TBI (Traumatic Brain Injury) Clinical Trials

19 studies are recruiting for tbi (traumatic brain injury) in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Feasibility of SUPPORT-TBI

   Many people who have had a traumatic brain injury (TBI) struggle to stay connected with others. They often lose friendships, become isolated, and have strained family relationships. This lack of social support is linked to worse physical and mental health, lower quality of life, and even a shorter …

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Washington University School of Medicine, St Louis, Missouri

   Run by

   Washington University School of Medicine

   See if you can join NCT07625098 on ClinicalTrials.gov

2. ENGAGE-TBI Feasibility Study

   This study will first evaluate the feasibility of delivering the ENGAGE-TBI intervention in a community setting with adults with TBI.

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Washington University School of Medicine, St Louis, Missouri

   Run by

   Washington University School of Medicine

   See if you can join NCT07549997 on ClinicalTrials.gov

3. Evaluation of Decision-Making Fatigue After Traumatic Brain Injury

   This is a preliminary, prospective, cohort study to investigate the feasibility of using the COGED and Restless Bandit tasks after a mild to moderate traumatic brain injury as well as in healthy controls.

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Minnesota, Minneapolis, Minnesota

   Run by

   University of Minnesota

   See if you can join NCT07103200 on ClinicalTrials.gov

4. Cognitive Rehabilitation for Victims of War and Related Traumas With Traumatic Brain Injury and Cognitive Impairment

   Researchers at Massachusetts General Hospital are looking to see if a program created to help improve thinking and memory can work for people affected by trauma, including asylum seekers and refugees, survivors of intimate partner violence (IPV) and others with traumatic brain injury (TBI). They're…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT06839079 on ClinicalTrials.gov

5. Emergency Department Implementation of the i-STAT Alinity Traumatic Brain Injury Whole Blood Test

   The objective of this study is to identify determinants for implementing the i-STAT Alinity whole blood traumatic brain injury (TBI) test for its Food and Drug Administration (FDA)-indicated use and to evaluate other potential outcomes with clinical implications. The main questions it aims to answe…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Pittsburgh, Pittsburgh, Pennsylvania

   Run by

   Shawn Eagle

   See if you can join NCT07373509 on ClinicalTrials.gov

6. Cerebral Autoregulation, Brain Perfusion, and Neurocognitive Outcomes After Traumatic Brain Injury

   Cognitive impairment after moderate to severe traumatic brain injury (msTBI) not only significantly affects the quality of life in individuals with msTBI, but also increases the possibility of late-life dementia. The goal of this study is to determine whether acute (< 1 week) cerebrovascular injury…

   Stage

   Not phased

   Ages

   18 to 80

   Site

   Texas Health Presbyterian Hospital, Dallas, Texas

   Locations

   3 in total

   Run by

   University of Texas Southwestern Medical Center

   See if you can join NCT06480838 on ClinicalTrials.gov

7. fNIRS for Disorders of Consciousness

   The goal of this observational study is to learn whether functional near-infrared spectroscopy (fNIRS) can measure brain activity in healthy adults and in people with disorders of consciousness (DoC) in the neuro-intensive care unit (Neuro-ICU). DoC include conditions such as coma and minimally con…

   Stage

   Not phased

   Ages

   18 and older

   Site

   UCLA School of Nursing; Ronald Reagan Medical Center, Los Angeles, California

   Run by

   University of California, Los Angeles

   See if you can join NCT07485361 on ClinicalTrials.gov

8. Individual Cerebral Hemodynamic Oxygenation Relationships (ICHOR 1)

   This is an observational study in patients who require clinical anesthesia. The main purpose of this study is to understand whether there are differences in the cerebral blood flow, and oxygen metabolism affected by different types of anesthesia. Subjects who require clinical anesthesia for a clini…

   Stage

   Not phased

   Ages

   Up to 18

   Site

   Children's Hospital Los Angeles, Los Angeles, California

   Run by

   Children's Hospital Los Angeles

   See if you can join NCT06195345 on ClinicalTrials.gov

9. Stimulating After Recovery From Traumatic Brain Injury

   This is a preliminary, prospective interventional study to investigate the feasibility of using transcutaneous alternating current stimulation (TACS) after a traumatic brain injury (TBI) to improve cognitive function and decision-making.

   Stage

   EARLY_Phase 1

   Ages

   18 and older

   Site

   Hennepin County Medical Center, Minneapolis, Minnesota

   Run by

   University of Minnesota

   See if you can join NCT05327829 on ClinicalTrials.gov

10. Depth Electrode Detection of Cortical Spreading Depolarization After Traumatic Brain Injury

    Preliminary evaluation of depth electrode recording and novel algorithms to determine Cortical Spreading Depolarization's (CSD) following traumatic brain injury (TBI) requiring neurosurgical intervention.

    Stage

    Not phased

    Ages

    Any age

    Site

    Hennepin County Medical Center, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT05205174 on ClinicalTrials.gov

11. Transcutaneous Auricular Neurostimulation for ICU Patients With Traumatic Brain Injury

    The overarching goal of this pilot study is to assess the feasibility and safety of transcutaneous auricular neurostimulation (tan) in ICU patients with TBi and to determine the effect of tan on serum markers of inflammation. exploratory analyses will examine effects on such physiological parameter…

    Stage

    Not phased

    Ages

    18 and older

    Site

    UT Southwestern Medical Center, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT06467708 on ClinicalTrials.gov

12. Augmented Renal Clearance in Neurocritical Care

    Stroke, severe brain injury, uncontrolled seizures and brain infections are the most common life-threatening neurological illnesses in the world with an estimated combined annual hospital management cost of up to 44 billion dollars. Seizures and infections are common complications following acute n…

    Stage

    Not phased

    Ages

    18 to 85

    Site

    UK HealthCare, Lexington, Kentucky

    Locations

    3 in total

    Run by

    University of Alberta

    See if you can join NCT07410624 on ClinicalTrials.gov

13. Veterans' Cognitive Function, Mental Health, and Quality of Life After Hyperbaric Oxygen Therapy

    The purpose of this study is to evaluate how hyperbaric oxygen therapy (HBOT) may affect cognitive functioning, post-traumatic stress disorder (PTSD), depression, anxiety, and overall quality of life in veterans. 1. Does Hyperbaric Oxygen Therapy improve cognitive functioning, psychological well-be…

    Stage

    Phase 2

    Ages

    18 to 75

    Site

    Summit Hyperbarics and Wellness, Boise, Idaho

    Run by

    Summit Hyperbarics and Wellness

    See if you can join NCT07214415 on ClinicalTrials.gov

14. Behavioral Treatment of Insomnia in Active-Duty Service Members With Traumatic Brain Injury

    The objective of the study is to conduct a randomized controlled trial of Cognitive Behavioral Therapy for Insomnia (CBT-I) in a sample of active-duty sailors with a history of traumatic brain injury (TBI). The investigators will test the impact of CBT-I on insomnia symptoms as well as post-concuss…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Naval Medical Center San Diego, San Diego, California

    Run by

    Noctem, LLC

    See if you can join NCT06867666 on ClinicalTrials.gov

15. Mindfulness for Cognition in Early-stage Alzheimer's Disease

    The goal of this clinical trial is to learn if mindfulness meditation can improve outcomes in older adults with and without cognitive impairment. The main questions it aims to answer are: 1. How does mindfulness impact thinking and memory? 2. How does mindfulness influence brain function and struct…

    Stage

    Not phased

    Ages

    50 to 100

    Site

    VA Boston Healthcare System - Jamaica Plain Campus, Boston, Massachusetts

    Run by

    VA Boston Healthcare System

    See if you can join NCT06792877 on ClinicalTrials.gov

16. Evaluation of Well-being Interventions in Adults With TBI

    The purpose of this research is to evaluate the potential benefits of two Intervention programs in adults with TBI to improve well-being and other outcomes that are maintained over time.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Kessler Foundation, East Hanover, New Jersey

    Run by

    Kessler Foundation

    See if you can join NCT05943756 on ClinicalTrials.gov

17. Combined Transcranial Magnetic Stimulation and Therapy for MTBI Related Headaches

    This study will assess the combined effectiveness of repetitive transcranial magnetic stimulation (rTMS) and telehealth based therapy in helping manage mild traumatic brain injury (mTBI) related headaches. The investigators hypothesize that active rTMS combined with telehealth therapy will provide …

    Stage

    Not phased

    Ages

    18 to 65

    Site

    VA San Diego Healthcare System, San Diego, California

    Run by

    Veterans Medical Research Foundation

    See if you can join NCT05176392 on ClinicalTrials.gov

18. InMotion - Telehealth Delivered Exercise Promotion to Treat Major Depression After TBI

    The purpose of this randomized controlled trial is to evaluate whether the InMotion intervention, delivered via telehealth (using a HIPAA-compliant video platform or phone), which uses evidence-based behavioral and motivational counseling to increase daily physical activity, is an effective treatme…

    Stage

    Not phased

    Ages

    18 to 64

    Site

    University of Washington Medical Center, Seattle, Washington

    Run by

    University of Washington

    See if you can join NCT06005194 on ClinicalTrials.gov

19. Growth Hormone Replacement Therapy for Retried Professional Football Players

    This is a randomized, double-blind, placebo-controlled, parallel-group trial with an open-label extension to evaluate the efficacy of growth hormone (GH) on cognitive functions of retired professional football players with growth hormone deficiency (GHD).

    Stage

    Phase 2

    Ages

    18 to 76

    Site

    Center for Neurolgoical Studies (CNS), Dearborn, Michigan

    Run by

    Center for Neurological Studies

    See if you can join NCT04121780 on ClinicalTrials.gov