Stress Clinical Trials

55 studies are recruiting for stress in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. State-dependent Interoception, Value-based Decision-making, and Introspection

   Background: Negative emotional states can affect a person s behavior as they make decisions. For example, hunger may make people more impatient; they may then make riskier choices. Other negative emotional states that can change behavior include stress, pain, and sadness. By learning more about how…

   Stage

   Not phased

   Ages

   18 to 55

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Mental Health (NIMH)

   See if you can join NCT05666726 on ClinicalTrials.gov

2. Effects of Beef-Forward Ready-to-Eat Meals on Recovery Following Simulated Fire Suppression Activities

   This clinical trial aims to determine whether consuming beef-based protein before and after physically demanding simulated firefighting activities improves recovery, physical performance, and cognitive performance in healthy adult firefighters. The study will also compare beef-based protein meals w…

   Stage

   Not phased

   Ages

   18 to 60

   Site

   Bob Bolen Public Safety Complex Administration, Fort Worth, Texas

   Locations

   2 in total

   Run by

   Sam Houston State University

   See if you can join NCT07822048 on ClinicalTrials.gov

3. Effects of Pork Protein on Recovery Following Simulated Fireground Activity

   The goal of this clinical trial is to learn whether consuming pork-based protein before and after physically demanding simulated firefighting activities can improve recovery, physical performance, and cognitive performance in healthy adult firefighters. The study will also compare pork-based protei…

   Stage

   Not phased

   Ages

   18 to 60

   Site

   Bob Bolen Public Safety Complex Administration, Fort Worth, Texas

   Locations

   2 in total

   Run by

   Sam Houston State University

   See if you can join NCT07819565 on ClinicalTrials.gov

4. Impact of Peanut Consumption on Stress, Immune Function, Inflammation, and Cardiovascular Health in High-Stress Individuals

   The purpose of this research is to determine whether peanut consumption improves indicators of cardiovascular disease (CVD) risk in human subjects following the consumption of study foods.

   Stage

   Not phased

   Ages

   18 to 65

   Site

   Western Human Nutrition Research Center, Davis, California

   Run by

   USDA, Western Human Nutrition Research Center

   See if you can join NCT07735221 on ClinicalTrials.gov

5. Study of Cannabidiol and Neuroimaging on Stress

   Dysregulation in stress responsivity is a growing psychiatry-transdiagnostic fundamental phenomenon, with limited therapeutic strategies. With the legalization of medical and recreational cannabis, many people consume cannabidiol (CBD; a nonintoxicating cannabinoid) to alleviate stress response, wi…

   Stage

   Phase 1

   Ages

   18 to 25

   Site

   Ichan School of Medicine at Mount Sinai, New York, New York

   Run by

   Icahn School of Medicine at Mount Sinai

   See if you can join NCT07278505 on ClinicalTrials.gov

6. STRess Assessment of INterventional Cardiology Fellows and Attendings

   Interventional cardiology (IC) fellows and attendings experience high levels of stress. In a recent study, IC fellowship was considered very stressful by 22%, somewhat stressful by 62%, and not stressful by 16%(1). In a different study, 29% of the IC fellows considered leaving their job during the …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Minneapolis Heart Institute Foundation, Minneapolis, Minnesota

   Run by

   Minneapolis Heart Institute Foundation

   See if you can join NCT07804927 on ClinicalTrials.gov

7. The Impact of a Race-Based Stress Reduction Intervention

   The goal of this clinical trial is to learn whether a stress reduction program called Resilience, Stress, and Ethnicity (RiSE) improves well-being, inflammation, and the epigenome in African American (AA) women who have risk factors for heart or metabolic disease. The main question it aims to answe…

   Stage

   Not phased

   Ages

   50 to 75

   Site

   Loyola University Chicago, Maywood, Illinois

   Run by

   Loyola University

   See if you can join NCT05902741 on ClinicalTrials.gov

8. EEG-Guided Binaural Beat Audio to Reduce Performance-Related Stress and Improve Cognition

   Performance-related stress can impair sustained attention, inhibitory control, and memory. This randomized, double-blinded, sham-controlled parallel-arm trial evaluates whether a 30-minute EEG-guided binaural beat audio intervention reduces subjective stress/performance anxiety and improves cogniti…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Texas Tech University, Lubbock, Texas

   Run by

   Texas Tech University Health Sciences Center

   See if you can join NCT07407426 on ClinicalTrials.gov

9. Aromatherapy and Music Impact on Nurses' Stress at Work

   The purpose of the Doctor of Nursing Practice research project is to determine if nurses who receive chamomile-lavender aromatherapy and listen to music during a 20-minute break once per shift for 8 weeks, will experience report decreased work stress (measured by self-reported symptoms of anxiety) …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Northwestern Medicine Academic Medical Center, Chicago, Illinois

   Run by

   Northwestern University

   See if you can join NCT07732179 on ClinicalTrials.gov

10. Effects of Cannabidiol on Stress and Nicotine Withdrawal

    The purpose of this study is to examine the effect of doses of cannabidiol (CBD) during exposure to stress and nicotine withdrawal in nicotine users. The main objectives of the study include examining the effect CBD has on stress, tobacco dependence, tobacco withdrawal, and sex differences between …

    Stage

    Phase 1

    Ages

    21 to 70

    Site

    Behavioral Pharmacology Research Unit, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT07001930 on ClinicalTrials.gov

11. Supporting Mental Health and Reducing Care Stress in Caregivers of Persons With Cardiovascular Disease

    The purpose of this study is to evaluate the preliminary efficacy, feasibility, acceptability, and barriers and facilitators to implementation of the Confident Caregiver intervention among family caregivers of persons with cardiovascular disease participating in cardiac rehabilitation. Caregivers r…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of California Davis Health System, Sacramento, California

    Run by

    University of California, Davis

    See if you can join NCT07717723 on ClinicalTrials.gov

12. Internet Based Psychological Support

    The investigators have developed interactive, multimedia-intensive, computer-based treatment programs that include depression (Problem-Solving Therapy), stress management, and conflict management. Together the three modules are called PATH. The problem-solving module is based on an evidence-based p…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire

    Run by

    Dartmouth-Hitchcock Medical Center

    See if you can join NCT02726061 on ClinicalTrials.gov

13. Adaptive Coping Skills Training to Improve Psychological Distress Among Cardiorespiratory Failure Survivors

    Conditions treated in intensive care units (ICUs) such as the acute respiratory distress syndrome (ARDS), congestive heart failure, COVID pneumonia, and sepsis are common. These can lead to high rates of depression, anxiety, and PTSD that worsen quality of life. Yet there are few effective strategi…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Duke University Medical Center, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT06538246 on ClinicalTrials.gov

14. Cannabidiol (CBD) and Stress Response: Psychobiological Mechanisms

    The aim of this study is to determine the effects of regular cannabidiol (CBD) use on the psychobiological mechanisms of the stress response. This will be achieved by comparing acute stress responses of adults who either use or do not use CBD regularly. Correlates of CBD use, including tobacco use,…

    Stage

    Not phased

    Ages

    21 to 70

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT07069478 on ClinicalTrials.gov

15. Impact of Serial Bedside Video Calls on Stress Level in Parents of Infants Admitted to NICU

    The goal of this randomized prospective interventional study is to determine if serial bedside video calls w/audio feature to NICU parents in addition to the routine phone and/or bedside updates can reduce parental stress level. The main question it aims to answer is if the impact of audio-visual c…

    Stage

    Not phased

    Ages

    0 to 0

    Site

    John H. Stroger Hospital of Cook County, Chicago, Illinois

    Run by

    Cook County Health

    See if you can join NCT06252883 on ClinicalTrials.gov

16. Biofield Therapy for the Support of Immunotherapy-related Symptoms Among Adult Cancer Patients - A Pilot Study

    Cancer treatment with immunotherapy is often associated with symptoms such as fatigue, pain, and emotional distress, which may affect patients' daily functioning and quality of life. Additional supportive care approaches are being studied to better understand their potential role in supporting thes…

    Stage

    Not phased

    Ages

    18 and older

    Site

    UCI Health Susan Samueli Integrative Health Institute, Irvine, California

    Locations

    2 in total

    Run by

    University of California, Irvine

    See if you can join NCT07581080 on ClinicalTrials.gov

17. Efficacy and Safety of Magnesium Vitamin B6 in First Episode Bipolar Disorder

    This is a randomized, double-blind, placebo-controlled proof-of-concept clinical trial to assess the efficacy and safety of Magnesium-vitamin B6in combination with treatment as usual for treating symptoms of depression, stress, and anxiety in patients with first episode bipolar I disorder.

    Stage

    Phase 2

    Ages

    18 to 50

    Site

    McLean Hospital, Belmont, Massachusetts

    Run by

    Mclean Hospital

    See if you can join NCT05837104 on ClinicalTrials.gov

18. ACT Together: Implementing a Web-Based Program With Brief Coaching for Parents of Children With Disabilities in Pediatric Outpatient Clinics

    The goal of this clinical trial is to evaluate the feasibility, usability, and preliminary benefits of implementing ACT Together for parents of children with disabilities in pediatric outpatient clinics. ACT Together includes six self-paced, web-based modules and brief weekly one-on-one coaching se…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of South Florida, Tampa, Florida

    Run by

    University of South Florida

    See if you can join NCT07360600 on ClinicalTrials.gov

19. A Randomized Controlled Trial to Assess the Impact of Live and Recorded Music-Based Interventions on Pre-operative Stress, Mood, Pain and Biomarkers, in Neurosurgical Patients (Music-STAR Trial)

    The study plans to enroll a total of 132 patients. The goal of this study is to measure pre-and post-music intervention changes in patients' vital signs, serum- and plasma-level biomarkers by broad-spectrum proteomics analysis, metabolic analysis, and perceived pain, anxiety, and mood states as mea…

    Stage

    Not phased

    Ages

    18 and older

    Site

    MD Anderson Cancer Center, Houston, Texas

    Run by

    M.D. Anderson Cancer Center

    See if you can join NCT06536504 on ClinicalTrials.gov

20. Assessing MB-Spirit for Psychological Well-being

    The goal of this clinical trial is to test two new behavioral interventions designed to reduce stress and improve spiritual well-being in stressed adults. The main questions it aims to answer are: 1. Can the program decrease stress and improve spiritual well-being? 2. What brain changes accompany p…

    Stage

    Not phased

    Ages

    18 to 50

    Site

    149 13th St, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Sara W Lazar

    See if you can join NCT07325448 on ClinicalTrials.gov

21. Pilot Study Evaluating the Impact of Stress Reduction on Atherosclerotic : Heart and Mind Study

    The plot study aims to evaluate the effect of 8 weeks of stress reducing intervention on atherosclerotic plaque inflammation in adults, as quantified by positron emission tomography (PET) with fluorine-2-deoxy-D-glucose (FDG) in individuals with increased psychosocial stress.

    Stage

    Not phased

    Ages

    30 to 65

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT04496947 on ClinicalTrials.gov

22. Smartphone-based Cognitive Emotion Regulation Training for Unpaid Primary Caregivers of Persons With Alzheimer's Disease

    Alzheimer's Disease (AD) and Alzheimer's Disease-Related Dementias (ADRD) not only exact a heavy toll on patients, they also impose an enormous emotional, physical, and financial burden on unpaid, often family, caregivers. The strain of providing care for a loved one diagnosed with AD, often across…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Rice University, Houston, Texas

    Run by

    Bryan Denny

    See if you can join NCT05949047 on ClinicalTrials.gov

23. Stress Phenotypes and Preterm Birth

    Pregnancy ends in preterm birth (PTB) for approximately 1 in 10 women, though more often for Non-Hispanic Black women, 14.12% PTB rate, compared to 9.09% for Non-Hispanic White women. Psychosocial stress and childhood trauma each are associated with risk for PTB and PTB has an intergenerational imp…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Columbia University Irving Medical Center, New York, New York

    Run by

    Columbia University

    See if you can join NCT05229666 on ClinicalTrials.gov

24. Intranasal Oxytocin Intervention for Caregivers to Persons With Dementia

    More than 15 million family caregivers provide support for individuals with Alzheimer's disease (AD) or related dementias. This number is expected to grow with the increasing population of persons with dementia (PWD). Stress in caregivers to older adults with chronic diseases is already a significa…

    Stage

    Phase 2

    Ages

    50 and older

    Site

    University of Nebraska Medical Center, Department of Psychiatry, Omaha, Nebraska

    Run by

    University of Nebraska

    See if you can join NCT06364228 on ClinicalTrials.gov

25. Community Health Worker Navigation to Support Mental Health

    This pilot study tests the feasibility and preliminary impact of a protocolized promotora-led navigation intervention to improve behavioral health access among Latinx and Native American underserved adults. The study is embedded within a community cultural center, leveraging a trusted and culturall…

    Stage

    Not phased

    Ages

    18 to 120

    Site

    Cultura Y Arte Nativa De Las Americas, San Francisco, California

    Run by

    University of California, Riverside

    See if you can join NCT07387146 on ClinicalTrials.gov