Substance Use Disorders Clinical Trials

41 studies are recruiting for substance use disorders in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Charleston, South Carolina 4 Baltimore, Maryland 3 Boston, Massachusetts 3 Indianapolis, Indiana 3 New York, New York 3 Oklahoma City, Oklahoma 3

Studies now recruiting

  1. Recovery Inspired Support Engagement (RISE) Pilot

    The goal of this clinical trial is to learn if a 1-on-1 support program is easy to complete and acceptable for people supporting loved ones who have recently received treatment for substance use. The main questions it aims to answer are: How many people complete the program? How satisfied are peopl…

    Stage
    Not phased
    Ages
    18 and older
    Site
    McLean Hospital, Belmont, Massachusetts
    Run by
    Mclean Hospital

    See if you can join NCT07519759 on ClinicalTrials.gov

  2. Temporal Interference Methods for Addiction Treatment

    This clinical study is testing whether a new non-invasive brain stimulation method, called temporal interference (TI), can reduce nicotine cravings and usage in people who vape. TI delivers mild electrical currents to the scalp in a way that targets deep brain areas involved in addiction, without t…

    Stage
    Not phased
    Ages
    21 to 50
    Site
    Indiana University, Bloomington, Indiana
    Locations
    2 in total
    Run by
    Indiana University

    See if you can join NCT07210268 on ClinicalTrials.gov

  3. Development and Evaluation of a Virtual Reality Tool for At-Risk Trauma-Exposed Young People

    This is a multi-phased study, funded through a National Institute on Drug Abuse (NIDA) K24 grant that aims to ultimately refine a virtual reality tool through qualitative and quantitative research targeting HIV and substance abuse risk behavior among at-risk young people who have experienced psycho…

    Stage
    Not phased
    Ages
    15 to 30
    Site
    National Crime Victims Research and Treatment Center, Charleston, South Carolina
    Run by
    Medical University of South Carolina

    See if you can join NCT05816083 on ClinicalTrials.gov

  4. STEPS: Substance Use Trial of E-cigarettes or Pharmacotherapy for Smoking

    The purpose of this study is to investigate whether non-cigarette tobacco products, namely e-cigarettes (nicotine vapes), can help people who smoke and are in treatment for substance use disorder quit smoking by switching completely to e-cigarettes as compared to FDA-approved medications, namely ni…

    Stage
    Not phased
    Ages
    21 and older
    Site
    MUSC Charleston, Charleston, South Carolina
    Locations
    4 in total
    Run by
    Medical University of South Carolina

    See if you can join NCT06922617 on ClinicalTrials.gov

  5. Clinical and Neurobehavioral Changes With Weight Loss Drug Discontinuation and Reinitiation

    The goal of this clinical study with research procedures is to learn how stopping and restarting tirzepatide (a medication that helps regulate blood sugar and appetite) affects brain activity, behavior, and health in adults ages 18-70 who are currently taking tirzepatide. Specifically, the study ai…

    Stage
    Not phased
    Ages
    18 to 70
    Site
    Center for BrainHealth, Dallas, Texas
    Run by
    The University of Texas at Dallas

    See if you can join NCT07387796 on ClinicalTrials.gov

  6. Massed Prolonged Exposure for PTSD in Substance Use Treatment

    The goal of this clinical trial is to learn if receiving Prolonged Exposure Therapy for PTSD in massed format (multiple sessions weekly) is as effective as receiving it with sessions once per week among veterans with PTSD and substance use disorder in intensive outpatient substance use treatment. T…

    Stage
    Not phased
    Ages
    18 and older
    Site
    VA San Diego Healthcare System, San Diego, California
    Locations
    6 in total
    Run by
    Veterans Medical Research Foundation

    See if you can join NCT06296186 on ClinicalTrials.gov

  7. CARS: Cannabis and Alcohol Reduction Study

    The study will test a computerized treatment with subjects ages 13-17 years who are seeking treatment for alcohol and/or cannabis use. Follow-up assessments will be conducted at one- and three-months following treatment.

    Stage
    Not phased
    Ages
    13 to 17
    Site
    Medical University of South Carolina, Charleston, South Carolina
    Run by
    Medical University of South Carolina

    See if you can join NCT05486234 on ClinicalTrials.gov

  8. Feasibility of an Interdisciplinary Intervention to Improve Care Transitions for Hospitalized Patients With Substance Use Disorders

    The purpose of this study is to evaluate the feasibility and preliminary effectiveness of a primary care-based Interdisciplinary Addiction Care Transition (IntACT) team that will meet patients with substance use disorders (SUD) during a medical hospitalization and provide intensive care management,…

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of Utah Medical Center, Salt Lake City, Utah
    Run by
    Michael Incze

    See if you can join NCT07575373 on ClinicalTrials.gov

  9. Interprofessional Simulation Program for Clinical Resilience and Empathy: Project INSPIRE

    The goal of this clinical trial is to develop and evaluate INSPIRE, an intervention for healthcare teams to improve care for individuals with substance use disorder (SUD) during their peri-delivery care. The main question it aims to answer is whether healthcare provider stigmas and behaviors change…

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of Utah Health, Salt Lake City, Utah
    Run by
    University of Utah

    See if you can join NCT07707115 on ClinicalTrials.gov

  10. Project I Test: Implementing HIV Testing in Opioid Treatment Programs

    This study will test two active evidence-based "practice coaching" (PC) interventions to improve opioid treatment programs' (OTPs') provision and sustained implementation of on-site 1) HIV testing and linkage to care and 2) HIV/Hepatitis C virus (HCV) testing and linkage to care among patients seek…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Columbia University Medical Center, New York, New York
    Run by
    Columbia University

    See if you can join NCT03135886 on ClinicalTrials.gov

  11. Enhancing Addiction Treatment Through Psychoeducation

    Addiction is a brain disorder characterized by a broad range of both apparent and subtle cognitive impairments in attention, memory, executive functions, and decision-making. These cognitive problems are clinically significant and may contribute to poor treatment outcomes in people with Substance U…

    Stage
    Not phased
    Ages
    18 to 65
    Site
    Virginia Commonwealth University, Richmond, Virginia
    Run by
    Virginia Commonwealth University

    See if you can join NCT07178158 on ClinicalTrials.gov

  12. COPEWeb Training for Providers

    Post-traumatic stress disorder (PTSD) and substance use disorders (SUD) are two of the most common and debilitating mental health conditions afflicting military Veterans. PTSD and SUD frequently co-occur and are associated with poorer treatment outcomes. The investigators' team developed a trauma-f…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Ralph H. Johnson VA Medical Center, Charleston, SC, Charleston, South Carolina
    Run by
    VA Office of Research and Development

    See if you can join NCT05812131 on ClinicalTrials.gov

  13. Safe & Sound Protocol in Adults With Trauma and SUD

    This study will explore whether the use of the Safe and Sound Protocol (SSP) app is an effective adjunct to treatment as usual (TAU) in individuals with co-occurring substance use disorders and trauma. This study will recruit 129 participants (100 completers) randomized to receive either active or …

    Stage
    Not phased
    Ages
    18 to 75
    Site
    Caron Treatment Centers, Wernersville, Pennsylvania
    Run by
    Caron Treatment Centers

    See if you can join NCT07219056 on ClinicalTrials.gov

  14. Preconception Intervention for Incarcerated Women With Substance Use

    The goal of this pilot trial is to test the feasibility and acceptability as well as efficacy of the adapted intervention, CHOICES-PLEAS (Pregnancy Liberated from Exposure to Alcohol and Substances) among women will illicit polysubstance use participating in a court-mandated jail-based 90-day subst…

    Stage
    Not phased
    Ages
    18 to 49
    Site
    Buzz Westfall Justice Center, St Louis, Missouri
    Run by
    St. Louis University

    See if you can join NCT05854836 on ClinicalTrials.gov

  15. Impact of Federal and State Medications for Opioid Use Disorder (MOUD) Policy Changes During the Pandemic

    "Gold-standard" medications for opioid use disorder (MOUD) treatment combines FDA-approved medications, primarily methadone and buprenorphine, with behavioral therapies to provide "whole-patient" treatment. Prior to the pandemic, methadone and buprenorphine were subject to greater federal regulatio…

    Stage
    Not phased
    Ages
    18 and older
    Site
    VA Medical Center, Boston, Massachusetts
    Run by
    Boston University

    See if you can join NCT07232641 on ClinicalTrials.gov

  16. Exablate for LIFU Neuromodulation in Patients With Opioid Use Disorder (OUD) and/or Other Substance Use Disorders (SUDs)

    The purpose of this clinical trial is to investigate Low Intensity Focused Ultrasound (LIFU) using the Exablate® Model 4000 Type 2.0/2.1 as an adjunctive neuromodulatory treatment for OUD (Opioid Use Disorder) and/or other Substance Use Disorders (SUDs) by assessing its safety and tolerability in s…

    Stage
    Not phased
    Ages
    18 to 60
    Site
    University of Maryland, Baltimore, Baltimore, Maryland
    Locations
    4 in total
    Run by
    InSightec

    See if you can join NCT04197921 on ClinicalTrials.gov

  17. Shared Decision Making to Treat Or Prevent (STOP) HIV in Criminal Legal Involved Populations (R33)

    This study seeks to compare the effectiveness of two Patient Navigation models of care to evaluate the proportion who initiate PrEP/ART and substance use/substance use disorder (SU/SUD) treatment. A standardized Patient Navigation (PN) arm will be compared with a shared decision-making model in the…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Yale School of Medicine, New Haven, Connecticut
    Locations
    4 in total
    Run by
    Yale University

    See if you can join NCT07223398 on ClinicalTrials.gov

  18. Mitigating the Impact of Stigma and Shame Among People Living With HIV and Substance Use Disorders

    People living with HIV and substance use disorders (SUDs) are less likely to be virally suppressed, which can lead to HIV transmission and negative health outcomes. This hybrid type 1 study will assess the efficacy, mechanisms, as well as facilitators and barriers to implementing the MATTER interve…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Florida International University, Miami, Florida
    Locations
    2 in total
    Run by
    Boston University

    See if you can join NCT05934305 on ClinicalTrials.gov

  19. Neuroimaging of Adolescent Cannabis Use Treatment

    This study is testing whether brain activity related to learning can help predict how well teens respond to a treatment program designed to reduce cannabis use. Teens ages 14-17 will complete a brain scan and then take part in 10 weekly virtual sessions where they report cannabis use and complete d…

    Stage
    Not phased
    Ages
    14 to 17
    Site
    Indiana University School of Medicine, Indianapolis, Indiana
    Run by
    Indiana University

    See if you can join NCT07340554 on ClinicalTrials.gov

  20. tAN for Substance Use Disorder

    The study will involve a 5-day tAN treatment to attenuate alcohol withdrawal syndrome (AWS) and alter resting state functional connectivity (RSFC) between OFC and striatum in patients with alcohol use disorder (AUD). Enrolled participants will wear the tAN device on-site (at The Menninger Clinic) f…

    Stage
    Not phased
    Ages
    18 to 64
    Site
    The Menninger Clinic, Houston, Texas
    Run by
    Spark Biomedical, Inc.

    See if you can join NCT07281261 on ClinicalTrials.gov

  21. The Collaborative Care PrTNER Study

    A randomized controlled trial to assess the ability of a Collaborative Care Prevention, Treatment, Navigation, Engagement, Resource (PrTNER) intervention to increase initiation of preexposure prophylaxis (PrEP) (for those at-risk for HIV) and decrease viral load (for those living with HIV) among yo…

    Stage
    Not phased
    Ages
    15 to 29
    Site
    Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
    Locations
    2 in total
    Run by
    Children's Hospital of Philadelphia

    See if you can join NCT06585631 on ClinicalTrials.gov

  22. Prevent Language Delays and Disorders Among Children of Caregivers With Substance Use Disorders With Community Groups and Individualized Services

    The goal of this clinical trial is to test ways to improve early language development among young children of parents with substance use disorder (SUD). Children of parents with SUD are at increased risk for language delays, and early supports may help prevent long-term learning challenges. This st…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Prevention Science Institute, Eugene, Oregon
    Run by
    University of Oregon

    See if you can join NCT07529327 on ClinicalTrials.gov

  23. Family Support Protocol for Adolescent Internalizing Disorders

    This R34 will develop and test an adjunctive treatment protocol for addressing co-occurring internalizing disorders among adolescents enrolled in usual care for substance use problems. Internalizing disorders (ID), primarily depression and anxiety, are highly prevalent among youth receiving communi…

    Stage
    Not phased
    Ages
    13 to 21
    Site
    Gateway Community Services, Jacksonville, Florida
    Locations
    4 in total
    Run by
    The National Center on Addiction and Substance Abuse at Columbia University

    See if you can join NCT06413979 on ClinicalTrials.gov

  24. Peer-Delivered Behavioral Activation in a CCBHC

    Low-income individuals have limited access to evidence-based interventions for mental health. Peer recovery specialists, individuals in recovery from mental health and/or substance use problems, have the potential to increase access to evidence-based interventions for individuals from low-resource …

    Stage
    Not phased
    Ages
    18 and older
    Site
    Detroit Recovery Project, Detroit, Michigan
    Run by
    Wayne State University

    See if you can join NCT07219394 on ClinicalTrials.gov

  25. Written Exposure Therapy for Veterans With SUD and PTSD

    The proposed project will evaluate the efficacy of written exposure therapy (WET) among Veterans engaged in substance use disorder (SUD) treatment, who present with co-occurring posttraumatic stress disorder (PTSD). While SUD treatment programs traditionally do not address PTSD, effective trauma tr…

    Stage
    Not phased
    Ages
    18 and older
    Site
    VA Connecticut Healthcare System West Haven Campus, West Haven, CT, West Haven, Connecticut
    Run by
    VA Office of Research and Development

    See if you can join NCT05327504 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.