Stress Clinical Trials

54 studies are recruiting for stress in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Intranasal Oxytocin Intervention for Caregivers to Persons With Dementia

   More than 15 million family caregivers provide support for individuals with Alzheimer's disease (AD) or related dementias. This number is expected to grow with the increasing population of persons with dementia (PWD). Stress in caregivers to older adults with chronic diseases is already a significa…

   Stage

   Phase 2

   Ages

   50 and older

   Site

   University of Nebraska Medical Center, Department of Psychiatry, Omaha, Nebraska

   Run by

   University of Nebraska

   See if you can join NCT06364228 on ClinicalTrials.gov

2. Digital Intervention for Physical Activity

   The present study will assess the effects of a four-week digitally delivered intervention on physical activity and depressive symptoms among adults experiencing at least moderate depressive symptoms. The main questions this research aims to answer are: * Does a digitally-delivered intervention incr…

   Stage

   Not phased

   Ages

   19 to 40

   Site

   Kinesiology Building, Auburn, Alabama

   Run by

   Auburn University

   See if you can join NCT07130734 on ClinicalTrials.gov

3. The Impact of Music Medicine on Preterm Brain Development and Behavior

   The investigators are conducting a two-site randomized control trial with the aim of defining the impact of music (M) without or with parent voice (MPV) on very preterm infants' acute and cumulative stress, intranetwork connectivity on term brain MRI, and language and other neurodevelopmental outco…

   Stage

   Not phased

   Ages

   0 to 0

   Site

   Brigham and Women's Hospital, Boston, Massachusetts

   Locations

   2 in total

   Run by

   Brigham and Women's Hospital

   See if you can join NCT06536296 on ClinicalTrials.gov

4. Development of a College Student-Delivered Cognitive-Behavioral Therapy (CBT) Intervention for Rural High School Students

   This research is being done to find out the effectiveness, feasibility, and acceptability of a college student-delivered cognitive-behavioral therapy (CBT) intervention in high schools in rural Schuylkill County, Pennsylvania to treat mental health problems (i.e. depression and anxiety) in adolesce…

   Stage

   Not phased

   Ages

   13 to 18

   Site

   Penn State College of Medicine, Hershey, Pennsylvania

   Run by

   Milton S. Hershey Medical Center

   See if you can join NCT07240792 on ClinicalTrials.gov

5. GUT-FEELINGS: Using Citizen Science for Large-Scale Prebiotic Clinical Trials for Mental Wellness in Adults

   The goal of this study is to evaluate the effects of different products in participants experiencing feelings of anxiety. The main question it aims to answer is: - Do these products affect feelings of anxiety and related wellness outcomes compared with a placebo? Researchers will compare participan…

   Stage

   Not phased

   Ages

   21 to 80

   Site

   Radicle Science Inc., Del Mar, California

   Run by

   Holobiome, Inc.

   See if you can join NCT07752823 on ClinicalTrials.gov

6. CommunityRx-Dementia + Peer Navigation (CRxDpeer)

   The CRxDpeer intervention, delivered by a trained peer navigator, in practice called a "peer mentor", includes three evidence-based components: (a) focused education about common social (e.g., food and housing insecurity) and caregiving (e.g., respite and end of life care) needs, (b) activation of …

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Chicago, Chicago, Illinois

   Run by

   University of Chicago

   See if you can join NCT07346183 on ClinicalTrials.gov

7. Healing Hearts: A Mindfulness App for Parents Navigating Divorce or Separation

   This study examines online programs for parents navigating divorce or separation. Researchers will study whether a self-guided mindfulness app called Healing Hearts, followed by a self-guided online parenting program called the electronic New Beginnings Program, is feasible and acceptable to parent…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Connecticut, Stamford, Connecticut

   Run by

   University of Connecticut

   See if you can join NCT07871916 on ClinicalTrials.gov

8. Exercise Effects on the Neurobiology Underlying Stress-related Eating Behaviors in Veterans

   The purpose of this study is to learn more about how common lifestyle interventions, such as exercise, affect how our brains respond to performing thinking tasks and to viewing pictures of foods and various other objects. The investigators are also interested in how changes in hormones that might b…

   Stage

   Not phased

   Ages

   18 to 75

   Site

   Rocky Mountain Regional VA Medical Center, Aurora, CO, Aurora, Colorado

   Run by

   VA Office of Research and Development

   See if you can join NCT06627569 on ClinicalTrials.gov

9. State-dependent Interoception, Value-based Decision-making, and Introspection

   Background: Negative emotional states can affect a person s behavior as they make decisions. For example, hunger may make people more impatient; they may then make riskier choices. Other negative emotional states that can change behavior include stress, pain, and sadness. By learning more about how…

   Stage

   Not phased

   Ages

   18 to 55

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Mental Health (NIMH)

   See if you can join NCT05666726 on ClinicalTrials.gov

10. Adapting a Stress Management Intervention to Reduce Cardiovascular Disease Risk

    Women living with HIV have 2-4x higher risk for cardiovascular disease compared to women without HIV, with women living with HIV in the Southern US being particularly at risk. While an increased prevalence of traditional risk factors (e.g., hypertension, diabetes, and obesity) partially explain thi…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT06811896 on ClinicalTrials.gov

11. Effects of Beef-Forward Ready-to-Eat Meals on Recovery Following Simulated Fire Suppression Activities

    This clinical trial aims to determine whether consuming beef-based protein before and after physically demanding simulated firefighting activities improves recovery, physical performance, and cognitive performance in healthy adult firefighters. The study will also compare beef-based protein meals w…

    Stage

    Not phased

    Ages

    18 to 60

    Site

    Bob Bolen Public Safety Complex Administration, Fort Worth, Texas

    Locations

    2 in total

    Run by

    Sam Houston State University

    See if you can join NCT07822048 on ClinicalTrials.gov

12. Effects of Pork Protein on Recovery Following Simulated Fireground Activity

    The goal of this clinical trial is to learn whether consuming pork-based protein before and after physically demanding simulated firefighting activities can improve recovery, physical performance, and cognitive performance in healthy adult firefighters. The study will also compare pork-based protei…

    Stage

    Not phased

    Ages

    18 to 60

    Site

    Bob Bolen Public Safety Complex Administration, Fort Worth, Texas

    Locations

    2 in total

    Run by

    Sam Houston State University

    See if you can join NCT07819565 on ClinicalTrials.gov

13. Impact of Peanut Consumption on Stress, Immune Function, Inflammation, and Cardiovascular Health in High-Stress Individuals

    The purpose of this research is to determine whether peanut consumption improves indicators of cardiovascular disease (CVD) risk in human subjects following the consumption of study foods.

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Western Human Nutrition Research Center, Davis, California

    Run by

    USDA, Western Human Nutrition Research Center

    See if you can join NCT07735221 on ClinicalTrials.gov

14. Study of Cannabidiol and Neuroimaging on Stress

    Dysregulation in stress responsivity is a growing psychiatry-transdiagnostic fundamental phenomenon, with limited therapeutic strategies. With the legalization of medical and recreational cannabis, many people consume cannabidiol (CBD; a nonintoxicating cannabinoid) to alleviate stress response, wi…

    Stage

    Phase 1

    Ages

    18 to 25

    Site

    Ichan School of Medicine at Mount Sinai, New York, New York

    Run by

    Icahn School of Medicine at Mount Sinai

    See if you can join NCT07278505 on ClinicalTrials.gov

15. STRess Assessment of INterventional Cardiology Fellows and Attendings

    Interventional cardiology (IC) fellows and attendings experience high levels of stress. In a recent study, IC fellowship was considered very stressful by 22%, somewhat stressful by 62%, and not stressful by 16%(1). In a different study, 29% of the IC fellows considered leaving their job during the …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Minneapolis Heart Institute Foundation, Minneapolis, Minnesota

    Run by

    Minneapolis Heart Institute Foundation

    See if you can join NCT07804927 on ClinicalTrials.gov

16. The Impact of a Race-Based Stress Reduction Intervention

    The goal of this clinical trial is to learn whether a stress reduction program called Resilience, Stress, and Ethnicity (RiSE) improves well-being, inflammation, and the epigenome in African American (AA) women who have risk factors for heart or metabolic disease. The main question it aims to answe…

    Stage

    Not phased

    Ages

    50 to 75

    Site

    Loyola University Chicago, Maywood, Illinois

    Run by

    Loyola University

    See if you can join NCT05902741 on ClinicalTrials.gov

17. EEG-Guided Binaural Beat Audio to Reduce Performance-Related Stress and Improve Cognition

    Performance-related stress can impair sustained attention, inhibitory control, and memory. This randomized, double-blinded, sham-controlled parallel-arm trial evaluates whether a 30-minute EEG-guided binaural beat audio intervention reduces subjective stress/performance anxiety and improves cogniti…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Texas Tech University, Lubbock, Texas

    Run by

    Texas Tech University Health Sciences Center

    See if you can join NCT07407426 on ClinicalTrials.gov

18. Effects of Cannabidiol on Stress and Nicotine Withdrawal

    The purpose of this study is to examine the effect of doses of cannabidiol (CBD) during exposure to stress and nicotine withdrawal in nicotine users. The main objectives of the study include examining the effect CBD has on stress, tobacco dependence, tobacco withdrawal, and sex differences between …

    Stage

    Phase 1

    Ages

    21 to 70

    Site

    Behavioral Pharmacology Research Unit, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT07001930 on ClinicalTrials.gov

19. Supporting Mental Health and Reducing Care Stress in Caregivers of Persons With Cardiovascular Disease

    The purpose of this study is to evaluate the preliminary efficacy, feasibility, acceptability, and barriers and facilitators to implementation of the Confident Caregiver intervention among family caregivers of persons with cardiovascular disease participating in cardiac rehabilitation. Caregivers r…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of California Davis Health System, Sacramento, California

    Run by

    University of California, Davis

    See if you can join NCT07717723 on ClinicalTrials.gov

20. Internet Based Psychological Support

    The investigators have developed interactive, multimedia-intensive, computer-based treatment programs that include depression (Problem-Solving Therapy), stress management, and conflict management. Together the three modules are called PATH. The problem-solving module is based on an evidence-based p…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire

    Run by

    Dartmouth-Hitchcock Medical Center

    See if you can join NCT02726061 on ClinicalTrials.gov

21. Adaptive Coping Skills Training to Improve Psychological Distress Among Cardiorespiratory Failure Survivors

    Conditions treated in intensive care units (ICUs) such as the acute respiratory distress syndrome (ARDS), congestive heart failure, COVID pneumonia, and sepsis are common. These can lead to high rates of depression, anxiety, and PTSD that worsen quality of life. Yet there are few effective strategi…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Duke University Medical Center, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT06538246 on ClinicalTrials.gov

22. Cannabidiol (CBD) and Stress Response: Psychobiological Mechanisms

    The aim of this study is to determine the effects of regular cannabidiol (CBD) use on the psychobiological mechanisms of the stress response. This will be achieved by comparing acute stress responses of adults who either use or do not use CBD regularly. Correlates of CBD use, including tobacco use,…

    Stage

    Not phased

    Ages

    21 to 70

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT07069478 on ClinicalTrials.gov

23. Impact of Serial Bedside Video Calls on Stress Level in Parents of Infants Admitted to NICU

    The goal of this randomized prospective interventional study is to determine if serial bedside video calls w/audio feature to NICU parents in addition to the routine phone and/or bedside updates can reduce parental stress level. The main question it aims to answer is if the impact of audio-visual c…

    Stage

    Not phased

    Ages

    0 to 0

    Site

    John H. Stroger Hospital of Cook County, Chicago, Illinois

    Run by

    Cook County Health

    See if you can join NCT06252883 on ClinicalTrials.gov

24. Biofield Therapy for the Support of Immunotherapy-related Symptoms Among Adult Cancer Patients - A Pilot Study

    Cancer treatment with immunotherapy is often associated with symptoms such as fatigue, pain, and emotional distress, which may affect patients' daily functioning and quality of life. Additional supportive care approaches are being studied to better understand their potential role in supporting thes…

    Stage

    Not phased

    Ages

    18 and older

    Site

    UCI Health Susan Samueli Integrative Health Institute, Irvine, California

    Locations

    2 in total

    Run by

    University of California, Irvine

    See if you can join NCT07581080 on ClinicalTrials.gov

25. Efficacy and Safety of Magnesium Vitamin B6 in First Episode Bipolar Disorder

    This is a randomized, double-blind, placebo-controlled proof-of-concept clinical trial to assess the efficacy and safety of Magnesium-vitamin B6in combination with treatment as usual for treating symptoms of depression, stress, and anxiety in patients with first episode bipolar I disorder.

    Stage

    Phase 2

    Ages

    18 to 50

    Site

    McLean Hospital, Belmont, Massachusetts

    Run by

    Mclean Hospital

    See if you can join NCT05837104 on ClinicalTrials.gov