Total Knee Arthroplasty Clinical Trials

16 studies are recruiting for total knee arthroplasty in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Medrol Dosepak for Outpatient Total Knee Arthroplasty

   The purpose of this study is to evaluate the efficacy of an oral methylprednisolone taper on acute postoperative pain, function, opioid consumption, nausea, and complications following outpatient total knee arthroplasty (TKA). We hypothesize that administration of an oral methylprednisolone taper s…

   Stage

   Phase 4

   Ages

   18 and older

   Site

   Rush Oak Brook Outpatient Center, Oak Brook, Illinois

   Run by

   Rush University Medical Center

   See if you can join NCT05097976 on ClinicalTrials.gov

2. Methadone in the Management of Post-Operative Pain in Total Knee Replacement

   The goal of this study is to determine whether one dose of IV methadone given right before surgery will help patients' pain management after a total knee replacement and reduce the amount of pain medications taken in the weeks after surgery.

   Stage

   Phase 4

   Ages

   21 to 75

   Site

   AdventHealth Porter, Denver, Colorado

   Run by

   AdventHealth

   See if you can join NCT07485803 on ClinicalTrials.gov

3. Brain-Computer Interface Visualization Training to Optimize Muscle Activation Following Orthopaedic Surgery

   After orthopedic surgeries like knee or hip replacement, some patients struggle to fully activate their muscles due to a condition called Arthrogenic Muscle Inhibition (AMI). AMI can slow recovery and make physical therapy less effective. This clinical trial is testing whether a special type of bra…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Rush University Medical Center, Chicago, Illinois

   Run by

   Rush University Medical Center

   See if you can join NCT07020312 on ClinicalTrials.gov

4. Vancomycin in TKAs

   Periprosthetic joint infection (PJI) is a national health crisis and leads to very poor outcomes for patients undergoing elective joint replacement. Within the realm of elective total knee arthroplasty (TKA), various methods of infection prophylaxis are in place. These include sterile precautions, …

   Stage

   Phase 4

   Ages

   18 and older

   Site

   University of California, San Diego, San Diego, California

   Run by

   University of California, San Diego

   See if you can join NCT07282782 on ClinicalTrials.gov

5. Persona MC vs PS RCT With ROSA

   A randomized, controlled study comparing two total knee implant devices, Persona medial congruent (MC) vs posterior stabilized (PS). These surgeries will be performed using the ROSA robotic system. Patients will be followed up to 5 years.

   Stage

   Not phased

   Ages

   18 and older

   Site

   NYU Langone Health, New York, New York

   Run by

   NYU Langone Health

   See if you can join NCT05391828 on ClinicalTrials.gov

6. Binaural Beats for Postoperative Pain and Anxiety Reduction

   To deliver a 30-minute binaural beats audio intervention in PACU and collect pain and anxiety outcomes immediately following surgery, and 4 hours following surgery completion in adults undergoing ambulatory total knee arthroplasty and total hip arthroplasty (TKA and THA).

   Stage

   Not phased

   Ages

   18 to 99

   Site

   Univeristy of Miami Health System, Miami, Florida

   Run by

   University of Miami

   See if you can join NCT07437469 on ClinicalTrials.gov

7. Methylene Blue in Total Knee Arthroplasty (TKA)

   The purpose of this pilot study is to determine the volume of irrigation required to achieve macroscopic clearance of contaminants during a debridement, antibiotics, and implant retention (DAIR) procedure for periprosthetic joint infection (PJI) of the knee. Given the lack of robust data guiding ir…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   UHealth Tower, Miami, Florida

   Run by

   University of Miami

   See if you can join NCT07324954 on ClinicalTrials.gov

8. The Benefits Of Cryoablation In Patients Undergoing Total Knee Arthroplasty

   The purpose of this study is to evaluate the efficacy of cryoablation use on patient-reported outcomes (PROMs) and opioid consumption following total knee arthroplasty. This is a randomized study that will involve a 1:1 randomization to total knee arthroplasty +/- cryoablation.

   Stage

   Not phased

   Ages

   18 and older

   Site

   NYU Langone Health, New York, New York

   Run by

   NYU Langone Health

   See if you can join NCT06991231 on ClinicalTrials.gov

9. Improving Rehabilitation for Veterans After Total Knee Arthroplasty Using Individualized Recovery Trajectories

   This study will examine the impact of a new clinical decision support tool for rehabilitation after total knee arthroplasty (TKA). Typically, TKA rehabilitation is generic with most patients receiving the same dosage and contents of rehabilitation despite notable diversity among patients who underg…

   Stage

   Not phased

   Ages

   40 to 90

   Site

   Rocky Mountain Regional VA Medical Center, Aurora, CO, Aurora, Colorado

   Locations

   2 in total

   Run by

   VA Office of Research and Development

   See if you can join NCT05288803 on ClinicalTrials.gov

10. Observation of Wheeled Device Use After TKA

    Maneuverability is currently under appreciated by patients who are seeking mobility. This pilot study is examining how patients maneuverability and mobility will change with this novel mobility tool.

    Stage

    Not phased

    Ages

    18 to 99

    Site

    450 Broadway, Redwood City, California

    Run by

    Stanford University

    See if you can join NCT06080152 on ClinicalTrials.gov

11. Minimal Sedation During Knee Replacement Surgery

    This study will test the use of active noise cancelling headphones with music or a movie during knee replacement surgery. Feedback from the surgical team and from patients regarding the headset system will be gathered to see if using it can reduce the amount of sedation needed during knee replaceme…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mayo Clinic, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT07371390 on ClinicalTrials.gov

12. Investigating Patient Satisfaction With Smart Knee Implants

    The main goal of this study is to see if there is a connection between the social and economic resources available in a patient's neighborhood (measured by the Area Deprivation Index, ADI) and their recovery after knee replacement surgery, as tracked through remote monitoring. A secondary goal is t…

    Stage

    Not phased

    Ages

    18 and older

    Site

    The University of Chicago Medical Center, Chicago, Illinois

    Run by

    University of Chicago

    See if you can join NCT06968143 on ClinicalTrials.gov

13. Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplasty

    This is a prospective randomized controlled trial that will assess preoperative, perioperative, and long-term oxidative stress (OS); pain; and functional outcomes over a 12 month period and test the hypothesis that a potent antioxidant intervention (glycine + N-acetyl-cysteine(GlyNAC)) reduces oxid…

    Stage

    Phase 4

    Ages

    50 and older

    Site

    Vanderbilt University Medical Center, Nashville, Tennessee

    Run by

    Vanderbilt University Medical Center

    See if you can join NCT06083480 on ClinicalTrials.gov

14. Implementation of Neuromuscular Electrical Stimulation After Total Knee Arthroplasty

    Patients experience dramatic quadriceps strength loss after total knee replacement, which contributes to persistent weakness and reduced long-term function after surgery. Neuromuscular electrical stimulation (NMES) reduces quadriceps weakness and improves patient function after knee replacement, bu…

    Stage

    Not phased

    Ages

    18 and older

    Site

    UCHealth, Aurora, Colorado

    Locations

    3 in total

    Run by

    University of Colorado, Denver

    See if you can join NCT06953375 on ClinicalTrials.gov

15. Effectiveness of Exparel Anesthetic Administered by the Surgeon During Knee Surgery

    Intra-articular Posteromedial Surgeon Administered (IPSA) Block in this study describes a new type of medical procedure where a surgeon provides anesthetic medication directly into a specific area inside a knee joint to numb the pain during knee surgery. Intra-articular refers to inside of knee joi…

    Stage

    Not phased

    Ages

    Any age

    Site

    Cleveland Clinic Lutheran Hospital, Cleveland, Ohio

    Run by

    The Cleveland Clinic

    See if you can join NCT06946368 on ClinicalTrials.gov

16. Intraosseous (IO) Cefazolin and Vancomycin in Primary Total Knee Arthroplasty (TKA)

    The goal of this clinical trial is to compare the efficacy of intravenous (IV) and intraosseous (IO) antibiotic administration techniques during primary total knee arthroplasty (TKA) in adults undergoing a TKA procedure at Houston Methodist Hospital. The main questions it aims to answer are: Does I…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Houston Methodist Hospital, Houston, Texas

    Run by

    The Methodist Hospital Research Institute

    See if you can join NCT06640491 on ClinicalTrials.gov