Venous Leg Ulcer Clinical Trials

17 studies are recruiting for venous leg ulcer in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. MTX-001 for the Treatment of Non-Healing Venous Stasis Ulcers

   DL-VSU-201 is a randomized, double-blind, placebo-controlled study in subjects with a non-infected venous stasis ulcer (VSU) that has failed to demonstrate improvement after receiving at least 4 weeks of standard, conventional wound therapy to evaluate the efficacy and safety of MTX-001.

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Site 02, Tucson, Arizona

   Locations

   12 in total

   Run by

   Merakris Therapeutics

   See if you can join NCT04647240 on ClinicalTrials.gov

2. Randomized Controlled Trial for Treatment of Pain and Assessment of Wound Healing in Chronic Venous Leg Ulcers Using Near Infrared Laser Therapy

   The laser emits an infrared light that heats the skin and underlying tissues with the purpose of temporary relief of minor muscle and joint pain, as well as stiffness associated with arthritis. The laser also causes a temporary increase in blood flow. The purpose of this study is to evaluate whethe…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Wake Forest University Health Sciences, Winston-Salem, North Carolina

   Run by

   Wake Forest University Health Sciences

   See if you can join NCT03716167 on ClinicalTrials.gov

3. Evaluation of the Efficacy of Hyalomatrix® in the Healing of Chronic Venous Leg Ulcers

   This is a randomized controlled trial evaluating the efficacy of HYALOMATRIX in conjunction with standard of care vs. standard of care alone in treating venous leg ulcers.

   Stage

   Not phased

   Ages

   18 and older

   Site

   MedCentris of Alexandria, Alexandria, Louisiana

   Locations

   4 in total

   Run by

   NuScience Medical Biologics, LLC

   See if you can join NCT07335861 on ClinicalTrials.gov

4. Prospective Case Series Evaluating the Efficacy and Safety of NeoThelium FT for Venous Leg Ulcers

   This is a prospective case series evaluating the efficacy and safety of NeoThelium FT Amnion Skin Graft in the Mangement of Venous Leg Ulcers

   Stage

   Not phased

   Ages

   18 and older

   Site

   MedCentris of Slidell, Slidell, Louisiana

   Locations

   2 in total

   Run by

   NuScience Medical Biologics, LLC

   See if you can join NCT07061613 on ClinicalTrials.gov

5. Study Assessing Complete Wound Healing by Comparing Surgenex® PelloGraft in Treating DFU and SanoGraft® in Treating VLU to SOC

   The purpose of this study is to compare Pellograft to standard of care modalities in treating diabetic foot ulcers in human subjects, and to compare Sanograft to standard of care in treating venous leg ulcers. The study will demonstrate wound healing outcomes with comparators including time to woun…

   Stage

   Not phased

   Ages

   18 and older

   Site

   ILD Research, Vista, California

   Locations

   2 in total

   Run by

   Surgenex

   See if you can join NCT06515093 on ClinicalTrials.gov

6. Tissue Repair Gel in Venous Leg Ulcers (US)

   The goal of this clinical trial is to learn if TR987 0.1% gel + Standard of Care works better than Standard of Care alone to treat Venous Leg Ulcers (VLUs). It will also provide additional information about the safety of drug TR987 0.1% gel.

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Clincial Research Site 43C, Castro Valley, California

   Locations

   33 in total

   Run by

   TR Therapeutics

   See if you can join NCT06707090 on ClinicalTrials.gov

7. A Multicenter, Prospective, Controlled Modified Multi-Platform Trial Assessing the Efficacy of Human Placental Membrane Products and Standard of Care in the Management of Nonhealing Diabetic Foot Ulcers and Venous Leg Ulcers.

   The study is a multicenter, prospective, controlled modified multi-platform trial assessing the efficacy of human placental membrane products and standard of care in the management of nonhealing diabetic foot ulcers and venous leg ulcers.

   Stage

   Phase 4

   Ages

   18 and older

   Site

   Center for Foot and Ankle Disorders, Philidelphia, Pennsylvania

   Run by

   BioLab Holdings

   See if you can join NCT07364630 on ClinicalTrials.gov

8. CAMP RWE Trial: Amnion Grafts for Healing Hard-to-Heal Ulcers in RW Populations

   CAMP RWE Trial: A Multicenter hybrid platform trial comparing the effects of a prospective cohort treated with a tri-layer amnion graft or a single layer amnion graft to a coarsened exact matched retrospective control cohort of patients with hard-to-heal DFUs and VLUs

   Stage

   Not phased

   Ages

   18 and older

   Site

   FOMAT Medical Research, Oxnard, California

   Locations

   7 in total

   Run by

   Capsicure, LLC

   See if you can join NCT07046767 on ClinicalTrials.gov

9. INNOVEN: Efficacy of Porcine Placental Extracellular Matrix Plus Standard of Care (SOC) Versus SOC Alone

   INNOVEN is a multi-center randomized controlled clinical trial to evaluate the efficacy of porcine placental extracellular matrix (PPECM) and standard of care (SOC) versus SOC alone in the closure of non-healing venous leg ulcers (VLUs).

   Stage

   Not phased

   Ages

   21 and older

   Site

   Three Rivers Wound and Hyperbaric Center, North Port, Florida

   Run by

   ConvaTec Inc.

   See if you can join NCT06606210 on ClinicalTrials.gov

10. Trial Assessing the Efficacy of Human Placental Membrane Products and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot Ulcers and Venous Leg Ulcers

    The purpose of this study is to evaluate the efficacy of human placental membrane products and standard of care versus standard of care alone in the management of nonhealing diabetic foot ulcers and venous leg ulcers.

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Center for Foot and Ankle Disorders, Philidelphia, Pennsylvania

    Run by

    BioLab Holdings

    See if you can join NCT07089602 on ClinicalTrials.gov

11. Tissue Repair Gel in Venous Leg Ulcers in AU/US

    The goal of this clinical trial is to learn if TR987 0.1% gel + Standard of Care works better than Standard of Care alone to treat Venous Leg Ulcers (VLUs). It will also provide additional information about the safety of drug TR987 0.1% gel.

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Clincial Research Site 92, Jacksonville, Florida

    Locations

    12 in total

    Run by

    TR Therapeutics

    See if you can join NCT06707103 on ClinicalTrials.gov

12. Evaluating Several Cellular, Acellular, and Matrix-like Products (CAMPs) and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot and Venous Leg Ulcers.

    Title A Multicenter, Prospective, Randomized Controlled Modified Multi-Platform (Matriarch) Trial Evaluating Several Cellular, Acellular, and Matrix-like Products (CAMPs) and Standard of Care versus Standard of Care alone in the Management of Nonhealing Diabetic Foot and Venous Leg Ulcers.

    Stage

    Phase 4

    Ages

    21 and older

    Site

    Serena Group, Monroeville, Pennsylvania

    Run by

    Tiger Biosciences, LLC.

    See if you can join NCT06826339 on ClinicalTrials.gov

13. Evaluating the Durability of Closure for Venous Leg Ulcers

    The goal of this observational study is to determine the durability of closure for venous leg ulcer subjects that achieved closure in the THOR trial.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Serena Group, Monroeville, Pennsylvania

    Run by

    Kerecis Ltd.

    See if you can join NCT06697925 on ClinicalTrials.gov

14. Modified Multi-Platform Trial Assessing Multiple CAMPs and SOC vs SOC Alone in the Treatment of DFU and VLUs

    This is a multicenter, prospective, randomized controlled modified multi-platform (matriarch) trial evaluating several cellular, acellular, and matrix-like products (CAMPs) and standard of care versus standard of care alone in the management of nonhealing diabetic foot and venous leg ulcers.

    Stage

    Not phased

    Ages

    21 and older

    Site

    Cutting Edge Research, Circleville, Ohio

    Run by

    Stability Biologics

    See if you can join NCT06560502 on ClinicalTrials.gov

15. Real World Evidence with the Debritom+ TM Novel Micro Water Jet Technology At a Single Wound Center

    Prospective, single-blinded, single-center, parallel group, randomized controlled trial (RCT) to assess rate and frequency of wound healing and associated financial savings, when using Medaxis debritom+ versus standard of care as a choice of debridement method, where both arms follow normal wound c…

    Stage

    Not phased

    Ages

    18 and older

    Site

    MCR Health, Inc., Bradenton, Florida

    Run by

    Medaxis, LLC

    See if you can join NCT04920253 on ClinicalTrials.gov

16. A Clinical Investigation to Follow the Progress of Exuding Chronic Venous Leg Ulcers Using a Non-Bordered Foam Dressing

    The goal of this clinical trial to follow the progress of wounds in those with chronic venous leg ulcers while using a non-bordered foam dressing. The main objective is to follow the progress of these wounds over time from initial visit to each follow-up visit. Participants will be asked to wear th…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Miami, Miami, Florida

    Locations

    3 in total

    Run by

    Molnlycke Health Care AB

    See if you can join NCT05608317 on ClinicalTrials.gov

17. A Clinical Investigation to Follow the Progress of Exuding Chronic Wounds Using Mepilex® Up as the Primary Dressing.

    The goal of this clinical trial is to follow the progress of wounds in those with venous leg ulcers and diabetic foot ulcers while using an absorbent dressing called Mepilex Up. The main objective is to follow the progress of these wounds over time from initial visit to each follow-up visit. Partic…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Center for Clinical Research, Inc., Castro Valley, California

    Locations

    4 in total

    Run by

    Molnlycke Health Care AB

    See if you can join NCT05588583 on ClinicalTrials.gov