Trauma Clinical Trials

26 studies are recruiting for trauma in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Comparative Effectiveness of SPARCS and Unified Protocol for Youth With Chronic Medical Conditions and Trauma-Related Distress

   The goal of this clinical trial is to compare the effectiveness of trauma-focused therapies for improving mental health symptoms and daily functioning in youth with chronic medical conditions who have experienced psychological trauma and trauma-related distress. The study evaluates two evidence-bas…

   Stage

   Not phased

   Ages

   8 to 18

   Site

   Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois

   Run by

   Anthony Vesco

   See if you can join NCT07483333 on ClinicalTrials.gov

2. CAlcium and VAsopressin Following Injury Early Resuscitation (CAVALIER) Trial

   The CAlcium and VAsopressin following Injury Early Resuscitation (CAVALIER) Trial is a proposed 4 year, double-blind, mutli-center, prehospital and early in hospital phase randomized trial designed to determine the efficacy and safety of prehospital calcium and early in hospital vasopressin in pati…

   Stage

   Phase 2

   Ages

   18 to 90

   Site

   Chandler Regional Medical Center, Chandler, Arizona

   Locations

   17 in total

   Run by

   Jason Sperry

   See if you can join NCT05958342 on ClinicalTrials.gov

3. Onyx™ Liquid Embolic IDE Clinical Study

   The purpose of this study is to evaluate the safety and effectiveness of Onyx™ LES in the treatment of subjects with active arterial bleeding in the peripheral vasculature outside of the heart and brain.

   Stage

   Not phased

   Ages

   22 and older

   Site

   Mayo Clinic, Phoenix, Arizona

   Locations

   19 in total

   Run by

   Medtronic Endovascular

   See if you can join NCT06742801 on ClinicalTrials.gov

4. Study of Cannabidiol and Neuroimaging on Stress

   Dysregulation in stress responsivity is a growing psychiatry-transdiagnostic fundamental phenomenon, with limited therapeutic strategies. With the legalization of medical and recreational cannabis, many people consume cannabidiol (CBD; a nonintoxicating cannabinoid) to alleviate stress response, wi…

   Stage

   Phase 1

   Ages

   18 to 25

   Site

   Ichan School of Medicine at Mount Sinai, New York, New York

   Run by

   Icahn School of Medicine at Mount Sinai

   See if you can join NCT07278505 on ClinicalTrials.gov

5. Traumatic Cardiac Arrest

   This retrospective data repository will serve as a means to aggregate and analyze order of pre-hospital care (intubation, medication, etc) as it relates to Traumatic cardiac arrest.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Methodist Dallas Medical Center- Clinical Research Institute, Dallas, Texas

   Run by

   Methodist Health System

   See if you can join NCT07490171 on ClinicalTrials.gov

6. Acute Subdural Hematoma

   This retrospective data repository will serve as a means to aggregate and analyze standard surgical interventions and Middle Meningeal Arteryembolization as suitable treatment options for Acute Subdural Hematoma.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Methodist Dallas Medical Center- Clinical Research Institute, Dallas, Texas

   Run by

   Methodist Health System

   See if you can join NCT07490197 on ClinicalTrials.gov

7. Animal Assisted Therapy

   This study looks at whether walking with a therapy dog helps adult and pediatric trauma patients move more during their hospital stay. Early movement after an injury or surgery can prevent problems such as blood clots, pressure sores, and muscle loss, but pain and anxiety often make it hard for pat…

   Stage

   Not phased

   Ages

   4 to 99

   Site

   University of Kentucky Albert B. Chandler Hospital, Lexington, Kentucky

   Run by

   Andrew Bernard

   See if you can join NCT07227181 on ClinicalTrials.gov

8. OCT in Open Fracture and Infected Fracture

   This is a pilot prospective, observational study of patients with open or infected fracture evaluating the feasibility and acceptability of OCT, a light-based imaging modality that requires no drug or contrast agent.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire

   Run by

   Dartmouth-Hitchcock Medical Center

   See if you can join NCT05785182 on ClinicalTrials.gov

9. Enteric Anastomoses

   This retrospective data repository will serve as a means to aggregate and analyze best practices as relative to traumatic colon injury outcomes.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Methodist Dallas Medical Center- Clinical Research Institute, Dallas, Texas

   Run by

   Methodist Health System

   See if you can join NCT07490158 on ClinicalTrials.gov

10. Optimizing Recovery in Trauma Patients by Integrating Enhanced Nutrition Delivery

    This is a prospective, randomized, controlled trial designed to evaluate the impact of enhanced protein supplementation compared to a standard of care nutrition delivery in critically ill older adult trauma patients. Subjects will be randomized 1:1 to either enhanced nutrition or control arm. Subje…

    Stage

    Not phased

    Ages

    45 and older

    Site

    Duke University Hospital, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT06521086 on ClinicalTrials.gov

11. Women Focused Encounters for Resilience Independence Strength and Eudaimonia

    The goal of this combination Type 1 hybrid and observational study is to evaluate the impact of a peer delivered intervention of acceptance and commitment therapy (ACT) + exercise + social support to address the substance (ab)use, violence, and AIDS/HIV (SAVA) to improve medication adherence for wo…

    Stage

    Not phased

    Ages

    18 and older

    Site

    UC San Diego AntiViral Research Center (AVRC), San Diego, California

    Run by

    University of California, San Diego

    See if you can join NCT06216600 on ClinicalTrials.gov

12. Mg OSTEOCRETE Post-Treatment Outcomes

    Mg OSTEOCRETE is a bone substitute used to fill a defect in bone caused by excision of a tumor, orthopaedic hardware that has become loosened, or a trauma-related condition. The aim of this study is to determine the amount of time it takes for bone to heal after treatment with Mg OSTEOCRETE, and to…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Santiago Lozano-Calderon

    See if you can join NCT06720142 on ClinicalTrials.gov

13. Comparative Outcomes of PCC and Recombinant Activated Factor VIIa in Trauma-Associated Massive Transfusion

    This study aims to compare the incidence of thromboembolic complications among trauma patients receiving PCC, rFVIIa, both agents, or neither during massive transfusion. Secondary objectives include comparing mortality, transfusion requirements, intensive care unit (ICU) and hospital length of stay…

    Stage

    Not phased

    Ages

    18 and older

    Site

    UF Health Jacksonville (Shands Hospital), Jacksonville, Florida

    Locations

    2 in total

    Run by

    Zeliha Alicikus

    See if you can join NCT07290634 on ClinicalTrials.gov

14. Nonopioid Pain Control Regimen After Open Reduction and Internal Fixation of Traumatic Fractures

    An open reduction and internal fixation is a painful procedure requiring intensive postoperative pain management. Traditionally, opioid analgesia has been the gold standard for postoperative pain control. However, given the harmful side effect profile and opioid epidemic in the United States, it is…

    Stage

    Phase 4

    Ages

    18 to 80

    Site

    Henry Ford Hospital System, Detroit, Michigan

    Run by

    Henry Ford Health System

    See if you can join NCT06113211 on ClinicalTrials.gov

15. Multiphase Optimization Strategy (MOST) for Treating Pediatric Post-traumatic Stress Disorder (PTSD)

    The goal of this clinical trial is to test the extent to which different treatment components work to improve pediatric post-traumatic stress disorder (PTSD). It will also provide evidence for how these components work. The main research questions are: What are the effects of different components u…

    Stage

    Not phased

    Ages

    8 to 17

    Site

    The Mt. Hope Family Center, Rochester, New York

    Run by

    University of Rochester

    See if you can join NCT06956781 on ClinicalTrials.gov

16. Nitric Oxide (NO) and Endothelial Dysfunction in Women With PTSD

    This research study is conducted to better understand why women with post-traumatic stress disorder (PTSD) have higher risk of cardiovascular disease as they get older. This study looks at how trauma and PTSD affect blood vessels in young women by testing whether the dietary supplement beetroot jui…

    Stage

    Not phased

    Ages

    18 to 40

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT07485231 on ClinicalTrials.gov

17. Trauma Activation Criteria

    To quantify the over- and under-triage rates as relative to trauma activation criteria reform.

    Stage

    Not phased

    Ages

    Any age

    Site

    Methodist Dallas Medical Center- Clinical Research Institute, Dallas, Texas

    Run by

    Methodist Health System

    See if you can join NCT07490145 on ClinicalTrials.gov

18. The Role of Brain-Bone Marrow-Gut Interaction Following Major Trauma

    Traumatic injury followed by critical illness provokes pathophysiologic changes in the bone marrow and the gut that contribute to persistent anemia and changes in the microbiome which significantly impact long-term recovery. This project will define the interactions between the stress, chronic infl…

    Stage

    Not phased

    Ages

    18 to 100

    Site

    UF Academic Research Building, Gainesville, Florida

    Locations

    3 in total

    Run by

    University of Florida

    See if you can join NCT06606119 on ClinicalTrials.gov

19. Effectiveness, Implementation, and Cost of Cognitive Processing Therapy in Prisons

    Addiction and trauma exposure are common among the 5.5 million people (1 in 47 adults) in the U.S. who are in prison or under supervision. About 85% of people in prison have a substance use disorder or are there for a drug-related crime, and many have experienced serious trauma before being incarce…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Northeast Arkansas Community Corrections Center (NEACC), Osceola, Arkansas

    Locations

    6 in total

    Run by

    University of Arkansas

    See if you can join NCT06923423 on ClinicalTrials.gov

20. IlluminOss Photodynamic Bone Stabilization System for the Treatment of Impending and Actual Pelvis Fractures

    The aim of this project is to assess the effectiveness of the IlluminOss pelvic implants in patients with pelvic metastatic disease presenting with pain, risk of pathologic fracture, non-displaced or minimally displaced pathologic fracture of the pelvis, and geriatric patients with pelvic fragility…

    Stage

    Not phased

    Ages

    21 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT04842266 on ClinicalTrials.gov

21. Magnesium Infusion for Pain Management in Critically Ill Trauma Patients

    Magnesium is a naturally occurring mineral that is important for your body and brain. Magnesium sulfate (study drug) is a medication containing magnesium that is commonly used to improve low blood levels of magnesium. Magnesium sulfate has also proven to be successful in managing pain before and af…

    Stage

    Phase 4

    Ages

    18 and older

    Site

    UC Davis Health, Sacramento, California

    Run by

    University of California, Davis

    See if you can join NCT04166877 on ClinicalTrials.gov

22. REVIVE: Reducing Exsanguination Via In-Vivo Expandable Foam

    The purpose of this study is to demonstrate safety, effectiveness and benefit-risk profile of ResQFoam for the inhospital treatment of exsanguinating, intraabdominal haemorrhage due to trauma in patients where emergent laparotomy is required.

    Stage

    Not phased

    Ages

    15 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Locations

    2 in total

    Run by

    Arsenal Medical, Inc.

    See if you can join NCT02880163 on ClinicalTrials.gov

23. A Clinical Trial of Interventions to Support Family Surrogates of Critically Ill Patients

    Hypotheses 1a and 1b: Compared to Supportive Conversation arm, the EMPOWER intervention will significantly decrease surrogate decision makers' symptoms of grief and Post Traumatic Stress Disorder (PTSD) (primary outcomes); and H1b. experiential avoidance, depression, regrets, and increases in patie…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Memorial Sloan Kettering Cancer Center, New York, New York

    Locations

    3 in total

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT05587517 on ClinicalTrials.gov

24. Respiratory Training in the Treatment of Transdiagnostic Pathological Anxiety

    Purpose of the Research: The primary aim of the proposed study is to conduct a randomized parallel-group 2-arm clinical trial investigating capnometry-guided respiratory intervention (CGRI) for pathological anxiety. CGRI aims to raise end-tidal CO2 levels thereby lowering hyperventilation-induced r…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Texas at Austin, Austin, Texas

    Run by

    University of Texas at Austin

    See if you can join NCT05427708 on ClinicalTrials.gov

25. PRESERVE & CONNECT: Impact Study of the BPC

    The PRESERVE \& CONNECT project is a multi-site randomized control trial of the Breakthrough Parenting Curriculum: Navigating Trauma Across Generations (BPC) in rural and racially and ethnically diverse communities in Vermont and Connecticut.

    Stage

    Not phased

    Ages

    Any age

    Site

    University of Connecticut, Hartford, Connecticut

    Locations

    2 in total

    Run by

    University of Vermont

    See if you can join NCT06160050 on ClinicalTrials.gov