Type 1 Diabetes (T1D) Clinical Trials

22 studies are recruiting for type 1 diabetes (t1d) in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. METabolic MODulation to Enhance Insulin Sensitivity and Mitochondrial Function in Type 1 Diabetes (MetMod-T1D)

   The study is a randomized, double-blind, parallel-group clinical trial to examine the effects of 24 weeks of oral AMX0035 (sodium phenylbutyrate + taurursodiol) versus placebo in 60 adults with Type 1 Diabetes (T1D) (n=30 per arm). Enrollment will be distributed equally between the University of Wa…

   Stage

   Phase 2

   Ages

   18 to 69

   Site

   University of Washington Medicine Diabetes Institute (UWMDI), Seattle, Washington

   Locations

   2 in total

   Run by

   University of Washington

   See if you can join NCT07699380 on ClinicalTrials.gov

2. App-Based Certified Diabetes Education Therapy (AB-CDE)

   The purpose of this study is to learn more about a smartphone application (app) called DailyDose, an investigational decision support tool that may help in managing your diabetes. DailyDose tracks your continuous glucose monitoring (CGM) data, insulin use, and exercise, and uses this information to…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Southern California, Los Angeles, California

   Locations

   6 in total

   Run by

   Oregon Health and Science University

   See if you can join NCT07282639 on ClinicalTrials.gov

3. Advancing Precision Nutrition: Wearable Technology for Noninvasive Insulin Monitoring

   Noninvasively monitoring insulin is crucial for advancing precision nutrition and promoting healthy living by enabling a deeper understanding of individual metabolic responses to dietary intake. Insulin is a key regulator of blood sugar and energy metabolism, and its dysregulation is linked to cond…

   Stage

   Not phased

   Ages

   18 to 90

   Site

   Texas A&M University, College Station, Texas

   Run by

   Texas A&M University

   See if you can join NCT07254364 on ClinicalTrials.gov

4. Safety Evaluation of MODI, an Insulin Titration Algorithm, in Adults With Diabetes

   A 13-week multi-center single-arm trial, preceded by a 2-week standard therapy phase, will be conducted to assess the safety of MODI, an insulin titration algorithm, in adults with type 1 diabetes (T1D) who use multiple daily insulin injections (MDI), or with type 2 diabetes (T2D) who use MDI, basa…

   Stage

   Not phased

   Ages

   18 to 80

   Site

   Henry Ford Health System, Detroit, Michigan

   Locations

   6 in total

   Run by

   DreaMed Diabetes

   See if you can join NCT07599982 on ClinicalTrials.gov

5. A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus

   This study is First In Human study for Encapsulated Porcine Islet Cells for Xenotransplantation (OPF-310). The purpose of this study to assess the safety, tolerability, and efficacy of OPF-310 transplantation and to define the recommended Phase 2 dose (RP2D) in adult subjects with unstable Type 1 D…

   Stage

   Phase 1

   Ages

   35 to 70

   Site

   University of Illinois Hospital & Health Sciences System, Chicago, Illinois

   Run by

   Otsuka Pharmaceutical Factory, Inc.

   See if you can join NCT06575426 on ClinicalTrials.gov

6. Integrating New Skills Into Diabetes Education With CGM

   This study is designed to test the preliminary efficacy of a three-stage continuous glucose monitor (CGM) integration program for older adults who are taking insulin. This study will learn if a three-stage CGM integration program ("intervention") that includes sessions focused on CGM technology ski…

   Stage

   Not phased

   Ages

   65 and older

   Site

   University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

   Run by

   University of North Carolina, Chapel Hill

   See if you can join NCT07463209 on ClinicalTrials.gov

7. A Study of GNTI-122 in Adults Recently Diagnosed With T1D

   This is a 78-week single arm, multi-center, Phase 1 study to evaluate the safety, tolerability, cellular kinetics, and biomarker changes in C-peptide over time of GNTI-122, an investigational cell therapy manufactured from a participant's own blood cells in adult participants with recently diagnose…

   Stage

   Phase 1

   Ages

   18 to 55

   Site

   City of Hope Medical Center, Duarte, California

   Locations

   10 in total

   Run by

   GentiBio, Inc

   See if you can join NCT06919354 on ClinicalTrials.gov

8. Adapting Single Sessions Interventions for Type 1 Diabetes

   The goal of this clinical trial is to learn if implementing a single-session depression intervention for youth with type 1 diabetes (T1D) is feasible and acceptable to patients. can help improve mood and health outcomes. It will also learn about the initial efficacy of the intervention. The main qu…

   Stage

   Not phased

   Ages

   12 to 17

   Site

   Nemours Children's Hospital - FL, Orlando, Florida

   Run by

   Nemours Children's Health System

   See if you can join NCT06752369 on ClinicalTrials.gov

9. Building and Sustaining Exercise Habits for Adults With Type 1 Diabetes

   The challenges of living with type 1 diabetes often stand in the way of getting enough exercise. Continuous blood sugar monitoring has revolutionized type 1 diabetes care but remains underutilized to sustainably support exercise and related behaviors. This remote participation-based research will d…

   Stage

   Not phased

   Ages

   30 to 65

   Site

   Yale School of Medicine, New Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT06967701 on ClinicalTrials.gov

10. Automated Insulin for Management of Intrapartum Glycemia

    The goal of this clinical trial is learn if automated insulin delivery (AID) systems can be used for glucose management during labor/delivery for pregnant people with type 1 diabetes (T1D). The main questions this study aims to answer are * What are the neonatal glycemic outcomes with use of AID sy…

    Stage

    Not phased

    Ages

    18 to 55

    Site

    University of California, Los Angeles, Los Angeles, California

    Locations

    3 in total

    Run by

    University of California, San Francisco

    See if you can join NCT06883344 on ClinicalTrials.gov

11. Monocytes in Subjects With Type 1 Diabetes and Chronic Kidney Disease

    This is a cross-sectional study in patients with Type 1 diabetes (TID) and chronic kidney disease (CKD) to test if time in range (TIR) affects the degree of hyperglycemia required for monocyte activation, podocyte injury, and assess if monocyte activation is attenuated by glucagon-like peptide (GLP…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Cleveland Clinic, Cleveland, Ohio

    Run by

    The Cleveland Clinic

    See if you can join NCT06694558 on ClinicalTrials.gov

12. Circadian Mechanisms, Glucose, and CV Risks in T1D

    People with type 1 diabetes are disproportionately affected by cardiovascular disease (CVD). Short and irregular sleep have been associated with cardiovascular risk in this population. Improving sleep regularity has been associated with improved glycemic markers however mechanisms by which improvin…

    Stage

    Not phased

    Ages

    18 to 50

    Site

    University of Illinois Chicago, Chicago, Illinois

    Run by

    University of Illinois at Chicago

    See if you can join NCT06624046 on ClinicalTrials.gov

13. Insulin Delivery With Self-Adjusting Closed-Loop and Behavioral Glycemic Control Enhanced by Prediction

    This study is a randomized cross-over trial comparing AIDANET with Anticipation to AIDANET in FCL without Anticipation. Participants will complete 4 weeks of AID data collection which will be used to establish baseline and initialize the control algorithm. Participants will then be randomized to on…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Virginia Center for Diabetes Technology, Charlottesville, Virginia

    Run by

    Sue Brown

    See if you can join NCT07507708 on ClinicalTrials.gov

14. Primary Care Pragmatic, Real World Experience for Automated Insulin Delivery

    The goal of this randomized controlled trial is to compare the efficacy and safety of the iLet Bionic Pancreas (BP) System in adults with insulin-treated diabetes (type 1 diabetes or type 2 diabetes) compared to standard of care when ordered by primary care providers. The main question it aims to a…

    Stage

    Not phased

    Ages

    18 to 89

    Site

    University of Colorado Anschutz Medical Campus, Aurora, Colorado

    Locations

    2 in total

    Run by

    University of Colorado, Denver

    See if you can join NCT07011147 on ClinicalTrials.gov

15. Type 1 Diabetes REst for Metabolic Health

    Research has shown a link between poor sleep health and late circadian timing with cardiometabolic health in adolescents with type 1 diabetes (T1D). Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in T1D, which begins as early as adolescence, and current therapies are l…

    Stage

    Not phased

    Ages

    14 to 19

    Site

    Children's Hospital Colorado, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT06627504 on ClinicalTrials.gov

16. Kidney Precision Medicine Project

    Acute kidney injury (AKI) and chronic kidney disease (CKD) impose a significant global health burden. Yet, no effective therapies currently exist for AKI, and only a few are available for CKD. Despite significant effort from industry and academia, development of pharmacologic therapies for AKI and …

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Arizona, Tucson, Arizona

    Locations

    13 in total

    Run by

    Icahn School of Medicine at Mount Sinai

    See if you can join NCT04334707 on ClinicalTrials.gov

17. Evaluation of a Novel Insulin Sensitizer in People With Type 1 Diabetes

    The purpose of this study is to see if the study drug CIR-0602K will improve glucose time-in-range and/or lower total daily insulin dose in people with type 1 diabetes who are using closed-loop automated insulin delivery. Researchers will compare CIR-0602K to a placebo (a look-alike substance that …

    Stage

    Phase 2

    Ages

    18 to 45

    Site

    University of Virginia, Charlottesville, Virginia

    Run by

    University of Virginia

    See if you can join NCT07186660 on ClinicalTrials.gov

18. Digital Mindfulness for Young Adults With Type 1 Diabetes

    The purpose of this research study is to test a mindfulness app called Calm Health among young adults with type 1 diabetes or other absolute insulin deficiency diabetes. Mindfulness is the practice of being aware of your thoughts and feelings in the moment without judgment or negative reaction. All…

    Stage

    Not phased

    Ages

    18 to 30

    Site

    Yale University School of Medicine, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT07062887 on ClinicalTrials.gov

19. Twiist Postmarket Surveillance Study for Type 1 Diabetes

    The goal of this surveillance study is to collect real-world data on adults and youth with type 1 diabetes (T1D) using twiist(TM) for insulin delivery.

    Stage

    Not phased

    Ages

    6 and older

    Site

    Jaeb Center for Health Research, Tampa, Florida

    Run by

    Deka Research and Development

    See if you can join NCT07356089 on ClinicalTrials.gov

20. Type 1 Diabetes and Obstructive Sleep Apnea

    The purpose of the study is to investigate the role of sleep apnea in glycemic dysregulation in adults with Type 1 diabetes.

    Stage

    Not phased

    Ages

    18 to 50

    Site

    University of Chicago, Chicago, Illinois

    Run by

    University of Chicago

    See if you can join NCT06915831 on ClinicalTrials.gov

21. Utilizing Community Health Workers as Diabetes Technology Coaches for Children With Type 1 Diabetes Using Automated Insulin Delivery

    This study uses community health workers (CHW) as diabetes technology coaches for African American children using automated insulin delivery systems but have an HbA1c of 8% or higher. Families will meet with the CHW monthly x 6 months with additional visits as needed. All participants and parents/g…

    Stage

    Not phased

    Ages

    5 to 17

    Site

    University Hospitals Cleveland Medical Center, Cleveland, Ohio

    Run by

    University Hospitals Cleveland Medical Center

    See if you can join NCT07154251 on ClinicalTrials.gov

22. Pragmatic Clinic-Based Trial of a Mindfulness Based Intervention for Mood Concerns in Youth With Type 1 Diabetes

    Type 1 diabetes (T1D) is a common chronic illness among children requiring a high degree of self-management for good glycemic control. Adolescents are at risk for poor disease management and health outcomes due to a number of factors, including high rates of depression, anxiety, and stress. Accessi…

    Stage

    Not phased

    Ages

    13 to 17

    Site

    Children's National Hospital, Washington D.C., District of Columbia

    Locations

    2 in total

    Run by

    Children's National Research Institute

    See if you can join NCT06618027 on ClinicalTrials.gov