Type 2 Diabetes Mellitus Clinical Trials

15 studies are recruiting for type 2 diabetes mellitus in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Type 2 Diabetes

   Study ASC30-302 (AURORA-2) is a Phase III, global, multicenter, randomized, double-blind, placebo-controlled study to investigate the long-term efficacy, safety, and tolerability of three maintenance doses of once-daily oral ASC30 compared with placebo in participants with obesity or overweight and…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   AURORA-2 Clinical Site, Phoenix, Arizona

   Locations

   135 in total

   Run by

   Ascletis Pharma (China) Co., Limited

   See if you can join NCT07743450 on ClinicalTrials.gov

2. A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight and Type 2 Diabetes

   The purpose of this study is to assess the efficacy and safety of enicepatide, a dual glucagon-like peptide-1 (GLP-1)/glucose-dependent insulinotropic polypeptide (GIP) receptor agonist (RA), at multiple doses compared with placebo for weight management in participants with obesity or overweight an…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Lakeview Clinical Research, Guntersville, Alabama

   Locations

   204 in total

   Run by

   Hoffmann-La Roche

   See if you can join NCT07351058 on ClinicalTrials.gov

3. A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus

   The purpose of this study is to evaluate the efficacy, safety, and tolerability of elecoglipron compared with oral semaglutide in adults with T2DM and increased cardiovascular risk that is inadequately managed alone or on stable treatment with other background glucose-lowering medication(s).

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Research Site, Buenos Aires,

   Locations

   209 in total

   Run by

   AstraZeneca

   See if you can join NCT07662213 on ClinicalTrials.gov

4. A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Compared With Placebo in Adults With Type 2 Diabetes Mellitus and Impaired Renal Function on Background Dapagliflozin

   The purpose of this study is to evaluate the efficacy, safety, and tolerability of elecoglipron, compared with placebo in adults with type 2 diabetes mellitus (T2DM) and impaired renal function, who are or will be on a background of sodium-glucose cotransporter 2 inhibitor (SGLT2i) dapagliflozin 10…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Research Site, Sacramento, California

   Locations

   186 in total

   Run by

   AstraZeneca

   See if you can join NCT07662135 on ClinicalTrials.gov

5. A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Alone or in Combination With Dapagliflozin Compared With Placebo in Adults With Type 2 Diabetes Mellitus

   The purpose of this study is to evaluate the efficacy, safety, and tolerability of elecoglipron alone or in combination with dapagliflozin compared with placebo in adults with type 2 diabetes mellitus (T2DM) inadequately managed with lifestyle management alone or treated with other background gluco…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Research Site, Kaohsiung City,

   Locations

   149 in total

   Run by

   AstraZeneca

   See if you can join NCT07662044 on ClinicalTrials.gov

6. A Phase III Study to Investigate the Efficacy and Safety of the Combination of Elecoglipron and Dapagliflozin in Adults With Type 2 Diabetes Mellitus

   The purpose of this study is to evaluate the efficacy, safety, and tolerability of elecoglipron and dapagliflozin in combination, compared with elecoglipron alone and dapagliflozin alone, in adults with type 2 diabetes mellitus (T2DM) inadequately managed with lifestyle management alone or treated …

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Research Site, Kaohsiung City,

   Locations

   272 in total

   Run by

   AstraZeneca

   See if you can join NCT07662109 on ClinicalTrials.gov

7. Study to Evaluate HM15275 in Subjects With Type 2 Diabetes Mellitus

   This study is a Phase 2 clinical trial to evaluate the efficacy, safety, and tolerability of HM15275 in subjects with type 2 diabetes mellitus over 36 weeks.

   Stage

   Phase 2

   Ages

   18 to 75

   Site

   Desert Clinical Research, Mesa, Arizona

   Locations

   15 in total

   Run by

   Hanmi Pharmaceutical Company Limited

   See if you can join NCT07527650 on ClinicalTrials.gov

8. The GRoceries Aimed at Increasing Nutrition Study

   Only 2% of Americans meet the recommended levels of whole grain consumption, despite its association with reduced risk of type 2 diabetes. This study aims to assess if consumers with prediabetes or type 2 diabetes can be encouraged to switch from buying refined grain products to whole grain product…

   Stage

   Not phased

   Ages

   45 to 70

   Site

   University of Pennsylvania, Philadelphia, Pennsylvania

   Run by

   University of Pennsylvania

   See if you can join NCT07167004 on ClinicalTrials.gov

9. A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Compared With Placebo in Adults With Type 2 Diabetes Mellitus on Background Insulin

   The purpose of this study is to evaluate the efficacy, safety, and tolerability of elecoglipron compared with placebo in adults with Type 2 Diabetes Mellitus (T2DM), treated with a background insulin and other background glucose-lowering medication(s)

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Research Site, Ocoee, Florida

   Locations

   132 in total

   Run by

   AstraZeneca

   See if you can join NCT07664553 on ClinicalTrials.gov

10. Evaluation of the Fully Closed Loop Omnipod® System in Type 2 Diabetes

    A multi-center, 26-week randomized controlled trial (RCT) to evaluate the safety and efficacy of the fully closed loop Omnipod M System in adults with type 2 diabetes using basal/bolus insulin therapy or basal-only insulin therapy, with the primary endpoint after 15 weeks and secondary analysis at …

    Stage

    Not phased

    Ages

    18 to 75

    Site

    University of Southern California, Los Angeles, California

    Locations

    27 in total

    Run by

    Insulet Corporation

    See if you can join NCT07521475 on ClinicalTrials.gov

11. Efficacy of the Omnipod® 6 System Compared With the Omnipod® 5 System

    This multi-center, randomized, cross-over trial will evaluate the efficacy of the Omnipod 6 System compared with the Omnipod 5 System in individuals with type 1 or type 2 diabetes and suboptimal glycemia.

    Stage

    Not phased

    Ages

    14 to 75

    Site

    University of Southern California, Los Angeles, California

    Locations

    11 in total

    Run by

    Insulet Corporation

    See if you can join NCT07579702 on ClinicalTrials.gov

12. An Observational Study Called FINEROD to Learn More About the Use of the Treatment Finerenone Including How Safe it is and How Well it Works Under Real-world Conditions

    This is an observational study, in which data from people in Asia and in the United States with chronic kidney disease (CKD) together with type 2 diabetes (T2D) are studied. The participants in this study are already receiving the study treatment finerenone as part of their regular care from their …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Bayer, Berlin,

    Locations

    4 in total

    Run by

    Bayer

    See if you can join NCT06278207 on ClinicalTrials.gov

13. A Study of Glycemic Control in Left Ventricular Assist

    The study is being conducted to understand if the hemoglobin A1c, a measurement of control of blood sugars over a 3-month time, is valid in patients with Left Ventricular Assist Devices (LVADs) in place. To understand whether it is an adequate measurement, the investigators will compare the A1c to …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mayo Clinic in Rochester, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT05933161 on ClinicalTrials.gov

14. A U.S. Pilot Human Investigation of RadiofrEquency Vapor Ablation System to Evaluate Safety, TOleRability, and Effectiveness for Proximal Intestinal Mucosal Ablation in Patients With Type 2 Diabetes Mellitus (RESTORE-1 Study)

    The purpose of this study is to assess the safety, tolerability and effectiveness of RF vapor ablation of the proximal intestinal mucosa. This study will test the hypothesis that RF vapor ablation will result in improvement in glycemic parameters, without Serious Adverse Events (SAE) or Unanticipat…

    Stage

    Not phased

    Ages

    22 to 65

    Site

    Mayo Clinic, Scottsdale, Arizona

    Locations

    4 in total

    Run by

    Aqua Medical, Inc.

    See if you can join NCT07355270 on ClinicalTrials.gov

15. Puberty, Diabetes, and the Kidneys, When Eustress Becomes Distress (PANTHER Study)

    Early diabetic kidney disease (DKD) occurs in 50-70% of youth with type 2 diabetes (T2D) and confers high lifetime risk of dialysis and premature death. Youth-onset T2D typically manifests during or shortly after puberty in adolescents with obesity. Epidemiological data implicate puberty as an acce…

    Stage

    Not phased

    Ages

    8 to 14

    Site

    Children's Hospital Colorado, Aurora, Colorado

    Locations

    2 in total

    Run by

    Petter Bjornstad

    See if you can join NCT05008276 on ClinicalTrials.gov