Tobacco Use Disorder Clinical Trials

18 studies are recruiting for tobacco use disorder in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Modulating Neural Mechanisms of Reward Processing in Tobacco Users

   The goal of this clinical trial is to learn if a personalized, brain-scan-guided form of transcranial magnetic stimulation (TMS) works better than a standard TMS approach at changing reward-related brain activity in adults who smoke cigarettes. The main questions it aims to answer are: Does persona…

   Stage

   Not phased

   Ages

   18 to 60

   Site

   Rutgers University Center for Molecular and Behavioral Neuroscience, Newark, New Jersey

   Run by

   Rutgers, The State University of New Jersey

   See if you can join NCT07812753 on ClinicalTrials.gov

2. Varenicline for Smoking Reduction in Veterans Not Ready To Quit

   In order to reduce the prevalence of cigarette smoking among Veterans, it is vital that healthcare providers offer effective tobacco treatment to all Veterans who smoke, including those not ready to make a quit attempt. Smoking treatments currently available to Veterans who are not ready to quit ar…

   Stage

   Phase 4

   Ages

   21 and older

   Site

   VA San Diego Healthcare System, San Diego, CA, San Diego, California

   Locations

   4 in total

   Run by

   VA Office of Research and Development

   See if you can join NCT06966362 on ClinicalTrials.gov

3. Contingency Management for Veteran Smokers Undergoing Major Elective Surgery

   The goal of this study is to design and test the first mobile contingency management (CM) smoking cessation intervention for military Veterans undergoing major elective surgery. Smoking is the leading risk factor for postoperative complications and is associated with longer hospital stays, reoperat…

   Stage

   Not phased

   Ages

   18 and older

   Site

   San Francisco VA Health Care System, San Francisco, California

   Run by

   University of California, San Francisco

   See if you can join NCT06678672 on ClinicalTrials.gov

4. Project Q: Cue-based Treatment Intervention to Promote Cessation Among People Who Smoke Lightly or Non-daily

   This study aims to test the feasibility and acceptability of a remotely delivered cue-based treatment intervention to promote smoking cessation among people who smoke lightly or non-daily. Secondary objectives include assessing preliminary efficacy on cessation and examining cue reactivity. Partici…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Duke University, Durham, North Carolina

   Run by

   Duke University

   See if you can join NCT07425119 on ClinicalTrials.gov

5. Young Adult Tobacco/Nicotine and Cannabis Co-use

   The goal of this project is to better understand the relationship between tobacco/nicotine and cannabis using behavioral economics during a tobacco/nicotine quit attempt. All participants will receive tobacco/nicotine cessation treatment (smoking and/or vaping treatment) for 12 weeks. To qualify, p…

   Stage

   Not phased

   Ages

   18 to 25

   Site

   Medical University of South Carolina - Charleston, Charleston, South Carolina

   Run by

   Medical University of South Carolina

   See if you can join NCT06239350 on ClinicalTrials.gov

6. 5-HT2A Agonist Psilocybin in the Treatment of Tobacco Use Disorder

   This is a multi-site, double-blind, randomized clinical trial of the 5-HT2A receptor agonist psilocybin for smoking cessation. Four sites with experience in conducting psilocybin research will be involved in this trial: Johns Hopkins University (JHU), the University of Alabama at Birmingham (UAB), …

   Stage

   Phase 2

   Ages

   21 and older

   Site

   University of Alabama at Birmingham, Birmingham, Alabama

   Locations

   3 in total

   Run by

   Johns Hopkins University

   See if you can join NCT05452772 on ClinicalTrials.gov

7. E-cigarette Cessation in Adults Who Co-use Cannabis

   The purpose of this study is to better understand tobacco outcomes using a commonly prescribed stop smoking medication (varenicline) and financial incentives for adults who also use cannabis. Varenicline is not FDA approved for e-cigarette cessation, but is FDA approved for cigarette cessation. Inv…

   Stage

   Phase 4

   Ages

   18 to 40

   Site

   MUSC Charleston, Charleston, South Carolina

   Locations

   3 in total

   Run by

   Medical University of South Carolina

   See if you can join NCT06688539 on ClinicalTrials.gov

8. Multilevel Intervention for LDCT Lung Cancer Screening and Smoking Cessation Among African Americans

   This study aims to reduce disparities and the burden of lung cancer among African American smokers by supporting a Multiple-level intervention integrating lung cancer screening and smoking cessation (MILS), followed the NIH DEIA strategies using multilevel interventions that impact determinants of …

   Stage

   Not phased

   Ages

   50 to 80

   Site

   LSUHSC School of Public Health, New Orleans, Louisiana

   Locations

   2 in total

   Run by

   Louisiana State University Health Sciences Center in New Orleans

   See if you can join NCT07576595 on ClinicalTrials.gov

9. Beta-Adrenergic Modulation of Drug Cue Reactivity

   This study is designed to investigate the effects of a beta-adrenergic antagonist (Propranolol; 40 mg IR) and nicotine patch (14 mg) administered alone and in combination on neurobiological and behavioral responses to smoking cues in ongoing cigarette smokers. This is a basic experimental study in …

   Stage

   Phase 4

   Ages

   21 to 60

   Site

   Hardesty Center for Clinical Research and Neuroscience, Tulsa, Oklahoma

   Run by

   University of Oklahoma

   See if you can join NCT05587361 on ClinicalTrials.gov

10. Cannabidiol for Reducing Cigarette Use

    The goal of this research is to evaluate the efficacy of cannabidiol (CBD) in reducing cigarette smoking. Although there are safe and effective treatments for smoking cessation, not everyone who attempts smoking cessation is successful, even with these treatments. Relapse rates are high, leaving a …

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    CRI-Help, Inc., North Hollywood, California

    Run by

    University of California, Los Angeles

    See if you can join NCT06218056 on ClinicalTrials.gov

11. Cannabis-Tobacco Co-Use Treatment Study

    The purpose of the RECLAIM study is to evaluate the effectiveness of varenicline (sometimes known as Chantix) compared to placebo (an inactive substance) for the treatment of cigarettes and cannabis (marijuana). Varenicline is not FDA approved for the combination treatment of cigarette abstinence a…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Medical University of South Carolina - Charleston, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT06883162 on ClinicalTrials.gov

12. Neuroimaging Correlates and Feasibility of Transcranial Magnetic Stimulation (TMS) to Improve Smoking Cessation Outcomes in Veterans With Comorbid PTSD

    Tobacco use is the number one preventable cause of the death in the United States, and is high among US Veterans, and those who have experienced trauma are more likely to smoke. Despite the efficacy of current evidence-based treatments for smoking cessation, there is a critical need for alternative…

    Stage

    Phase 2

    Ages

    18 to 75

    Site

    Durham VA Medical Center, Durham, NC, Durham, North Carolina

    Run by

    VA Office of Research and Development

    See if you can join NCT05723588 on ClinicalTrials.gov

13. Oral Cannabidiol for Tobacco Cessation

    Cannabidiol is a compound found in cannabis plants that is well tolerated, has low abuse liability, and might be an effective medication to promote tobacco cessation. This clinical study will use a validated approach for screening tobacco cessation medications to determine if oral cannabidiol incre…

    Stage

    Phase 1

    Ages

    18 to 65

    Site

    Johns Hopkins Behavioral Pharmacology Research Unit, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT05445804 on ClinicalTrials.gov

14. Examining the Effects of Cytisinicline on Neural Substrates of Cigarette Cue-reactivity

    This study will randomize 64 non-treatment seeking individuals who smoke cigarettes daily in a double-blind, placebo-controlled laboratory study testing the effects of cytisinicline on the neural substrates of cigarette cue reactivity.

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    University of California Los Angeles, Los Angeles, California

    Run by

    University of California, Los Angeles

    See if you can join NCT06617312 on ClinicalTrials.gov

15. An fMRI Study of the Effects of Clavulanic Acid on Drug Addiction

    This research study is looking into the effects of clavulanic on smoking behavior in adult cigarette smokers. The primary study hypothesis is that, compared to placebo, clavulanic acid will reduce smoking over the course of the study.

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    University of Missouri - Columbia, Columbia, Missouri

    Run by

    University of Missouri-Columbia

    See if you can join NCT03713424 on ClinicalTrials.gov

16. Smoking Cessation CM for Veterans With or at Risk for Cancer

    Tobacco use among US Veterans poses significant health problems and challenges to their overall well-being. The aim of this project is to evaluate the effectiveness of a program called Contingency Management (CM) in helping Veterans quit smoking during lung cancer screening or cancer care at VA cli…

    Stage

    Not phased

    Ages

    18 and older

    Site

    San Francisco VA Medical Center, San Francisco, CA, San Francisco, California

    Run by

    VA Office of Research and Development

    See if you can join NCT06432985 on ClinicalTrials.gov

17. Nicotine Regulation for Dual Users of E-cigarettes and Cigarettes

    Cigarette smoking remains the leading cause of preventable morbidity and mortality in the US. Use of multiple tobacco products is becoming increasingly prevalent, with dual use of e-cigarettes and cigarettes representing the most common combination. Though e-cigarettes are not without risk, complet…

    Stage

    Phase 2

    Ages

    21 and older

    Site

    Brown University, Providence, Rhode Island

    Locations

    2 in total

    Run by

    University of Vermont

    See if you can join NCT06614504 on ClinicalTrials.gov

18. Low Intensity Focused Ultrasound for Tobacco Use Disorder: High Resolution Targeting of the Human Insula

    The goal of this clinical trial is to to inhibit the dorsal anterior insula (dAI) with low intensity focused ultrasound (LIFU) to determine the causal role for the dAI in smoking cue induced craving in individuals with tobacco use disorder (TUD); smoking cue induced craving is a clinically importan…

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Veterans Affairs Medical Center, Washington D.C., District of Columbia

    Run by

    Washington D.C. Veterans Affairs Medical Center

    See if you can join NCT06405074 on ClinicalTrials.gov