial intelligence (AI)-powered clinical decision support (CDS) system designed to help emergency department (ED) doctors detect and manage acute kidney injury (AKI) earlier. The goal is to see whether the tool improves patient care, clinician decision-m…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Johns Hopkins Hospital, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT06840210 on ClinicalTrials.gov

18. Groundbreaking Renal Assist Device Intervening to ENhance cardioThoracic Surgery Outcomes

    Patients with renal insufficiency who undergo cardiac surgery with cardiopulmonary bypass (CPB) are at significant risk for exacerbation of renal dysfunction postoperatively. This in turn is associated with an increased risk of prolonged intensive care unit (ICU) length of stay, other comorbidities…

    Stage

    Not phased

    Ages

    22 to 85

    Site

    Cleveland Clinic Florida, Weston, Florida

    Locations

    7 in total

    Run by

    3ive Labs

    See if you can join NCT07017933 on ClinicalTrials.gov

19. Effects of Creatine Supplementation on Cognitive Measures and Markers of Acute Kidney Injury After Exercise in the Heat

    The goal of this clinical trial is to learn if one week of creatine monohydrate supplementation alters inflammation, markers of acute kidney injury (AKI) risk, and cognitive performance in active, young, healthy volunteers. The main questions it aims to answer are: 1. Does one-week of creatine supp…

    Stage

    Not phased

    Ages

    18 to 45

    Site

    Wellness and Recreation Center, Cedar Falls, Iowa

    Run by

    University of Northern Iowa

    See if you can join NCT07472426 on ClinicalTrials.gov

20. Initial Resuscitation for Acute Kidney Injury in Cirrhosis

    The goal of this interventional study is to evaluate two strategies for how to provide intravenous (IV) fluids for treating patients with acute kidney injury (AKI) in cirrhosis. The main question it aims to answer is: what is the safety, efficacy, and feasibility of providing a recommendation to us…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT06525623 on ClinicalTrials.gov

21. Sodium-Glucose Cotransporter-2 Inhibitor for Patients With Acute Cardiorenal Syndrome

    The overall objective of this study is to determine whether the addition of SGLT2 inhibitors to usual care in hospitalized patients with heart failure associated acute kidney injury is safe and efficacious. Investigators will assess if SGLT2 inhibition improves a composite cardio-renal outcome (mor…

    Stage

    Phase 2

    Ages

    18 to 85

    Site

    Yale New Haven Hospital-St. Raphael Campus, New Haven, Connecticut

    Locations

    2 in total

    Run by

    Yale University

    See if you can join NCT07273838 on ClinicalTrials.gov

22. Allogeneic HB-adMSCs vs Placebo for the Treatment of Acute Kidney Injury

    This study aims to investigate, through the collection of valid scientific evidence necessary to determine safety and effectiveness, the potential use of Allogeneic Hope Biosciences Adipose-derived Mesenchymal Stem Cells (HB-adMSCs) to prevent progression of trauma-induced Acute Kidney Injury (AKI).

    Stage

    Phase 1

    Ages

    18 to 75

    Site

    University of Texas Health Science Center at Houston (UTHealth Houston), Houston, Texas

    Locations

    3 in total

    Run by

    Hope Biosciences LLC

    See if you can join NCT06654193 on ClinicalTrials.gov

23. Comparison of Early Proton Pump Inhibitor Initiation Versus Usual Care on Acute Kidney Injury in Hemorrhagic Shock Patients

    The investigators propose a single-center, randomized, controlled trial to determine whether early initiation of proton pump inhibitor (PPI), pantoprazole, will decrease acute kidney injury (AKI) for trauma patients presenting with hemorrhagic shock compared to routine timing of initiation of PPI. …

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Memorial Hermann Texas Medical Center, Houston, Texas

    Run by

    The University of Texas Health Science Center, Houston

    See if you can join NCT06531642 on ClinicalTrials.gov

24. A Pragmatic Clinical Trial Comparing the Risk of Acute Kidney Injury During Treatment With Vancomycin and Piperacillin-Tazobactam vs. Vancomycin and Cefepime in Hospitalized Patients

    Hospitalized patients with suspected or confirmed infection are commonly treated with vancomycin (VN) in combination with either piperacillin-tazobactam (PT) or cefepime (CP). Although these regimens have similar effectiveness, recent observational evidence suggests they may differ in terms of the …

    Stage

    Phase 4

    Ages

    18 and older

    Site

    University of Pennsylvania Health System, Philadelphia, Pennsylvania

    Run by

    University of Pennsylvania

    See if you can join NCT06954129 on ClinicalTrials.gov

25. Melatonin for Prevention of Kidney Injury

    This study will evaluate the safety and effectiveness of melatonin for the prevention of antibiotic associated acute kidney injury in hospitalized patients.

    Stage

    Phase 3

    Ages

    18 to 75

    Site

    Robert Wood Johnson University Hospital, New Brunswick, New Jersey

    Locations

    2 in total

    Run by

    Rutgers, The State University of New Jersey

    See if you can join NCT05084196 on ClinicalTrials.gov