Substance Use Disorder (SUD) Clinical Trials

20 studies are recruiting for substance use disorder (sud) in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

Search these by distance from you

Studies now recruiting

1. Real-time Opioid Study

   This feasibility study collects initial data on the use of an fMRI neurofeedback protocol for treating anhedonia in methadone-treated individuals with opioid use disorder (OUD). The intervention tested has previously been shown to reduce anhedonia in individuals with depression and this study is co…

   Stage

   Not phased

   Ages

   18 to 50

   Site

   APT Foundation, New Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT07768007 on ClinicalTrials.gov

2. Project SHIELD 2.0: Police Education to Support Public Health in Kentucky

   The project is a pragmatic, quasi-experimental hybrid type II effectiveness-implementation trial of a structural HIV prevention intervention to address police behavior (arrests and referrals) and ultimately improve health among people who use drugs. The study involves a novel implementation strateg…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Kentucky, Lexington, Kentucky

   Run by

   Johns Hopkins Bloomberg School of Public Health

   See if you can join NCT07804121 on ClinicalTrials.gov

3. Connecting Loved Ones to Support and Empowering Recovery

   Substance use disorders are highly prevalent. However, recovery from them is possible. The recovery process can benefit greatly from support from loved ones. Loved ones may need guidance in the most helpful ways to support recovery. This study aims to refine and test a web-based intervention, known…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Rhode Island Hospital, Providence, Rhode Island

   Run by

   Rhode Island Hospital

   See if you can join NCT07740395 on ClinicalTrials.gov

4. Contingency Management for Veteran Smokers Undergoing Major Elective Surgery

   The goal of this study is to design and test the first mobile contingency management (CM) smoking cessation intervention for military Veterans undergoing major elective surgery. Smoking is the leading risk factor for postoperative complications and is associated with longer hospital stays, reoperat…

   Stage

   Not phased

   Ages

   18 and older

   Site

   San Francisco VA Health Care System, San Francisco, California

   Run by

   University of California, San Francisco

   See if you can join NCT06678672 on ClinicalTrials.gov

5. The Many Roads to Trauma Recovery: A Clinical Trial Comparing Empirically Supported Treatments for Veterans With Co-Morbid Posttraumatic Stress and Substance Use Disorder Symptoms

   Veterans with co-morbid posttraumatic stress disorder (PTSD) and substance use disorders (SUDs) are at substantial risk of developing hypertension and cardiovascular diseases that often lead to premature death, with some evidence that they may die over 10 years earlier than their counterparts. As s…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Coatesville VA Medical Center, Coatesville, Pennsylvania

   Run by

   Coatesville VA Medical Center

   See if you can join NCT07756723 on ClinicalTrials.gov

6. Reducing Parental Substance Use and Enhancing Family Resilience Among Rural Families Through Ohio START

   The goal of this observational study is to learn about the roles played by parental activity spaces and social networks in reducing parental substance use and promoting child and family health outcomes in the context of Ohio START (Sobriety, Treatment, and Reducing Trauma) for families in rural are…

   Stage

   Not phased

   Ages

   18 and older

   Site

   The Ohio State University, Columbus, Ohio

   Run by

   Ohio State University

   See if you can join NCT07278427 on ClinicalTrials.gov

7. The Trans-Led Care Study

   This study is testing a new mutual-help group called "the TLC program" for transgender adults who use substances or are recently in recovery. The TLC Program is based on Acceptance and Commitment Therapy or "ACT" which is a type of mental health counseling that focuses on using mindfulness skills t…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Illinois Institute of Technology, Chicago, Illinois

   Run by

   Illinois Institute of Technology

   See if you can join NCT06880705 on ClinicalTrials.gov

8. Adolescent Stress and Substance Intervention Subsequent to Trauma

   The long-term goal of this study is to address the adoption of the new trauma center requirement to establish best practices of screening for acute stress with an intervention to prevent both adolescent PTSD and substance use. The investigators will develop, refine, and pilot test the Adolescent St…

   Stage

   Not phased

   Ages

   12 to 17

   Site

   Rhode Island Hospital, Providence, Rhode Island

   Run by

   Rhode Island Hospital

   See if you can join NCT07197476 on ClinicalTrials.gov

9. Implementation of TBI-RECOVER in Substance Use Treatment

   The goal of this hybrid type 2 pilot trial is to understand the implementation and effectiveness of the TBI-RECOVER intervention model (e.g., brain injury screening, cognitive and behavioral challenges screening, and neurocognitive accommodations) on patient retention in outpatient substance use di…

   Stage

   Not phased

   Ages

   18 and older

   Site

   OSU Hospital System, Columbus, Ohio

   Run by

   Ohio State University

   See if you can join NCT07215221 on ClinicalTrials.gov

10. WORTH Paths Intervention

    Women in the criminal legal system are more likely to experience substance use disorders and unintended pregnancy than women in the general public. However, they often face barriers to accessing substance use treatment and sexual and reproductive health services. This study tests the feasibility an…

    Stage

    Not phased

    Ages

    18 to 44

    Site

    Fairleigh Dickinson University, Teaneck, New Jersey

    Run by

    Fairleigh Dickinson University

    See if you can join NCT06889831 on ClinicalTrials.gov

11. Pathways to Perinatal Mental Health Equity

    Mental health conditions occurring during pregnancy and up to one year postpartum (the perinatal period) occur in 1 in 5 perinatal individuals. To improve mental health care during the perinatal period, this study will implement and compare a health care model of improving mood and anxiety disorder…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    UMass Chan Medical School, Shrewsbury, Massachusetts

    Run by

    University of Massachusetts, Worcester

    See if you can join NCT06790641 on ClinicalTrials.gov

12. California MEPS Hub

    The California Hub for HIV/SUD Prevention Research with Reentry Populations addresses the question: "Can the evidence-based MEPS intervention be adapted and implemented at a range of organizations to effectively serve a wider range of clients?" The Mobile Enhanced Prevention Support (MEPS) interven…

    Stage

    Not phased

    Ages

    18 to 59

    Site

    CAL-PEP, Oakland, California

    Locations

    3 in total

    Run by

    University of California, Los Angeles

    See if you can join NCT07433985 on ClinicalTrials.gov

13. Identifying Substance Use Consequences

    The goal of this study is to develop a new tool for measuring substance use disorder treatment outcome. We will start by interviewing people and gathering advisory groups to develop the items for this new tool.

    Stage

    Not phased

    Ages

    18 and older

    Site

    McLean Hospital, Belmont, Massachusetts

    Run by

    Mclean Hospital

    See if you can join NCT07503067 on ClinicalTrials.gov

14. Long-acting Cabotegravir Injectable Pre-exposure Prophylaxis for People Who Inject Drugs

    The goal of this study is to determine the feasibility and impact of delivering long-acting injectable cabotegravir HIV pre-exposure prophylaxis and suite of support services to adults who inject non-prescription drugs who are risk for HIV through known sexual risk.

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Massachusetts General Hospital

    See if you can join NCT07199335 on ClinicalTrials.gov

15. Calls and Coordination for Transitions of Care at Re-entry

    The goal of this clinical trial is to learn if a short program for people being released from prison can help connect them to medical care. The main question it aims to answer is: * Will there be more non-emergency, outpatient clinic visits? Researchers will compare the number of clinic visits betw…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Wisconsin, Madison, Wisconsin

    Run by

    University of Wisconsin, Madison

    See if you can join NCT06794983 on ClinicalTrials.gov

16. Open-Label Psilocybin Study in Transdiagnostic Population

    The primary objective of this study is to investigate the safety, feasibility, and tolerability of psilocybin treatment in individuals with functional impairment due to psychiatric symptoms. The secondary objective of this study is to determine whether individuals with functional impairments due to…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Connecticut Mental Health Center - Yale School of Medicine, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT06442423 on ClinicalTrials.gov

17. Transcranial Direct Current Stimulation (tDCS) for Treatment of Cocaine Use Disorder

    The researchers will test whether cognitively enhanced transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex can reduce craving in inpatients with cocaine use disorder. Neuroimaging before and after stimulation will establish the neural correlates of recovery and allo…

    Stage

    Not phased

    Ages

    18 to 60

    Site

    Icahn School of Medicine at Mount Sinai, New York, New York

    Run by

    Icahn School of Medicine at Mount Sinai

    See if you can join NCT07318480 on ClinicalTrials.gov

18. Effectiveness, Implementation, and Cost of Cognitive Processing Therapy in Prisons

    Addiction and trauma exposure are common among the 5.5 million people (1 in 47 adults) in the U.S. who are in prison or under supervision. About 85% of people in prison have a substance use disorder or are there for a drug-related crime, and many have experienced serious trauma before being incarce…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Northeast Arkansas Community Corrections Center (NEACC), Osceola, Arkansas

    Locations

    6 in total

    Run by

    University of Arkansas

    See if you can join NCT06923423 on ClinicalTrials.gov

19. Individualized Adaptive Deep Brain Stimulation in Opioid Use Disorder

    The purpose of this study is to determine if personalized (adaptive) Deep Brain Stimulation (DBS) based upon invasive brain mapping is safe and can lead to better outcomes like reductions in craving and opioid use.

    Stage

    Not phased

    Ages

    22 to 75

    Site

    University of California, San Francisco, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT07214467 on ClinicalTrials.gov

20. Evaluating Pain Control Strategies in Postpartum Patients on Opioid Use Disorder Medications.

    The purpose of this study is to investigate the efficacy of three different modalities of post-operative pain control in parturient with opioid use disorders. The investigators aim to determine whether the different approach utilized show better outcomes with pain management and if there are any as…

    Stage

    EARLY_Phase 1

    Ages

    18 to 40

    Site

    Froedtert Hospital Milwaukee, Wisconsin 53226, Milwaukee, Wisconsin

    Locations

    2 in total

    Run by

    Medical College of Wisconsin

    See if you can join NCT06617949 on ClinicalTrials.gov