Weight Loss Clinical Trials

27 studies are recruiting for weight loss in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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New York, New York 5

Studies now recruiting

  1. Randomized Study on Transoral Outlet Reduction and Lifestyle Changes for Weight Regain After Gastric Bypass

    The goal of this clinical trial is to evaluate weight loss with TORe and intensive lifestyle modification versus intensive lifestyle modification alone in subjects who have regained weight following a Roux-en-Y gastric bypass. Participants will randomized 2:1. Those randomized to the TORe arm will …

    Stage
    Not phased
    Ages
    18 and older
    Site
    Hoag Memorial Hospital, Irvine, California
    Locations
    12 in total
    Run by
    Boston Scientific Corporation

    See if you can join NCT07015424 on ClinicalTrials.gov

  2. Planning Grant for TOPS for Breast Cancer Survivors

    The purpose of this study is to help make a community led weight loss program known as Take Off Pounds Sensibly (TOPS) more relevant for breast cancer survivors. This study is made up to two parts. The first part includes using focus groups to review current materials that the investigators plan to…

    Stage
    Not phased
    Ages
    21 to 90
    Site
    Duke University, Durham, North Carolina
    Run by
    Duke University

    See if you can join NCT06658912 on ClinicalTrials.gov

  3. Effects of GLP-1 RAs on Human Lactation Outcomes

    There is increasing interest in using GLP-1 Receptor Agonist (GLP-1 RA) medications after pregnancy. This study is designed to determine if these medications affect breastmilk production or the nutritional makeup of breastmilk. The main questions the study will address are: * Does GLP-1 RA-induced …

    Stage
    Not phased
    Ages
    Any age
    Site
    University of Colorado Anschutz School of Medicine, Aurora, Colorado
    Run by
    University of Colorado, Denver

    See if you can join NCT07720414 on ClinicalTrials.gov

  4. Mitigation of Cardiovascular Disease Risks in Children With Extreme Obesity

    The goal of this clinical trial is to learn if the drug semaglutide changes markers of disease risk as it relates to weight in children ages 12-15 years old who are obese (class 2 or 3). The main questions it aims to answer are: * How do the rate of weight loss, body mass index (BMI), body composit…

    Stage
    Not phased
    Ages
    12 to 17
    Site
    University of Kentucky, Lexington, Kentucky
    Run by
    John Bauer

    See if you can join NCT06967389 on ClinicalTrials.gov

  5. Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial

    Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease globally. While weight loss through lifestyle modification is the standard treatment, most patients regain weight limiting ultimate improvement in liver disease. On the other end of the spectru…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Brigham and Women's Hospital, Boston, Massachusetts
    Locations
    2 in total
    Run by
    Pichamol Jirapinyo, MD, MPH

    See if you can join NCT06138821 on ClinicalTrials.gov

  6. Exercise Effects on Adipose Tissue Structure and Function

    Participants will be randomized into one of two different experimental groups: 1) Exercise group and 2) No exercise (control group). Subject participation in the study will involve a series of metabolic tests before and after participants undergo a 10% weight loss program (with or without exercise …

    Stage
    Not phased
    Ages
    18 to 40
    Site
    University of Michigan, Ann Arbor, Michigan
    Run by
    University of Michigan

    See if you can join NCT04812314 on ClinicalTrials.gov

  7. Metabolic Health, Bones and Nuts During Weight Loss in Adults

    The aging population is rapidly increasing, and it is important to identify dietary factors that can prevent disease and promote health in this group. Legumes, such as peanuts, are a plant-based food high in protein and unsaturated fat making this a healthy choice but are not consumed frequently en…

    Stage
    Not phased
    Ages
    50 to 75
    Site
    Rutgers University - NJ Inst Food Nutrition & Health, New Brunswick, New Jersey
    Run by
    Rutgers, The State University of New Jersey

    See if you can join NCT06949280 on ClinicalTrials.gov

  8. Testing a Tailored Approach to Long-Term Weight Loss Success

    The purpose of this study is to develop and test an adaptive, individually tailored intervention to prevent weight regain in people who have intentionally lost weight. The main questions it aims to answer are: * Is an adaptive intervention with tailored re-engagement support feasible for individual…

    Stage
    Not phased
    Ages
    18 to 65
    Site
    University of Utah, Salt Lake City, Utah
    Run by
    University of Utah

    See if you can join NCT07577765 on ClinicalTrials.gov

  9. Adipocyte-Derived Extracellular Vesicles, Weight Loss, and Endothelial Function

    Changes in adipose tissue biology are now recognized as a key factor underlying the increased risk of metabolic and cardiovascular disease with obesity. Clinical interest in adipocyte-derived extracellular vesicles (Ad-EVs) has intensified due to their potential as circulating biomarkers of adipose…

    Stage
    Not phased
    Ages
    40 and older
    Site
    University of Colorado Boulder Clinical and Translational Research Center (CTRC), Boulder, Colorado
    Run by
    University of Colorado, Boulder

    See if you can join NCT06776081 on ClinicalTrials.gov

  10. Endoscopic Bariatric Therapies (EBTs): A Retrospective and Prospective Multicenter Registry

    The purpose of this registry study is to collect data through medical chart review and in patient visits on the efficacy and safety of various Endoscopic Bariatric therapies (EBTs). This is a retrospective and prospective, observational, medical chart review study for at least 6 standard of care vi…

    Stage
    Not phased
    Ages
    18 to 89
    Site
    Weill Cornell Medicine, New York, New York
    Run by
    Weill Medical College of Cornell University

    See if you can join NCT04494048 on ClinicalTrials.gov

  11. Effects of Tirzepatide on Muscle and Vascular Health in Obese Older Adults

    Obesity and type 2 diabetes mellitus (T2DM) represent major public health concerns in the aging community. Tirzepatide, a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist recently approved for the treatment of T2DM and obesity has be…

    Stage
    Phase 2
    Ages
    50 and older
    Site
    University of Texas Health Science Center at San Antonio, San Antonio, Texas
    Run by
    The University of Texas Health Science Center at San Antonio

    See if you can join NCT06811324 on ClinicalTrials.gov

  12. Family COMIDA (Consumo de Opciones Más Ideales De Alimentos) (Eating More Ideal Food Options)

    The purpose of this study is to determine the most effective family-centered intervention (FCI) for weight loss and obesity prevention in Hispanic families. FCI is a type of program that involves family (such as parents and caregivers) supporting their children to promote healthy habits.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Memorial Sloan Kettering Cancer Center (All Protocol Activities), New York, New York
    Run by
    Memorial Sloan Kettering Cancer Center

    See if you can join NCT07144800 on ClinicalTrials.gov

  13. Metabolic Adaptations to Weight Loss With and Without Exercise

    Study Purpose: The combination of caloric restriction and exercise is the most common first-line treatment for obesity-related disorders, yet we know very little about how these two very different treatments work together. A deeper understanding about mechanisms underlying the health benefits of ad…

    Stage
    Not phased
    Ages
    18 to 40
    Site
    University of Michigan, Ann Arbor, Michigan
    Run by
    University of Michigan

    See if you can join NCT05806801 on ClinicalTrials.gov

  14. The Sleep2BWell Trial

    Improving multiple domains of cardiometabolic health (CMH) through contextual behavioral interventions has the potential to substantially reduce persistent chronic disease disparities. Sleep is critical for preserving CMH and is amenable to intervention in real-world settings. Although sleep health…

    Stage
    Not phased
    Ages
    20 and older
    Site
    Weill Cornell Medicine, New York, New York
    Locations
    2 in total
    Run by
    Columbia University

    See if you can join NCT06565104 on ClinicalTrials.gov

  15. Fasted vs. Fed State Exercise

    Although many medications exist for both heart disease and obesity, cost, lack of access for all people, side effects and the desire for a more natural solution have left many people seeking lifestyle treatments such as exercise. Scientists know that exercise is highly beneficial for heart health. …

    Stage
    Phase 2
    Ages
    18 to 59
    Site
    Arkansas Colleges of Health Education Research Institure Health and Wellness Center, Fort Smith, Arkansas
    Run by
    Arkansas Colleges of Health Education

    See if you can join NCT07487090 on ClinicalTrials.gov

  16. Individualized Pharmacological Approach to Obesity in Patients With Bipolar Disorder

    The goal of this clinical trial is to identify the specific characteristics (phenotypes) that may be useful to help select the right medication for weight loss, and to study the effect of individualized guided medication in patients with bipolar disorder ages 18-65. The main questions it aims to an…

    Stage
    Phase 4
    Ages
    18 to 65
    Site
    Mayo Clinic, Rochester, Minnesota
    Run by
    Mayo Clinic

    See if you can join NCT07213466 on ClinicalTrials.gov

  17. WISE-2B Brain Study (Weight Loss Intervention Surgical Effects on Brain Function)

    The goal of the study to understand the effects of weight loss and improvements in diabetes following bariatric surgery on brain function and thinking. This study will also examine whether non-invasive transcutaneous vagal nerve stimulation (tVNS) intervention initiated 30 days post-surgery improve…

    Stage
    Not phased
    Ages
    20 to 75
    Site
    University of Florida - College of Public Health and Health Professions, Gainesville, Florida
    Run by
    University of Florida

    See if you can join NCT06861790 on ClinicalTrials.gov

  18. Effectiveness Study of a Lifestyle Intervention Versus Metformin in Mothers With Recent Gestational Diabetes

    The goal of this clinical trial is to evaluate the effectiveness of a 6-month lifestyle intervention compared to Metformin in postpartum women who have delivered a singleton, live born infant within the last 12 weeks to 1 year and had a pregnancy complicated by gestational diabetes. The main questi…

    Stage
    Phase 2
    Ages
    18 to 45
    Site
    Milken Institute School of Public Health - The George Washington University, Washington D.C., District of Columbia
    Run by
    George Washington University

    See if you can join NCT06948825 on ClinicalTrials.gov

  19. Optimizing an Extended Care Intervention to Promote Weight Loss Maintenance

    The purpose of this study is to find out what combination of components, if any, offers the best support for keeping weight off after someone loses weight. Long term weight loss maintenance is a challenge for many people who lose weight. There are many strategies, or components, people may use to a…

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of Alabama at Birmingham, Birmingham, Alabama
    Run by
    University of Alabama at Birmingham

    See if you can join NCT06785064 on ClinicalTrials.gov

  20. Time Restricted Eating for WeIght LoSs MainTenance-2

    The TWIST 2.0 Study is a 12-month, 2-arm RCT in adults with recent weight loss. We will examine the efficacy of TRE on weight (Aim 1a) and fat mass (Aim 1b) regain, and describe changes in subjective appetite following a mixed-meal tolerance test (Exploratory).

    Stage
    Not phased
    Ages
    25 to 65
    Site
    NYU Langone Health, New York, New York
    Run by
    NYU Langone Health

    See if you can join NCT07190170 on ClinicalTrials.gov

  21. BrainWeighve App Feasibility Study

    Childhood obesity within the United States has been a growing concern over the past number of years, and if not addressed, leads to detrimental health outcomes for youth as they move into adulthood. The literature suggests that over-eating, especially when framed in terms of food addiction, plays a…

    Stage
    Not phased
    Ages
    14 to 21
    Site
    UCLA Marion Davies Children's Center, Los Angeles, California
    Run by
    University of California, Los Angeles

    See if you can join NCT05530538 on ClinicalTrials.gov

  22. A Novel Intervention for Weight Loss in Young Adults

    Obesity and cardiometabolic risks are significant public health issues, with about two-thirds of U.S. adults overweight or obese. Weight loss can prevent these health problems, but current lifestyle interventions have limited success. New, effective strategies are needed to address this rising issu…

    Stage
    Not phased
    Ages
    18 to 40
    Site
    University of Chicago, Chicago, Illinois
    Run by
    University of Chicago

    See if you can join NCT06230744 on ClinicalTrials.gov

  23. Weight Loss and Physical Fitness Following Pregnancy in Active Duty Women

    Pregnancy and delivery are major stressors on the female body and contribute significantly to permanent weight gain and associated morbidity in women. This can profoundly affect the ability of active duty (AD) women to advance in their career. The first 12 weeks postpartum are the time period durin…

    Stage
    Not phased
    Ages
    18 to 44
    Site
    Tripler Army Medical Center, Honolulu, Hawaii
    Locations
    2 in total
    Run by
    Tripler Army Medical Center

    See if you can join NCT05518604 on ClinicalTrials.gov

  24. Identifying Changes in Food Behaviors Associated With Beginning GLP-1 Medication

    In recent years, GLP-1 medications have become a widely employed approach by physicians to address weight concerns in patients and lead to weight loss. Little is known, however, about how these medications may alter an individual's attitude towards food, food reactivity, or the specific types and a…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Health, Ingestive Behavior, and Technology Laboratory of Pennsylvania State University, State College, Pennsylvania
    Run by
    Penn State University

    See if you can join NCT06843512 on ClinicalTrials.gov

  25. FAMily-centered WEight Loss for Black Adults (FAM WEL B-ing)

    The goal of this clinical trial is to learn the best combination of family components that yields optimal weight loss among Black adults. The main question it aims to answer is: What combination of four family components in combination with a standard behavioral weight loss program yields optimal w…

    Stage
    Not phased
    Ages
    18 to 75
    Site
    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    Run by
    University of North Carolina, Chapel Hill

    See if you can join NCT06724406 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.